Associate Professor, Surgery, UCSF
| CONTACT | |
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nancyjb@itsa.ucsf.edu Box 1302, UCSF; San Francisco, CA 94143-1302 |
| EDUCATION | |
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Dalhousie University, Halifax, Nova Scotia, Canada, B.Sc. (Hon), 1981, Biology
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| PROFESSIONAL EXPERIENCE | |
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9/85-9/87 |
Research Assistant, Division of Cardiovascular Research, Hospital for Sick Children, Toronto, Ontario, Canada; Maintenance of vascular cell differentiated phenotype in culture |
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9/87-1/91 |
Graduate Student, Department of Pathology, University of Toronto; Extracellular matrix and vascular cell behavior. |
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7/91-9/95 |
Postdoctoral Fellow, Laboratory of Cell and Molecular Biology, LBL, University of California, Berkeley; Susceptibility of endothelium to transformation in the chick embryo: Apoptosis and the regulation of gene expression by the extracellular matrix. |
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9/95-11/96 |
Postdoctoral Fellow, Department of Vascular Biology and Immunology, The Scripps Research Institute, La Jolla, CA; Extracellular matrix regulation of endothelial homeobox expression and regulation of endothelial integrin expression in angiogenesis. |
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12/96-6/98 |
Assistant Professor, Department of Anatomy, Medical College of Virginia, Richmond, VA; Homeobox genes and angiogenesis and regulation of endothelial gene expression by the extracellular matrix |
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7/98-6/03 |
Assistant Professor, Department of Surgery, University of California, San Francisco |
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7/02-present |
Acting Director, Surgical Research Lab, San Francisco General Hospital |
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7/03-present |
Associate Professor, Department of Surgery, University of California, San Francisco |
| HONORS & AWARDS | |
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1989 |
Ontario Graduate Scholarship |
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1989 |
University of Toronto Open Graduate Fellowship |
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1989 |
Emmanuel Farber Award in Pathology |
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1990 |
Canadian Society of Clinical Investigation Trainee Award |
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1990 |
Medical Research Council of Canada Studentship |
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1992-1995 |
Medical Research Council of Canada Fellowship |
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1995-1996 |
Joseph Drown Foundation Fellowship |
| SELECTED PUBLICATIONS | |
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Martins-Green, M., Boudreau, N. and Bissell, M.J. (1994) Inflammation is responsible for the development of wound-induced tumors in chickens infected with Rous sarcoma virus. Cancer Research 54:4334-4341. |
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Boudreau, N., Sympson, C., Werb, Z. and Bissell, M. (1995) Extracellular matrix suppresses apoptosis and expression of interleukin-1 converting enzyme (ICE) in mammary epithelial cells. Science 287:891-893. |
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Boudreau, N., Myers, C.A. and Bissell, M.J. (1995) From laminin to lamin: Regulation of tissue-specific gene expression by the ECM. Trends in Cell Biology 5:1-4. |
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Jones, P.L., Boudreau, N., Myers, C.A., Erikson, H. and Bissell, M. (1995) Tenascin-C inhibits extracellular matrix-dependent gene expression in mammary epithelial cells. J. Cell Science 108:519-527. |
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Boudreau, N., Reddy, S., Stoker, A., Fairman, C. and Bissell, M. (1995) The extracellular matrix attenuates v- src oncogenesis in chick chondroblasts. Molec. Cell Diff. 3:261-274. |
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Boudreau, N., Martins-Green, M. and Bissell, M.J. (1994) Oncogenic transformation in chick embryos correlates with cell differentiation. Molec. Biol. Cell 4, 355a. |
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Boudreau, N., Werb, Z., and Bissell, M.J. (1996) Suppression of apoptosis requires basement membrane induced three-dimensional tissue organization and cell cycle withdrawal. Proc. Natl. Acad. Sci. USA 93:3509-3513. |
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Boudreau, N., and Bissell, M.J. (1996) Regulation of Gene Expression by the Extracellular Matrix, In: Structure and Function of Extracellular Matrices of Connective Tissue, Comper, W., ed., Gordon and Breach, Volume 2. |
