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Helen Diller Family Compr Cancer Ctr
ROBERT C. BRASCH, MD

Professor, Radiology, Pediatrics, UCSF; and Director, Center for Pharmaceutical and Molecular Imaging, UCSF

CONTACT

(415) 476-2275 (appts)
(415) 476-0616 (fax)

Box 1753, UCSF; San Francisco, CA 94143-1753

additional websites:

UCSF Physician Referral Directory

EDUCATION

Miami University, Oxford, OH, B.A., 1966, Biology (Honors)
Washington University, St. Louis, MO, M.D., 1970, Medicine

PROFESSIONAL EXPERIENCE

1970

Internship, University of California San Diego (Medical Service)

1971-1973

Senior Assistant Surgeon, USPHS, NHLI, NIH

1973-1977

NIH-sponsored Resident, Research Fellow, Pediatric Radiology Fellow, Department of Radiology, UCSF

1977-present

Assistant/Associate/Full Professor, Departments of Radiology and Pediatrics, UCSF

HONORS & AWARDS

1996

Phi Beta Kappa

1970

Alpha Omega Alpha

1976

Memorial Award of the Association of University Radiologists

1977

James Picker Foundation Fellow in Radiology Research

1984

Baker Visiting Professor to Australasian Congress

1989

Fellow of the American College of Radiology

1992, 1997

Recipient of Caffey Award for Research by Society for Pediatric Radiology

1997

Harry Fischer Award of RSNA for excellence in Contrast Media Research

1984-present

Editorial Boards of Academic Radiology, Magnetic Resonance Imaging, Pediatric Radiology and JMRI

2003

RSNA 2003 Outstanding Researcher, recipient, December 1st, 2003 RSNA, Chicago, IL.,

SELECTED PUBLICATIONS

Rockoff SD, Brasch RC, Kuhn C, Charplyvy M: Contrast media as histamine liberators I. Mast-cell histamine release in vitro by sodium salts of contrast media. Invest Radiology, Nov 5:503, 1970.

Brasch RC, Caldwell JL: Antibodies to radiographic contrast agents. Demonstration of antibody activity in the sera of patients suffering severe reactions. Invest Radiol., Sept-Oct 11:347, 1976.

Brasch RC: Methods of contrast enhancement for NMR imaging and potential applications. Radiology, 147:781-778, 1983.

Weinmann HJ, Brasch RC, Press WR, Wesbey GE: Characteristics of gadolinium-DTPA complex: a potential NMR contrast agent. Am J Roentgenology, 142:619-624, 1984.

Brasch RC, Weinmann HJ, Wesbey GE: Contrast-enhanced NMR imaging: animal studies using gadolinium-DTPA complex. Am J Roentgenology, 142:625-630, 1984.

Schmiedl U, Ogan MD, Paajanen H, Marotti M, Crooks LE, Brito AC and Brasch RC: Albumin labeled with Gd-DTPA as an intravascular, blood pool-enhancing agent for MR imaging: Biodistribution and imaging studies. Radiology, 162:205-210, 1987.

Aicher KP, Dupon JW, White DL, Aukerman SL, Moseley ME, Juster R, Rosenau W, Winkelhake JL, Brasch RC: Contrast-enhanced magnetic resonance imaging of tumor-bearing mice treated with human recombinant tumor-necrosis factor (TNF). Cancer Research, 50:7376-7381, 1990.

Brasch RC: State of the Art: New directions in the development of MR contrast medium. Radiology, 183:1-11, 1992.

Shames DM, Kuwatsuru R, Vexler VS, MŸhler AR, Brasch RC: Measurement of capillary permeability to macromolecules by dynamic magnetic resonance imaging: A quantitative non-invasive technique. Magnetic Resonance in Medicine, 29:616-622, 1993.

Schwickert HC, Stiskal M, van Dijke CF, Mann J, MŸhler A, Shames DM, Demsar F, Brasch RC: Contrast-enhanced MRI assessment of tumor capillary permeability: The effect of pre-irradiation on the tumor deliver of chemotherapy. Radiology, 198(3):893-898, 1995.

van Dijke CF, Brasch RC, Roberts TPL, Weidner N, Mathur A, Shames DM, Mann JS, Demsar F, Lang P, Schwickert HC: Mammary carcinoma model: correlation of macromolecular contrast-enhanced MR imaging characterizations of tumor microvasculature and histologic capillary density. Radiology,198(3):813-8, 1995.

