Professor, Microbiology and Immunology, UCSF
Member, UCSF Biomedical Sciences Graduate Program (BMS) and Tetrad Program
| CONTACT | |
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Raul.Andino@ucsf.edu Box 2280, UCSF; San Francisco, CA 94158-2517 |
additional websites: |
| EDUCATION | |
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University of Buenos Aires, School of Science (FCEyN), Argentina, Masters, 1980, Biology
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| PROFESSIONAL EXPERIENCE | |
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1986-1991 |
Postdoctoral Associate, Whitehead Institute for Biomedical Research, Cambridge, MA |
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1991-1992 |
Research Associate, Laboratory of David Baltimore, Rockefeller University, New York, NY |
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1992-1995 |
Assistant Investigator, Gladstone Institute of Virology and Immunology, San Francisco, CA |
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1992-1999 |
Assistant Professor, Department of Microbiology & Immunology, University of California, San Francisco |
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1999-2003 |
Associate Professor, Department of Microbiology & Immunology, University of California, San Francisco |
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2003-present |
Professor, Department of Microbiology & Immunology, University of California, San Francisco |
| HONORS & AWARDS | |
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1994 |
Contract Grant for Infectious Disease Research, Eli Lilly and Company |
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1995 |
American Cyanamid Research Award |
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2004 |
Sandler Award for Innovation in Basic Science |
| SELECTED PUBLICATIONS | |
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(from 2003-present) |
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Du, Z., Yu, J., Andino, R., and James, T.L. (2003) Extending the family of UNCG-like tetraloop motifs: NMR structure of a CACG tetraloop from coxsackievirus B3. Biochemistry 42: 4373-4383. PMID: 12693932 |
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Crotty, S., Gohara D., Gilligan, D.K., Karelsky, S., Cameron, C.E., and Andino, R. (2003) Manganesedependent polioviruses caused by mutations within the viral polymerase. J Virol 77: 5378-5388. PMID: 12692240 |
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Andino, R. (2003) RNAi puts a lid on virus replication. Nat Biotechnol 21: 629-630. PMID: 12776148 |
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Gitlin, L., and Andino, R. (2003) Nucleic Acid-based immune system: the antiviral potential of Mammalian RNA silencing. J Virol 77: 7159-7165. PMID: 12805414 |
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Goodfellow, I.G., Polacek, C., Andino, R., and Evans D.J. (2003) The poliovirus 2C cis-acting replication element-mediated uridylylation of VPg is not required for synthesis of negative-sense genomes. J Gen Virol 84: 2359-2363. PMID: 12917456 |
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Du, Z., Yu, J., Ulyanov, N.B., Andino, R., James, T.L. (2004) Solution structure of a consensus stemloop D RNA domain that plays important roles in regulating translation and replication in enteroviruses and rhinoviruses. Biochemistry 43: 11959-72. PMID: 15379536 |
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Du, Z., Yu, J., Chen, Y., Andino, R., James, T.L. (2004) Specific recognition of the C-rich strand of human telomeric DNA and the RNA template of human telomerase by the first KH domain of human poly(C)-binding Protein-2. J Biol Chem 279: 48126-34. PMID: 15331611 |
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Du, Z., Ulyanov NB, Yu, J., Andino, R., James, T.L. (2004) NMR structures of loop B RNAs from the stem-loop IV domain of the enterovirus internal ribosome entry site: a single C to U substitution drastically changes the shape and flexibility of RNA. Biochemistry 43: 5757-71. PMID: 15134450 |
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Crotty, S., and Andino, R. (2004) Poliovirus vaccine strains as mucosal vaccine vectors and their potential use to develop an AIDS vaccine. Advanced Drug Delivery Reviews, 56: 835-52. PMID: 15063593 |
