Neil J. Risch, PhD

California Institute of Technology, BS, 1972, Mathematics
Univ of Illinois at Urbana, MS, 1973, Mathematics
Univ of California, Los Angeles, PhD, 1979, Biomathematics

• 1972-1973
  Teaching Assistant in Mathematics, University of Illinois
• 1973-1976
  Medical Statistician, Brentwood-Los Angeles VA Hospital
• 1974-1975
  UCLA Regents Fellowship
• 1975-1978
  NIH Genetics Traineeship, UCLA
• 1979-1982
  Research Scientist, Dept. of Med. Genetics, New York State Psychiatric Institute
• 1980-1981
  Research Associate, Dept. of Psychiatry, Columbia Univ. College of Physicians and Surgeons
• 1981-1984
  Asst. Prof. of Public Health (Biostatistics) in Psychiatry, Columbia University
• 1984-1987
  Asst. Prof. of Public Health (Biostatistics) and Genetics, Yale Univ. School of Medicine
• 1987-1992
  Assoc. Prof. of Public Health (Biostatistics) and Genetics, Yale Univ. School of Medicine
• 1992-1994
  Prof. of Public Health (Biostatistics) and Genetics, Yale Univ. School of Medicine
• 1995-2004
  Prof. of Genetics, Stanford University School of Medicine
• 1997-2004
  Prof. of Statistics (by courtesy), Stanford University
• 2005-present
  Prof. of Epidemiology and Biostatistics, Lamond Family Foundation Distinguished Professorship in Human Genetics, UCSF

• 1972
  University Fellow, University of Illinois
• 1974
  UCLA Regents Fellow
• 1978
  UCLA University Fellow
• 1987
  NIH Research Career Development Award
• 1987
  American Mental Health Fund Research Award
• 1993
  Honorary Master of Arts Degree, Yale University
• 2004
  Curt Stern Award, Amer Society of Human Genetics
• 2005
  First Interviewee, PLoS Genetics

• Hallmayer, J., Glasson E.J., Bower, C., Petterson, B., Croen, L., Grether, J., Risch, N. "On the twin risk in autism." Am J Hum Genet 71:941-946, 2002
• Shifman, S., Bronstein, M., Sternfeld, M., Pisante-Shalom, A., Lev-Lehman, E., Weizman, A., Reznik, I., Spivak, B., Grisaru, N., Karp, L., Schiffer R., Kotler, M., Strous, R.D., Swartz-Vanetik, M., Knobler, H.Y., Shinar, E., Beckmann, J.S., Yakir, B., Risch, N., Zak, N.B., Darvasi, A. "A highly significant association between COMT haplotype and schizophrenia." Am J Hum Genet 71:1296-1302, 2002
• Bressman, S.B., Raymond, D., Wendt, K., Saunders-Pullman, R., DeLeon, D., Fahn, S., Ozelius, L., Risch, N. "Diagnostic criteria for dystonia in DYT1 families." Neurology 10:1780-1782, 2002
• Ranade, K., Hinds, D., Hsiung, A., Chuang, L-M., Chang, M-S., Chen, Y-T., Pesich, R., Hebert, J., Chen, Y.I., Dzau, V., Olshen, R., Curb, D., Botstein, D., Cox, D.R., Risch, N. "A genome scan for hypertension susceptibility loci in populations of Chinese and Japanese origins." Am J Hypertens 16:158-162, 2003
• Kim, U.K., Jorgenson, E., Coon, H., Leppert, M., Risch, N., Drayna, D. "Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide." Science 299:1221-1225, 2003
• Botstein, D., Risch, N. "Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease." Nat Genet 33 Suppl:228-237, 2003
• Risch, N., Tang, H., Katzenstein, H., Ekstein, J. "Geographic distribution of disease mutations in the Ashkenazi Jewish population supports genetic drift over selection." Am J Hum Genet 72:812-822, 2003
• Burchard, E.G., Ziv, E., Coyle, N., Lin-Gomez, S., Tang, H., Karter, A.J., Mountain, J.L, Perez-Stable, E.J., Sheppard, D., Risch, N. "The importance of race and ethnic background in biomedical research and clinical practice." N Engl J Med 348:1170-1175, 2003
• Merikangas, K.R., Risch, N. "Will the genomics revolution revolutionize psychiatry?" Am J Psychiatry 160:625-635, 2003
