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Helen Diller Family Compr Cancer Ctr
RESEARCH & TRAINING:Breast Cancer SPORE

Project:
Screening Breast MRI Use in Women at High Risk of Breast Cancer

Principal Investigator - Mary Beattie, MD, MAS


ABSTRACT

Background
Screening breast MRI is recommended by the American Cancer Society in BRCA carriers, their first-degree relatives, and in women with lifetime breast cancer risks of over 20%. The uptake of screening breast MRI in these high risk groups is unknown. It is also not known how many women who receive screening breast MRI are truly at high risk. False-positive MRIs are a growing problem, and as MRI becomes more popular, it will become necessary to identify predictors for false-positive MRI.

Research Questions

  1. Are women at the highest risk of breast cancer receiving screening breast MRI?
  2. Are women who uptake screening breast MRI at the highest risk of breast cancer?
  3. In practice, what is the false-positive rate of screening breast MRIs and what factors predict false-positive screening breast MRI?

Methods
This research will leverage the recently completed 2008 Cancer Risk Program (CRP) Survey with carefully collected clinical data in a cohort of over 1000 women at high risk of hereditary breast cancer. For RQ1, we will identify all women who meet American Cancer Society (ACS) criteria for screening breast MRI. For each ACS criteria, we will determine the proportion of women who undergo screening breast MRI and predictors of receiving this screen. For RQ2, we will identify all women who have received screening breast MRI and we will calculate their 10-year and lifetime breast cancer risks using 3 models: BRCAPRO, Claus, and Gail. We will examine any association between breast cancer risk and uptake of screening breast MRI. For RQ3, we will verify all screening breast MRI results and determine false-positive rates. We will also examine predictors for false-positive screening breast MRIs.

Strengths

  • Unique cohort of over 1000 high-risk women, > 80% follow-up
  • Carefully collected and verified family histories and BRCA results
  • Precise estimates of breast cancer risk using 3 models
  • Up to the moment

 

 

 

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