Adjunct Professor, Dept of Anatomy and Cancer Research Institute, UCSF
| CONTACT | |
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rakhurst@cc.ucsf.edu Box 0875, UCSF; San Francisco, CA 94143-0875 |
additional websites: |
| EDUCATION | |
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Imperial College of Science and Technology, University of London, UK, BSc (Hons), 1st class, 1975-1978, Biochemistry |
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| PROFESSIONAL EXPERIENCE | |
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1982-1984 |
Post-doctoral fellow, California Institute of Technology, Pasadena, CA |
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1984-1988 |
Lecturer, Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, London University, UK |
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1988-1990 |
Lecturer, Department of Medical Genetics, Glasgow University, UK |
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1990-1992 |
Senior Lecturer, Department of Medical Genetics, Glasgow University, UK |
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1992-1996 |
Reader, Department of Medical Genetics, Glasgow University, UK |
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1997-1999 |
Senior Scientist, Onyx Pharmaceuticals, Richmond, CA |
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1999-2004 |
Research Scientist, Cancer Research Institute, UCSF |
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2004-present |
Adjunct Professor, Dept of Anatomy and Cancer Research Institute, UCSF |
| HONORS & AWARDS | |
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1975, 1976 |
Imperial College Entrance Scholarship |
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1978 |
Ewart Stickings Award for Excellence in Biochemistry (Top Biochemistry Student, Imperial College, London) |
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1978 |
Associate of the Royal College of Science |
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1982-4 |
European Molecular Biology Organization (EMBO) Fellowship Award |
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1984 |
"New Blood" Lectureship, London University, UK |
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2005-2010 |
American Heart Association - National Center -Vascular Wall Biology 1 Study Group |
| SELECTED PUBLICATIONS | |
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Akhurst, R.J., Fee, F., & Balmain, A. Localized production of TGF-β mRNA in tumour promoter-stimulated mouse epidermis. Nature, 331: 363-365, 1988. | |
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Lehnert, S.A., & Akhurst, R.J. Embryonic expression pattern of TGF β type-1 RNA suggests both paracrine and autocrine mechanisms of action. Development, 104: 263-273, 1988. | |
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Gatherer,D., ten Dijke,P., Baird,D.T. & Akhurst, R.J. Expression of TGF β isoforms during human embryogenesis. Development, 111: 445-460, 1990. | |
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Fitzpatrick, D.R., Denhez, F., Kondaiah, P., & Akhurst, R.J. Differential expression of TGF β isoforms in murine palatogenesis. Development, 109: 585-595, 1990. | |
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Akhurst, R.J., Lehnert, S.A., Faissner, A.J., & Duffie, E. TGF β in murine morphogenetic processes: the early embryo and cardiogenesis. Development, 108: 645-656, 1990. | |
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Cui, W., Kemp, C.J., Duffie, E., Balmain, A. & Akhurst, R.J. Lack of TGFβ1 expression in benign skin tumors of p53null mice is prognostic for a high risk of malignant conversion. Cancer Res. 54: 5831-5836, 1994. | |
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Cui,W., Fowlis, D. J., Cousins, F., Duffie, E., Bryson, S., Purchio, A. F., Balmain, A. & Akhurst, R. J., Concerted action of TGFβ1 and its type II receptor in control of epidermal homeostasis in transgenic mice. Genes and Development 9: 945-955, 1995. | |
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Dickson, M.C., Martin, J. S., Cousins, F., Kulkarni, A. B., Karlsson, S. & Akhurst, R. J. Defective haematopoiesis and vasculogenesis in TGFβ1 knock out mice. Development 121: 1845-1854, 1995. | |
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Martin, J. S., Dickson, M. C., Cousins, F. M., Kulkarni, A., Karlsson, S. & Akhurst, R.J. Analysis of homozygous TGFβ1 null mouse embryos demonstrates defects in yolk sac vasculogenesis & hematopoiesis. Ann. N. Y. Acad. Sci. USA 1995, 752: 300-308. | |
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Alexander, M.Y. & Akhurst, R.J. Liposome-mediated gene transfer and expression via the skin. Human Molecular Genetics 4: 2279-2285, 1995. | |
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Alexander,M.Y., Bidichandani, S., Robinson, C.J.M., Cousins, F.M., Duffie, E. & Akhurst, R.J. Biologically-active factor IX produced in keratin promoter transgenic mice: A feasibility study for the treatment of haemophilia B. Human Molecular Genetics 4: 993-999, 1995. | |
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Cui, W., Fowlis, D.J., Bryson, S. Duffie, E., Ireland, H., Balmain, A. & Akhurst, R.J. TGFβ1 inhibits the formation of benign skin tumours but enhances progression to invasive spindle carcinomas in transgenic mice. Cell 86: 531-542, 1996. | |
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Bonyadi, M., Cui, W., Nagase, H. & Akhurst,R.J. The TGFβ type II receptor, Tgfbr2, maps on distal mouse chromosome 9. Genomics 33: 328-329, 1996. | |
