University of California San Francisco
Helen Diller Family Comprehensive Cancer Center

Breast Oncology Program Seminar

September 25, 2019, 8:30 am – 10:00 am

Mount Zion
2340 Sutter Street
Lurie Seminar Room
San Francisco, CA 94143

Jennifer Rosenbluth, MD, PhD, Dana Farber Cancer Institute   >view speaker profile

Title: Modeling cancer prevention in breast organoids

Abstract: We demonstrate that mammary organoids can be used to preserve complex lineages in long-term culture. Using mass cytometry to profile cell states in patient-derived breast organoids, we identify a specific cell population that is expanded in the breast tissue of BRCA1/2 mutation carriers. This approach is being extended to model early stages of cancer development as well as aggressive breast cancer subtypes.

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