University of California San Francisco
Helen Diller Family Comprehensive Cancer Center

Conference 2015

Third International Biannual Evolution and Cancer Conference (IBECC 2015)

Theme: Evolutionary Tradeoffs and Clinical Consequences

Thursday, December 10th at 5:00 pm -
Sunday, December 13th at 12:00 pm

Mission Bay Conference Center, San Francisco

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About this Conference

IBECC brings together cancer researchers, clinicians, evolutionary biologists and social scientists from across the world to address the applications of evolutionary thinking to cancer research and treatment.

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IBECC 2015: Evolutionary Tradeoffs and Clinical Consequences

Tradeoffs are pervasive in biological systems, and the evolutionary dynamics underlying cancer are no exception. The Third International Biannual Evolution and Cancer Conference (IBECC) explores the ways in which tradeoffs have shaped the evolution of cancer suppression systems and the role of tradeoffs in the progression of tumors from benign to malignant. A consideration of evolutionary tradeoffs can also help us to identify challenges and opportunities in cancer therapy and new horizons for cancer prevention.

We welcome scientists coming from different disciplines, including but not limited to oncology, cell biology, evolutionary biology and mathematics. Abstract submissions relating to the theme of evolutionary tradeoffs and clinical consequences are encouraged but submission on all evolution and ecology of cancer topics are welcome.



Thursday, December 10, 2015  |  Hotel Nikko, San Francisco
3:00 pm - 8:00 pm


5:00 pm - 6:00 pm

Welcome Reception (wine, beer, appetizers)

6:00 pm - 7:00 pm

Evolution Keynote Address
How Bacteria and Cancer Cells Regulate Mutagenesis and Their Ability to Evolve

Susan Rosenberg, PhD
Baylor College of Medicine

Friday, December 11, 2015  |  Mission Bay Conference Center
7:15 am

Shuttle departs from Hotel Nikko

8:00 am - 6:00 pm

Registration (coffee and light breakfast served)

9:00 am - 10:00 am

Cancer as a Component of Life-History Theory 

Hanna Kokko, PhD 
University of Zurich

10:00 am - 10:30 am

Poster flash talks (Chair: Amy Boddy)

10:30 am - 11:00 am

Coffee break

11:00 am - 12:20 am

Morning Session: Organismal Evolution & Peto's Paradox (Chair: Josh Schiffman)

  1. Josh Schiffman, The Power of Comparative Oncology
  2. Michael Hochberg, Coevolution between Cancer Defense and Life-History as a Basis for Understanding Peto's Paradox
  3. Robert Noble, Peto's Paradox and Human Cancers
  4. Leonard Nunney, The Trade-Off between Height and Cancer
12:20 pm - 1:45 pm


1:45 pm - 2:45 pm

Losing despite Winning and Winning despite Losing: Life History Tradeoffs and Vulnerability to Cancer

Sarah Hill, PhD
Texas Christian University

2:45 pm - 3:00 pm

Coffee break

3:00 pm - 4:00 pm

Afternoon Session: Somatic Evolution & Cancer Stem Cells (Chair: Leonard Nunney)

  1. James DeGregori, Connecting cancer to aging - An evolutionary approach using in vivo and silico modeling
  2. Lucie Laplane, Causal relationship between CSCs and clonal evolution - Analysis from a philosopher
  3. Vincent Cannataro, Quantifying the burden of somatic evolution in the context of small stem cell population sizes, aging, and cancer
4:00 pm - 5:30 pm

Poster Session and Reception (wine, beer, appetizers)

5:30 pm - 6:30 pm

Public Lecture
The Evolutionary Connection: How Veterinary Science Can Transform Human Medicine

Barbara Natterson-Horowitz, MD
University of California, Los Angeles

6:45 pm

Shuttle departs from Mission Bay Conference Center; returns to Hotel Nikko

7:30 pm

Invited Speaker & Program Committee Dinner (Waterfront, Pier 7, The Embarcadero)

Saturday, December 12, 2015  |  Mission Bay Conference Center
7:15 am

Shuttle departs from Hotel Nikko

8:00 am - 6:00 pm

Registration (coffee and light breakfast served)

9:00 am - 10:00 am

Bottom of the Heap: Early-Life Social Adversity Affects Cellular Aging in the European Starling

Daniel Nettle, PhD
Newcastle University

10:00 am - 10:30 am

Coffee break

10:30 am - 12:30 pm

Parallel Session A: Tumor Heterogeneity (Chair: Carlo Maley)

