Jeffrey A. Bluestone, PhD

Cook College, Rutgers University, B.S., 1974, Biology
Rutgers - State University, NJ, M.S., 1977, Microbiology
Cornell Graduate School of Medical Science (Sloan-Kettering Division), Ph.D., 1980, Immunology

• 1980-1982
  Anna Fuller Fund Postdoctoral Fellow, Immunology Branch, National Cancer Institute, NIH
• 1982-1982
  Laboratory Leader, Senior Staff Fellow, Transplantation Biology Section, Immunology Branch, NCI, NIH
• 1986-1982
  Senior Investigator, Transplantation Biology Section, Immunology Branch, NCI, NIH
• 1987-1992
  Associate Professor, Ben May Institute, Dept. of Pathology and the Committee on Immunology, University of Chicago
• 1991-2002
  Professor, Ben May Institute, Department of Pathology and the Committee on Immunology, University of Chicago and Chairman, Committee on Immunology
• 1995-2002
  Director, Ben May Institute for Cancer Research
• 1999-present
  Director, Juvenile Diabetes Center, University of Chicago and University of Minnesota
• 1999-present
  Director, Immune Tolerance Network
• 2000-present
  A.W. and Mary Margaret Clausen Distinguished Professor of Metabolism and Endocrinology; and Director, UCSF Diabetes Center, the Metabolic Research Unit and the Hormone Research Institute, UCSF

• 1987-1982
  Gould Foundation Faculty Scholar
• 1982
  American Cancer Society Faculty Scholar
• 1992
  Guggenheim Senior Fellowship
• 1992
  Fogarty Senior Research Fellowship
• 1992
  Cornell Medical School - Distinguished Alumni Award
• 2002
  Priscilla White Lecturer, Brigham & Women's Hospital, Joslin Diabetes Center
• 2002
  Juvenile Diabetes Research Foundation Gerold & Kayla Grodsky Basic Science Award
• 2002
  American Society for Transplantation Roche Distinguished Research Award
• 2002
  Mary Tyler Moore & Robert Levine Excellence in Clinical Research Award, Juvenile Diabetes Research Foundation
• 2002
  Elected, American Academy of Arts and Sciences

