Nancy J. Boudreau, PhD

Dalhousie University, Halifax, Nova Scotia, Canada, B.Sc. (Hon), 1981, Biology
Dalhousie University, Halifax, Nova Scotia, Canada, M.Sc., 1984, Pharmacology
University of Toronto, Ph.D., 1991, Pathology

• 1985-1987
  Research Assistant, Division of Cardiovascular Research, Hospital for Sick Children, Toronto, Ontario, Canada; Maintenance of vascular cell differentiated phenotype in culture
• 1987-1991
  Graduate Student, Department of Pathology, University of Toronto; Extracellular matrix and vascular cell behavior. Ontario Graduate Scholarship-1989; University of Toronto Open Graduate Fellowship-1989; Emmanuel Farber Award in Pathology-1989; Canadian Society of Clinical Investigation Trainee Award-1990; Medical Research Council of Canada Studentship-1990
• 1991-1995
  Postdoctoral Fellow, Laboratory of Cell and Molecular Biology, LBL, University of California, Berkeley; Susceptibility of endothelium to transformation in the chick embryo: Apoptosis and the regulation of gene expression by the extracellular matrix. Medical Research Council of Canada Fellowship-1992-1995.
• 1995-1996
  Postdoctoral Fellow, Department of Vascular Biology and Immunology, The Scripps Research Institute, La Jolla, CA; Extracellular matrix regulation of endothelial homeobox expression and regulation of endothelial integrin expression in angiogenesis. Joseph Drown Foundation Fellowship–1995-1996.
• 1996-1998
  Assistant Professor, Department of Anatomy, Medical College of Virginia, Richmond, VA; Homeobox genes and angiogenesis and regulation of endothelial gene expression by the extracellular matrix
• 1998-2003
  Assistant Professor, Department of Surgery, University of California, San Francisco
• 2003-present
  Director, Surgical Research Lab, San Francisco General Hospital
• 3003-present
  Associate Professor, Department of Surgery, University of California, San Francisco
• 2009-present
  Professor, Department of Surgery, University of California San Francisco

• 1989
  Ontario Graduate Scholarship
• 1989
  University of Toronto Open Graduate Fellowship
• 1989
  Emmanuel Farber Award in Pathology
• 1990
  Canadian Society of Clinical Investigation Trainee Award
• 1990
  Medical Research Council of Canada Studentship
• 1992-1995
  Medical Research Council of Canada Fellowship
• 1995-1996
  Joseph Drown Foundation Fellowship

• Martins-Green, M., Boudreau, N. and Bissell, M.J. (1994) Inflammation is responsible for the development of wound-induced tumors in chickens infected with Rous sarcoma virus. Cancer Research 54:4334-4341.
• Boudreau, N., Sympson, C., Werb, Z. and Bissell, M. (1995) Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix. Science 287:891-893.
• Boudreau, N., Myers, C.A. and Bissell, M.J. (1995) From laminin to lamin: Regulation of tissue-specific gene expression by the ECM. Trends in Cell Biology 5:1-4.
• Jones, P.L., Boudreau, N., Myers, C.A., Erikson, H. and Bissell, M. (1995) Tenascin-C inhibits extracellular matrix-dependent gene expression in mammary epithelial cells. J. Cell Science 108:519-527.
• Boudreau, N., Reddy, S., Stoker, A., Fairman, C. and Bissell, M. (1995) The extracellular matrix attenuates v-src oncogenesis in chick chondroblasts. Molec. Cell Diff. 3:261-274.
• Boudreau, N., Martins-Green, M. and Bissell, M.J. (1994) Oncogenic transformation in chick embryos correlates with cell differentiation. Molec. Biol. Cell 4, 355a.
• Boudreau, N., Werb, Z., and Bissell, M.J. (1996) Suppression of apoptosis requires basement membrane induced three-dimensional tissue organization and cell cycle withdrawal. Proc. Natl. Acad. Sci. USA 93:3509-3513.
• Boudreau, N., and Bissell, M.J. (1996) Regulation of Gene Expression by the Extracellular Matrix, In: Structure and Function of Extracellular Matrices of Connective Tissue, Comper, W., ed., Gordon and Breach, Volume 2.
• Zhou, B., Boudreau, N., Hammabeck, J., Coulber, C. and Rabinovitch, M. (1997) Microtubule associated protein-1 light chain 3 is a fibronectin mRNA binding protein linked to mRNA translation. J. Clin. Invest. 100:3070-3082.