  1. Oana Carja, The evolutionary tradeoff of phenotypic heterogeneity in cancer cell populations
  2. Henry Heng, Effective drug treatment drives drug resistance through rapid genome alteration-mediated cancer evolution
  3. Diego Mallo, Agent-based simulation of somatic evolution: Modeling the progression of Barrett’s esophagus to Esophageal adenocarcinoma
  4. Diego Chowell, Dynamics of clonal evolution in cancer cell populations
  5. Pierre Martinez, Longitudinal single cell clonal analysis reveals evolutionary stasis and predetermined malignant potential in non-dysplastic Barrett’s esophagus
  6. Jeffrey Townsend, Metastatic lineages can arise early and originate from multiple lineages within primary tumors
10:30 am - 12:30 pm

Parallel Session B: Methods and Experimental Biology (Chair: Michael Hochberg)

  1. Robert Beardmore, Stable genetic polymorphisms from trade-offs in simple (and fairly simple) environments
  2. Carlos Reding, Resource-dependent growth efficiency supports, and extends, the `r-K selection theory'
  3. Ivana Gudelj, The shape of a trade-off underpins diversity
  4. Luca Ermini, An evolutionary perspective on cancer susceptibility in humans
  5. Mary Kuhner, Hazards of the driver/passenger paradigm
12:30 pm - 2:00 pm


2:00 pm - 3:00 pm

Mechanisms of Coexistence and Tumor Heterogeneity

Joel Brown, PhD
University of Illinois

3:00 pm - 3:30 pm

Coffee break

3:30 pm - 4:50 pm

Afternoon Session: Evolutionary Approaches to Cancer Treatment (Chair: Amy Boddy)

  1. Mark Robertson-Tessi, Harnessing phenotypic plasticity and heterogeneity to design better combination therapies
  2. Amy Boddy, Using agent-based modeling to understand the emergence of resistant cancer phenotypes
  3. Chandler Gatenbee, The importance of space in immune escape strategies: An evolutionary game
  4. William Chang, Modeling ecological therapy against tumor-associated macrophages in glioblastoma
4:50 pm - 5:30 pm

International Society for Evolution, Ecology, and Cancer (ISEEC) business meeting

5:30 pm - 6:15 pm

Reception (wine, beer, appetizers)

6:15 pm - 7:15 pm

Cancer Keynote Address
Reconstructing and Predicting Cancer Evolution

Marco Gerlinger, MD
The Institute of Cancer Research, London

7:30 pm

Shuttle departs from Mission Bay Conference Center; returns to Hotel Nikko

Sunday, December 13, 2015  |  Mission Bay Conference Center
7:15 am

Shuttle departs from Hotel Nikko

8:00 am

Coffee and light breakfast served

9:00 am - 10:00 am

Exploiting Trade-Offs to Expose Cancer’s Evolutionary Vulnerabilities

Aurora Nedelcu, PhD
University of New Brunswick

10:00 am - 10:30 am

Coffee break

10:30 am - 12:30 pm

Morning Session: Cancer and the Evolution of Life (Chair: Athena Aktipis)

  1. Frederic Thomas, Cancer and life-history traits: lessons from host-parasite interactions
  2. Athena Aktipis, Multicellularity and cancer susceptibility: Costs, benefits and tradeoffs in scaling up cellular cooperation
  3. Jekaterina Erenpreisa, Evolution of life-cycles, sex, and cancer
  4. Carlo Maley, Evolution’s solutions to the big problems in cancer
12:30 pm

Conference ends

12:45 pm

Shuttle departs from Mission Bay Conference Center; service to Ferry Terminal Building or Hotel Nikko


Abstract submissions are now closed. Selections will be made by November 10th.

Travel Information


San Francisco International Airport (SFO) is the closest major airport. Alternatively, the Oakland International Airport (OAK) is a 40-minute drive over the Bay Bridge and is also accessible by BART.


Hotel Nikko is the official hotel for IBEEC 2015. A block of rooms is available for conference attendees at the discounted rate of $209/night + 16.445% occupancy tax. To book a room, call the hotel (415-403-1800) and mention the "International Biannual Evolution and Cancer Conference" or book online.

Hotel Nikko
222 Mason Street San Francisco, CA 94102

Ground Transportation

Taxis or the BART (Bay Area Regional Transportation) are both good options for transportation from the airport to Hotel Nikko. If you take BART, you can go directly from the airport to the Powell stop and Hotel Nikko is a 5 minute walk.

Conference Shuttle

A daily shuttle will be provided once per morning and once per afternoon. The shuttle will depart from Hotel Nikko at 7:15am on Friday, Saturday, and Sunday. The shuttle will depart from Mission Bay Conference Center and return to the hotel at 6:45pm on Friday, 7:30 pm on Saturday, and 12:45pm on Sunday. (The shuttle times are also represented in the agenda above.)

If the shuttle times are inconvenient, you can take a taxi or the Muni K/T line, which runs right alongside the UCSF Mission Bay campus.


For questions about registration, please contact Sara Brashier at