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Fowlis, D. J., Cui, W., Johnson, S. A., Balmain, A. & Akhurst, R. J. Altered epidermal cell growth control in vivo by inducible expression of TGFβ1 in the skin of transgenic mice. Cell Growth Diff. 7: 679-687, 1996. | |
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Bonyadi, M., Rusholme, S., Cousins, F.M., Su, H., Biron, C., Farrall M. & Akhurst, R.J. Mapping of a major genetic modifier of embryonic lethality in TGFβ1-deficient mice. Nat. Genetics 15: 207-211,1997. | |
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Portella, G., Cumming S.A., Liddell, J., Cui, W., Ireland, H., Akhurst, R.J., & Balmain, A. TGFβ is essential for spindle cell conversion of mouse skin carcinoma in vivo: implications for invasion. Cell Growth Diff. 9 : 393-4041, 1998. | |
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Balmain,A., Nagase, H., Brown, K & Akhurst, R.J. The use of transgenic, knockout and interspecific hybrid mice in studies of cancer predisposition and tumour progression. In gNovel systems for the study of human disease : From basic research to applicationsh OECD Proceedings, p193-200, 1998. | |
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Akhurst, R.J. & Balmain, A. Genetic Events and the Role of TGFβ in Epithelial Tumour Progression. J. Pathol. 187, 82-90, 1999. | |
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Derynck, R., Akhurst, R.J. & Balmain, A. (2001) Multiple roles of TGF-β in cancer development: growth inhibitor and metastasis inducer. Nature Genetics, 29: 117-129. | |
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Akhurst,R.J.(2002)TGFβ antagonists:Why suppress a tumor suppressor?J.Clin.Invest. (2002)109,1-4. | |
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Ewan, KB., Ravani, S.A., Shyamala, G., Tang, Y., Akhurst, R.J., Wakefield, L. & Barcellos-Hoff, M.H. (2002) Latent TGFβ activation in mammary gland: Regulation by ovarian hormones affects ductal and alveolar proliferation. Am. J. Pathol. 160(6):2081-93. | |
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Oft, M., Akhurst, R.J. & Balmain, A. (2002) Elevated levels of activated Smad2 and H-ras control epithelial-mesenchymal transformation, tumor cell extravasation and metastasis. Nature Cell Biology 4(7):487-94. | |
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Ewan KB, Henshall-Powell RL, Ravani SA, Pajares MJ, Arteaga C, Warters R, Akhurst RJ, Barcellos-Hoff MH. Transforming growth factor-beta1 mediates cellular response to DNA damage in situ. (2002) Cancer Res. 62(20):5627-31. | |
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Tang, Y., McKinnon, M.L., Leong, L.M., Rusholme, S.A.B., Wang, S. & Akhurst, R.J. (2003) Genetic modifiers interact with maternal determinants in vascular development of Tgfb1-/- mice. Human Molecular Genetics. | |
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Chan, C.K., Pham, L.N., Chinn, C, Spee, C. Ryan, S.J., Akhurst, R.J. & Hinton, D. R. (2004) Mouse Strain-dependent Heterogeneity of Resting Limbal Vasculature. Invest Ophthal.l Vis Sci 45:441-447. | |
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Balmain, A. & Akhurst, R.J. (2004) Dangerous Liaisons. Nature 428, 271-2. | |
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Akhurst, R.J. (2004) TGFβ signaling in health and disease. Nature Genetics 36, 790-792. | |
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Tang, Y., Lee, K.S., Yang, H.T., Logan, D.W., Wang, S., McKinnon, M.L., Holt, L.J., Condie, A., Luu, M.T. & Akhurst R. J. (2005) Epistatic interactions between modifier genes confer strain-specific redundancy for Tgfb1 in developmental angiogenesis. Genomics 85, 60-70. | |
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Saunier, E. F. & Akhurst, R.J. (2006) TGF β inhibition for cancer therapy. Current Cancer Drug Targets, 6(7):565-78. | |
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Akhurst, R.J. (2006) Large and small molecule inhibitors of TGFβ in cancer therapy. Current Opinion in Investigational Drugs 7 (6): 513-521. | |
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Harradine, K.A. & Akhurst, R.J. (2006) Mutations of TGF-β signaling molecules in human diseases. Annals Med. 38(6):403-14. | |
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Akhurst, R.J. (2006) A sweet link between TGFβ and vascular disease? Nature Genetics 38, 400-401. | |
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Poon, E., Clermont, F., Firpo, M.T. & Akhurst, R.J. (2006) TGFβ inhibition of yolk sac-like differentiation of human embryonic stem cell-derived embryoid bodies illustrates differences between early mouse and human development. J. Cell Sci. 119, 759-68 | |
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Lacher, M.D., Tiirikainen, M.I., Saunier, E.F., Christian, C., Anders, M., Oft, M., Balmain, A., Akhurst, R.J. & Korn, W.M. (2006) TGFβ Receptor Inhibition Enhances Adenoviral Infectivity of Carcinoma Cells Via Up-regulation of CAR in Conjunction with Reversal of Epithelial-Mesenchymal-Transition. Cancer Res. 66:1648-57. | |
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Mao, J-H., Saunier, E.F., de Koning, J., McKinnon, M.M., Higgins, M.N., Nicklas, K., Yang, H-T., Balmain, A. & Akhurst, R.J. (2006) Genetic variants of Tgfb1 act as context-dependent modifiers of mouse skin tumor susceptibility. Proc. Natl. Acad. Sci (USA) 103(21):8125-30. |
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12/11/06 |
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