• Boudreau, N., Andrews, C., Srebrow, A., Ravanpay, A., and Cheresh, D.A. (1997) Hox D3 mediates an angiogenic phenotype in endothelial cells. J. Cell Biol. 139:257-264.
• Boudreau, N., and Bissell, M.J. (1998) Extracellular matrix signaling: Integration of form and function in normal and malignant cells. Curr. Op. Cell Biol. 10(5):640-646.
• Boudreau, N., and Jones, P.L. (1999) Extracellular matrix and integrin signaling: The shape of things to come. Biochem. J. 339:481-488.
• Myers, C.A., Charboneau, A. and Boudreau, N. (2000) Homeobox B3 promotes capillary morphogenesis and angiogenesis. J. Cell Biol. 148:348-351.
• Boudreau, N. and Bissell, M.J. (2001) Extracellular Matrix: The Networking Solution. IN: The Cancer Handbook, Gullick, W. and Saloman, D., Eds., MacMillan Press. In Press.
• Uyeno, L., Newman-Keagle, J., Cheung, I., Hunt, T.K., Young, D.M. and Boudreau, N. (2001) Homeobox D3 in normal and impaired wound healing. J. Surg. Res. 100:46-56.
• Hashimoto, T., Lam, T. X., Boudreau, N., Bollen, A. and Young, W.L. (2001) Abnormal Balance in Angiopoietin-Tie-2 Signaling in Human Brain Arteriovenous Malformations. Circ. Res. 89:111-113.
• Myers, C. A., Charboneau, A., Cheung, I. and Boudreau, N. (2002) Homeobox D10 inhibits VEGF-induced angiogenesis in vivo. Am. J. Pathol. 161:2099-2019.
• Hashimoto T., Wen G., Boudreau N., Lawson M.T. Yang G-Y.Barbaro N.M., Dowd C.F., Halbach V.V. and Yung W.L. (2002) Abnormal expresson of MMP and TIMPs in BAVMs. Stroke 34:925-931.
• Boudreau, N. and C. Myers (2002) Angiogenesis in breast cancer- the role of the microenvironment Breast Cancer Res. 5:140-146.
• Zhong, J., Zhu, Y., Elicieri, B., Stupack, D., Howell, G., Wilson, E., Penta, K., Sakamoto, G., Quertermous, T., Boudreau, N., Colemen, M. and Varner, J. (2002) Neovascularization of ischemic tissue by gene delivery of Del-1. J. Clin. Invest. 112:30-41.
• Boudreau, N. (2003) Organized Living: From cell surfaces to basement membranes. Science STKE 196:34.
• Hansen, S.L., Myers, C.A., Young, D.M. and Boudreau, N. (2003) Gene transfer of Hox D3 accelerates wound repair in diabetic (db/db) mice. Am. J. Pathology 163:1-11.
• Hansen, S.L., Young, D. and Boudreau, N. (2003) Hox D3 and collagen expression in diabetic fibroblasts. Wound Rep. Regen. 11:474-480.
• Boudreau, N., and Varner, J.A. (2004) The homeobox transcription factor Hox D3 directly regulates Beta3 and Alpha 5 integrin expression in angiogenic endothelium. J. Biol. Chem. 279(6):4862-8.
• Hashimoto, T., Wu, Y., Boudreau, N., Li, J., Matsumoto, M., and Young, W. (2004) Regulation of Tie2 expression by angiopoietin-potential feedback system. Endothelium 11(3-4):207-210.
• Chen Y, Xu B, Arderiu G, Hashimoto T, Young WL, Boudreau N, et al. Retroviral delivery of Homeobox D3 gene induces cerebral angiogenesis in mice (2004). J Cereb Blood Flow Metab. 24:1280-1287.
• Cambier, S., Gline, S.E., Araya, J, Collins, R., Einheber, S., Dolganov, G., Boudreau, N., Nishimura, S.L., (2005) Integrin alpha(v)beta8-mediated activation of TGF-beta: an angiogenic control switch, Am. J. Path., 166, 1883-1894
• Mace K.A. Hansen, S.L., Myers, C., Young, D. and Boudreau, N. (2005) Hox A3 induces angiogenesis and wound repair. J. Cell Sci. . 118, 2567-2577.
• Carrio, M., Myers, C.A. G. Arderiu and Boudreau, N. (2005) Hox D10 inhibits breast tumor cell migration and growth in vivo. Cancer Research, 65, 1-10.
