Harold S. Bernstein, MD, PhD

Harvard College, Cambridge, MA, A.B., 1982, Biology
Mount Sinai School of Medicine, New York, NY, M.Phil., 1983, Biomedical Science
Mount Sinai School of Medicine, New York, NY, Ph.D., 1986, Human Molec. Genetics
Mount Sinai School of Medicine, New York, NY, M.D., 1990, Medicine

• 1986-1982
  Postdoctoral Fellow, Human Genetics, Mount Sinai School of Medicine, New York, NY
• 1990-1992
  Resident, Pediatrics, University of California San Francisco (UCSF), San Francisco, CA
• 1992-1992
  Clinical Fellow, Pediatric Cardiology, UCSF
• 1994-1992
  Postdoctoral Fellow, Cardiovascular Research Institute, UCSF
• 1997-2002
  Assistant Professor of Pediatrics, UCSF
• 1998-present
  Member, Cancer Center, UCSF
• 1998-present
  Member, Program in Biomedical Science, UCSF
• 1999-present
  Investigator, Cardiovascular Research Institute, UCSF
• 1999-present
  Member, Program in Human Genetics, UCSF
• 2000-present
  Member, Molecular Medicine Training Program, UCSF
• 2003-present
  Member, Program in developmental and Stem Cell Biology, UCSF
• 2003-2008
  Associate Professor of Pediatrics, UCSF
• 2008-present
  Professor of Pediatrics, UCSF

• 1982
  Harvard College Honorary Scholarship
• 1982
  Assoc. Med. Schools of NY Award for Distinguished Performance in Research
• 1992
  Upjohn Achievement Award for Clinical Excellence, Mount Sinai School of Med.
• 1992
  Alpha Omega Alpha Honor Medical Society, Lambda Chapter
• 1992
  Excellence in Teaching Award, University of California San Francisco
• 1992
  Diplomate, National Board of Medical Examiners
• 1992
  Diplomate, American Board of Pediatrics
• 1994-1992
  American Heart Association, Postdoctoral Research Fellowship
• 1995-2002
  National Institutes of Health, Clinical Investigator Development Award
• 1992
  Richard Rowe Research Award in Perinatal Cardiology, Soc. for Pediatric Research
• 1992
  Melvin Grumbach Research Award, UCSF, San Francisco
• 1997-1992
  Innovation in Basic Science Award, UCSF, San Francisco
• 1998-2002
  March of Dimes, Basil O'Connor Starter Scholar Research Award
• 1998-2002
  American Heart Association National Center, Grant-in-Aid (9750068N)
• 1992
  Member, Society for Pediatric Research
• 1992
  Ross Research Award, Society for Pediatric Research
• 1992
  Young Investigator Award, Heart Failure Society of America
• 1999-2002
  National Institutes of Health, New Research Grant (R01 HL62174)
• 2001-2002
  American Heart Association National Center, Grant-in-Aid (0150062N)
• 2003-2002
  American Heart Association National Center, Established Investigator Award (0340039N)

