Kathleen M. Plant Distinguished Professor
, UCSF
Chair, Neurological Surgery; Director, Brain Tumor Research Center, UCSF
Co-Leader, Neurologic Oncology Program, UCSF Helen Diller Family Comprehensive Cancer Center
| CONTACT | |
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bergerm@neurosurg.ucsf.edu Box 0112, UCSF; San Francisco, CA 94143-0112 |
additional websites: |
| EDUCATION | |
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Harvard University, Cambridge, MA, A.B., 1975, Social Psychology
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| PROFESSIONAL EXPERIENCE | |
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1980 - 1985 |
Residency, Dept. of Neurological Surgery, University of California, San Francisco, CA (UCSF) |
1986 - 1990 |
Asst. Professor, Dept. of Neurological Surgery, University of Washington, Seattle, WA |
1990 - 1996 |
Assoc. Professor, Dept. of Neurological Surgery, University of Washington, Seattle, WA |
1995 - 1997 |
American Cancer Society Prof. of Clinical Oncology, University of Washington, Seattle, WA |
1996 - 1997 |
Professor, Dept. of Neurological Surgery, University of Washington, Seattle, WA |
1997 - present |
Professor and Chair, Dept. of Neurological Surgery, UCSF, San Francisco, CA |
1997 - present |
Director, Brain Tumor Research Center, Dept. of Neurological Surgery, UCSF |
| HONORS & AWARDS | |
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1997-present |
Joint Section on Tumors Advisory Council, American Association of Neurological Surgeons & Congress of Neurological Surgeons |
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1997-1999 |
Vice-President, Congress of Neurological Surgeons |
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2002 Ð present |
America's Top Doctors, peer-nominated referral index from The Best In American Medicine: a Castle Connolly Guide |
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2006 |
Tumor Section, 2006 Ronald L. Bittner Lecturer / 2006 Farber Award Winner |
| SELECTED PUBLICATIONS | |
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Weber F, Asher A, Bucholz R, Berger M, Prados M, Bruce J, Hall W, Rainov NG, Westphal M, Warnick R, Rand RW, Floeth F, Rommel F, Pan H, Hingorani VN, Puri RK : Safety, tolerability, and tumor response of IL4-Pseudomonas exotoxin (NBI-3001) in patients with recurrent malignant glioma. J Neuro-Oncol 64:125-137, 2003. | |
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Prados MD, McDermott M, Chang SM, Wilson CB, Fick J, Culver K, Van Gilder J, Spence A, Berger MS : Treatment of progressive or recurrent glioblastoma multiforme in adults with herpes simplex virus thymidine kinase gene vector-producer cells followed by intravenous ganciclovir administration: a phase I/II multi-institutional trial. J Neuro-Oncol 65:269-278, 2003. | |
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Schold Jr C, Kokkinakis D, Chang SM, Berger MS, Hess K, Schiff D, Robins HI, Mehta M, Fink K, Davis RL, Prados MD : O6-Benzylguanine suppression of O6-alkylguanine-DNA alkyltransferase in anaplastic gliomas. Neuro-Oncology 6: 28-32, 2004 | |
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Saito R, Bringas JR, McKnight TR, Mamot C, Drummond DC, Kirpotin DB, Park JW, Berger MS, Bankiewicz KS : Distribution of liposomes into brain and rat brain tumor models by convection-enhanced delivery monitored with magnetic resonance imaging. Cancer Res 64: 2572-2579, 2004. | |
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Pirzkall A, Li X, Oh J, Chang S, Berger MS, Larson DA, Verhey LJ, Dillon WP, Nelson SJ : 3D MR-Spectroscopy for resected high-grade gliomas prior to RT: Tumor extent according to metabolic activity in relation to MRI. Int J Radiat Oncol Biol Phys 59 (1):126-137, 2004. | |
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Kanamori M, VandenBerg S, Bergers G, Berger MS, Pieper RO : Integrin 3 Overexpression Suppresses Tumor Growth in a Human Model of Gliomagenesis: Implications for the Role of 3 Overexpression in Glioblastoma Multiforme. Cancer Res 64: 2751-2758, 2004 | |
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Mamot C, Nguyen JB, Pourdehnad M, Hadaczek P, Saito R, Bringas J, Drummond DC, Hong K, Kirpotin DB, McKnight T, Berger MS, Park JW, Bankiewicz KS : Extensive distribution of lipsomes in rodent brains and brain tumors following convection enhanced delivery (CED). J Neuro-Oncol 68 (1):1-9, 2004 | |
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2003 Jun 1;56(2):511-8. Erratum in: Int J Radiat Oncol Biol Phys 57(1):306l, 2003 | |
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Saito R, Bringas J, Tamas M, Pieper RO, Berger MS, Bankiewicz KS : Convection enhanced delivery of tumor necrosis factor-related apoptosis-inducing ligand with systemic administration of temozolomide prolongs survival in a U87MG intracranial xenograft. Cancer Res. 64(19):6858-62, 2004 | |
