Donna G. Albertson, PhD

Mount Holyoke College, MA, B.A., 1969, Biology and Chemistry
Harvard University, MA, Ph.D., 1972, Biological Chemistry
Harvard University, MA, Postdoc, 1973-1974, Molecular Cytogenetics
MRC Laboratory of Molecular Biology, UK, Postdoc, 1974-1978, Molecular Biology/Genetics

• 1978-1979
  Visiting Research Associate, Dept. of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO.
• 1981-1986
  Scientific Staff, MRC Laboratory of Molecular Biology, Cambridge, U.K.
• 1986-1991
  Scientific Staff, MRC Molecular Genetics Unit, Cambridge, U.K.
• 1991-1996
  Scientific Staff, MRC Laboratory of Molecular Biology, Cambridge, U.K.
• 1995-1998
  Scientist, Life Sciences Division, E. O. Lawrence Berkeley National Laboratory, Berkeley, CA
• 1998-present
  Professor, Cancer Research Institute, University of California, San Francisco, CA
• 2005-present
  Associate Director, Cancer Research Institute, University of California San Francisco, San Francisco, CA

• 1973-1975
  N.I.H. Postdoctoral Fellowship
• 1975-1977
  Muscular Dystrophy Association of America, Inc.
• 1981-1982
  Usher Fellow, MRC Laboratory of Molecular Biology, Cambridge, U.K.
• 2008
  Second Annual AACR Team Science Award