• (from over 300 full-length publications)
• Tang, Q., Smith, J.A., Szot, G.L., Zhou, P., Alegre, M.-L., Thompson, C.B., and Bluestone, J.A. The CD28/B7 regulation of anti-CD3 mediated immunosuppression in vivo. J. Immunol. 170:1510-1516, 2003.
• Chikuma, S., Imboden, J. B. and Bluestone, J.A. Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte associated antigen-4, J. Exp. Med. 197:129-135, 2003.
• Belghith, M., Bluestone, J.A., Barriot, S., Garcia, C., Bach, J-F., Chatenoud, L. TGF- dependent mechanisms mediate restoration of self-tolerance induced by anti-CD3 antibodies in overt autoimmune diabetes. Nature Medicine 9:1202-8, 2003.
• Tang, Q., Henriksen, K.J., Boden, E.K., Tooley, A.J., Subudhi, S.K., Zheng X.X., Strom, T.B., Bluestone J.A. Cutting Edge: CD28 controls peripheral homeostasis of CD4+CD25+ regulatory T cells. J. Immunol 171:3348-52, 2003.
• Bour-Jordan, H., Grogan, J.L. Tang Q., Auger, J.A., Locksley, R.M., and Bluestone, J.A. CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment, Nature Immunol. 4:182-188, 2003.
• Ogasawara, K., Hamerman, J.A., Hsin, H., Chikuma, S., Jordan, H., Chen, T., Pertel, T., Carnaud, C., Bluestone, J.A., and Lanier, L.L. (co-senior authors). Impairment of NK cell function by NKG2D modulation in NOD mice, Immunity. 18:41-51, 2003.
• Tang, Q., Henriksen, K.J., Bi, M., Finger, E.B., Szot, G., Ye, J., Masteller, E., McDevitt, H., Bonyhadi, M, and Bluestone, J.A. In vitro expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J. Exp. Med., 199:1455-1465, 2004.
• Eagar, T.N., Turley, D.M., Padilla, J., Karandikar, N.J., Tan, L.J., Bluestone, J.A., and Miller, S.D. CTLA-4 regulates expansion of differentiation of Th1 cells following induction of peripheral T-cell tolerance. J. Immunol. 172: 7442-7450, 2004.
• Bour-Jordan, H., Salomon, B., Thompson, H., Szot, G.L., Bernhard, M., Bluestone, J.A. Costimulation controls the development of diabetes in NOD mice by altering the balance of pathogenic and regulatory T cells. J. Clin. Invest. 114:979-987 2004.
• Tang Q., Boden E. K., Henriksen, K.J., Bour-Jordon, H., Bi, M., and Bluestone, J.A. Distinct roles of CTLA-4 and TGF- in CD4+CD25+ regulatory T cell function. Eur. J. Immunol. 34:2996-3005, 2004.
• Ogasawara, K., Hamerman, J.A., Ehrlich, L.R., Bour-Jordan, H., Bluestone, J.A., and Lanier, L.L. NKG2D blockade prevents autoimmune diabetes in NOD mice. Immunity 20:757-767, 2004.
• Eagar, T.N., Tang, Q., Wolfe, M., He, Y., Pear, W.S., and Bluestone, J.A. Notch 1 signaling regulates peripheral T cell activation. Immunity 20:407-15, 2004.
• Anderson, M.S. and Bluestone J.A.: The NOD mouse: A model of immune dysregulation Annu. Rev. Immunol. 23:447-85, 2005.
• Herold, K.C., Gitelman, S.E., Masharani, U., Hagopian, W., Bisikirska, B., Donaldson, D., Rother, K., Diamond, B., Harlan, D.M., Bluestone, J.A. A single course of anti-CD3 monoclonal antibody hOKT31 (Ala-Ala) results in improvement in c-peptide responses and clinical parameters for at least 2 years after onset of Type 1 Diabetes. Diabetes 54:1763-9, 2005.
• Chikuma, S., Abbas, A. and Bluestone, J.A. B7 independent inhibition of T cells by CTLA-4. J. Immunol. 175: 177-181, 2005.
• Bour-Jordan, H., Thompson, H.l., and Bluestone, J.A. Distinct Effector Mechanisms in the Development of Autoimmune Neuropathy versus Diabetes in Nonobese Diabetic Mice, J. Immunol. 175: 5649-5655, 2005.
• Bluestone, J.A., St. Clair, E.W., and Turka, L.A. CTLA-4: Bridging the basic immunology with clinical application, Immunity 24:1-6, 2002
  
• Bresson, D., Togher, L., Rodrigo, E., Chen, Y., Bluestone, J.A., Herold, K.C., and von Herrath M.: Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs. J. Clin. Invest. 116:1371-1381, 2006.
• Masteller, E. L., Warner, M.R., Tang, Q., Tarbell, K.V. McDevitt, H., and Bluestone, J.A. Expansion of functional endogenous antigen-specific CD4+CD25+ regulatory T cells from NOD mice. J. Immunol. 175:3053-9, 2005.
• Tang, Q., Adams, J.Y., Tooley, A.J., Bi, M., Fife, B.T., Serra, P., Santamaria, P., Locksley, R.M., Krummel, M.F. and Bluestone, J.A.. Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat. Immunol. 7:83-92, 2006.
• Fife, B.T., Griffin, M.D., Abbas, A.K., Locksley, R.M., Bluestone, J.A. Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist. J. Clin. Invest. 116:2252-2261, 2006. Comment in: J. Clin. Invest. 116:2080-2083, 2006.
• Liu, W., Putnam, A.L., Zhou, X-Y., Szot, G.L., Lee, M.R., Zhu, S., Gottlieb, P.K., Gingeras, T.R., de St. Groth, B.F., Clayberger, C., Soper, D.M., Ziegler, S.F., Bluestone, J.A. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J. Exp. Med. 203:1701-11, 2006.