Associate Professor, Pediatrics, UCSF
Member, Biomedical Sciences Graduate Program (BMS) , UCSF
| CONTACT | |
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hsbernstein@pedcard.ucsf.edu Box 0130, UCSF; San Francisco, CA 94143-0130 |
additional websites: |
| EDUCATION | |
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Harvard College, Cambridge, MA, A.B., 1982, Biology
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| PROFESSIONAL EXPERIENCE | |
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1986-1988 |
Postdoctoral Fellow, Human Genetics, Mount Sinai School of Medicine, New York, NY |
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1990-1992 |
Resident, Pediatrics, University of California San Francisco (UCSF), San Francisco, CA |
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1992-1994 |
Clinical Fellow, Pediatric Cardiology, UCSF |
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1994-1997 |
Postdoctoral Fellow, Cardiovascular Research Institute, UCSF |
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1997-2002 |
Assistant Professor of Pediatrics, UCSF |
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1998-present |
Member, Cancer Center, UCSF |
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1998-present |
Member, Program in Biomedical Science, UCSF |
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1999-present |
Investigator, Cardiovascular Research Institute, UCSF |
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1999-present |
Member, Program in Human Genetics, UCSF |
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2000-present |
Member, Molecular Medicine Training Program, UCSF |
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2003-present |
Member, Program in developmental and Stem Cell Biology, UCSF |
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2003-present |
Associate Professor of Pediatrics, UCSF |
| HONORS & AWARDS | |
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1980 |
Harvard College Honorary Scholarship |
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1989 |
Assoc. Med. Schools of NY Award for Distinguished Performance in Research |
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1990 |
Upjohn Achievement Award for Clinical Excellence, Mount Sinai School of Med. |
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1990 |
Alpha Omega Alpha Honor Medical Society, Lambda Chapter |
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1990 |
Excellence in Teaching Award, University of California San Francisco |
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1991 |
Diplomate, National Board of Medical Examiners |
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1993 |
Diplomate, American Board of Pediatrics |
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1994-1995 |
American Heart Association, Postdoctoral Research Fellowship |
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1995-2000 |
National Institutes of Health, Clinical Investigator Development Award |
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1996 |
Richard Rowe Research Award in Perinatal Cardiology, Soc. for Pediatric Research |
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1996 |
Melvin Grumbach Research Award, UCSF, San Francisco |
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1997-1998 |
Innovation in Basic Science Award, UCSF, San Francisco |
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1998-2000 |
March of Dimes, Basil O'Connor Starter Scholar Research Award |
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1998-2001 |
American Heart Association National Center, Grant-in-Aid (9750068N) |
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1999 |
Member, Society for Pediatric Research |
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1999 |
Ross Research Award, Society for Pediatric Research |
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1999 |
Young Investigator Award, Heart Failure Society of America |
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1999-2004 |
National Institutes of Health, New Research Grant (R01 HL62174) |
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2001-2004 |
American Heart Association National Center, Grant-in-Aid (0150062N) |
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2003-2008 |
American Heart Association National Center, Established Investigator Award (0340039N) |
| SELECTED PUBLICATIONS | |
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Calhoun, D.H., Bishop, D.F., Bernstein, H.S., Quinn, M., Hantzopoulos, P., and Desnick, R.J. (1985) Fabry disease: Isolation of a cDNA clone encoding human a_galactosidase A. Proc Natl Acad Sci USA 82:7364-7368. |
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Desnick, R.J., Bernstein, H.S., Astrin, K.H., Potluri V.R., and Bishop, D.F. (1986) Fabry disease: Strategies for molecular diagnosis and therapy. Jap J Inher Metabol Dis 2:1-18. |
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Bishop, D.F., Calhoun, D.H., Bernstein, H.S., Hantzopoulos, P., Quinn, M., and Desnick, R.J. (1986) Human a_galactosidase A: Nucleotide sequence of a cDNA clone encoding the mature enzyme. Proc Natl Acad Sci USA 83:4859-4863. |
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Bernstein, H.S. (1986) Cloning of human a_galactosidase A and molecular genetic studies of Fabry disease. Doctoral dissertation in Biomedical Sciences, City University of New York. |
