Manish K. Aghi, MD, PhD

Stanford University (Stanford, CA), BS, 1993, Biological Sciences
Stanford University (Stanford, CA), MS, 1993, Biological Sciences
Harvard Medical School (Boston, MA), MD, 2000, Medicine
Harvard Medical School (Boston, MA), PhD, 2000, Neuroscience

• 2000-2001
  Intern, General Surgery, Massachusetts General Hospital, Boston, MA
• 2001-2007
  Resident, Neurosurgery, Massachusetts General Hospital, Boston, MA
• 2007
  Assistant Professor, Neurosurgery, Massachusetts General Hospital, Boston, MA
• 2008-present
  Assistant Professor in Residence, Neurosurgery, University of California, San Francisco, CA

• 2004
  Preuss Award, best basic science brain tumor research, American Association of Neurologic Surgeons (AANS) meeting, "Generation of Brain Tumor Neovasculature from Transplanted Bone Marrow."
• 2005
  Ronald L. Bittner Award, best brain tumor research, American Association of Neurologic Surgeons (AANS) meeting
• 2005
  William Scoville Resident Research Award, New England Neurosurgery meeting, "Generation of Glioma Neovasculature from Transplanted Bone Marrow."
• 2005
  Congress of Neurologic Surgeons (CNS) Resident Research Award, "Enhanced Replication of Oncolytic HSV in Glioma Cells that Evade Temozolomide Chemotherapy Through DNA Repair."
• 2005
  American Academy of Neurologic Surgeons Resident Research Award, "Stromal Derived Factor-1 Interacts with Environmental Cues to Induce Bone Marrow-Derived Cells to Differentiate into Tumor Endothelium and Pericytes."
• 2006
  Mahaley Award, best clinical study in neuro-oncology, presented at American Association of Neurologic Surgeons (AANS) meeting
• 2006
  Integra Foundation Award, best benign brain and peripheral nerve tumor research, presented at Congress of Neurologic Surgeons (CNS) meeting
• 2007
  Synthes Skull Base Award, Congress of Neurologic Surgeons (CNS) meeting
• 2009
  American Brian Tumor Association (ABTA) Young Investigator Award, Congress of Neurological Surgeons (CNS) meeting

