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Helen Diller Family Compr Cancer Ctr
ELEANOR A. BLAKELY, PHD

Senior Staff Biophysicist, Life Sciences Division, Lawrence Berkeley National Laboratory

CONTACT

eablakely@lbl.gov
(510) 486-6595 (voice)
(510) 486-4475 (fax)

Lawrence Berkeley Nat'l Lab; Mailstop 70A-1118
1 Cyclotron Road; Berkeley, CA 94720-8174

additional websites:

Blakely Lab Website

EDUCATION

University of San Diego, San Diego, CA, BA, 1969, Biology (Chem. Minor)
University of Illinois, Urbana, IL, MS, 1971, Biophysics
University of Illinois, Urbana, IL, PhD, 1975, Physiology

PROFESSIONAL EXPERIENCE

1975-1989

Staff Biophysicist, Lawrence Berkeley Laboratory (LBL), Univ. of California at Berkeley

1975-1988

Project Scientific Director of the Cellular and Molecular Radiobiology Program within a Program Project Grant funded by the National Cancer Institute (NCI); Deputy Scientific Director and Financial Manager of the Budgets for the NCI Program Project Grant and a DOE Grant within the Radiation Biophysics Group, Donner Laboratory, LBL

1988-1993

Principal Investigator of two DOE Grants

1988-1994

Member of the LBL-wide Technical Salary Committee

1988-present

LBL Grievance Hearing Officer

1988-1992

Deputy Leader, Radiat. Biol. & DNA Repair Group, Life Sci. Div., Cell & Molec. Biol., LBL

1989-present

Senior Staff Biophysicist, LBL, University of California

1990-1992

Cell and Molecular Biology Division Safety Coordinator

1990-1992

Deputy Executive Secretary, Bevalac Biomedical Program Advisory Committee

1991-1996

Project Director of a NASA-funded NSCORT (NASA Specialized Center of Research and Training for Radiation Health); Faculty Affiliate Appointment, Department of Radiological Health Sciences, Colorado State University, Fort Collins, CO

1993-present

Member of the LBL-wide Radioactive Drug Research Committee

1994-present

Clinical Professor of Radiation Medicine (non-tenured), Loma Linda University, School of Medicine, Loma Linda, CA

HONORS & AWARDS

1969-72

U.S. A.E.C. Special Fellowship in Radiat. Sci. & Protect., Dept. of Phys. & Biophys. Univ. of Ill.

1974

Robert Emerson Graduate Teaching Award, School of Life Sciences, University of Illinois

1979

Nominated for listing in American Men and Women in Science

1992

Lawrence Berkeley Laboratory Outstanding Performance Award

2002

DOE Office of Science Outstanding Mentor Award

2004

Lawrence Berkeley Laboratory Outstanding Performance Award

2004

Lawrence Berkeley Laboratory Technology Transfer Award

2005

RD100 award from R&D (Research & Development) Magazine as a member of a team that developed one of the 100 best new technologies in the year 2005

SELECTED PUBLICATIONS

Blakely, E.A., F.Q.H. Ngo, S.B. Curtis, and C.A. Tobias. Heavy-ion radiobiology: Cellular studies. Adv. in Radiat. Biol. 11, 295-389, 1984.

Blakely, E.A., P.Y. Chang, and L. Lommel. Cell-cycle-dependent recovery from heavy-ion damage. Radiat. Res. 104, S145-S157, 1985.

Blakely, E., R. Roots, P. Chang, L. Lommel, L. Craise, E. Goodwin, and E. Yee. Cell-cycle-dependent X-ray OER: Role of endogenous glutathione. NCI Mono-Interact. of Rad.&Chemotherapy.Vol.6, 217-223, 1988.

Kronenberg, A. and E.A. Blakely. Locus specificity of mutation in human lymphoblastoid cells: LET effects. In Cell Transformation and Radiation-Induced Cancer in Man (Eds. K.H. Chadwick, C. Seymour, and B. Barnhart). Adam Hilger Ltd., pp. 215-222, 1989.

Castro, J.R., E.A. Blakely, and D.A. Linstadt. Particle therapy in treatment of urologic tumors. Adv. in Urologic Oncology, Vol. II, pp. 149-160, 1990.

Chang, P.Y., C.A. Tobias, and E.A. Blakely. Protein synthesis modulates the biological effectiveness of the combined action of hyperthermia and high-LET radiation. Radiat. Res. 129, 272-280, 1992.

Blakely, E.A. Cell inactivation by heavy-charged particles. Radiat. and Environ. Biophys. 31,181-196, 1992.

Castro, J.R., P.L.Petti, I.K.Daftari, J.M.Collier, T. Renner, B. Ludewigt, W. Chu, S. Pitluck, T. Fleming, J. Alonso, and E. Blakely. Clinical gain from improved beam delivery systems. Radiat. Environ. Biophys. 31, 233-240, 1992.

Blakely, E.A., I.K. Daftari, W.J. Meecham, L.C. Alonso, et al. Helium-ion-induced human cataractogenesis. Adv. Space Res., Vol. 14, No. 10, pp. (10)501-(10)505, 1994.

