Trever G. Bivona, MD, PhD

Vanderbilt University, B.S., 1998, Molecular Biology
New York University, School of Medicine, Ph.D., 2004, Cell and Mol. Biology
New York University, School of Medicine, M.D., 2005, Medicine
Brigham and Women’s Hospital/Harvard, 2005-2007, Internal Medicine
Memorial Sloan-Kettering Cancer Center, 2007-2011, Medical Oncology

• 1998-2005
  MD-PhD, Medical Scientist Training Program, NYU School of Medicine
• 2005-2007
  Resident House Staff, Internal Medicine, Brigham and Women’s Hospital
• 2007-2011
  Medical Oncology Fellow, Memorial Sloan-Kettering Cancer Center
• 2008-2011
  Research Fellow, Laboratory of Charles Sawyers, Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
• 7/2011-present
  Assistant Professor, Department of Medicine, Division of Hematology/Oncology, University of California, San Francisco
• 7/2011- present
  Member, UCSF Helen Diller Comprehensive Cancer Center
• 7/2011- present
  Faculty Member, California Institute for Quantitative Biosciences (QB3)

• 1998
  Vanderbilt University Honors Degree in Molecular Biology
• 1998
  Vanderbilt University Research Excellence Award
• 1998-2005
  NIH Medical Scientist Training Program Award
• 2005
  Medical Science Writing Award, NYU School of Medicine
• 2007
  US Patent 20060083742 Prenyl-electrostatic Switch
• 2008-2010
  Charles A. Dana Foundation Clinical Scholars Research Fellowship
• 2009
  Julia Zelmanovich Young Alumnus Award, NYU School of Medicine
• 2010
  American Society of Clinical Oncology Young Investigator Award
• 2010
  Uniting Against Lung Cancer Research Investigator
• 2011
  NIH/NCI Clinical Investigator Career Development Award (K08)
• 2012
  National Lung Cancer Partnership Young Investigator Award
• 2012
  Sidney Kimmel Foundation Kimmel Scholar Award
• 2012
  Damon Runyon Clinical Investigator Award Finalist
• 2012
  Doris Duke Clinical Scientist Development Award
• 2012
  American Lung Association Lung Cancer Discovery Award