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Desnick, R.J., Bernstein, H.S., Astrin, K.H., and Bishop, D.F. (1987) Fabry disease: Molecular diagnosis of hemizygotes and heterozygotes. Enzyme 38:54-64. |
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Bernstein, H.S., Bishop, D.F., Astrin, K.H., Kornreich, R., Eng, C.M., Sakuraba, H., and Desnick, R.J. (1989) Fabry disease: Six gene rearrangements and an exonic point mutation in the a_galactosidase gene. J Clin Invest 83:1390-1399. |
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Bernstein, H.S., Filly, R.A., Goldberg, J.D., and Golbus, M.S. (1991) Prognosis of fetuses with a cystic hygroma. Prenat Diagn 11:349-355. |
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Bernstein, H.S., Moore, P., Stanger, P., and Silverman, N.H. (1995) The levoatriocardinal vein: morphologic and echocardiographic evaluation of the pulmonary-systemic connection. J Am Coll Cardiol 26(4):995-1001. |
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Bernstein, H.S., Brook, M.M., Silverman, N.H., and Bristow, J. (1995) Development of pulmonary arteriovenous fistulae in children following cavopulmonary shunt. Circulation 92(9):II-309-II-314. |
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Chen, J., Bernstein, H.S., Chen, M., Wang, L., Ishii, M., Turck, C.W., and Coughlin, S.R. (1995) Tethered ligand library for discovery of peptide agonists. J Biol Chem 270(40):23398-23401. |
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Bernstein, H.S., Ursell, P.C., Hanley, F.C., Brook, M.M., Silverman, N.H., and Bristow, J. (1996) Fulminant development of pulmonary arteriovenous fistulae in an infant following total cavopulmonary shunt. Pediatr Cardiol 17:46-50. |
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Bernstein, H.S., Ursell, P.C., and Teitel, D.F. (1997) Primary involvement of the mitral and aortic valves in TakayasuÕs arteritis. Cardiol Young 7(2):228-231. |
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Bernstein, H.S., and Coughlin, S.R. (1997) Pombe Cdc5-related protein: A putative human transcription factor implicated in mitogen-activated signaling. J Biol Chem 272(9):5833-5837. |
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Bernstein, H.S., and Coughlin, S.R. (1998) A mammalian homolog of fission yeast Cdc5 regulates G2 progression and mitotic entry. J Biol Chem 273(8):4666-4671. |
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Bristow, J.D., and Bernstein, H.S. (1998) Counseling families with chromosome 22q11 deletions: The catch in CATCH-22. J Am Coll Cardiol 32(2):499-501. |
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Chu, M.H., Xu, X., Lei, X., Turck, C.W., and Bernstein, H.S. (1999) A transcriptional regulator of G2/M responds to mitogen-activated signals through phosphorylation by protein kinase C. Circ 100:I-690. |
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Bernstein, H.S. (2000) Cell cycle regulation and myocardial regeneration. Japan Circ J 64:I-168. |
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Lei, X.-H., Shen, X., Xu, X.-Q., and Bernstein, H.S. (2000) Human Cdc5, a regulator of mitotic entry, can act as a site-specific DNA binding protein. J Cell Sci 113:4523-4531. |
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Hlaing, M., Shen, X., Dazin, P., and Bernstein, H.S. (2002) The hypertrophic response in C2C12 myoblasts recruits the G1 cell cycle machinery. J Biol Chem 277:23794-23799. |
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Shen, X., Collier, J.M., Hlaing, M., Zhang, L., Delshad, E.H., Bristow, J., and Bernstein, H.S. (2003) Genome-wide examination of myoblast cell cycle withdrawal during differentiation. Devel Dynam 226:128-138. |
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Liu, L., Gr·ub, R., Hlaing, M., Epting, C.L., Turck, C.W., Zhang, L., Xu, X.-Q., and Bernstein, H.S. (2003) Distinct domains of human Cdc5 direct its nuclear import and association with the spliceosome. Cell Biochem Biophys 39:119-131. |
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Epting, C.L., Shen, X., Liu, L., Zhang, L., Bristow, J., and Bernstein, H.S. (2003) GPI-anchored proteins regulate cell cycle withdrawal and myoblast fusion during differentiation. Ped Res 53:36A. |
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Hlaing, M., Spitz, P., Padmanabhan, K., Cabezas, B., Barker, C., and Bernstein, H.S. (2004) E2F-1 regulates a subset of target genes during cell growth without division. J Biol Chem in press. |
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Williams, S.D., Bernstein, H.S., and Zhu, H. (2004) Adenoviral delivery of human Cdc5 regulates G2/M progression and promotes cardiac myocyte proliferation. In review. |
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Epting, C.L., Shen, X., Liu, L., Bristow, J., and Bernstein, H.S. (2004) Stem cell antigen-1 is necessary for myoblast fusion and cell cycle withdrawal during skeletal myogenesis. In review. |
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Hansel, D.E., Dhara, S., Huang, R.C., Ashfaq, R., Diesel, M., Shimada, Y., Bernstein, H.S., Harmon, J., Brock, M., Forastiere, A., Washington, M.K., Maitra, A., and Montgomery, E. CDC2/CDK1 expression in esophageal adenocarcinoma and precursor lesions serves as a cancer progression marker and novel drug target. In review. |
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10/01/04 |
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