University of California San Francisco
Helen Diller Family Comprehensive Cancer Center

Breast Oncology Program Seminar

May 23, 2018, 8:30 am – 10:00 am

Mount Zion
2340 Sutter Street
Lurie Seminar Room
San Francisco, CA

Alexander D. Borowsky, MD, UC Davis   >view speaker profile

Title: The Precancer Problem: What mouse MIN can teach us about DCIS

Abstract: DCIS is the obligate precursor to invasive mammary carcinoma, but progression rates vary from immediate to never. Although there are many cytomorphologic and molecular correlations, even the definition of DCIS is imprecise, relying on decades old epidemiological assessment of invasive cancer occurrence. In mice, precancer can be defined experimentally, and the processes related to progression can be determined. In these model systems, precancer metabolism affects the regional tumor microenvironment, potentially conditioning and creating a tumor promoting environment.

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