Carolyn R. Bertozzi, PhD

Harvard University, Cambridge, MA, B.A., 1988, Chemistry
University of California, Berkeley, CA, Ph.D., 1993, Chemistry
University of California, San Francisco, CA, Postdoc, 1993-1995, Immunology

• 1993-1992
  American Cancer Society Postdoctoral Fellow, Department of Anatomy, UCSF
• 1996-1992
  Assistant Professor, Department of Chemistry, UC Berkeley, UCB
• 1996-present
  Faculty Associate, Materials Sciences Division, LBNL
• 1999-2002
  Associate Professor, Departments of Chemistry and Molecular and Cell Biology, UCB
• 1999- 2002
  Department Head, Biological Nanostructures Facility of the Molecular Foundry, LBNL
• 2000-present
  Investigator, HHMI
• 2001-present
  Vice Chair, Department of Chemistry, UC Berkeley
• 2002-present
  Professor, Departments of Chemistry and Molecular and Cell Biology, UCB
• 2002-present
  Professor, Department of Molecular Pharmacology, UCSF
• 2006-present
  Director, Molecular Foundry, LBNL

• 1992
  Camille and Henry Dreyfus New Faculty Award
• 1992
  Pew Scholars Award
• 1992
  Burroughs Wellcome New Investigator Award in Pharmacology
• 1992
  Alfred P. Sloan Research Fellow
• 1992
  Horace S. Isbell Award in Carbohydrate Chemistry (ACS)
• 1992
  Research Corporation Research Innovation Award
• 1992
  Glaxo Wellcome Scholar
• 1992
  Beckman Young Investigator Award
• 1992
  Arthur C. Cope Scholar Award (ACS)
• 1992
  Camille Dreyfus Teacher-Scholar Award
• 1992
  MacArthur Foundation Award
• 2002
  Presidential Early Career Award in Science and Engineering (PECASE)
• 2002
  Merck Academic Development Program Award
• 2002
  ACS Award in Pure Chemistry
• 2002
  UC Berkeley Distinguished Teaching Award
• 2002
  Donald Sterling Noyce Prize for Excellence in Undergraduate Teaching
• 2002
  Fellow of the AAAS
• 2002
  Irving Sigal Young Investigator Award of the Protein Society
• 2002
  Member of the American Academy of Arts and Sciences
• 2002
  Agnes Fay Morgan Research Award from Iota Sigma Pi

• (from more than 150)
• Mahal, L. K.; Yarema, K. J.; Bertozzi, C. R. Engineering Chemical Reactivity on Cell Surfaces Through Oligosaccharide Biosynthesis. Science 1997, 276, 1125-1128..
• Lemieux, G. A.; Yarema, K. J.; Jacobs, C. L.; Bertozzi, C. R. Exploiting Differences in Sialoside Expression for Selective Targeting of MRI Contrast Reagents. J. Am. Chem. Soc. 1999, 121, 4278-4279.
• Shin, Y.; Winans, K. A.; Backes, B. J.; Kent, S. B. H.; Ellman, J. A.; Bertozzi, C. R. Fmoc-Based Synthesis of Peptide-aThioesters: Application to the Total Chemical Synthesis of a Glycoprotein by Native Chemical Ligation. J. Am. Chem. Soc. 1999, 121, 11684-11689.
• Saxon, E.; Bertozzi, C. R. Cell Surface Engineering by a Modified Staudinger Reaction. Science 2000, 287, 2007-2010.
• Hang, H. C., Bertozzi, C. R. Ketone Isosteres of 2-N-Acetamido Sugars as Substrates for Metabolic Cell Surface Engineering. J. Am. Chem. Soc. 2001, 123, 1242-1243.
• Bertozzi, C. R.; Kiessling, L. L. Chemical Glycobiology. Science 2001, 291, 2357-2364.
• Lemieux, G. A.; Bertozzi, C. R. Modulating Cell Surface Immunoreactivity by Metabolic Induction of Unnatural Carbohydrate Antigens. Chem. Biol. 2001, 8, 265-275.
