Breast Oncology Program Seminar

May 30, 2018, 8:30 am – 10:00 am

Mount Zion
2340 Sutter Street
Lurie Seminar Room
San Francisco, CA 94143

Zena Werb, PhD, UCSF >view speaker profile

Title: Myeloid Cell Skewing in Response to Breast Cancer

Abstract: Cancer immunotherapy has proven to be a promising treatment improving the survival of patients with cancer; however, currently there are no immunotherapies available for advanced breast cancer. Most immunotherapies target T cells, whereas few are directly targeted to myeloid cells, which are critical regulators of tumor growth and metastasis. Within monocytes/macrophages and neutrophils there are subpopulations that can be either pro-tumor or anti-tumor. This seminar will examine the heterogeneity of myeloid cells accumulating in primary breast cancers and metastases and the mechanisms by which they are generated.