• Calhoun, D.H., Bishop, D.F., Bernstein, H.S., Quinn, M., Hantzopoulos, P., and Desnick, R.J. (1985) Fabry disease: Isolation of a cDNA clone encoding human a_galactosidase A. Proc Natl Acad Sci USA 82:7364-7368.
• Desnick, R.J., Bernstein, H.S., Astrin, K.H., Potluri V.R., and Bishop, D.F. (1986) Fabry disease: Strategies for molecular diagnosis and therapy. Jap J Inher Metabol Dis 2:1-18.
• Bishop, D.F., Calhoun, D.H., Bernstein, H.S., Hantzopoulos, P., Quinn, M., and Desnick, R.J. (1986) Human a_galactosidase A: Nucleotide sequence of a cDNA clone encoding the mature enzyme. Proc Natl Acad Sci USA 83:4859-4863.
• Bernstein, H.S. (1986) Cloning of human a_galactosidase A and molecular genetic studies of Fabry disease. Doctoral dissertation in Biomedical Sciences, City University of New York.
• Desnick, R.J., Bernstein, H.S., Astrin, K.H., and Bishop, D.F. (1987) Fabry disease: Molecular diagnosis of hemizygotes and heterozygotes. Enzyme 38:54-64.
• Bernstein, H.S., Bishop, D.F., Astrin, K.H., Kornreich, R., Eng, C.M., Sakuraba, H., and Desnick, R.J. (1989) Fabry disease: Six gene rearrangements and an exonic point mutation in the a_galactosidase gene. J Clin Invest 83:1390-1399.
• Bernstein, H.S., Filly, R.A., Goldberg, J.D., and Golbus, M.S. (1991) Prognosis of fetuses with a cystic hygroma. Prenat Diagn 11:349-355.
• Bernstein, H.S., Moore, P., Stanger, P., and Silverman, N.H. (1995) The levoatriocardinal vein: morphologic and echocardiographic evaluation of the pulmonary-systemic connection. J Am Coll Cardiol 26(4):995-1001.
• Bernstein, H.S., Brook, M.M., Silverman, N.H., and Bristow, J. (1995) Development of pulmonary arteriovenous fistulae in children following cavopulmonary shunt. Circulation 92(9):II-309-II-314.
• Chen, J., Bernstein, H.S., Chen, M., Wang, L., Ishii, M., Turck, C.W., and Coughlin, S.R. (1995) Tethered ligand library for discovery of peptide agonists. J Biol Chem 270(40):23398-23401.
• Bernstein, H.S., Ursell, P.C., Hanley, F.C., Brook, M.M., Silverman, N.H., and Bristow, J. (1996) Fulminant development of pulmonary arteriovenous fistulae in an infant following total cavopulmonary shunt. Pediatr Cardiol 17:46-50.
• Bernstein, H.S., Ursell, P.C., and Teitel, D.F. (1997) Primary involvement of the mitral and aortic valves in Takayasu's arteritis. Cardiol Young 7(2):228-231.
• Bernstein, H.S., and Coughlin, S.R. (1997) Pombe Cdc5-related protein: A putative human transcription factor implicated in mitogen-activated signaling. J Biol Chem 272(9):5833-5837.
• Bernstein, H.S., and Coughlin, S.R. (1998) A mammalian homolog of fission yeast Cdc5 regulates G2 progression and mitotic entry. J Biol Chem 273(8):4666-4671.
• Bristow, J.D., and Bernstein, H.S. (1998) Counseling families with chromosome 22q11 deletions: The catch in CATCH-22. J Am Coll Cardiol 32(2):499-501.
• Chu, M.H., Xu, X., Lei, X., Turck, C.W., and Bernstein, H.S. (1999) A transcriptional regulator of G2/M responds to mitogen-activated signals through phosphorylation by protein kinase C. Circ 100:I-690.
• Bernstein, H.S. (2000) Cell cycle regulation and myocardial regeneration. Japan Circ J 64:I-168.
• Lei, X.-H., Shen, X., Xu, X.-Q., and Bernstein, H.S. (2000) Human Cdc5, a regulator of mitotic entry, can act as a site-specific DNA binding protein. J Cell Sci 113:4523-4531.
• Hlaing, M., Shen, X., Dazin, P., and Bernstein, H.S. (2002) The hypertrophic response in C2C12 myoblasts recruits the G1 cell cycle machinery. J Biol Chem 277:23794-23799.
• Shen, X., Collier, J.M., Hlaing, M., Zhang, L., Delshad, E.H., Bristow, J., and Bernstein, H.S. (2003) Genome-wide examination of myoblast cell cycle withdrawal during differentiation. Devel Dynam 226:128-138.
• Liu, L., Graub, R., Hlaing, M., Epting, C.L., Turck, C.W., Zhang, L., Xu, X.-Q., and Bernstein, H.S. (2003) Distinct domains of human Cdc5 direct its nuclear import and association with the spliceosome. Cell Biochem Biophys 39:119-131.
• Epting, C.L., Shen, X., Liu, L., Zhang, L., Bristow, J., and Bernstein, H.S. (2003) GPI-anchored proteins regulate cell cycle withdrawal and myoblast fusion during differentiation. Ped Res 53:36A.
• Hlaing, M., Spitz, P., Padmanabhan, K., Cabezas, B., Barker, C., and Bernstein, H.S. (2004) E2F-1 regulates a subset of target genes during cell growth without division. J Biol Chem in press.
• Williams, S.D., Bernstein, H.S., and Zhu, H. (2004) Adenoviral delivery of human Cdc5 regulates G2/M progression and promotes cardiac myocyte proliferation. In review.
• Epting, C.L., Shen, X., Liu, L., Bristow, J., and Bernstein, H.S. (2004) Stem cell antigen-1 is necessary for myoblast fusion and cell cycle withdrawal during skeletal myogenesis. In review.
• Hansel, D.E., Dhara, S., Huang, R.C., Ashfaq, R., Diesel, M., Shimada, Y., Bernstein, H.S., Harmon, J., Brock, M., Forastiere, A., Washington, M.K., Maitra, A., and Montgomery, E. CDC2/CDK1 expression in esophageal adenocarcinoma and precursor lesions serves as a cancer progression marker and novel drug target. In review.