• Leabman, M.K., Huang, C.C., DeYoung, J., Carlson, E.J., Taylor, T.R., de la Cruz, M., Johns, S.J., Stryke, D., Kawamoto, M., Urban, T.J., Kroetz, D.L., Ferrin, T.E., Clark, A.G., Risch, N., Herskowitz, I., Giacomini, K.M. "Natural variation in human membrane transporter genes reveals evolutionary and functional constraints." Proc Natl Acad Sci USA 100:5896-5901, 2003
• Willer, C.J., Dyment, D.A., Risch, N.J., Sadovnick, A.D., Ebers, G.C. "Twin concordance and sibling recurrence rates in multiple sclerosis." Proc Natl Acad Sci USA 100:12877-12882, 2003
• McIntire, J.J., Umetsu, S.E., Macaubas, C., Hoyte, E.G., Cinnioglu, C., Cavalli-Sforza, L.L., Barsh, G.S., Hallmayer, J.F., Underhill, P.A., Risch, N.J., Freeman, G.J., DeKruyff, R.H., Umetsu, D.T. "Immunology: hepatitis A virus link to atopic disease." Nature 425:576, 2003
• Varon-Mateeva, R., Gooding, R., Steglich, C., Marns, L., Tang, H., Angelicheva, D., Yong, K.K., Ambrugger, P., Reinhold, A., Morar, B., Baas, F., Kwa, M., Tournev, I., Guerguelcheva, V., Kremensky, I., Lochmuller, H., Mullner-Eidenbock, A., Merlini, L., Neumann, L., Burger, J., Walter, M., Swoboda, K., Thomas, P.K., von Moers, A., Risch, N., Kalaydjieva, L. "Partial deficiency of the C-terminal-domain phosphatase of RNA polymerase II is associated with congenital cataracts facial dysmorphism neuropathy syndrome." Nat Genet 35:185-189, 2003
• Tukel, T., Shalata, A., Present, D., Rachmilewitz, D., Mayer, L., Grant, D., Risch, N., Desnick, R.J. "Crohn disease: frequency and nature of CARD15 mutations in Ashkenazi and Sephardi/Oriental Jewish families." Am J Hum Genet 74:623-636, 2004
• Li, J., Nguyen, L., Gleason, C., Lotspeich, L., Spiker, D., Risch, N., Myers, R.M. "Lack of evidence for an association between WNT2 and RELN polymorphisms and autism." Am J Med Genet 126B:51-57, 2004
• Dyment, D.A., Sadovnick, A.D., Willer, C.J., Armstrong, H., Cader, Z.M., Wiltshire, S., Kalman, B., Risch, N., Ebers, G.C. "An extended genome scan in 442 Canadian multiple sclerosis-affected sibships: a report from the Canadian Collaborative Study Group." Hum Mol Genet 13:1005-1015, 2004
• Ebers, G.C., Sadovnick, A.D., Dyment, D.A., Yee, I.M., Willer, C.J., Risch, N. "Parent-of-origin effect in multiple sclerosis: observations in half siblings." Lancet 363:1773-1774, 2004
• Dyment, D.A., Steckley, J.L., Morrison, K., Willer, C.J., Cader, M.Z., DeLuca, G.C., Sadovnick, A.D., Risch, N., Ebers, G.C. "TCR beta polymorphisms and multiple sclerosis." Genes Immun 5:337-342, 2004
• Huang, J., Lin, A., Narasimhan, B., Quertermous, T., Hsuing, C.A., Ho, L.T., Grove, J.S., Olivier, M., Ranade, K., Risch, N.J., Olshen, R.A. "Tree-structured supervised learning and the genetics of hypertension." Proc Natl Acad Sci USA 101:10529-10534, 2004
• Ekstein, J., Rubin, B.Y., Anderson, S.L., Weinstein, D.A., Bach, G., Abeliovich, D., Webb, M., Risch, N. "Mutation frequencies for glycogen storage disease Ia in the Ashkenazi Jewish population." Am J Med Genet 30;129A(2):162-4, 2004
• Heiman, G.A., Ottman, R., Saunders-Pullman, R.J., Ozelius, L.J., Risch, N.J., Bressman, S.B. "Increased risk for recurrent depression in DYT1 dystonia mutation carriers." Neurology 24;63(4):631-7. 2004
• Mountain, J.L., Risch, N. "Assessing genetic contributions to phenotypic differences among 'racial' and 'ethnic' groups." Nat Genet 36(11 suppl):S48-53, 2004
• Tang, H., Quertermous, T., Rodriguez, B., Kardia, S.L., Zhu, X., Brown, A., Pankow, J.S., Province, M.A., Hunt, S.C., Boerwinkle, E., Shork, N.J., Risch, N.J. "Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies." Am J Hum Genet, 76(2):268-75, 2005
• Jorgenson, E., Tang, H., Gadde, M., Province, M., Leppert, M., Kardia, S., Schork, N., Cooper, R., Rao, D.C., Boerwinkle, E., Risch, N. "Ethnicity and human genetic linkage maps." Am J Human Genet 76(2):276-90, 2005. Winner of the Cotterman Prize, American Society of Human Genetics, 2005.
