Diane L. Barber, PhD

University of California, Davis, B.S., 1975, Biological Sciences
University of California, Davis, M.S., 1977, Physiology
University of California, Los Angeles, Ph.D., 1985, Anatomy

• 1977-1980
  Lecturer, Department of Biology, University of California, Los Angeles
• 1980-1985
  Predoctoral Fellow, Department of Anatomy, University of California, Los Angeles
• 1985-1987
  NIH Postdoctoral Fellow (NRSA), Department of Physiology, University of Massachusetts Medical Center, Worcester, MA
• 1987-1991
  Assistant Professor, Department of Surgery/Section of Anatomy, Yale University
• 1991-1995
  Assistant Professor, Departments of Stomatology and Surgery, UCSF
• 1993-present
  Member, Biomedical Sciences Graduate Program, UCSF
• 1995-2001
  Associate Professor, Departments of Stomatology and Surgery, UCSF
• 2001-present
  Professor, Department of Cell and Tissue Biology (previously Stomatology), UCSF
• 2005- present
  Vice Chair, Department of Cell and Tissue Biology, UCSF

• 1985-87
  NIH Individual NRSA Postdoctoral Fellowship
• 1986
  Joseph P. Healy Research Award, University of Massachusetts
• 1995-2000
  Established Investigator, American Heart Association
• 1998-present
  Editorial Board, American Journal of Physiology: Cell Physiology
• 1998-1999
  American Heart Association, National Review Committee for Transport and Metabolism
• 1998
  Innovation in Basic Sciences Award, UCSF
• 2000-2002
  American Heart Association, Co-chair National Review Committee for Transport and Metabolism
• 2001/2003
  Vice-chair/Chair, Gordon Conference on Molecular Pharmacology
• 2001-2003
  Member, NIH CDF3 Study Section
• 2003-present
  Editorial Board, Journal of Biological Chemistry
• 2005
  Sandler Program Integrative Award

• (of 67 total)
• Denker, S.P. Huang, D.C., Orlowski, J., Furthmayr, H., and Barber, D.L. 2000 Direct binding the Na-H exchanger NHE1 to ERM proteins regulates the cortical cytoskeleton and cell shape independently of H+ translocation. Molecular Cell 6:1425-1436.
• Yan, W., Nerke, K., J., Choi, J., and Barber, D.L. 2001 The Nck-interacting kinase (NIK) phosphorylates the Na-H exchanger NHE1 and regulates NHE1 activation by platelet-derived growth factor. J. Biol Chem. 276:31349-31356.
• Denker, SP, Barber, DL. 2002 Ion transport proteins anchor and regulate the cytoskeleton. Current Opinion in Cell Biology 14:214-220.
• Buchan, A.M.J., Lin, C.-Y., Choi, J., and Barber, D.L. 2002 Somatostatin acting at receptor subtype SSTR1, inhibits Rho activity, the assembly of actin stress fibers, and cell migration. J. Biol. Chem. 277:28431-28432.
• Denker, S.P. and Barber, D.L. 2002 Cell migration requires both ion translocation and cytoskeletal anchoring by the Na-H exchanger NHE1. J. Cell Biol. 159:1087-1096. (Highlighted in Journal and cited in Faculty of 1000; Factor 8.1)
• Lin, C.-Y., Varma, M.G., Joubel, A., Madabushi, S., Lichtarge, O. and Barber, D.L. 2003 Conserved motifs common to somatostatin, D2-dopamine, and alpha2B-adrenergic receptors for inhibiting the Na-H exchanger NHE1. J. Biol. Chem. 278:15128-15135.
• Putney, L.K. and Barber D.L. 2003 Na-H exchange-dependent increase in intracellular pH times G2/M entry and transition. J. Biol. Chem. 278:44645-9. (Cited in Faculty of 1000; Factor 4.8)
• Putney, L.K., and Barber, D.L. 2004 Expression profile of genes regulated by activity of the Na-H exchanger NHE1. BMC Genomics 16:46-59
• Baumgartner, M., Patel, H. and Barber, D.L. 2004 The Na-H exchanger NHE1 as a plasma membrane scaffold in the assembly of signaling complexes. Am. J. Physiol: Cell Physiol 287:C844-C805.
• Patel, H. and Barber, D.L. 2005 A developmentally-regulated Dictyostelium Na-H exchanger is necessary for cell polarity and chemotaxis. J Cell Biol 169:321-329.
• Baumgartner, M.*, Sillman, A.*, Blackwood, E.M., Srivastava, J., Madson, N., Schilling, J.W., Wright, J.H. and Barber, D.L. 2006 The Nck-Interacting Kinase NIK Phosphorylates ERM Proteins for Formation of Lamellipodium by Growth Factors. Proc. Natl. Acad. Sci. 103:13391-13396. *Co-first authors
• Svrivastava, J., Barber, D.L. and Jacobson, M.P. 2007 Intracellular pH sensors: design principles and functional significance. Physiology 22:30-39.
• Meima, M.E., Mackley, J.R. and Barber, D.L. 2007 Beyond ion translocation: structural functions of the Na-H exchanger NHE1. Curr Opin Nephrol Hypertens 16:365-372.
• Frantz, C., Karydis, A., Nalbant, P., Hahn, K.M. and Barber, D.L. 2007 Positive feedback between Cdc42 activity and H+ efflux by the Na-H Exchanger NHE1 for polarity of migrating cells. J. Cell Biol. 179:403-410. (Highlighted in Journal)
• LeClaire, L.L., 3rd, Baumgartner, M., Iwasa, J.H., Mullins, R.D., and Barber, D.L. 2008 Phosphorylation of the Arp2/3 complex is necessary to nucleate actin filaments. J. Cell Biol. 182:647-654. (Highlighted in Journal; Cited in Faulty of 1000, Factor 6.0)
• Srivastava, J., Barreiro, G., Groscurth, S., Gingras, A.R., Goult, B.T., Critchley, D.R., Kelly, M.J., Jacobson, M.P., and Barber, D.L. 2008 Structural model and functional significance of pH-dependent talin-actin binding for focal adhesion remodeling. Proc. Natl. Acad. Sci. USA 105:14436-14441.
• Frantz, C., Barreiro, G., Dominguez, L., Chen, X., Eddy, R., Condeelis, J., Kelly, M.J., Jacobson, M.P., and Barber, D.L. 2008 Cofilin is a pH sensor for actin free barbed end formation: role of phosphoinositide binding. J. Cell Biol. 183:865-879. (Highlighted in Journal; Cited in Faulty of 1000, Factor 6.0)