A.W. and Mary Margaret Clausen Distinguished Professorship in Metabolism and Endocrinology, UCSF
Director, Diabetes Center, UCSF
Member, Biomedical Sciences Program (BMS) and Immunology Graduate Program, UCSF
| CONTACT | |
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jbluestone@immunetolerance.org Box 0540, UCSF; San Francisco, CA 94143-0540 |
additional websites: |
| EDUCATION | |
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Cook College, Rutgers University, B.S., 1974, Biology
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| PROFESSIONAL EXPERIENCE | |
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1980-1981 |
Anna Fuller Fund Postdoctoral Fellow, Immunology Branch, National Cancer Institute, NIH |
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1982-1986 |
Laboratory Leader, Senior Staff Fellow, Transplantation Biology Section, Immunology Branch, NCI, NIH |
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1986-1987 |
Senior Investigator, Transplantation Biology Section, Immunology Branch, NCI, NIH |
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1987-1991 |
Associate Professor, Ben May Institute, Dept. of Pathology and the Committee on Immunology, University of Chicago |
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1991-2000 |
Professor, Ben May Institute, Department of Pathology and the Committee on Immunology, University of Chicago and Chairman, Committee on Immunology |
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1995-2000 |
Director, Ben May Institute for Cancer Research |
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1999-present |
Director, Juvenile Diabetes Center, University of Chicago and University of Minnesota |
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1999-present |
Director, Immune Tolerance Network |
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2000-present |
A.W. and Mary Margaret Clausen Distinguished Professor of Metabolism and Endocrinology; and Director, UCSF Diabetes Center, the Metabolic Research Unit and the Hormone Research Institute, UCSF |
| HONORS & AWARDS | |
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1987-1989 |
Gould Foundation Faculty Scholar |
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1989 |
American Cancer Society Faculty Scholar |
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1997 |
Guggenheim Senior Fellowship |
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1997 |
Fogarty Senior Research Fellowship |
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1998 |
Cornell Medical School - Distinguished Alumni Award |
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2003 |
Priscilla White Lecturer, Brigham & Women's Hospital, Joslin Diabetes Center |
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2004 |
Juvenile Diabetes Research Foundation Gerold & Kayla Grodsky Basic Science Award |
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2004 |
American Society for Transplantation Roche Distinguished Research Award |
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2005 |
Mary Tyler Moore & Robert Levine Excellence in Clinical Research Award, Juvenile Diabetes Research Foundation |
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2006 |
Elected, American Academy of Arts and Sciences |
| SELECTED PUBLICATIONS | |
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(from over 300 full-length publications) |
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Tang, Q., Smith, J.A., Szot, G.L., Zhou, P., Alegre, M.-L., Thompson, C.B., and Bluestone, J.A. The CD28/B7 regulation of anti-CD3 mediated immunosuppression in vivo. J. Immunol. 170:1510-1516, 2003. |
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Chikuma, S., Imboden, J. B. and Bluestone, J.A. Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte associated antigen-4, J. Exp. Med. 197:129-135, 2003. |
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Belghith, M., Bluestone, J.A., Barriot, S., Garcia, C., Bach, J-F., Chatenoud, L. TGF-β dependent mechanisms mediate restoration of self-tolerance induced by anti-CD3 antibodies in overt autoimmune diabetes. Nature Medicine 9:1202-8, 2003. |
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Tang, Q., Henriksen, K.J., Boden, E.K., Tooley, A.J., Subudhi, S.K., Zheng X.X., Strom, T.B., Bluestone J.A. Cutting Edge: CD28 controls peripheral homeostasis of CD4+CD25+ regulatory T cells. J. Immunol 171:3348-52, 2003. |
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Bour-Jordan, H., Grogan, J.L. Tang Q., Auger, J.A., Locksley, R.M., and Bluestone, J.A. CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment, Nature Immunol. 4:182-188, 2003. |
