University of California San Francisco
Helen Diller Family Comprehensive Cancer Center

Margaret Tempero, MD

Gastrointestinal Oncology UCSF

Our Care Team

Dr. Margaret Tempero is Director, UCSF Pancreas Center and Rombauer Family Distinguished Professorship in Pancreas Cancer Clinical and Translational Science at the UCSF Helen Diller Family Comprehensive Cancer Center. 

Her research career has focused on pancreatic ductal adenocarcinoma especially in the area of investigational therapeutics. She was a pioneer in the use of antibody-based therapies and helped develop the fixed dose rate concept for gemcitabine. Her group has developed effective gemcitabine combinations and provided a foundation for using CA19-9 as a surrogate for survival in clinical trials. Currently her group is assessing molecular subtypes and molecular enrichment for selecting new drugs for clinical evaluation. 

Dr. Tempero recently served on the Oncology Drug Advisory Committee for the FDA. She served as Deputy Director and Interim Director for the UNMC Eppley Cancer Center until 1999, Chief Emeritus of the Division of Medical Oncology at UCSF (2000 – 2007) and Deputy Director and Director of Research Programs at the UCSF Helen Diller Family Comprehensive Cancer Center (HDFCCC) from 2000 to 2012.