• Zhu, X., Luke, A., Cooper, R.S., Quertermous, T., Hanis, C., Mosley, T., Gu, C.C., Tang, H., Rao, D.C., Risch, N., Weder, A. "Admixture mapping for hypertension loci with genome-scan markers." Nat Genet 37(2):177-81, 2005
• Urban, T.J., Giacomini, K.M., Risch, N. "Haplotype structure and ethnic-specific allele frequencies at the OCTN locus: implications for the genetics of Chrohn's disease." Inflamm Bowel Dis 11(1):78-9, 2005
• Tang, H., Peng, J., Wang, P., Risch, N.J. "Estimation of individual admixture: analytical and study design considerations." Genet Epidemiol 28:289-301, 2005
• Chiu, Y.F., Chuang, L.M, Hsiao, C.F., Hung, Y.J., Lin, M.W, Chen, Y.T., Grove, J., Jorgenson, E., Quertermous, T., Risch, N., Hsiung, C.A. "An autosomal genome-wide scan for loci linked to pre-diabetic phenotypes in nondiabetic Chinese subjects from the Stanford Asia-Pacific Program of Hypertension and Insulin Resistence Family Study." Diabetes 54:1200-6, 2005
• Salari, K., Choudhry, S., Tang, H., Naqvi, M., Lind, D., Avila, P.C., Coyle, N.E., Ung, N., Nazario, S., Casal, J., Torres-Palacios, A., Clark, S., Phong, A., Gomez, I., Matallana, H., Perez-Stable, E.J., Shriver, M.D., Kwok, P.Y., Sheppard, D., Rodriguez-Cintron, W., Risch, N.J., Burchard, E.G., Ziv, E. "Genetic admixture and asthma-related phenotypes in Mexican American and Puerto Rican asthmatics." Genet Epidemiol 29:76-86, 2005
• Dyment, D.A., Herrera, B.M., Cader, M.Z., Willer, C.J., Lincoln, M.R., Sadovnick, A.D., Risch, N., Ebers, G.C. "Complex interactions among MHC haplotypes in multiple sclerosis: susceptibility and resistance." Hum Mol Genet 14:2019-26, 2005
• Gonzalez Burchard, E., Borrell, L.N., Choudhry, S., Naqvi, M., Tsai, H.J., Rodriguez-Santana, J.R., Chapela, R., Rogers, S.D., Mei, R., Rodriguez-Cintron, W., Arena, J.F., Kittles, R., Perez-Stable, E.J., Ziv, E., Risch, N. "Latino populataions: a unique opportunity for the study of race, genetics and social environment in epidemiological research." Am J Public Health 95:2161-8, 2005
• Urban T.J., Sebro, R., Hurowitz, E.H., Leabman, M.K., Badagnani, I., Lagpacan, L.L., Risch, N., Giacomini, K.M. "Functional genomics of membrane transporters in human populations." Genome Res 16:223-230, 2006
• Choudhry, S., Coyle, N.E., Tang, H., Salari, K., Lind, D., Clark, S.L., Tsai, H.J., Naqvi, M., Phong, A., Ung, N., Matallana, H., Avila, P.C., Casal, J., Torres, A., Nazario, S., Castro, R., Battle, N.C., Perez-Stable, E.J., Kwok, P.Y., Sheppard, D., Shriver, M.D., Rodriguez-Cintron, W., Risch, N., Ziv, E., Burchard, E.G. "Genetics of Asthma in Latino Americans (GALA) Study. Population stratification confounds genetic association studies among Latinos." Hum Genet 118:652-64, 2006
• Ozelius, L.J., Senthil, G., Saunders-Pullman, Ohmann, E., Deligtisch, A., Tagliata, M., Hunt, A.L., Klein, C., Henick, B., Hailpern, S.M., Lipton, R.B., Soto-Valencia, J., Risch, N., Bressman, S.B. "LRRK2 G2019S as a cause of Parkinson's Disease in Ashkenazi Jews." N Engl J Med 354:424-425, 2006
• Tang, H., Jorgenson, E., Gadde M., Karda, S.L., Rao, D.C., Zhu, X., Schork, N.J., Hanis, C.L., and Risch, N. Racial admixture and its impact on BMI and blood pressure in African and Mexican Americans. Hum Gen 119:624-33, 2006.
• Gunderson, E.P., Tsai, A.L., Selby, J.V., Caan, B., Mayer-Davis, E.J., and Risch, N. Twins of mistaken zygosity (TOMZ): Evidence for genetic contributions to dietary patterns and physiologic traits. Twin Res Hum Gen 9:540-549, 2006.