Professor & Chairman, Pathology, UCSF
Member, UCSF Biomedical Sciences Graduate Program (BMS)
| CONTACT | |
|
aabbas@itsa.ucsf.edu Box 0511, UCSF; San Francisco, CA 94143-0511 |
| EDUCATION | |
|
All-India Institute of Medical Science, New Delhi, India, MBBS (MD equivalent), 1968, Medicine |
|
| PROFESSIONAL EXPERIENCE | |
|
1977-81 |
Assistant Professor of Pathology, Harvard Medical School |
|
1977-99 |
Staff Pathologist, Brigham & Women's Hospital |
|
1981-91 |
Associate Professor of Pathology, Harvard Medical School |
|
1991-99 |
Professor of Pathology, Harvard Medical School |
|
1991-99 |
Head, Immunology Research Division, Department of Pathology, Brigham & Women's Hospital |
|
1999-present |
Professor and Chairman, Department of Pathology, University of California, San Francisco |
| HONORS & AWARDS | |
|
1983 |
Associate Editor, The Journal of Immunology |
|
1984-88 |
Pathology B Study Section, NIH (Chairman, 1986-88) |
|
1987 |
Warner-Lambert/Parke-Davis Award, American Association of Pathologists |
|
1987-91 |
Section Editor, The Journal of Immunology |
|
1988 |
Irving M. London Award, Harvard-MIT MD Program in Health Sciences and Technology |
|
1992-96 |
Associate Editor, American Journal of Pathology |
|
1993-96 |
Editor, Immunity |
|
1997-present |
Editorial Board, Immunity |
|
2000-present |
Associate Editor, Cell |
|
2002 |
Member, Institute of Medicine, National Academy of Sciences |
|
2003-04 |
President, American Society of Investigative Pathology |
| SELECTED PUBLICATIONS | |
|
Singer GG and Abbas AK. The Fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. Immunity, 1994; 1:365-371. |
|
|
Van Parijs L, Ibraghimov A and Abbas AK. The roles of costimulation and Fas in T cell apoptosis and peripheral tolerance. Immunity, 1996; 4:321-328. |
|
|
Schweitzer AN, Borriello F, Wong RCK, Abbas AK, Sharpe AH. The role of costimulators in T cell differentiation: studies using antigen-presenting cells lacking expression of CD80 or CD86. J. Immunol., 1997; 158:2713-2722. |
|
|
Perez VL, Van Parijs L, Biuckians A, Zheng X, Strom TB and Abbas AK. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. Immunity, 1997; 6:411-417. |
|
|
Van Parijs L, Biuckians A, Ibraghimov A, Alt FW, Willerford D and Abbas AK. Functional responses and apoptosis of CD25 (IL-2R)-deficient T cells expressing a transgenic antigen receptor. J. Immunol., 1997; 158:3738-3745. |
|
|
Van Parijs L, Perez VL, Biuckians A, Maki RG, London CA, Abbas AK. Roles of IL-12 and costimulators in T cell anergy in vivo. J. Exp. Med., 1997; 186:1119-1128. |
|
|
Van Parijs L, Sethna MP, Schweitzer AN, Borriello F, Sharpe AH, Abbas AK. Functional consequences of deregulated B7-1 (CD80) or B7-2 (CD86) expression in B or T lymphocytes of transgenic mice. J. Immunol., 1997; 159; 5336-5344. |
|
|
Van Parijs L, Biuckians A, Abbas AK. Functional roles of Fas and Bcl-2 regulated apoptosis of T lymphocytes. J. Immunol., 1998; 160:2065-2071. |
|
|
Van Parijs L, Peterson DA, Abbas AK. The Fas/Fas ligand pathway and Bcl-2 regulate T cell responses to model self and foreign antigens. Immunity 1998; 8:265-274. |
|
|
Refaeli Y, Van Parijs L, London CA, Tschopp J, Abbas AK. Biochemical mechanisms of IL-2 regulated Fas-mediated T cell apoptosis. Immunity 1998; 8:615-623. |
|
|
London CA, Perez VL, Abbas AK. Functional characteristics and cytokine responsiveness of memory CD4+ T lymphocytes. J. Immunol., 1998; 162:766-773. |
|
|
London CA, Lodge M, Abbas AK. Functional responses and costimulator dependence of memory CD4+ T lymphocytes. J. Immunol. 1999; 164:265-272. |
|
|
Van Parijs, L., Refaeli, Y., Lord, J. D., Nelson, B. H., Abbas, A. K. and Baltimore, D. Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death. Immunity; 1999, 11:281-286. |
|
|
Dahl, A. M., Klein, C., London, C. A., Mulligan, R. C. and Abbas, A. K. Retrovirus mediated expression of Bcl-x prolongs survival of CD28- T cells but does not correct defects in proliferation and Th2 differentiation. J. Exp. Med. 2000; 191:2031-2038. |