• Yarema, K. J.; Goon, S.; Bertozzi, C. R. Metabolic Selection of Glycosylation Defects in Human Cells. Nature Biotechnol. 2001, 19, 553-558.
• Jacobs, C. L.; Goon, S.; Yarema, K. J.; Hinderlich, S.; Hang, H. C.; Chai, D. H.; Bertozzi, C. R. Substrate Specificity of the Sialic Acid Biosynthetic Pathway. Biochemistry 2001, 40, 12864-12874.
• Mahal, L. K.; Charter, N. W.; Angata, K.; Fukuda, M.; Koshland, D. E., Jr.; Bertozzi, C. R. A Small Molecule Modulator of Poly- 2,8-Sialic Acid Expression on Cultured Neurons and Tumor Cells. Science 2001, 294, 380-382.
• Marcaurelle, L. A.; Mizoue, L. S.; Wilken, J.; Oldham, L.; Kent, S. B. H.; Handel, T. M.; Bertozzi, C. R. Chemical Synthesis of Lymphotactin, a Glycosylated Chemokine with a C-terminal Mucin-like Domain. Chem. Eur. J. 2001, 7, 1129-1132.
• Marcaurelle, L. A.; Bertozzi, C. R. Chemoselective Elaboration of O-Linked Glycopeptide Mimetics by Alkylation of 3-ThioGalNAc. J. Am. Chem. Soc. 2001, 123, 1587-1595.
• Kiick, K. L.; Saxon, E.; Tirrell, D. A.; Bertozzi, C. R. Incorporation of Azides into Recombinant Proteins for Chemoselective Modification by the Staudinger Ligation. Proc. Natl. Acad. Sci. U.S.A. 2002, 99, 19-24.
• Winans, K. A.; Bertozzi, C. R. An Inhibitor of the Human UDP-GlcNAc 4-Epimerase Identified from a Uridine-Based Library: A Strategy to Inhibit O-Linked Glycosylation. Chem. Biol. 2002, 9, 113-129.
• Verdugo, D. E.; Bertozzi, C. R. A 96-Well Dot-Blot Assay for Carbohydrate Sulfotransferases. Anal. Biochem. 2002, 307, 330-336.
• Mougous, J. D.; Green, R. E.; Williams, S. J.; Brenner, S. E.; Bertozzi, C. R. Sulfotransferases and Sulfatases in Mycobacteria. Chem. Biol. 2002, 9, 767-776.
• Saxon, E.; Luchansky, S. J.; Hang, H. C.; Yu, C.; Lee, S. C.; Bertozzi, C. R. Investigating Cellular Metabolism of Synthetic Azidosugars Using the Staudinger Ligation. J. Am. Chem. Soc. 2002, 124, 14893-14902.
• Luchansky, S. J.; Hang, H. C.; Saxon, E.; Grunwell, J. R.; Yu, C.; Dube, D. H.; Bertozzi, C. R. Constructing Azide-Labeled Cell Surfaces Using Polysaccharide Biosynthetic Pathways. Meth. Enzymol. 2003, 362, 249-272.
• Lemieux, G. A.; de Graffenried, C. L.; Bertozzi, C. R. A Fluorogenic Dye Activated by the Staudinger Ligation. J. Am. Chem. Soc. 2003, 128, 4708-4709.
• Goon, S.; Schilling, B.; Tullius, M. V.; Gibson, B. W.; Bertozzi, C. R. Metabolic Incorporation of Unnatural Sialic Acids into Haemophilus ducreyi Lipooligosaccharides. Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 3089-3094.
• Vocadlo, D. J.; Hang, H. C.; Kim, E. J.; Hanover, J. A.; Bertozzi, C. R. A Chemical Approach for Identifying O-GlcNAc Modified Proteins in Cells. Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 9116-9121.