• 1. Kramm CM, Chase M, Herrlinger U, Jacobs A, Pechan PA, Rainov NG, Sena-Esteves M, Aghi M, Barnett FH, Chiocca EA, Breakefield XO. Therapeutic efficacy and safety of a second-generation replication-conditional HSV-1 vector for brain tumor gene therapy. Human Gene Therapy 8(17): 2057-2068. 1997.
• 2. Aghi M, Kramm CM, Chou TC, Breakefield XO, Chiocca EA. Synergistic anticancer effects of ganciclovir/thymidine kinase and 5-fluorocytosine/cytosine deaminase gene therapies. Journal of the National Cancer Institute 90: 370-380. 1998.
• 3. Aghi M, Kramm CM, Breakefield XO. Folylpolyglutamyl synthetase gene transfer and glioma antifolate sensitivity in culture and in vivo. Journal of the National Cancer Institute 91: 1233-1241. 1999.
• 4. Aghi M, Chou TC, Suling K, Breakefield XO, Chiocca EA. Multimodal cancer treatment mediated by a replicating oncolytic virus that delivers the ozaphosphorine/CYP2B1 and ganciclovir/HSV-TK gene therapies. Cancer Research 59: 3861-3865. 1999.
• 5. Pechan P, Herrlinger U, Aghi M, Jacobs A, Breakefield XO. Combined HSV-1 recombinant and amplicon piggyback vectors: Replication-competent and defective forms, and therapeutic efficacy for experimental gliomas. Journal of Gene Medicine 1: 176-185. 1999.
• 6. Aghi M, Hochberg F, Breakefield XO. Prodrug activation enzymes in cancer gene therapy. Journal of Gene Medicine. 2:148-164. 2000.
• 7. Herrlinger U, Jacobs A, Aghi M, Schuback DE, Breakefield XO. HSV-1 vectors for gene therapy of experimental CNS tumors. In: Methods in Molecular Medicine, Gene Therapy of Cancer: Methods and Protocols, Walther W, Stein U, Ed. Humana Press Inc., Totowa, NJ: 287-312. 2000.
• 8. Aghi M, Chiocca EA. Genetically engineered herpes simplex viral vectors in the treatment of brain tumors: a review. Cancer Investigation 21: 278-292. 2003.
• 9. Chiocca EA, Aghi M, Fulci G. Viral therapy for glioblastoma. Cancer Journal 9: 167-179. 2003.
• 10. Aghi M, Valery-Coumans J, Brisman JL. Subarachnoid hematoma, hydrocephalus, and aseptic meningitis resulting from a high cervical myelogram. Journal of Spinal Disorders and Techniques 17: 348-351. 2004.
• 11. Aghi M, Kiehl T-R, Brisman JL. Breast adenocarcinoma metastatic to epidural cervical spine meningioma: case report and review of the literature. Journal of Neuro-Oncology 75: 149-155. 2005.
• 12. Aghi M, Gaviani P, Henson JW, Batchelor TT, Louis DN, Barker FG. Magnetic resonance imaging characteristics predict EGFR amplification status in glioblastoma. Clinical Cancer Research 11: 8600-8605. 2005.
• 13. Aghi M, Chiocca EA. Contribution of bone marrow derived cells to blood vessels in ischemic tissues and tumors: a review. Molecular Therapy 12: 994-1005. 2005.
• 14. Aghi M, Martuza RL. Oncolytic Viral Therapies - The Clinical Experience. Oncogene 24: 7802-7816. 2005.
• 15. Aghi M, Rabkin S. Viral vectors as therapeutic agents for glioblastomas. Current Opinion in Molecular Therapeutics 7: 419-430. 2005.
• 16. Hoh BL, Aghi M, Pryor JC, Ogilvy CS. Heparin Induced Thrombocytopenia Type II in Subarachnoid Hemorrhage Patients: Incidence and Complications. Neurosurgery 57: 243-248. 2005.
• 17. Aghi M, Kluwe L, Webster MT, Jacoby L, Barker FG, Ojemann R, Mautner V-F, MacCollin M. Unilateral vestibular schwannoma with other NF2-related tumors: clinical and molecular study of a unique phenotype. Journal of Neurosurgery 104: 201-207. 2006.
• 18. Aghi M, Rabkin S, Martuza RL. The effect of chemotherapy-induced DNA repair on oncolytic herpes simplex viral replication. Journal of the National Cancer Institute 98: 38-50. 2006.
• 19. Aghi M, Cohen KS, Klein RJ, Scadden DT, Chiocca EA. Tumor SDF-1 recruits vascular progenitors to mitotic neovasculature, where microenvironment influences their differentiated phenotypes. Cancer Research 66: 9054-9064. 2006. [caption and figure from this manuscript featured on the cover of this issue]
• 20. Aghi M, Chiocca EA. Gene therapy for glioblastoma. Neurosurgical Focus 20: E18. 2006.
• 21. Aghi M, Barker FG. Benign Adult Brain Tumors: An Evidence-Based Medicine Review. Progress in Neurological Surgery 19: 80-96. 2006.
• 22. Aghi M, Rabkin S, Martuza RL. Angiogenic response caused by oncolytic herpes simplex virus-induced reduced thrombospondin expression can be prevented by specific viral mutations or by administering a thrombospondin-derived peptide. Cancer Research 67: 440-444. 2007.
• 23. Aghi M, Eskandar EN, Carter BS, Curry WT, Barker FG. Increased prevalence of obesity and obesity-related postoperative complications in male meningioma patients. Neurosurgery 61: 754-760. 2007.
• 24. Aghi M, Visted T, DePinho R, Chiocca EA. Oncolytic herpes virus with defective ICP6 specifically replicates in quiescent cells with homozygous genetic mutations in p16. Oncogene 27: 4249-4254. 2008.
• 25. Aghi M. Management of recurrent and refractory Cushing's disease. Nature Clinical Practice Endocrinology and Metabolism 4: 560-568. 2008.
• 26. Aghi M, Liu TC, Rabkin S, Martuza RL. Hypoxia enhances oncolytic herpes simplex viral replication. Molecular Therapy 17: 1-56. 2008.
• 27. Aghi M, Chiocca EA. Phase Ib trial of oncolytic herpes virus G207 shows safety of multiple injections and documents viral replication. Molecular Therapy 17: 8-9. 2009.
• 28. Aghi M, Carter BS, Cosgrove GR, Ojemann RS, Amin-Hanjani S, Martuza RL, Curry WT, Barker FG. Long-term recurrence rates of atypical meningiomas after gross total resection without or with postoperative adjuvant radiation. Neurosurgery 64: 56-60. 2009.
• 29. Aghi M, Petit J, Chapman P, Loeffler J, Klibanski A, Biller BMK, Swearingen B. Management of recurrent and refractory Cushing's disease with reoperation and/or proton beam radiosurgery. Clinical Neurosurgery 55: 141-144, 2009.
• 30. Aghi M, Batchelor TT, Louis DN, Barker FG, Curry WT. Decreased rate of infection in glioblastoma patients with allelic loss of chromosome 10q. Journal of Neuro-oncology 93: 115-120. 2009.
• 31. Chang SM, Nelson S, Vandenberg S, Cha S, Prados M, Butowski N, McDermott M, Parsa AT, Aghi M, et al. Integration of preoperative anatomic and metabolic physiologic imaging of newly diagnosed glioma. Journal of Neuro-oncology 92: 401-415. 2009.
• 32. Wakimoto H, Kesari S, Farrell C, Curry WT, Zaupa C, Aghi M, et al. Human glioblastoma-derived cancer stem cells: Establishment of invasive glioma models and treatment with oncolytic herpes simplex virus vectors. Cancer Research 69: 3472-3481. 2009.