• Wilson (Albertson), D.A. and Thomas, C.A., Jr. 1974. Palindromes in chromosomes. J. Mol. Biol. 84, 115-144.
• Albertson, D.G. and Thomson, J.N. 1976. The pharynx of Caenorhabditis elegans. Phil. Trans. R. Soc. Lond. B 275, 297-325.
• Albertson, D.G., Sulston, J.E. and White, J.G. 1978. Cell cycling and DNA replication in a mutant blocked in cell division in the nematode Caenorhabditis elegans. Develop. Biol. 63, 165-178.
• White, J.G., Albertson, D.G. and Anness, M.A.R. 1978. Connectivity changes in a class of motor neurons during development of a nematode. Nature 271, 764-766.
• Albertson, D.G. and Thomson, J.N. 1982. The kinetochores of Caenorhabditis elegans. Chromosoma (Berl.) 86, 409-428.
• Albertson, D.G. 1984. Formation of the first cleavage spindle in nematode embryos. Develop. Biol. 101, 61-72.
• Albertson, D.G. 1984. Localization of the ribosomal genes in Caenorhabditis elegans chromosomes by in situ hybridization using biotin-labeled probes. EMBO J. 3, 1227-1234.
• Albertson, D.G. 1985. Mapping muscle protein genes by in situ hybridization using biotin-labeled probes. EMBO J. 4, 2493-2498.
• Albertson, D.G. Fishpool, R., Sherrington, P., Nacheva, E. and Milstein, C. 1988. Sensitive and high resolution in situ hybridization to human chromosomes using biotin labelled probes: assignment of the human thymocyte CD1 antigen genes to chromosome 1. EMBO J. 7, 2801-2805.
• Albertson, D.G. and Thomson, J.N. 1993. Segregation of holocentric chromosomes at meiosis in the nematode, Caenorhabditis elegans. Chromosome Res. 1, 15-26.
• Birchall, P. S., Fishpool, R. M. and Albertson, D. G. 1995. Visualization of gene expression in whole organisms by FISH: cellular and subcellular localization of mRNAs for predicted genes from the C. elegans genome sequence. Nature Genet. 11, 314-320.
• Pinkel, D., Segraves, R., Sudar, D., Clark, S., Poole, I., Kowbel, D., Collins, C., Kuo, W.-L., Chen, C., Zhai, Y., Dairkee, S. H., Ljung, B.-M., Gray, J. W., and Albertson, D. G. 1998. Quantitative high resolution analysis of DNA copy number variation in breast cancer using comparative genomic hybridization to DNA microarrays. Nature Genet. 20, 207-211.
• Albertson, D. G., Ylstra, B., Segraves, R., Collins, C., Dairkee, S. H., Kowbel, D., Kuo, W.-L., Gray, J. W. and Pinkel, D. 2000. Quantitative Mapping of amplicon structure by array CGH identifies CYP24 as a candidate oncogene. Nature Genet. 25, 144-146.
• Snijders, A. M., Nowak, N., Segraves, R., Blackwood, S., Brown, N., Conroy, J., Hamilton, G., Hindle, A. K., Huey, B., Kimura, K., Law, S., Myambo, K., Palmer, J., Ylstra, B., Yue, J. P., Gray, J. W., Jain, A. N., Pinkel, D. and Albertson, D. G. 2001. Assembly of microarrays for genome-wide measurement of DNA copy number by CGH. Nature Genet. 29, 263-264.
• Howe, M., McDonald, K.L., Albertson, D.G. and Meyer B.J. 2001. HIM-10 is required for kinetochore structure and function on Caenorhabditis elegans holocentric chromosomes. J. Cell Biol. 153, 1227-1238.
• Jain, A. N., Tokuyasu, T., Snijders, A. M., Segraves, R., Albertson, D. G. and Pinkel, D. 2001. Fully automatic quantification of microarray image data. Genome Res. 12, 325-332.
• Zardo, G., Tiirikainen, M. I., Hong, C., Misra, A., Feuerstein, B. G., Volik, S., Collins C. C., Lamborn, K. R., Bollen, A., Pinkel, D., Albertson, D. G. and Costello, J. F. 2002. Integrated genomic and epigenomic analyses pinpoint biallelic gene inactivation in tumors. Nature Genet. 32, 453-458.
• Snijders, A. M., Fridlyand, J., Mans, D. A., Segraves, R., Jain, A. N., Pinkel, D. and Albertson, D. G. 2003. Shaping tumor and drug resistant genomes by instability and selection. Oncogene 20, 4370-4379.
• Albertson, D. G., Collins, C., McCormick, F. and Gray, J. W. 2003. Chromosome aberrations in solid tumors. Nature Genet. 34, 369-376.
• Ishkanian, A. S., Malloff, C. A., Watson, S. K., deLeeuw, R. J., Chi, B., Coe, B. P., Snijders, A., Albertson, D. G., Pinkel, D. Marra, M. A., Ling, V., MacAulay, C. and Lam, W. L. 2004. A tiling resolution DNA microarray with complete coverage of the human genome. Nature Genet. 36, 299-303.
• Fridlyand, J., Snijders, A. M., Pinkel, D., Albertson, D. G. and Jain, A. N. 2004. Hidden Markov Models Approach to the Analysis of Array CGH Data. J. Mulitvariate Anal. 90, 132-153.
• Snijders, A. N., Nowak, N. J., Huey, B., Fridlyand, J., Law, S., Conroy, J., Tokuyasu, T., Demir, K., Chiu, R., Mao, J.-H., Jain, A. N., Jones, S. J. M., Balmain, A., Pinkel, D. and Albertson, D.G. 2005. Mapping segmental and sequence variations among laboratory mice using BAC array CGH. Genome Res. 15, 302-311.
• Hermsen, M., Snijders, A., Alonso Guervos, M., Taenzer, S., Koemer, U., Baak, J., Pinkel, D., Albertson, D., van Diest, P., Meijer, G. and Schrock, E. 2005. Centromeric chromosomal translocations show tissue-specific differences between squamous cell carcinomas and adenocarcinomas. Oncogene 24, 1571-1579.
• Snijders, A. M., Schmidt, B. L., Fridlyand, J., Dekker, N., Pinkel, D., Jordan, R. C. K. and Albertson, D. G. 2005. Rare amplicons implicate frequent deregulation of cell fate specification pathways in oral squamous cell carcinoma. Oncogene 24, 4232-4242.
• Pinkel, D. and Albertson, D. G. 2005. Array comparative genomic hybridization and its applications in cancer. Nature Genet. 37 Suppl:S11-7.
• Chao, R.C., Pyzel, U., Fridlyand, J., Kuo, Y.M., Teel, L., Haaga, J., Borowsky, A., Horvai, A., Kogan, S.C., Bonifas, J., Huey, B., Jacks, T.E., Albertson, D.G., Shannon, K.M. 2005. Therapy-induced malignant neoplasms in Nf1 mutant mice. Cancer Cell. 8, 337-348.
• Albertson, D. G., Snijders, A. M., Fridlyand, J., Jordan, R., Pinkel, D., Schmidt, B. L. 2006. Genomic analysis of tumors by array comparative genomic hybridization: more is better. Cancer Res. 66, 955-3956.
• Fridlyand, J., Snijders, A. M., Ylstra, B., Li H., Olshen, A., Segraves, R., Dairkee, S., Tokuyasu, T., Ljung, B. M., Jain, A. N., McLennan, J., Ziegler, J., Chin, K., Devries, S., Feiler, H., Gray, J. W., Waldman, F., Pinkel, D., Albertson, D. G. 2006. Breast tumor copy number aberration phenotypes and genomic instability. BMC Cancer 6, 96 [Epub ahead of print]
• Albertson, D. G. 2006. Gene amplification in cancer. Trends Genet. 22, 447-455.
• Chin, K., DeVries, S., Fridlyand, J., Spellman, P. T., Roydasgupta, R., Kuo, W. L., Lapuk, A., Neve, R. M., Qian, Z., Ryder, T., Chen, F., Feiler, H., Tokuyasu, T., Kingsley, C., Dairkee, S., Meng, Z., Chew, K., Pinkel, D., Jain, A., Ljung, B. M., Esserman, L., Albertson, D. G., Waldman, F. M., and Gray, J. W. 2006. Genomic and transcriptional aberrations linked to breast cancer pathophysiologies. Cancer Cell 10, 529-541.
• Okabe, H., Lee, S. H., Phuchareon, J., Albertson, D. G., McCormick, F., and Tetsu, O. 2006. A Critical Role for FBXW8 and MAPK in Cyclin D1 Degradation and Cancer Cell Proliferation. PLoS ONE, 1: e128.
• Gajduskova, P., Snijders, A.M., Kwek S., Roydasgupta, R., Fridlyand, J., Tokuyasu, T., Pinkel, D. and Albertson, D.G. 2007. Genome position and gene amplification. Genome Biol 8(6):R120.
• Byrd, K.N., Huey, B., Roydasgupta, R., Fridlyand, J., Snijders, A.M. and Albertson, D.G. 2008. FBXW7 and DNA copy number instability. Breast Cancer Res. Treat. 109, 47-54. Epub 2007 Jun 23.
• Snijders, A.M., Hermsen, M.A., Baughman, J, Buffart, T.E., Huey, B., Gajduskova, P., Roydasgupta, R., Tokuyasu, T., Meijer, G.A., Fridlyand, J. and Albertson, D.G. 2008. Acquired genomic aberrations associated with methotrexate resistance vary with background genomic instability. Genes Chromosomes Cancer 47, 71-83.