mhbarcellos-hoff@lbl.gov
(510) 486-6371 (voice)
(510) 495-2535 (fax)

Life Sciences Division, LBNL, Bldg. 977
1 Cyclotron Road, Berkeley, CA 94720

additional websites:

Barcellos-Hoff Lab Website, LBNL

The University of Chicago, IL, AB, 1978, Biopsychology
University of California, San Francisco, PhD, 1986, Experimental Pathology
Lawrence Berkeley Laboratory, Postdoctoral,1986-1988, Cell Biology

Bissell, M.J. & M.H. Barcellos-Hoff: The influence of extracellular matrix on gene expression: Is the structure the message? J Cell Sci 8:327-344, 1987.

Barcellos-Hoff M.H., Aggeler J., Ram T. & Bissell M.J.: Functional differentiation and alveolar morphogenesis of primary mammary cultures on reconstituted basement membrane. Development 105:223-235, 1989.

Aggeler J.A., Ward J., MacKenzie-Blackie L., Barcellos-Hoff M.H., Streuli C.H. & Bissell M.J.: Cytodifferentiation of mouse mammary epithelial cells cultured on a reconstituted basement membrane reveals striking similarities to development in vivo. J Cell Science 99:407-417, 1991.

Barcellos-Hoff, M.H., Linfoot, P.J., Marton, L.J. & Deen, D.F.: Production of stable phenotypes from 1,3 bis(2-chloroethyl)-1-nitrosourea-treated 9L rat brain tumor multicellular spheroids. Int J Cancer 52:409-413, 1992.

Barcellos-Hoff, M.H.: Mammary epithelial reorganization on extracellular matrix is mediated by cell surface galactosyltransferase. Expt Cell Res 117:1321-1330, 1992.

Barcellos-Hoff, M.H.: Radiation-induced changes in transforming growth factor β and subsequent extracellular matrix reorganization in irradiated murine mammary gland. Cancer Res 53:3880-3886, 1993.

Barcellos-Hoff, M.H., Derynck, R., Tsang, M.L. & Weatherbee, J.: Transforming growth factor β activation in irradiated murine mammary gland. J Clin Invest 93:892-899, 1994.

Barcellos-Hoff, M.H., Ehrhart, E.J., Kalia, M., Flanders, K., Jirtle, R. & Tsang, M. L.-S: Immunohistochemical detection of active transforming growth factor β using engineered tissue. Am J Pathol 147:1228-1237, 1995.

Barcellos-Hoff, M.H. & Dix, T.: Redox-mediated activation of latent transforming growth factor-β. Molec Endocrin 10: 1077-1083, 1996.

Reiss, M. and M.H. Barcellos-Hoff: The role of TGF-β in breast cancer: A working hypothesis. Breast Can Treat Rpt 45:81-95, 1997.

Ehrhart, E.J., Carroll, A.G., Segarini, P., Tsang, M.-L. & Barcellos-Hoff, M.H.: Latent transforming growth factor-β1 activation in situ: Quantitative and functional evidence following low dose ƒÁ-irradiation. FASEB J 11:991-1002, 1997.

Barcellos-Hoff, M.H. & Ravani, S.A.: Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells. Cancer Res, 60:1254-1260, 2000.

Barcellos-Hoff, M.H. and Ewan, K.B.: Transforming growth factor β1 and breast cancer: Mammary gland development. Breast Cancer Res 2:92-100, 2000.

Park, C., Bissell, M.J. and Barcellos-Hoff, M.H.: The role of the microenvironment in the malignant phenotype: Critical role of cytokines and integrin signaling. Molecular Medicine Today 6:324-329, 2000.

Barcellos-Hoff, M.H.: It takes a tissue to make a tumor: Epigenetics, cancer and the microenvironment. J Mammary Gland Biol Neoplasia 6:213-221, 2001.

Barcellos-Hoff, M.H. and A.L. Brooks: Extracellular signaling via the microenvironment: A hypothesis relating carcinogenesis, bystander effect and genomic instability. Radiat Res 156(5):618-627, 2001.