• Charbonneau A., N . Malek , L. East , M. Rohde and N. Boudreau (2005). The co-factor Pbx-1 is required for HoxD3–dependent angiogenesis in vivo- Angiogenesis-In Press
• Morimoto-Tomita,M., K. Uchimura, A. Bistrup, D. Lum, M. Egeblad, N. Boudreau Z. Werb, and S. D. Rosen (2005) SULF-2, a proangiogenic heparan sulfate endosulfatase, is upregulated in breast cancer–Neoplasia 7, 1001-1010.
• Rhoads, K., Arderiu, G., Charboneau A., Hansen,S.L., Hoffman,W., and N. Boudreau (2005) A role for Hox A5 in regulating angiogenesis and vascular patterning –Lymphatic Research and Biology 3(4) 240-252
• Charbonneau A., N . Malek , L. East , M. Rohde and N. Boudreau (2005). The co-factor Pbx-1 is required for HoxD3–dependent angiogenesis in vivo- Angiogenesis November 19, 1-8 2005- epub online, Boudreau, N. and WM Weaver (2006) Forcing the Third Dimension Cell 125, 11-12.
• Hansen, S.L. A. Dosanjh, D. M. Young, N. Boudreau, and W. Y. Hoffman, (2006) Hemangiomas and Homeobox Gene Expression- J. Craniofacial Surg 17, 767-71 Vlahakis,N.E. B. A. Young, A. Atakilit, A. E. Hawkridge, R. B Issaka, N. Boudreau, D. Sheppard (2007)
• Integrin alpha9beta1 directly binds to vascular endothelial growth factor (VEGF)-A and is necessary for VEGF-A and tumor induced angiogenesis.- J. Biol. Chem. 282, 15187-15196.
• Yu,DH, K A. Mace, S L. Hansen,. N. Boudreau, DM. Young, (2007) Effects of Decreased IGF-1 Stimulation of Hif-1alpha Protein Synthesis and Function on Impaired Diabetic Wound Healing- J. Invest. Dermatol. 15, 628-35
• Mace,K.A. ., D. H. Yu,., K. Z. Paydar N. Boudreau., D. M. Young, (2007) Sustained Expression of Hif-1alpha in the Diabetic Environment Results in Upregulation of Hif-1 Target Genes and Accelerates Wound Repair J. Invest. Dermatol. 15, 636-645
• Arderiu, G., I. Cuevas, L. East, M. Carrio and N.. Boudreau (2007) HoxA5 promotes vascular stability via increases in Akt and retention of beta catenin in junctions-Cell Adhesion and Migration 1(4). 185-195
• Zhu, Y., Cuevas, I. Gabriel RA, Su, H, Fields A., Hao Q., Young WL, Yang G-Y and N.Boudreau (2009) Restoring HoxA5 expression inhibits growth of experimental hemangiomas in brain. J. Neurol and Exper. Neurol. 68 -626-632
• Mace, KA, Restivo, T, RinnJL, Paquet, A., Change H. Young DM and N.Boudreau (2009) HoxA3 modulates injury induced mobilization and recruitment of bone marrow derived cells. Stem Cells 27, 1654-1665.
• Chen, A. Cuevas I, Kenny P, Boudreau A, Ghagar, C Bissell MJ and N.Boudreau ( 2009) Restoring Polarity in Breast Tumor cells attenuates VEGF expression and Angiogenesis. Cancer Research, 69, 6721-6729.
• Cuevas, I and N. Boudreau (2009) Managing Tumor Angiogenesis: Lessons from VEGF resistant tumors and wounds Adv. Cancer Res. 103 25-42.
• Mace, K. and N. Boudreau (2009) Plasmid Based gene transfer of Homeobox genes and improved wound healing- Advances in Wound Care Vol. 1 pp. 388-394
• Sounni NE, , Dehne K , van Kempen Leon LCL, Lee, J., Overall CM. , Krane SM, Werb Z , Boudreau, N and LM. Coussens (2010) Metallpproteinase and TGFbeta regulation of vascular stability and leakage –Disease Models and Mech. 3, 317-332
• Gilbert PM, Mouw J., Unger MA, Lakins J. N Boudreau, Tsai KK, Welm A, Feldman MD, Weber B and VM Weaver (2010) HoxA9 regulates BRCA1 expression to modulate breast tumor phenotype-. J. Clin Invest. 120, 1535-1550.
• Kuri, M. and N. Boudreau (2010) "Homeobox genes and wound healing-evidence linking development and skin regeneration. Adv. Wound Care Vol2. in press June 2010