Meecham, W.J., S.M. Kroll, D.H. Char, J.R. Castro and E.A. Blakely. Anterior segment complications after helium ion radiation therapy for uveal melanoma, I. Radiation cataract. Arch.Ophthalmol. 112,197-203,1994.

Goodwin, E.H., E.A. Blakely, and C.A. Tobias. Chromosomal damage and repair in G1-phase CHO cells exposed to charged particle beams. Radiat. Res, 138, 343-351, 1994.

Blakely, E. A. and R.J.M. Fry. Radiation protection in space, Radiat. Environ. Biophys. 34,129-131, 1995.

Blakely, E. A., Biological Beam Characterization. In Ion Beams in Tumor Therapy (Ed. U. Linz). Chapman & Hall, New York, pp. 63-72, 1995.

Daftari, I., D. Char, L.Verhey, J. Castro, P. Petti, W. Meecham, S. Kroll, E.A. Blakely. Anterior normal tissue sparing as a means of reducing complications of charged particle radiotherapy in uveal melanoma. Int. J. Radiat. Oncol., Biol., Physics 39, 989-996, 1997.

Castro, J., D. Char, P. Petti, I. Daftari, J. Quivey, R.P. Singh, E.A. Blakely and T. Phillips. 15 years experience with helium ion radiotherapy for uveal melanoma. Int. J. Radiat. Oncol, Biol., Physics 39, 997-1010, 1997.

Blakely, E.A., and A. Kronenberg. Heavy-ion radiobiology: New approaches to delineate mechanisms underlying enhanced biological effectiveness. Radiat. Res. 150, S126-S145, 1998.

Castro, J.R., P.L. Petti, E.A.Blakely and D.E. Linstadt. Particle Radiation Therapy. In Textbook of Radiation Oncology (Eds. Leibel and Phillips), W. B. Saunders Co., Philadelphia, PA, 1998.

Callahan, D.E., T.M. Forte, S.M.J. Afzal, D.F. Deen, S.B. Kahl, K.A. Bjornstad, W.F. Bauer and E.A. Blakely. Boronated protoporphyrin (BOPP): Localization in lysosomes of the human glioma cell line SF-767 with uptake modulated by lipoprotein levels. Int. J. Radiat. Oncol. Biol. Physics 45,761-771, 1999.

Maletinska, L., E.A. Blakely, K.A. Bjornstad, D.F. Deen, L.J. Knoff and T.M. Forte. Human glioblastoma cell lines: Levels of low density lipoprotein receptor and low density lipoprotein receptor-related protein. Cancer Research 60, 2300-2303, 2000.

Holman, H.Y., M.C. Martin, E.A. Blakely, K. Bjornstad and W.R. McKinney. Infrared spectroscopic characteristics of cell cycle and cell death probed by synchrotron-based FTIR spectromicroscopy. Biospectroscopy 57, 329-335, 2000.

Chang, P.Y., K.A. Bjornstad, E. Chang, M. McNamara, M.H. Barcellos-Hoff, S.P. Lin, G. Aragon, J.R. Polansky, G.M. Lui and E.A. Blakely. Particle irradiation induces FGF-2 expression in normal human lens cells. Radiat. Res. 154,477-484, 2000.

Blakely, E.A., K.A. Bjornstad, P.Y. Chang, M.P. McNamara, E. Chang, G. Aragon, S.P. Lin, G.M. Lui and J.R. Polansky. Growth and differentiation of human lens epithelial cells in vitro on matrix. Invest. Ophthalmol. & Visual Sci. 41, 3898-3907, 2000.

Blakely, E.A. Biological Effects of Cosmic Radiation: Deterministic & Stochastic. Health Phys. 79,495-505, 2000.

McNamara, M.P.J., K.A. Bjornstad, P.Y. Chang, W. Chou, S.J. Lockett and E.A. Blakely. Modulation of lens cell adhesion molecules by particle beams. Physica Medica, Vol. XVII, Supplement 1, pp. 247-248, 2001.

Blakely, E. A. New measurements for hadrontherapy and space radiation: Biology. Physica Medica, Vol XVII, Supplement 1, pp. 50-58, 2001.

Holman, H.Y., K.A. Bjornstad, M.P. McNamara, M.C. Martin, W.R. McKinney and E.A. Blakely. Synchrotron infrared spectromicroscopy as a novel bioanalytical microprobe for individual living cells: cytotoxicity considerations. J. Biomed. Optics 7(3), 417-424, 2002, & selected for Virtual J. Biol. Phys. Res. 4(3), 2002.

Mainardi, E., R.J. Donahue, W.E. Wilson, and E.A. Blakely, Comparison of microdosimetric simulations using PENELOPE and PITS for a 25 keV electron microbeam in water, Radiat. Res. 162,326-331, 2004.

Blakely, E.A. and P. Y. Chang, Late effects from hadron therapy, Radiotherapy & Oncology, Suppl. 2, Vol. 73, S134-S140, 2004.

Chang, PY, KA Bjornstad, CJ Rosen, MP McNamara, R Mancini, LE Goldstein, LT Chylack, and EA Blakely Effects of iron ions, protons and xrays on human lens cell differentiation, Radiat. Res. 164(4): 531-539, 2005.

7/11/06

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