|
|
Van Parijs, L, Refaeli Y, Abbas AK and Baltimore D., Autoimmunity as a consequence of retrovirus-mediated expression of c-FLIP in lymphocytes. Immunity 1999; 11:763-770. |
|
|
Howland KC, Ausubel LJ, London CA, and Abbas AK. The roles of CD28 and CD40 ligand in T cell activation and tolerance. J. Immunol., 2000; 164:4465-4470. |
|
|
Kane, LG, Andres, PG, Abbas, AK and Weiss, A. Akt, acting through the RE/AP element, provides the CD28 costimulatory signal for upregulation of IL-2 but not Th2 cytokines. Nature Immunology 2000; 2:37-44. |
|
|
Greenwald RJ, Boussiotis VA, Lorbach RB, Abbas AK and Sharpe AH. CTLA-4 regulates induction of anergy in vivo. Immunity 2001; 14:145-155. |
|
|
Refaeli Y, Van Parijs L, Anderson S and Abbas AK. IFN- is required for Fas-mediated apoptosis T cells. J. Exp. Med. 2002; 196:999-1005. |
|
|
Walker LS, Ausubel L, Chodos A, Bekarian N and Abbas AK. CTLA-4 differentially regulates T cell responses to endogenous tissue protein and exogenous immunogen. J. Immunol. 2002; 169:6206-9. |
|
|
Lohr J, Knoechel B, Jiang S, Sharpe AH and Abbas AK. The inhibitory function of B7 costimulators in immune responses to foreign and self antigens. Nature Immunology 2003; 4:664-669. |
|
|
Walker LS, Chodos A, Dooms H, Eggena M and Abbas AK. Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo. J. Exp. Med. 2003, 198:249-258. |
|
|
Andres P, Howland K, Nirula A, Kane LP, Barron L, Dresnek D, Sadra A, Imboden J, Weiss A and Abbas AK. Distinct regions in the CD28 cytoplasmic domain are required for T helper type 2 differentiation. Nature Immunology 2004; 5:435-442. |
|
|
Dooms H, Kahn E, Zhu S, Hu D, Knoechel B and Abbas AK. Interleukin-2 imprints a competitive survival advantage in T lymphocytes. J. Immunol. 172:5973-5979, 2004. |
|
|
Andres PG, Howland KC, Jacopelli J, Abbas AK and Krummel MF. CD28 regulates membrane-proximal signals and early T cell function. J. Immunol. 172:5880-5886, 2004. |
|
|
Eggena ME, Walker LS, Nagabhushanam V, Chodos A and Abbas AK. CTLA-4 and regulatory T cells cooperate to maintain tolerance to a tissue antigen. J. Exp. Med. 199:1725-1730, 2004. |
|
|
Sarween N, Chodos A, Raykundalia C, Kahn M, Abbas AK and Walker LSK. Prevention of diabetes by CD4+CD25+ regulatory T cells is associated with inhibition of T cell cytokine differentiation, CXCR-3 expression, and tissue invasion. J. Immunol. 2004; 173:2942-2951. |
|
|
Lohr J, Knoechel B, Kahn E, and Abbas AK. The role of B7 in T cell tolerance. J. Immunol., 173:5928-5035, 2004. |
|
|
Knoechel B, Lohr J, Kahn E, and Abbas AK. The link between lymphocyte deficiency and autoimmunity: Role of endogenous T and B lymphocytes in self-tolerance. J. Immunol., 2005; 175:21-26. |
|
|
Chikuma S, Abbas AK, and Bluestone JA. B7-independent inhibition of T cells by CTLA-4. J. Immunol. 2005; 175:177-181. |
|
|
Knoechel B, Lohr J, Kahn E, Bluestone JA, and Abbas AK. Sequential development of effector and regulatory T lymphocytes in response to endogenous systemic antigen. J. Exp. Med. 2005; 202:1375-1386. |
|
|
Knoechel B, Lohr JG, Kahn EC, Zhu S, Wong L, Hu D, Ausubel LJ and Abbas AK. Functional and molecular comparison of anergic and regulatory T lymphocytes. J. Immunol. 2006; 176:6473-83. |
|
|
Selected Invited Papers: |
|
|
Abbas AK. Murphy KM, Sher A. Functional diversity of helper T lymphocytes. Nature, 1996; 383:787-793. |
|
|
Van Parijs L, Abbas AK. Homeostasis and self-tolerance in the immune system: turning lymphocytes off. Science 1998; 280:243-248. |
|
|
Walker LS and Abbas AK. Peripheral T cell tolerance. Nature Reviews Immunology 2002; 2:11-19. |
|
|
Bluestone JA and Abbas AK. Natural versus adaptive regulatory T cells. Nat. Rev. Immunol. 2003; 3:253-257. |
|
|
Lohr J, Knoechel B, Nagabhushanam V, and Abbas AK. T cell tolerance to tissue-restricted and systemic self antigens. Immunological Reviews, in press. |
|
|
Rioux JD, and Abbas AK. Paths to understanding the genetic basis of autoimmune disease. Nature 2005; 435:2-7. |
|
|
8/21/06 |
|
