Study Sheds Light on Angiogenesis Inhibitors, Points to Limitations, Solutions

March 2, 2009

A new generation of cancer drugs designed to starve tumors of their blood supply -- called "angiogenesis inhibitors" -- succeeds at first, but then promotes more invasive cancer growth -- sometimes with a higher incidence of metastases, according to a new study in animals. The ...

UCSF Center to Host Symposium on Tobacco Research and Education

February 18, 2009

Tobacco affects about a billion lives globally each year. According to the World Health Organization (WHO), tobacco kills about half of those who use it. Most of tobacco's damages don't become apparent until decades after a person begins using it. On Friday, Feb. 20, the ...

Aggressive Treatment, Fighting Spirit Help UCSF Cancer Patient Beat the Odds

February 11, 2009

One of the first things you notice about Lori Nichols is her smile. It fills the space around her with light and warmth and draws people in closer, especially when it's accompanied by her easy, musical laugh. "My life has been just wonderful," Nichols tells ...

Cancer Drug Cost May Be Unbearable, Even for Insured

February 10, 2009

Cancer doctors may be writing the prescriptions for new generations of drugs, but some financially hard-pressed patients are not having those prescriptions filled. The trend is worsening, according to Marilyn Stebbins, PharmD, health sciences clinical professor of pharmacy at UCSF. Stebbins, the pharmacy utilization director ...

Drug Discovery Short-circuits Cancer Growth

February 9, 2009

A new drug that blocks cancer's main source of growth has been created in the lab and proven effective in mice, scientists are reporting. It is now being readied for clinical trials in patients. Far more potent than similar compounds already in clinical trial, the ...

Lung Cancer Now Is the Focus of Powerful Genetics Research

February 4, 2009

Lung cancer research at UCSF is poised to leap forward, thanks to a big bank. No, not some teetering financial institution down the street. What UCSF has is an invaluable tissue bank. When it comes to lung tumors, the quantity and quality of UCSF's chilly-vault ...

Brain Cells Growing Bad: A Conversation with David Rowitch

February 2, 2009

The deadliest brain cancers, called gliomas, remain somewhat mysterious to researchers, which may be why they are difficult to treat. Recently, a molecule called olig has emerged as a prime suspect from the lab of physician-researcher David Rowitch, MD, and his longtime collaborator, Charles D.

Hypertension Lowers Survival in African American Women with Breast Cancer

January 27, 2009

Higher rates of hypertension in African American women compared with white women may account for some of the previously found racial disparities in overall survival among women with breast cancer, according to new research. UCSF epidemiologist Dejana Braithwaite, PhD, is among the significant number of ...

Cancer-causing Gene Discovery Suggests New Therapies

January 23, 2009

Scientists have discovered a novel way by which a much-studied cancer-promoting gene accelerates the disease. The finding suggests a new strategy to halt cancer's progress. Up to now, research has largely focused on how the mutated gene, Myc, disrupts the ability of DNA to be ...

In a Human Virus, New Method to ID MicroRNA Targets Proves Its Value

January 20, 2009

MicroRNAs are a very important, newly recognized type of molecule naturally encoded within the human genome. MicroRNAs, or miRNAs, help determine which gene products are produced in a cell. Some miRNAs have been found to act abnormally in cancers, and a few years ago miRNAs ...