Daniel D. Bikle, MD, PhD

Harvard University, AB, 1961-1965
University of Pennsylvania, MD, 1965-1969
Peter Bent Brigham Hospital, Boston, Intern, Resident, 1970-1971
University of Pennsylvania, PhD, 1971-1974, Biochemistry

• 1974-1972
  Research Internist & Staff Endocrinologist, Letterman Army Institute of Research, San Francisco, CA
• 1979-1982
  Assistant Professor of Medicine, University of California, San Francisco, CA
• 1979-present
  Co-director, Special Diagnostic & Treatment Unit, Veterans Affairs Medical Center, San Francisco, CA
• 1986-1992
  Associate Professor of Medicine, University of California, San Francisco, CA
• 1991-present
  Professor of Medicine, University of California, San Francisco, CA
• 1993-present
  Professor of Dermatology, University of California, San Francisco, CA

• 1962
  Harvard Honorary Scholarship
• 1964, 1962
  National Science Foundation Summer Fellowship
• 1962
  Henderson Memorial Prize in Biochemistry
• 1962
  Magna Cum Laude, Harvard University
• 1962
  Baldwin Lucke Memorial Prize
• 1967-1962
  Medical Scientist Fellowship
• 1962
  Alpha Omega Alpha, Honorary Medical Society
• 1962
  Horatio C Wood Prize in Pharmacology
• 1962
  Bordon Research Award in Medicine
• 1962
  Spencer Morris Prize
• 1971, 1972
  National Institutes of Health Special Postdoctoral Fellowship
• 1982
  Fellowship, American College of Physicians
• 1982
  American Society of Clinical Investigation
• 1982
  Western Association of Physicians
• 1992
  Association of American Physicians

• (Selected from a total of 232)
• Sessions ND, Halloran BP, Bikle DD, Wronski TJ, Cone CM, Morey-Holton E 1989 Bone res-ponse to normal weightbearing after a period of skeletal unloading. Am J Physiol 257:E606-610.
• Patterson-Buckendahl P, Globus RK, Bikle DD, Cone CE, Morey-Holton E 1989 Effect of simulated weightlessness on rat osteocalcin and bone calcium. Amer J Physiol 257:R1103-9, 1989.
• Bikle DD, Halloran BP, McGalliard-Cone C, Morey-Holton E 1990 Different responses to trabecular and cortical bone to 1,25(OH)2D3 infusion. Am J Physiol 259:E715-22.
• Halloran BP, Bikle DD, Harris J, Foskett HC, Morey-Holton E 1993 Skeletal unloading decreases the production of 1,25 dihydroxyvitamin D. Amer J Physiol 264: E712-716.
• Bikle DD, Harris J, Halloran BP, Roberts Jr. CT, LeRoith D, Morey-Holton E 1994 Expression of the genes for the insulin like growth factors and their receptors in bone during skeletal growth. Amer J Physiol 267: E278-E286.
• Bikle DD, Harris J, Halloran BP, Morey-Holton E 1994 Skeletal unloading induces resistance to insulin like growth factor 1. J Bone Miner Res 9: 1789-1796.
• Bikle DD, Morey-Holton E, Doty SB, Currier PA, Tanner SJ, Halloran BP 1994 Alendronate increases skeletal mass of growing rats during unloading by inhibiting resorption of calcified cartilage. J Bone Miner Res 9: 1777-1787.
• Bikle DD, Harris J, Halloran BP, Morey-Holton E 1994 Altered skeletal pattern of gene expression in response to space flight: comparison to the response to hindlimb elevation. Amer J Physiol 267: E822-E827.
• Bikle DD, Halloran BP, Morey-Holton E 1994 Impact of skeletal unloading on bone formation: role of systemic and local factors. Acta Astron 33:119-129.
• Bikle DD, Harris J, Halloran BP, Currier PA, Tanner S, Morey-Holton E 1995 The molecular response of bone to growth hormone during skeletal unloading: regional differences. Endocrinology 136: 2099-2109.
• Halloran BP, Bikle DD, Harris J, Autry CP, Currier P, Tanner S, Patterson-Buckendahl P, Morey-Holton E 1995 Skeletal unloading induces selective resistance to the anabolic actions of growth hormone on bone. J Bone Miner Res 10: 1168-1176.
• Halloran BP, Bikle DD, Harris J, Tanner S, Curren T, Morey-Holton E 1997 Regional responsiveness of the tibia to intermittent administration of parathyroid hormone as affected by skeletal unloading. J Bone Miner Res 12:1068-1074.
• Kostenuik PJ, Halloran BP, Morey-Holton ER, Bikle DD, 1997. Skeletal unloading inhibits the in vitro proliferation and differentiation of rat osteoprogenitor cells. Amer J Physiol 273:E1133. E1139.
• Dehority W, Halloran BP, Bikle DD, Curren T, Kostenuik PJ, Wronski TJ, Shen Y, Rabkin B, Bouraoui A, Morey-Holton E 1999. Bone and mineral changes induced by skeletal unloading in the mature male rat. Amer J Physiol 276:E62-E62
  
