University of California San Francisco
Helen Diller Family Comprehensive Cancer Center

Breast Oncology Program Seminar

January 24, 2018, 8:30 am – 10:00 am

Mount Zion
2340 Sutter Street
Lurie Seminar Room
San Francisco, CA

Tak Mak, PhD, Senior Scientist, Princess Margaret Cancer Centre   >view speaker profile

Title: From Bench to Bedside: Targeting Genomic Instability in Cancer

Abstract: The maintenance of genomic integrity is essential for organism survival and inheritance of genetic information to offspring. Interestingly, organisms have developed the ability to maintain the integrity of the genome while allowing specific mutational and genomic changes to occur and drive adaptation and evolution. This ability has been achieved by a coordinated interplay of different mechanisms of DNA repair. However, defects in maintaining genomic stability can occur and are associated with susceptibility to cancer, abnormal immune responses, and genetic diseases. Since breast cancer, like many other cancers is a heterogeneous disease, we will explore the role of genomic instability in each subtype of breast cancer, as defined by advanced genomic and expression profiling studies. This concept has been exploited successfully to the treatment of BRCA mutated ovarian cancer with PARP inhibitors. Development of anti-cancer therapeutics based on utilizing this approach will be described.

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