• Wojczyk, B. S.; Stwora-Wojczyk, M. M.; Hagen, F. K.; Striepen, B.; Hang, H. C.; Bertozzi, C. R.; Roos, D. S.; Spitalnik, S. L. cDNA Cloning and Expression of UDP-N-acetyl-D-galactosamine:Polypeptide N-Acetylgalactosaminyltransferase T1 from Toxoplasma gondii. Mol. Biochem. Parasitol., 2003, 131, 93-107.
• de Graffenried, C. L.; Laughlin, S. T.; Kohler, J. J.; Bertozzi, C. R. A Small-Molecule Switch for Golgi Sulfotransferases. Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 16715-16720.
• Kohler, J. J.; Czlapinski, J. L.; Laughlin, S. T.; Schelle, M. W.; de Graffenried, C. L.; Bertozzi, C. R. Directing Flux in Glycan Biosynthetic Pathways with a Small Molecule Switch. ChemBioChem 2004, 5, 1455-1458.
• Hang, H. C.; Yu, C.; Kato, D. L.; Bertozzi, C. R. A Metabolic Labeling Approach Towards Proteomic Analysis of Mucin-type O-Linked Glycosylation. Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 14846-14851.
• Hang, H. C.; Yu, C.; Pratt, M. R.; Bertozzi, C. R. Probing Glycosyltransferase Activities with the Staudinger Ligation. J. Am. Chem. Soc. 2004, 126, 6-7.
• Luchansky, S. J.; Goon, S.; Bertozzi, C. R. Expanding the Diversity of Unnatural Cell Surface Sialic Acids. ChemBioChem 2004, 5, 371-374.
• Hang, H. C.; Yu, C.; Ten Hagen, K. G.; Tian, E.; Winans, K. A.; Tabak, L. A.; Bertozzi, C. R. Small Molecule Inhibitors of Mucin-type O-Linked Glycosylation from a Uridine-based Library. Chem. Biol. 2004, 11, 337-345.
• Macmillan, D.; Bertozzi, C. R. Modular Assembly of Glycoproteins: Toward the Synthesis of GlyCAM-1 by Using Expressed Protein Ligation. Angew. Chem. Int. Ed. 2004, 43, 1355-1359.
• Pratt, M. R.; Hang, H. C.; Ten Hagen, K. G.; Rarick, J.; Gerken, T. A.; Tabak, L. A.; Bertozzi, C. R. Deconvoluting the Functions of Polypeptide N-a-Acetylgalactosaminyltransferase (ppGalNAcT) Family Members by Glycopeptide Substrate Profiling. Chem. Biol. 2004, 11, 1009-1016.
• Luchansky, S. J.; Bertozzi, C. R. Azido Sialic Acids can Modulate Cell Surface Interactions. ChemBioChem 2004, 5, 1706-1709.
• Prescher, J. A.; Dube, D. H.; Bertozzi, C. R. Chemical Remodelling of Cell Surfaces in Living Animals. Nature 2004, 430, 873-877.
• Luchansky, S. J.; Argade, S.; Hayes, B. K.; Bertozzi, C. R. Metabolic Functionalization of Recombinant Glycoproteins. Biochemistry 2004, 43, 12358-12366.
• Mougous, J. D.; Petzold, C. J.; Senaratne, R. H.; Lee, D. H.; Akey, D. L.; Lin, F. L.; Munchel, S. E.; Pratt, M. R.; Riley, L. W.; Leary, J. A.; Berger, J. M.; Bertozzi, C. R. Identification, Function and Structure of the Mycobacterial Sulfotransferase that Initiates Sulfolipid-1 Biosynthesis. Nature Struct. Mol. Biol. 2004, 11, 721-729.
• Agard, N. J.; Prescher, J. A.; Bertozzi, C. R. A Strain-Promoted [3+2] Azide-Alkyne Cycloaddition for Covalent Modification of Biomolecules in Living Systems. J. Am. Chem. Soc. 2004, 126, 15046-15047.
• Tian, E.; Ten Hagen, K. G.; Shum, L.; Hang, H. C.; Imbert, Y.; Young, W. W., Jr.; Bertozzi, C. R.; Tabak, L. A. An Inhibitor of O-Glycosylation Induces Apoptosis in NIH3T3 Cells and Developing Mouse Embryonic Mandibular Tissues. J. Biol. Chem. 2004, 279, 50382-50390.
