gabriele.bergers@ucsf.edu
(415) 476-6786 (voice)
(415) 476-0388 (fax)

Box 0520, UCSF; San Francisco, CA 94143-0520

additional websites:

Faculty Profile, Neuro Surgery

University of Munich, Germany, B.S., 1988, Biochemistry
Max-Planck-Institute, Martinsried, Germany, M.S., 1989, Biochemistry/Virology
Institute for Molecular Pathology, Vienna, Austria, Ph.D., 1993, Molecular Genetics
University of CA, San Francisco, CA Postdoctoral fellow, 1994-1997, Cancer Biology

Superti-Furga, G., Bergers, G., Picard, D. and Busslinger, M. (1991) Hormone-dependent transcriptional regulation and cellular transformation by Fos-steroid receptor fusion proteins. Proc. Natl. Acad. Sci. USA 88: 5114-5118.

Braselmann, S., Bergers, G., Wrighton, C., Graninger, P., Superti-Furga, G. and Busslinger, M. (1992) Identification of Fos target genes by the use of selective induction systems. J. Cell Sci. Suppl 16: 97-109.

Busslinger, M., Bergers, G. (1993) Identification of AP-1 regulated genes. In: “The Fos and Jun Families of Transcription Factors”, (Herrlich, P. and Angel, P., eds.; CRC press)

Bergers, G., Reikerstorfer, A., Braselmann, S., Graninger, P. and Busslinger, M. (1994) lternative promoter usage of the Fos-responsive Fit-1 gene generates mRNA isoforms coding for either secreted or membrane-bound proteins related to the IL-1 receptor. EMBO J. 13: 1176-1188.

Bergers, G., Graninger, P., Braselmann, S., Wrighton, C. and Busslinger M. (1995) Transcriptional activation of the fra-1 gene by AP-1 is mediated by regulatory sequences in the first intron. Mol. Cell. Biol. 15: 3748-3758.

Vu, T.H., Shipley, J.M., Bergers, G., Berger, J. E., Helms, J.A., Hanahan, D., Shapiro, S.D., Senior, R.M. and Werb, Z. (1998). MMP9/Gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hyperthrophic chondrocytes. Cell 93: 411-422

Bergers, G., Hanahan, D. and Coussens, L. (1999): Angiogenesis and apoptosis regulate neoplastic progression in transgenic mouse models of tumorigenesis. Int. J. of Dev. Biol. 42: 995-1002.

Bergers, G., Javaherian, K., Lo, K.-M., Folkman J. and Hanahan, D. (1999): Effects of Angiogenesis Inhibitors on Multistage Carcinogenesis in Mice. Science 284: 808-812

Coussens, L.M., Raymond, W.W., Bergers, G., Laig-Webster, M., Behrendtsen, O., Werb, Z., Caughey, G.H., and Hanahan, D. (1999): Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis.Genes & Development 13: 1382-1397.

Bergers, G. and Coussens L.M. (2000): Extrinsic regulators of epithelial tumor progression: metalloproteinases. Curr. Opin. in Genetics & Development 10, 120-127

Hanahan, D, Bergers, G. and Bergsland, E (2000): Less is more, regularly: Metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice. J.Clin.Invest. 105: .1045-1047.

Bergers, G., Brekken, R., McMahon, G., Vu, T.H., Itoh, T., Tamaki, K., Tanzawa, K., Thorpe, P., Itohara, S., Werb, Z. and Hanahan, D. (2000): Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nature Cell Biol. 2: 737-744

Sternlicht, M. and Bergers, G (2000): Matrix metalloproteinases as emerging targets in cancer: status and prospects. ETT 4: 609-633.

Bergers, G. and Hanahan, D. (2001): Building antiangiogenic cell factories for cancer therapy. Nature Biotech. News &Views 19, 20-21.

Toft, D.J., Rosenberg, S.B., Bergers, G., Volpert, O., and Linzer, D.I.H. (2001). Reactivation of proliferin gene expression is associated with increased angiogenesis in a cell culture model of fibrosarcoma tumor progression. Proc. Natl. Acad. Sci. USA 98 13055-13059.

Shan Man, Guido Bocci, Giulio Francia, Shane K Green, Serge Jothy, Douglas Hanahan, Peter Bohlen, Dan Hicklin, Gabriele Bergers and Robert S Kerbel (2002): Anti-tumor Effects in Mice of Low-Dose (Metronomic) Cyclophosphamide Administered Continuously through the Drinking Water. Cancer Res 62 2731-2735.

Bergers, G. and Hanahan, D (2002).: Combining anti-angiogenic agents with metronomic chemotherapy enhances efficacy against late-stage pancreatic islet carcinomas in mice. Cold Spring Harbor Symp. Quant. Biol. 67: 293-300.

Bergers, G., Song S., Meyer-Morse N., Bergsland E. and D. Hanahan (2003):. Benefits of targeting both pericytes and endothelial cells in the tumor vasculature J Clin. Invest 111: 1287-1295.

Bergers, G. and Benjamin, L.E. (2003): The Angiogenic Switch in Tumorigenesis, Article for Nature Reviews Cancer 3: 401-410.

Blouw, B., Song, H., Tihan, T., Bosze, J., Ferrara, N., Gerber H.-P., Johnson R.S. and Gabriele Bergers (2003): The hypoxic response of tumors is dependent on their microenvironment . Cancer Cell 3: 347-361

Joyce, J.A., Laakkonen, P., Bernasconi, M., Bergers, G., Ruoslahti, E. and D. Hanahan (2003): Stage-specific vascular markers revealed by phage display in a mouse model of pancreatic islet tumorigenesis. Cancer Cell 4: 393-403.

12/15/04