Wang, F., Hansen, R. K., Radisky, D., Yoneda, T., Barcellos-Hoff, M. H., Petersen, O. W., Turley, E. A., and Bissell, M. J. Combined alteration of intracellular signaling pathways in a three-dimensional context leads to phenotypic reversion or cell death of human breast cancer cells. JNCI Cancer Spectrum 94:1494-1503, 2002..

Ewan, K.B., Ravani, S.A., Shyamala, G., Akhurst, R., Tang, Y., Wakefield, L., and M.H. Barcellos-Hoff: Latent TGF-β activation in mammary gland: Regulation by ovarian hormones affects ductal and alveolar proliferation. Am J Pathol 160: 2081-2093, 2002.

Parvin, B., Yang, Q., Fontenay, G. and M.H. Barcellos-Hoff: BioSig: an imaging bioinformatics system for studying phenomics. IEEE Computer 35: 65-71, 2002.

Ewan, K.B., Henshall-Powell, R., Ravani, S.A., Pajares, M.J., Arteaga, C., Warters, R., Akhurst, R.J., and M.H. Barcellos-Hoff: Transforming growth factor-β1 mediates cellular response to DNA damage in situ. Cancer Res 62:5627-5631, 2002.

Erickson, A.C. and M.H. Barcellos-Hoff: The not-so innocent bystander: Microenvironment as a therapeutic target in cancer. Expert Opin Ther Targets 7(1):71-88, 2003.

Park, C., Henshall-Powell, R.L., Erickson, A.C., Talhouk, R., Parvin, B., Bissell, M.J. and M.H. Barcellos-Hoff. Ionizing radiation induces heritable disruption of epithelial cell interactions. Proc Natl Acad Sci USA 100 (19): 10728 10733, 2003.

Muraoka, R.S., Kurokawa, H., Koh, Y., Forbes, J.T., Roebuck, L.R., Barcellos-Hoff, M.H., Moody, S.E., Chodosh, L.A. and C.L. Arteaga. Conditional overexpression of active transforming growth factor βaccelerates metastases of transgenic mammary tumors. Cancer Res 64:9002-9011, 2004.

Barcellos Hoff, M.H. Integrative Radiation Carcinogenesis: Interactions between cell and tissue responses to DNA damage. Sem Cancer Biology 15(2):138 147, 2005.

Barcellos Hoff, M.H. and D. Medina. New highlights on stroma epithelial interactions in breast cancer. Breast Cancer Res 7:33 36, 2005.

Barcellos Hoff, M.H. How tissues respond to damage at the cellular level. BJR Suppl. 2005;27:123 7, 2005.

Ewan, K.B., Oketch Rabah, H.A., S.A. Ravani, G. Shyamala, H.L. Moses, and Barcellos Hoff, M.H. Proliferation of Adult Estrogen Receptor Positive Mammary Epithelial Cells is Restrained by TGFβ 1. Am J Pathol 167(2):409 17, 2005.

Fernandez Gonzalez, R., Barcellos Hoff, M.H. and C. Ortiz de Solorzano, A tool for the quantitative spatial analysis of complex cellular systems, IEEE Transactions on Image Processing 14(9):1300-13, 2005.

Grimm, S. L., Contreras, A., Barcellos Hoff, M.H. and J. Rosen: Cell cycle defects contribute to a block in hormone induced mammary gland proliferation in C/EBPbeta null mice. J Biol Chem. 2005 Aug 24;

Muraoka-Cook, R. S., Shin, I., Yi, J. Y., Easterly, E., Barcellos-Hoff, M. H., Yingling, J. M., Zent, R., and Arteaga, C. L. Activated type I TGFβ receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression. Oncogene, doi:10.1038/sj.onc.1208964: 1-16, 2005.

Barcellos Hoff, M.H., Park, C., Wright, E.G. Radiation effects via the microenvironment: Implications for carcinogenesis and radiation oncology. Nature Cancer Rev, 5(11):867-75, 2005.

Barcellos-Hoff, M.H. and S. Costes. A systems biology approach to multicellular and multi generational radiation responses. Mut Res Jan 14; [Epub ahead of print]2006 PMID: 16417910

5/12/06