HIV Malignancies Symposium

November 21, 2013, 1:00 pm – 5:00 pm


Hosted by the Cancer, Immunity, and the Microenvironment Program of the UCSF Helen Diller Family Comprehensive Cancer Center (HDFCCC).

Unlike the classic AIDS-defining malignancies, the incidence of many non-AIDS-defining malignancies, including HPV-associated malignancies, in HIV-infected men and women has increased since the introduction of antiretroviral therapy. At the same time, there is a critical need for new approaches in the field of HIV-related malignancies and their precursors. The mechanisms underlying the increased risk of HIV-associated cancers in the setting of HIV infection remain poorly understood. Newer, targeted molecular approaches to prevention or treatment of cancers occurring in the setting of HIV infection are urgently needed.

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1:00 pm – 1:05 pm Welcome
Joel Palefsky, MD
1:05 pm – 1:15 pm Historical Perspective of HIV-Malignancies
John Ziegler, MD, MSc
Session 1: Epidemiology and Treatment of AIDS Malignancies
1:15 pm – 1:40 pm Changing Incidence of AIDS-defining and Non-AIDS-defining Malignancies
Eric Engels, MD, MPH
1:40 pm – 2:05 pm

Kaposi’s Sarcoma in the ART era in Resource Limited Settings
Jeffrey Martin, MD, MPH

Session 2: HPV-Related Malignancies
2:05 pm – 2:30 pm Development of a Therapeutic HPV Vaccine
T.C. Wu, MD, PhD, MPH
2:30 pm – 2:55 pm HIV-HPV Interactions in HPV-Associated Neoplasia
Sharof Tugizov, DVM, PhD, DSc
2:55 pm – 3:10 pm Break
Session 3: HIV-Related Lymphoma
3:10 pm – 3:35 pm Evolving Treatment of Lymphoma
Lawrence Kaplan, MD
3:35 pm – 4:00 pm Topology of the Hosthogen Genome
JJ Miranda, PhD
Session 4: Kaposi's Sarcoma
4:00 pm – 4:25 pm Kaposi's Sarcoma in the Post-ART Era
Toby Maurer, MD
4:00 pm – 4:50 pm Validation of KSHV Protease as a Therapeutic Target through Allosteric Inhibition
Charles Craik, PhD
4:50 pm – 5:00 pm Wrap-Up
Lewis Lanier, PhD


Organizer Description:

UCSF HDFCCC Cancer, Immunity, and the Microenvironment Program

The HDFCCC has long been active in the field of HIV-related malignancies research. Much of this research is centered in the HDFCCC Cancer, Immunity, and the Microenvironment Program. A scientific goal of the Program is to study the relationship between viral infections and malignancy, particularly in immunodeficient patients with HIV infection, and to develop new approaches for the prevention and treatment of malignancy in this population.


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Jordan Brainerd

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