mjbissell@lbl.gov
(510) 486-4365 (office); (510) 486-4368 (lab)
(510) 486-5586 (fax)

Lawrence Berkeley Lab, One Cyclotron Road
MS 83-101, Berkeley, CA 94720

additional websites:

Bissell Lab Website, LBNL

Bryn Mawr College, Bryn Mawr, PA, Transferred, 1959-61, Chemistry
Radcliffe College, Cambridge, MA, A.B., 1963, Chemistry (Honors)
Harvard University, Cambridge, MA, M.A., 1965, Bacteriology/Biochemistry
Harvard University, Cambridge, MA, Ph.D., 1969, Microbiology/Molecular Genetics

(Publications selected since 2001; total 228)

Simian M, Hirai Y, Navre M, Werb Z, Lochter A and Biss! ell MJ. (2001) The interplay of matrix metalloproteinases, morphogens and growth factors is necessary for branching of mammary epithelial cells. Development 28:3117-3131.

Muthuswamy SK, Li D, Lelièvre SA, Bissell MJ and Brugge JS. (2001) Erbb2, but not Erbb1, reinitiates proliferation and induces luminal repopulation in epithelial acini. Nature Cell Biol 3(9):785-792.

Bissell MJ and Radisky D. Putting tumours in context. (2001) Nature Reviews (Cancer) 1:48-54.

Gudjonsson T, Rønnov-Jessen L, Villadsen R, Bissell MJ and Petersen OW. (2002) Normal and tumor-derived myoepithelial cells differ in their ability to signal to luminal breast epithelial cells for polarity and basement membrane deposition. J Cell Science 115(1):39-50.

Gudjonsson T, Villadsen R, Nielsen HL, RÀnnov-Jensen L, Bissell MJ, and Petersen OW. (2002) Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties. Genes & Development 16(6):693-706.

Wang F, Hansen RK, Radisky D, Yoneda T, Barcellos-Hoff MH, Petersen OW, Turley EA and Bissell MJ. (2002) Phenotypic Reversion or Death of Cancer Cells by Altering Signaling Pathways in Three-Dimensional Contexts. J Nat'l Cancer Inst 94(19):1494-1503.

Weaver VM, Lelièvre SA, Lakins JN, Chrenek MA, Jones JCR, Giancotti F, Werb Z and Bissell MJ. (2002) b4 Integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. Cancer Cell 2:205-216; News & Views, Nature 419:790-791 (2002). Minireview (Cell) 111:923-925 (2002).

Muschler J, Levy D, Boudreau R, Henry M, Campbell K and Bissell MJ. (2002) A role for dystroglycan in epithelial polarization: Loss of function in breast tumor cells. Cancer Research 62:7102-7109.

Bissell MJ, Radisky D, Rizki A, Weaver, VM and Petersen, OW. (2002) The organizing principle: microenvironmental influences in the normal and mal! ignant breast. Differentiation 70(9-10):537-46.

Petersen OW, Nielsen HL, Gudjonsson T, Villadsen R, Rank F, Niebuhr E, Bissell MJ and Rønnov-Jessen L. (2003) Epithelial to Mesenchymal transition in human breast cancer can provide a nonmalignant stroma. Am J Pathol 162:2:391-402.

Bissell MJ, Mian IS, Radisky D and Turley E. (2003) Tissue-specificity: Structural cues allow diverse phenotypes from a constant genotype. In: Origination of Organismal Form: Beyond the Gene in Developmental and Evolutionary Biology, MÄller GB and Newman SA (Eds.). The Vienna Series in Theoretical Biology. MIT Press 7:103-117.

Bissell MJ and Bilder D. (2003) COMMENTARY: Polarity determination in breast tissue: desmosomal adhesion, myoepithelial cells, and laminin 1. Breast Cancer Res 5:2:117-119.

Anders M, Hansen R, Ding R-X, Waldman FW, Rauen K, Bissell MJ, and Korn WM. (2003) Disruption of 3D tissue integrity facilitates adenovirus infection by deregulating the coxsackievirus and adenovirus receptor. Proc Natl Acad Sci 100:4:1943-1948.

Bhatacharyya C, Grate LR, Rizki A, Radisky D, Molina FJ, Jordan MI, Bissell MJ, Mian IS. (2003) Simultaneous relevant feature identification and classification in high-dimensional spaces: Application to molecular profiling data. Signal Processing 83:4:729-743.

Novaro V, Roskelley C and Bissell MJ. (2003) Collagen-IV or laminin-1 together with lactogenic hormones regulate estrogen receptor-alpha expression and function in mouse mammary epithelial cells. J Cell Science 116(14) 2975-2986.

Schmeichel, KL and Bissell MJ. (2003) Modeling tissue-specific signaling and organ function in three dimensions. J Cell Sci. 116:2377-2388

Radisky, DC, Hirai, Y and Bissell MJ. (2003) Delivering the message: epimorphin and mammary epithelial morphogenesis. Trends Cell Biol 13(8):426-34.

Park, CC, Henshall-Powell, RL, Erickson, AC, Talhouk, R, Parvin, B, Bissell MJ and Barcellos-Hoff MH. Ionizing radiation induc! es heritable disruption of epithelial cell interactions. Proc Natl Acad Sci 100:19:10728-10733.

Fata JE, Zahedi R, Werb, Z and Bissell MJ. Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes. 2003 Breast Cancer Res Review (In press).

Kenny, PA and Bissell MJ. Tumor reversion: Correction of malignant behavior by microenvironmental cues. 2003 Int J Cancer Review (In press).

Myers C, Lee E, Bissell MJ Three-Dimensional Culture of Human Breast Epithelial Cells to Resemble in vivo-like Architecture and Function. In Cell Biology:A Laboratory Handbook, Third Edition, Julio Celis, Editor 2003 (In press).

Rizki A and Bissell MJ. Extracellular Matrix: Tissue Specific Regulator of Cell Proliferation. In Cell Cycle & Growth Control: Biomolecular Regulation and Cancer, Gary Stein, Editor 2003 (In press).

9/01/04