University of California San Francisco
Helen Diller Family Comprehensive Cancer Center

Breast Oncology Program Seminar

January 10, 2018, 8:30 am – 10:00 am

Mount Zion
2340 Sutter Street
Lurie Seminar Room
San Francisco, CA 94143

Marleen Kok, MD, PhD, Netherlands Cancer Institute   >view speaker profile

Title: Strategies to improve response to immune checkpoint blockade in breast cancer

Abstract: Immunotherapeutic interventions that reactivate the endogenous tumor-specific T cell compartment form the most significant development in cancer treatment of the past decade. Although anti-PD(L)1 monotherapy can result in durable responses in patients with metastatic breast cancer, only a small subgroup has substantial clinical benefit. Therefore, our research projects focus on the identification of classical treatment strategies that render the breast tumor micro-environment more sensitive to PD-1 blockade. First data of our adaptive phase II clinical trial in metastatic TNBC evaluating response to anti-PD1 after immune induction using low dose chemotherapy or radiation will be presented.

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