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Ogasawara, K., Hamerman, J.A., Hsin, H., Chikuma, S., Jordan, H., Chen, T., Pertel, T., Carnaud, C., Bluestone, J.A., and Lanier, L.L. (co-senior authors). Impairment of NK cell function by NKG2D modulation in NOD mice, Immunity. 18:41-51, 2003. |
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Tang, Q., Henriksen, K.J., Bi, M., Finger, E.B., Szot, G., Ye, J., Masteller, E., McDevitt, H., Bonyhadi, M, and Bluestone, J.A. In vitro expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J. Exp. Med., 199:1455-1465, 2004. |
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Eagar, T.N., Turley, D.M., Padilla, J., Karandikar, N.J., Tan, L.J., Bluestone, J.A., and Miller, S.D. CTLA-4 regulates expansion of differentiation of Th1 cells following induction of peripheral T-cell tolerance. J. Immunol. 172: 7442-7450, 2004. |
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Bour-Jordan, H., Salomon, B., Thompson, H., Szot, G.L., Bernhard, M., Bluestone, J.A. Costimulation controls the development of diabetes in NOD mice by altering the balance of pathogenic and regulatory T cells. J. Clin. Invest. 114:979-987 2004. |
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Tang Q., Boden E. K., Henriksen, K.J., Bour-Jordon, H., Bi, M., and Bluestone, J.A. Distinct roles of CTLA-4 and TGF-β in CD4+CD25+ regulatory T cell function. Eur. J. Immunol. 34:2996-3005, 2004. |
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Ogasawara, K., Hamerman, J.A., Ehrlich, L.R., Bour-Jordan, H., Bluestone, J.A., and Lanier, L.L. NKG2D blockade prevents autoimmune diabetes in NOD mice. Immunity 20:757-767, 2004. |
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Eagar, T.N., Tang, Q., Wolfe, M., He, Y., Pear, W.S., and Bluestone, J.A. Notch 1 signaling regulates peripheral T cell activation. Immunity 20:407-15, 2004. |
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Anderson, M.S. and Bluestone J.A.: The NOD mouse: A model of immune dysregulation Annu. Rev. Immunol. 23:447-85, 2005. |
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Herold, K.C., Gitelman, S.E., Masharani, U., Hagopian, W., Bisikirska, B., Donaldson, D., Rother, K., Diamond, B., Harlan, D.M., Bluestone, J.A. A single course of anti-CD3 monoclonal antibody hOKT3γ1 (Ala-Ala) results in improvement in c-peptide responses and clinical parameters for at least 2 years after onset of Type 1 Diabetes. Diabetes 54:1763-9, 2005. |
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Chikuma, S., Abbas, A. and Bluestone, J.A. B7 independent inhibition of T cells by CTLA-4. J. Immunol. 175: 177-181, 2005. |
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Bour-Jordan, H., Thompson, H.l., and Bluestone, J.A. Distinct Effector Mechanisms in the Development of Autoimmune Neuropathy versus Diabetes in Nonobese Diabetic Mice, J. Immunol. 175: 5649-5655, 2005. |
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Bluestone, J.A., St. Clair, E.W., and Turka, L.A. CTLA-4: Bridging the basic immunology with clinical application, Immunity 24:1-6, 2006 |
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Bresson, D., Togher, L., Rodrigo, E., Chen, Y., Bluestone, J.A., Herold, K.C., and von Herrath M.: Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs. J. Clin. Invest. 116:1371-1381, 2006. |
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Masteller, E. L., Warner, M.R., Tang, Q., Tarbell, K.V. McDevitt, H., and Bluestone, J.A. Expansion of functional endogenous antigen-specific CD4+CD25+ regulatory T cells from NOD mice. J. Immunol. 175:3053-9, 2005. |
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Tang, Q., Adams, J.Y., Tooley, A.J., Bi, M., Fife, B.T., Serra, P., Santamaria, P., Locksley, R.M., Krummel, M.F. and Bluestone, J.A.. Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat. Immunol. 7:83-92, 2006. |
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Fife, B.T., Griffin, M.D., Abbas, A.K., Locksley, R.M., Bluestone, J.A. Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist. J. Clin. Invest. 116:2252-2261, 2006. Comment in: J. Clin. Invest. 116:2080-2083, 2006. |
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Liu, W., Putnam, A.L., Zhou, X-Y., Szot, G.L., Lee, M.R., Zhu, S., Gottlieb, P.K., Gingeras, T.R., de St. Groth, B.F., Clayberger, C., Soper, D.M., Ziegler, S.F., Bluestone, J.A. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J. Exp. Med. 203:1701-11, 2006. |
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2/8/07 |
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