Professor, Department of Cell and Tissue Biology, UCSF
Member, UCSF Biomedical Sciences Graduate Program (BMS)
| CONTACT | |
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barber@itsa.ucsf.edu Box 0512, UCSF; San Francisco, CA 94143-0512 |
additional websites: |
| EDUCATION | |
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University of California, Davis, B.S., 1975, Biological Sciences
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| PROFESSIONAL EXPERIENCE | |
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1977-1980 |
Lecturer, Department of Biology, University of California, Los Angeles |
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1980-1985 |
Predoctoral Fellow, Department of Anatomy, University of California, Los Angeles |
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1985-1987 |
NIH Postdoctoral Fellow (NRSA), Department of Physiology, University of Massachusetts Medical Center, Worcester, MA |
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1987-1991 |
Assistant Professor, Department of Surgery/Section of Anatomy, Yale University |
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1991-1995 |
Assistant Professor, Departments of Stomatology and Surgery, UCSF |
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1993-present |
Member, Biomedical Sciences Graduate Program, UCSF |
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1995-2001 |
Associate Professor, Departments of Stomatology and Surgery, UCSF |
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2001-present |
Professor, Department of Cell and Tissue Biology (previously Stomatology), UCSF |
| HONORS & AWARDS | |
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1985-87 |
NIH Individual NRSA Postdoctoral Fellowship |
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1986 |
Joseph P. Healy Research Award, University of Massachusetts |
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1995-2000 |
Established Investigator, American Heart Association |
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1998-present |
Editorial Board, American Journal of Physiology: Cell Physiology |
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1998-1999 |
American Heart Association, National Review Committee for Transport and Metabolism |
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1998 |
Innovation in Basic Sciences Award, UCSF |
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2000-2002 |
American Heart Association, Co-chair National Review Committee for Transport and Metabolism |
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2001/2003 |
Vice-chair/Chair, Gordon Conference on Molecular Pharmacology |
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2001-2003 |
Member, NIH CDF3 Study Section |
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2003-2007 |
Editorial Board, Journal of Biological Chemistry |
| SELECTED PUBLICATIONS | |
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(of 61 total) |
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Ganz, M.B., Pachter, J.A., Barber, D.L. 1990 Multiple receptors coupled to adenylate cyclase regulate Na H exchange independent of cAMP. J. Biol. Chem. 265:8989-8992. |
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Barber, D.L. and Ganz, M.B. 1992 Guanine nucleotides regulate -adrenergic activation of Na-H exchange independently of Gs. J. Biol. Chem. 267:20607-20612. |
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Voyno-Yasenetskaya, T., Conklin, B.R., Gilbert, R.L., Hooley, R., Bourne, H.R., and Barber, D.L. 1994 GÄÀ13 stimulates Na-H exchange. J. Biol. Chem. 269:4721-4724. |
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Hou, C., Gilbert, R.L., and Barber, D.L. 1994 Subtype-specific signaling mechanisms of somatostatin receptors SSTR1 and SSTR2. J. Biol. Chem. 269:10357-10362. |
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Hooley, R., Yu, C.-Y., Symons, M., and Barber, D.L. 1996 GÄÀ13 stimulates Na-H exchange through distinct Cdc42-dependent and Rho-dependent pathways. J. Biol. Chem. 271:6152-6158. |
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Vexler, Z., Symons, M., and Barber, D.L. 1996 Activation of Na-H exchange is necessary for RhoA-mediated stress fiber formation. J. Biol. Chem. 271:22281-22284. |
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Lin, X., Voyno-Yasenetskaya, T., Hooley, R., Lin, C., Orlowski, J., and Barber, D.L. 1996 GÄÀ12 differentially regulates Na-H exchanger isoforms. J. Biol. Chem. 271:22604-22610. |
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Lin, X. and Barber, D.L. 1996 A calcineurin homologous protein inhibits GTPase activation of Na-H exchange. Proc. Natl. Acad. Sci. 93:12631-12636. |
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Tominaga, T. and Barber, D.L. 1998 Na-H exchange acts downsteram of RhoA to regulate integrin-induced cell adhesion and spreading. Mol. Biol. Cell 9:2287-2303 |
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Tominaga, T., Ishizaki, T., Narumiya, S., and Barber, D.L. 1998 p160ROCK mediates RhoA activation of Na-H exchange. EMBO J. 17:4712-4722. |
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Lin, X., Sikkink, R., Rusnak, F., Barber, D.L. 1999 Inhibition of calcineurin phosphatase activity by a calcineurin B homologous protein.. J. Biol. Chem 274:36125-36131. |
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Chaudhry, F.A., Reimer, R.J., Krijaz, D., Barber, D.L., Storm-Mathisen, J., Copenhagen, D.R., and Edwards, R.H. 1999 Molecular analysis of system N suggests novel physiological roles in nitrogen metabolism and synaptic transmission. Cell 99:769-780. |
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Denker, S.P. Huang, D.C., Orlowski, J., Furthmayr, H., and Barber, D.L. 2000 Direct binding the Na-H exchanger NHE1 to ERM proteins regulates the cortical cytoskeleton and cell shape independently of H+ translocation. Molecular Cell 6:1425-1436. |
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Yan, W., Nerke, K., J., Choi, J., and Barber, D.L. 2001 The Nck-interacting kinase (NIK) phosphorylates the Na-H exchanger NHE1 and regulates NHE1 activation by platelet-derived growth factor. J. Biol Chem. 276:31349-31356. |
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Putney, L, Denker, SP, and Barber, DL. 2002 The changing face of the Na-H exchanger, NHE1: structure, regulation, and cellular actions. Annu. Rev. Pharmacol. Toxicol. 42:527-552. |
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Denker, SP, Barber, DL. 2002 Ion transport proteins anchor and regulate the cytoskeleton. Current Opinion in Cell Biology 14:214-220. |
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Buchan, AMJ, Lin, C-Y, Choi, J, and Barber, DL. 2002 Somatostatin acting at receptor subtype SSTR1, inhibits Rho activity, the assembly of actin stress fibers, and cell migration. J. Biol. Chem. 277:28431-28432. |
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Denker, SP and Barber, DL. 2002 Cell migration requires both ion translocation and cytoskeletal anchoring by the Na-H exchanger NHE1. J. Cell Biol. 159:1087-1096. (cited in Faculty of 1000) |
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Lin, C-Y, Varma, MG, Joubel, A, Madabushi, S, Lichtarge, O and Barber, DL. 2003 Conserved motifs common to somatostatin, D2-dopamine, and alpha2B-adrenergic receptors for inhibiting the Na-H exchanger NHE1. J. Biol. Chem. 278:15128-15135. |
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Putney, LK and Barber DL. 2003 Na-H exchange-dependent increase in intracellular pH times G2/M entry and transition. J. Biol. Chem. 278:44645-44649. (cited in Faculty of 1000) |
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Putney, LK and Barber DL. 2004 Expression profile of genes regulated by the Na-H exchanger NHE1. BMC Genomics 5:46. |
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Baumgartner, M, Patel, H and Barber DL. 2004 The Na-H exchanger NHE1 as a plasma membrane scaffold in the assembly of signaling complexes. Am. J Physiol. 287:C844-850 |
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Patel, H and Barber DL. A developmentally regulated Na-H exchanger in Dictyostelium discoideum is necessary for cell polarity during chemotaxis (revised manuscript in review J Cell Biol). |
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3/15/05 |
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