• Kostenuik PJ, Harris J, Halloran B, Turner R, Morey-Holton E, Bikle DD 1999. Skeletal unloading causes resistance of osteoprogenitor cells to parathyroid hormone an to insulin-like growth factor-I. J Bone Min Res 14:21-32
  
• Nauman EA, Satcher RL, Keaveny TM, Halloran BP, Bikle DD. 2001. Osteoblasts in culture respond to pulsatile fluid flow with short-term increases in PGE2 production but no change in cell proliferation or mineralization. J Appl Physiol 90:1849-1854.
• Bikle DD, Majumdar S, Laib A, Powell-Braxton L, Rosen C, Beamer W, Nauman E, Leary C, Halloran B. 2001. The skeletal structure of insulin-like growth factor-I deficient mice. J Bone Min Res 16:2320-2329.
• Bikle DD, Sakata T, Leary C, Elalieh H, Ginzinger D, Rosen CJ, Beamer W, Majumdar S, Halloran BP. 2002. Insulin like growth factor-I is required for the anabolic actions of parathyroid hormone on mouse bone. J Bone Min Res. 17:1570-78, 2002.
• Nauman EA, Ebenstein DM, Hughes KF, Pruitt L, Halloran BP, Bikle DD, Keaveny TM 2002. Mechanical and chemical characteristics of mineral produced by bFGF-treated bone marrow stromal cells in vitro. Tiss Engineer 8:931-939.
• Bikle DD, Sakata T, Halloran BP 2003. The Impact of Skeletal Unloading on Bone Formation. Grav Space Biol Bull 16:45-52
  
• Nauman EA, Sakata T, Keaveny TM, Halloran BP, Bikle DD 2003. bFGF administration lowers the phosphate threshold for mineralization in bone marrow stromal cells. Calc Tiss Internl 73: 147-152.
• Sakata T, Halloran BP, Elalieh HZ, Munson SJ, Rudner L, Venton L, Ginzinger D, Rosen CJ, Bikle DD 2003. Skeletal unloading induces resistance to insulin-like growth factor-I on bone formation. Bone 32:669-682
  
• Sakata T, Wang Y, Halloran BP, Elalieh HZ, Cao J, Bikle DD 2004. Skeletal unloading induces resistance to IGF-I by inhibiting activation of the IGF-I signaling pathways. J Bone Min Res 19:436-446.
• Huang JC, Sakata T, Pfleger LV, Bencsik M, Halloran BP, Bikle DD, and Nissenson RA. 2004 Effects of Parathyroid Hormone on RANKL and OPG Gene Expression During Osteoblast Differentiation. J Bone Min Res 19: 235-244.
• Rodriguez L, Tu C, Cheng Z, Chen T-H, Bikle D, Shoback D, Chang W 2005 Expression and functional assessment of an alternatively spliced extracellular Ca2+-sensing receptor in growth plate chondrocytes. Endocrinology 146: 5294-5302
  
• Wang Y, Sakata T, Elalieh HZ, Munson SJ, Burghardt A, Majumdar S, Halloran BP, Bikle DD 2006 Gender differences in the response of CD-1 mouse bone to parathyroid hormone: potential role of IGF-I. J Endocrinol 189: 279-282
  
• Wang Y, Nishida S, Sakata T, Elalieh HZ, Chang W, Halloran BP, Doty SB, Bikle DD.2006 Insulin-Like Growth Factor-I Is Essential For Embryonic Bone Development. Endocrinology 147:4753-4762