• Vocadlo, D. J.; Bertozzi, C. R. A Strategy for Functional Proteomic Analysis of Glycosidase Activity from Cell Lysates. Angew. Chem. Int. Ed. 2004, 43, 5338-5342.
• Lin, F., Hoyt, H. M.; van Halbeek, H.; Bergman, R. G.; Bertozzi, C. R. Mechanistic Investigation of the Staudinger Ligation. J. Am. Chem. Soc. 2005, 127, 2686-2695.
• Prescher, J. A.; Bertozzi, C. R. Chemistry in Living Systems. Nature Chem. Biol. 2005, 1, 13-21.
• Hang, H. C.; Bertozzi, C. R. The Chemistry and Biology of Mucin-Type O-Linked Glycosylation. Bioorg. Med. Chem. 2005, 13, 5021-5034.
• Carroll, K. S.; Gao, H.; Chen, H.; Leary, J. A.; Bertozzi, C. R. Investigation of the Iron-Sulfur Cluster in Mycobacterium tuberculosis APS Reductase: Implications for Substrate Binding and Catalysis. Biochemistry 2005, 44, 14647-14657.
• Mougous, J. D.; Lee, D. H.; Hubbard, S. C.; Schelle, M. W.; Vocadlo, D. J.; Berger, J. M.; Bertozzi, C. R. Molecular Basis for G protein Control of ATP Sulfurylase in Bacteria. Molecular Cell 2006, 21, 109-122.
• Rush, J. S.; Bertozzi, C. R. An -formylglycine building block for Fmoc-based solid phase peptide synthesis. Org. Lett. 2006, 8, 131-134.
• Carroll, K. S.; Gao, H.; Chen, H.; Stout, C. D.; Leary, J. A.; Bertozzi, C. R. A Conserved Mechanism for Sulfonucleotide Reduction. PloS Biology 2005, 3 (8), e250.
• Chandra, R. A.; Douglas, E. S.; Mathies, R. A.; Bertozzi, C. R.; Francis, M. B. Programmable Cell Adhesion Encoded by DNA Hybridization. Angew. Chem. Int. Ed., 2006, in press.
• Joseph D. Mougous, Ryan H. Senaratne, Christopher J. Petzold, Madhulika Jain, Dong H. Lee, Michael W. Schelle, Michael D. Leavell, Jeffery S. Cox, Julie A. Leary, Lee W. Riley & Carolyn R. Bertozzi. A Novel Sulfated Metabolite Produced by stf3 Negatively Regulates the Virulence of Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U.S.A. 2006, in press.
• Ryan H. Senaratne, Darshan DeSilva, Spencer J. Williams, Joseph D. Mougous, Tianjiao Zhang, Stephen Chan, Ben Sidders, John Chan, Carolyn R. Bertozzi, and Lee W. Riley. 5'-Adenosinephosphosulfate Reductase (CysH) Protects Mycobacterium tuberculosis Against Reactive Nitrogen and Oxygen Species and Adaptive Immunity. Molecular Microbiology 2006, in press.
• Juan Perez-Vilar, Raean Mabolo, Cheryl T. McVaugh, Carolyn R. Bertozzi, and Richard C. Boucher. Mucin Granule Intraluminal Organization in Living Mucous/Goblet cells. Roles of Protein Post-translational Modifications and Secretion. J. Biol. Chem. 2006, in press.
• Dube, D. H.; Prescher, J. A.; Quang, C. N.; Bertozzi, C. R. Probing Mucin-type O-linked Glycosylation in Living Animals. Proc. Natl. Acad. Sci. U.S.A. 2006, in press.
• Valdez, C. A.; Bertozzi, C. R. Synthesis of 5"-fluoro and 5",6"-difluoro uridine 5'-diphospho-N-acetylgalactosamine. J. Org. Chem. 2006, accepted.