• Robibaro B, Stedman TT, Coppens I, Ngo HM, Pypaert M, Bivona T, Nam HW, Joiner KA. Toxoplasma gondii Rab5 enhances cholesterol acquisition from hos cells.Cell Microbiol. 2002 Mar;4(3):139-52. PMID:11906451
• Chiu VK*, Bivona T*, Hach A, Sajous JB, Silletti J, Wiener H, Johnson RL 2nd, Cox AD, Philips MR. Ras signalling on the endoplasmic reticulum and the Golgi. Nature Cell Biol. 2002 May;4(5):343-50. * Equal Contribution PMID:11988737
• Bivona TG, Philips MR. Ras pathway signaling on endomembranes. Curr Opin Cell Biol. 2003 Apr;15(2):136-42. PMID:12648668
• Bivona TG, Perez De Castro I, Ahearn IM, Grana TM, Chiu VK, Lockyer PJ, Cullen PJ, Pellicer A, Cox AD, Philips MR. Phospholipase Cg activates Ras on the Golgi apparatus by means of RasGRP1. Nature. 2003 Aug 7;424(6949):694-8. PMID:12845332
• Mohney RP, Das M, Bivona TG, Hanes R, Adams AG, Philips MR, O'Bryan JP. Intersectin activates Ras but stimulates transcription through an independent pathway involving JNK. J Biol Chem. 2003 Nov 21;278(47):47038-45. PMID:12970366
• Bivona TG, Wiener HH, Ahearn IM, Silletti J, Chiu VK, Philips MR. Rap1 up-regulation and activation on plasma membrane regulates T cell adhesion. J Cell Biol. 2004 Feb 2;164(3):461-70. PMID:14757755
• Zhang SQ, Yang W, Kontaridis MI, Bivona TG, Wen G, Araki T, Luo J, Thompson JA, Schraven BL, Philips MR, Neel BG. Shp2 regulates SRC family kinase activity and ras/erk activation by controlling csk recruitment. Molecular Cell. 2004 Feb 13;(3):341-55. PMID:14967142
• Walker SA, Kupzig S, Bouyoucef D, Davies LC, Tsuboi T, Bivona TG, Cozier GE, Lockyer PJ, Buckler A, Rutter GA, Allen MJ, Philips MR, Cullen PJ. Identification of a Ras GTPase-activating protein regulated by receptor-mediated Ca(2+) oscillations. EMBO J. 2004 Apr 21;23(8):1749-60. PMID:15057271
• Dustin ML, Bivona TG and Philips MR. Membranes as messengers in T cell adhesion signaling. Nat Immunol. 2004 Apr;5(4):363-72. PMID:15052266
• Perez De Castro I, Bivona TG, Philips MR, Pellicer A. Ras Activation in Jurkat T cells following Low- Grade Stimulation of the T-Cell Receptor Is Specific to N-Ras and Occurs Only on the Golgi Apparatus. Mol Cell Biol. 2004 Apr;24(8):3485-96. PMID:15060167
• Jordan JD, He JC, Eungdamrong NJ, Gomes I, Ali W, Nhuyen T, Bivona TG, Philips MR, Devi LA, Iyengar R. Cannabinoid receptor-induced neurite outgrowth is mediated by Rap1 activation through G(alpha)o/i-triggered proteasomal degradation of Rap1GAPII. J Biol Chem. 2005 Mar 25;280(12):11413- 21. PMID:15657046
• Bivona TG, Philips MR. Analysis of Ras and Rap activation in living cells using fluorescent Ras binding domains. Methods. 2005 Oct;37(2):138-45.PMID: 16289969
• Bivona TG, Quatela S, Bodemann BO, Ahearn IM, Soskis MJ, Weiner HH, Saba SG, Yim D, Perez de Castro I, Thompson CR, Cox AD, Philips MR. PKC regulates a farnesyl electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis. Mol Cell. 2006 Feb 17;21(4):481-93. PMID:16483930
• Bivona TG, Quatela S, Philips MR. Analysis of Ras activation in living cells with GFP-RBD. Methods Enzymol. 2006;407:128-43. PMID:16757320
• Quatela SE, Sung PJ, Ahearn IM, Bivona TG, Philips MR. Analysis of K-Ras phosphorylation, translocation, and induction of apoptosis. Methods Enzymol. 2008;439:87- 102. PMID:18374158
• Rosell R, et al, Bivona TG, Sawyers CL, Taron M. Pre-treatment EGFR T790M mutation and BRCA1 mRNA expression in erlotinib-treated advanced non-small-cell lung cancer patients with EGFR mutations. Clin Cancer Res. 2011 Mar 1;17(5):1160-1168. PMID:21233402
• Bivona TG, Hieronymus H, Parker J, Chang K, Taron M, Rosell R, Moonsamy P, Dahlman K, Miller V, Costa C, Hannon G, Sawyers C. FAS and NF-kB, Signalling Modulate Dependence of Lung Cancers on Mutant EGFR. Nature. 2011 Mar 24;471: 523-526. PMID:2143078
• Morris LGT, Taylor BT, Bivona TG, Gong Y, Eng S, Brennan C, Kaufman A, Kastenhuber E, Banuchi V, Singh B, Heguy A, Viale A, Mellinghoff A, Huse J, Ganly I, Chan T. Genomic dissection of the EGFR/PI3K pathway reveals frequent deletion of the EGFR phosphatase PTPRS in head and neck cancers. PNAS. 2011 Nov 22;108(47):19024-9. PMID:22065749
• Lin Luping & Bivona TG. Mechanisms of resistance to epidermal growth factor receptor inhibitors and novel therapeutic strategies to overcome resistance in NSCLC patients. Chemotherapy Research and Practice. 2012. In press.
• Zhang Z, Lee JC, Lin L, Olivas V, Au V, LaFramboise T, Abdel-Rahman M, Wang X, Levine A, Rho J, Choi Y, Choi CM, Kim SW, Jang SJ, Park YS, Miller VA, Arcila M, Ladanyi M, Moonsamy P, Sawyers CL, Ma PC, Costa C, Taron M, Rosell R, Halmos B, Bivona TG. Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer. Nature Genetics. 2012. In press.