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Sanai N, Tramontin AD, Quinones-Hinojosa A, Barbaro NM, Gupta N, Kunwar S, Lawton MT, McDermott MW, Parsa AT, Verdugo JM-G, Berger MS, Alvarez-Bullya A : Unique astrocyte ribbon in adult human brain contains neural stems cells but lacks chain migration. Nature 427:1-5, 2004 | |
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Keles GE, Lundin DA, Lamborn KR, Chang EF, Berger MS : Intraoperative subcortical stimulation mapping for hemispherical perirolandic gliomas located with or adjacent to the descending pathways: evaluation of morbidity and assessment of function outcome in 294 patients. Journal of Neurosurgery 100:369-375, 2004 | |
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Keles E, Lamborn KR, Chang SM, Prados MD, Berger MS : Volume of residual disease as a predictor of outcome in adult patients with recurrent supratentorial glioblastoma multiforme undergoing chemotherapy. J Neurosurg, 100:41-46, 2004 | |
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Cha S, Tihan T, Crawford F, Fischbein N, Chang S, Parsa A, McDermott M, Bollen A, Lu Y, Prados M, Berger MS, Nelson SJ, Dillon WP : Differentiation of low-grade oligodendroglioma from low-grade astrocytoma by using quantitative blood-volume measurements derived from dynamic susceptibility contrast-enhanced MR imaging. Am J Neurorad, 2005 Feb;26(2):266-73 | |
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Chang S, Parney IF, Huang W, Asher T, Bernstein M, Lillihei K, Brem H, Berger MS, Laws E, and Glioma Outcomes Project Investigators : Patterns of care for adults with newly diagnosed malignant gliomas: data from the Glioma Outcomes Project Investigators. JAMA, 2005 Feb 2;293(5):557-64 | |
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Parney IF, Kunwar S, McDermott M, Berger M, Prados M, Cha S, Croteau D, Puri R, Chang SM : Neuroradiographic changes following convection-enhanced delivery of the conjugated toxin interleukin 13-PE38QQR for recurrent malignant glioma. J Neurosurg 2005 Feb,102(2):267-275 | |
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Smith J, Cha S, Mayo K, McDermott MW, Parsa AT, KunwarS, Chang S, Dillon WP, Prados MD, Berger MS : Serial diffusion-weighted MR imaging in glioma: distinguishing tumor recurrence from post-resection injury. J Neurosurg. 2005 Sep; 103(3):428-38. | |
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Liang Y, Diehn M, Aldape KD, Nicholas MK, Bollen AW, Lamborn KR, Berger MS, Botstein D, Brown PO, Israel MA : Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme. Proc Natl Acad Sci USA, 2005 April 19, 102(16):5814-5819. E-Pub April 12, 2005. | |
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Sanai N, Alvarez-Buylla A, Berger MS : Neural stem cells and the origin of gliomas. N Engl J Med. 2005 Aug 25; 353(8):811-22 | |
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Haas-Kogan DA, Prados MD, Tihan T, Eberhard DA, Jelluma N, Arvold ND, Baumber R, Lamborn KR, Kapadia A, Malec M, Berger MS, Stokoe D : Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib. J NCI, June 15, 2005 97(12):880-887 | |
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Wrensch M, Fisher JL, Schwartzbaum JA, Bondy M, Berger MS, Aldape K : The molecular epidemiology of gliomas in adults. Neurosurg Focus (electronic journal) 19(5):E5, November 2005, 1-11 | |
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Krauze MT, McKnight TR, Yamashita Y, Bringas J, Noble CO, Saito R, Geletneky K, Forsayeth J, Berger MS, Jackson P, Park JW, Bankiewicz KS : Real-time visualization and characterization of liposomal delivery into the monkey brain by magnetic resonance imaging. Cancer Res Brain Res Protoc. 2005 Dec;16(1-3):20-6. Epub 2005 Sep 21 | |
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Krauze MT, Saito R, Noble C, Tamas M, Bringas J, Park JW, Berger MS, Bankiewicz K : Reflux-free cannula for convection-enhanced high-speed delivery of therapeutic agents: technical note. J. Neurosurg 2005:103(5) November, 923-929 | |
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Noble CO, Krauze MT, Drummond DC, Yamashita Y, Saito R, Berger MS, Kirpotin DB, Bankiewicz KS, Park JW : Novel nanoliposomal CPT-11 infused by convection-enhanced delivery in intracranial tumors: pharmacology and efficacy. Cancer Res. 2006 Mar 1;66(5):2801-6. | |
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Ozturk E, Crane J, Cha S, Chang SM, Berger MS, Nelson SJ : Unaliasing lipid contamination for MR spectroscopic imaging of gliomas at 3T using sensitivity encoding (SENSE). Magn Reson Med. 2006 May 55(5) 1164-9; Epub Apr 4 | |
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Krauze M, Ryuta S, Noble C, Drummond D, Berger MS, Park J, Bankiewicz K : Convection-enhanced delivery of Ls-TPT enables an effective continuous low-dose chemotherapy against malignant glioma xenograft model. Neuro-Oncol 2006; 8(3):205-14. Epub 2006 May 24 | |
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12/7/06 |
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