University of California San Francisco
Helen Diller Family Comprehensive Cancer Center

Breast Oncology Program Seminar

February 28, 2018, 8:30 am – 10:00 am

Mount Zion
2340 Sutter Street
Lurie Seminar Room
San Francisco, CA

Donald McDonnell, PhD, Professor of MCB and Chairman, Department of Pharmacology and Cancer Biology, Duke University School of Medicine   >view speaker profile

Title: Identification of targetable proteins and processes downstream of steroid receptors in breast and prostate cancers

Abstract: The focus of the research in our group continues to be the development of strategies to target estrogen and androgen signaling pathways in breast and prostate cancer. Our most recent efforts in this regard have focused on identifying proteins and processes downstream of these receptors that can be targeted in cancer. This shift in emphasis reflects the growing feeling in the field that breast and prostate cancer cells are so addicted to AR and ER that inhibition of these receptors results in the compensatory up regulation of processes that increase the activity of the receptors (i.e. up regulation of coregulators or receptors), select for gain of function receptor mutations and/or splice variants, or which increase the intratumoral production of estrogens and androgens. Given that these receptors are key components in endocrine feedback loops that modulate their activity, such compensatory responses are hardwired into these signaling pathways. This understanding has directed us to explore the feasibility of targeting proteins/processes that are downstream of these receptors and which are not in and of themselves involved in feedback signaling. It is anticipated that the activity of such targets would not be self-limited by increased activity of the receptor signaling pathways.


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