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Zhou, B., Boudreau, N., Hammabeck, J., Coulber, C. and Rabinovitch, M. (1997) Microtubule associated protein-1 light chain 3 is a fibronectin mRNA binding protein linked to mRNA translation. J. Clin. Invest. 100:3070-3082. |
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Boudreau, N., Andrews, C., Srebrow, A., Ravanpay, A., and Cheresh, D.A. (1997) Hox D3 mediates an angiogenic phenotype in endothelial cells. J. Cell Biol. 139:257-264. |
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Boudreau, N., and Bissell, M.J. (1998) Extracellular matrix signaling: Integration of form and function in normal and malignant cells. Curr. Op. Cell Biol. 10(5):640-646. |
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Boudreau, N., and Jones, P.L. (1999) Extracellular matrix and integrin signaling: The shape of things to come. Biochem. J. 339:481-488. |
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Myers, C.A., Charboneau, A. and Boudreau, N. (2000) Homeobox B3 promotes capillary morphogenesis and angiogenesis. J. Cell Biol. 148:348-351. |
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Boudreau, N. and Bissell, M.J. (2001) Extracellular Matrix: The Networking Solution. IN: The Cancer Handbook, Gullick, W. and Saloman, D., Eds., MacMillan Press. In Press. |
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Uyeno, L., Newman-Keagle, J., Cheung, I., Hunt, T.K., Young, D.M. and Boudreau, N. (2001) Homeobox D3 in normal and impaired wound healing. J. Surg. Res. 100:46-56. |
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Hashimoto, T., Lam, T. X., Boudreau, N., Bollen, A. and Young, W.L. (2001) Abnormal Balance in Angiopoietin-Tie-2 Signaling in Human Brain Arteriovenous Malformations. Circ. Res. 89:111-113. |
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Myers, C. A., Charboneau, A., Cheung, I. and Boudreau, N. (2002) Homeobox D10 inhibits VEGF-induced angiogenesis in vivo. Am. J. Pathol. 161:2099-2019. |
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Hashimoto T., Wen G.,Boudreau N., Lawson M.T. Yang G-Y.Barbaro N.M., Dowd C.F., Halbach V.V. and Yung W.L. (2002) Abnormal expresson of MMP and TIMPs in BAVMs. Stroke 34:925-931. |
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Boudreau, N. and C. Myers (2002) Angiogenesis in breast cancer- the role of the microenvironment Breast Cancer Res. 5:140-146. |
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Zhong, J., Zhu, Y., Elicieri, B., Stupack, D., Howell, G., Wilson, E., Penta, K., Sakamoto, G., Quertermous, T., Boudreau, N., Colemen, M. and Varner, J. (2002) Neovascularization of ischemic tissue by gene delivery of Del-1. J. Clin. Invest. 112:30-41. |
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Boudreau, N. (2003) Organized Living: From cell surfaces to basement membranes. Science STKE 196:34. |
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Hansen, S.L., Myers, C.A., Young, D.M. and Boudreau, N. (2003) Gene transfer of Hox D3 accelerates wound repair in diabetic (db/db) mice. Am. J. Pathology 163:1-11. |
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Hansen, S.L., Young, D. and Boudreau, N. (2003) Hox D3 and collagen expression in diabetic fibroblasts. Wound Rep. Regen. 11:474-480. |
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Boudreau, N., and Varner, J.A. (2004) The homeobox transcription factor Hox D3 directly regulates 3 and Alpha 5 integrin expression in angiogenic endothelium. J. Biol. Chem. 279(6):4862-8. |
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Chen Y, Xu B, Arderiu G, Hashimoto T, Young WL, Boudreau N, et al. Retroviral delivery of homeobox D3 gene induces cerebral angiogenesis in mice. J Cereb Blood Flow Metab 2004;24(11):1280- |
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Hashimoto, T., Wu, Y., Boudreau, N., Li, J., Matsumoto, M., and Young, W. (2004) Regulation of Tie2 expression by angiopoietin-potential feedback system. Endothelium 11(3-4):207-210. |
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Cambier, S., Gline, S.E., Araya, J, Collins, R., Einheber, S., Dolganov, G., Boudreau, N., Nishimura, S.L., Integrin avb8-mediated activation of TGF-b: an angiogenic control switch, Am. J. Path., 2005, In press. |
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Mace K.A. Hansen, S.L., Myers, C., Young, D. and Boudreau, N. (2004) Hox A3 induces angiogenesis and wound repair. In press Jan. 2005 J. Cell Sci. . |
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Carrio, M., Myers, C.A. and Boudreau, N. (2005) Hox D10 inhibits breast tumor cell migration and growth in vivo. Submitted Cancer Research, October 2004.Revised mansucript submitted Feb. 2005. |
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Charbonneau A., N . Malek , L. east , M. Rohde and N. Boudreau (2005). The co-factor Pbx-1 is required for Hox D3-dependent angiogenesis in vivo-revised manuscript in siubmitted Feb. 2005 Circ. Res. |
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10/27/05 |
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