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Crotty, S., Saleh, M.C., Gitlin, L., Beske, O., and Andino, R. (2004) The poliovirus replication machinery can escape inhibition by an antiviral drug that targets a host cell protein. J Virol 78: 3378- 3386. PMID: 15016860. |
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Saleh, M.C., Van Rij, R.P., Andino, R. (2004) RNA silencing in viral infections: insights from poliovirus. Virus Res 102(1): 11-17. PMID: 15068875 |
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Arnold, J.J., Vignuzzi, M., Stone, J.K., Andino, R., Cameron, C.E. (2005) Remote site control of an active site fidelity checkpoint in a viral RNA-dependent RNA polymerase. J. Biol Chem, 280: 25706- 16. PMID: 15878882 |
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Vignuzzi, M., Stone, J.K., Andino, R. (2005) Ribavirin and lethal mutagenesis of poliovirus: molecular mechanisms, resistance and biological implications. Virus Res 107: 173-81. PMID: 15649563 |
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Gitlin, L., Stone, J.K., and Andino, R. (2005) Poliovirus escape from RNA interference: short interfering RNA-target recognition and implications for therapeutic approaches. J Virol 79: 1027-35. PMID: 15613331 |
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Vignuzzi, M., Stone, J.K., Arnold, J.J., Cameron, C.E., Andino, R., (2006) Quasispecies diversity determines pathogenesis through cooperative interactions within a viral population. Nature, 439: 344- 8. PMID: 16327776 |
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Saleh, M.C., van Rij, R.P., Hekele, A., Gillis, A., Foley, E., O'Farrell, P.H., Andino, R. (2006) Theendocytic pathway mediates cell entry of dsRNA to induce RNAi silencing. Nat Cell Biol, 8: 793-802. PMID: 16862146 |
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Van Rij, R.P., Saleh, M.C., Berry, B., Foo, C., Houk, A., Antoniewski, C., Andino, R. (2006) The RNA silencing endonuclease Argonaute 2 mediates specific antiviral immunity in Drosophila melanogaster. Gene & Development 20:2985-95. PMID: 17079687 |
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Van Ooij, M.J., Vogt, D.A., Paul, A., Castro, C., Kuijpers, J., van Kuppeveld, F.J., Cameron, C.E., Wimmer, E., Andino, R., Melchers, W.J. (2006) Structural and functional characterization of the coxsackievirus B3 CRE(2C): role of CRE(2C) in negative- and positive-strand RNA synthesis. J Gen Virol. 87(Pt 1):103-13. PMID: 16361422 |
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Van Rij, R.P., Andino, R. (2006) The silent treatment: RNAi as a defense against virus infection in mammals. Trends Biotechnol. 24(4):186-93. PMID: 16503061 |
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Van Ooij, M.J., Polacek, C., Glaudemans, D.H., Kuijpers, J., van Kuppeveld, F.J., Andino, R., Agol, V.I., Melchers, W.J. (2006) Polyadenylation of genomic RNA and initiation of antigenomic RNA in a positive-strand RNA virus are controlled by the same cis-element. Nucleic Acids Res. 31;34(10):2953- 65. PMID: 16738134 |
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Geller, R., Vignuzzi, M., Andino, R., Frydman, J. (2007) Evolutionary constraints on chaperonemediated folding provide an antiviral approach refractory to development of drug resistance. Gene & Development 21: 195-205. PMID: 17234885 |
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Beske, O., Reichelt, M., Taylor, M.P., Kirkegaard, K., Andino, R. (2007) Poliovirus infection blocks ERGIC-to-Golgi trafficking and induces microtubule-dependent disruption of the Golgi complex. J Cell Science 120: 3207-3218. PMID: 17711878 |
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Vignuzzi, M., Wendt, E., and Andino, R. (2008) Engineering attenuated virus vaccines by controlling replication fidelity. Nat Med. 14:154-61. PMID: 18246077 |
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Stone, J.K., Rijnbrand, R., Stein D. A., Ma, Y., Yang, Y., Iversen, P.L., Andino, R. (2008) A morpholino oligomer targeting highly conserved internal ribosome entry site sequence is able to inhibit multiple species of picornavirus. Antimicrob Agents Chemother. Mar 17 (Epub ahead of print). PMID: 18347107 | |
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7/3/08 |
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