Brasch RC, Pham C, Shames D, Roberts T, van Dijke K, van Bruggen N, Mann J, Ostrowitzki S, Melnyk O: Assessing tumor angiogenesis using macromolecular MRI contrast media. JMRI, 7:68-74, 1997.

Pham C, Roberts TPL, van Bruggen N, Melnyk O, Mann J, Ferrara N, Cohen RL, Brasch RC: Magnetic resonance imaging detects suppression of tumor vascular permeability after administration of antibody to vascular endothelial growth factor. Cancer Investigation, 16(4):225-230, 1998.

Daldrup H, Shames DM, Wendland M, Okuhata Y, Link TM, Rosenau W, Lu Y, Brasch RC: Correlations of dynamic contrast-enhanced magnetic resonance imaging with histologic tumor grade: Comparison of macromolecular and small molecular contrast media. Pediatric Radiology 28:67-78, 1998, and American Journal of Roentgenology, 171:941-949, 1998.

Daldrup H, Shames DM, Husseini W, Wendland WF, Okuhata Y, Brasch RC: Quantification of the extraction fraction for gadopentetate across breast cancer. MRM, 40(4):537-543, 1998.

Gossmann A, Helbich TH, Mesiano S, Shames DM, Wendland MF, Roberts TPL, Ferrara N, Jaffe RB, Brasch RC: Magnetic resonance imaging in ovarian cancer demonstrating altered microvascular permeability following inhibition of vascular endothelial growth factor. American Journal of Obstetrics and Gynecology, 183(4): 956-963, 2000.

Brasch RC, Li KCP, Husband JE, Keogan MT, Neeman M, Padhani AR, Shames DM, Turetschek K: In vivo monitoring of tumor angiogenesis with MR Imaging. Academic Radiology, 7(10): 812-823, 2000.

Daldrup-Link HE, Shames DM, Wendland MF, Muehler A, Gossmann A, Rosenau W, Brasch RC: Comparison of Gadomer-17 and Gadopentetate for differentiation of benign from malignant breast tumors by MR imaging. Academic Radiology, 7(11): 934-944, 2000.

Helbich TH, Roberts TPL, Gossmann A, Wendland MF, Shames DM, Adachi M, Yang S, Huber S, Daldrup H, Brasch RC: Quantitative gadopentetate-enhanced MR imaging of breast tumors: Testing of different analytic methods. Magnetic Resonance in Medicine, 44:915-924, 2000.

Turetschek K, Floyd E, Helbich TH, Roberts TPL, Shames DM, Wendland MF, Carter WO, Brasch RC: MRI assessment of microvascular characteristics in experimental breast tumors using a new blood pool contrast agent (MS-325) with correlations to histopathology.MRI, 14(3):237-242, 2001.

Brasch RC, Gossmann A, Helbich TH, Kuriyama N, Roberts TPL, Shames DM, van Bruggen N, Wendland MF, Israel MA: Can a small-molecular gadolinium contrast agent be applied successfully with dynamic MRI to quantitatively define brain tumor microvascular responses to angiogenesis inhibition? Contrast Media Research Symposium, Capri, Italy, Oct. 14-18, 2001 Acad. Radiology 9(S2):S326-7, 2002.

Fournier LS, Lucidi V, Rosenau W, Demos SG, Brasch RC: In-vivo NIR autofluorescence of rat mammary tumors discriminates pathological malignancy. SPIE, 5141:33, 2003.

Daldrup-Link HE, Okuhata Y, Wolfe A, Srivastav S, Oie S, Ferrara N, Cohen RL, Shames DM, Brasch RC: Decrease in tumor apparent permeability-surface area product to a MRI macromolecular contrast medium following angiogenesis inhibition with correlations to cytotoxic drug accumulation. Microcirculation, 11: 387-396, 2004.

Wiart M, Fournier LS, Novikov VY, Shames DM, Roberts TPL, Fu Y, Shalinsky DR, Brasch RC: Magnetic Resonance Imaging detects early changes in tumor microvascular permeability of xenograft tumors after treatment with the matrix metalloprotease inhibitor prinomastat. Technology for Cancer Research and Treatment, 3(4): 377-382, August 2004.

Brasch RC, Fournier L, Lucidi V, Berejnoi K, Fu Y, Palley J, Demos SG: Challenges for the development of clinically-useful fluorescing diagnostic contrast agents for optical imaging: A radiologist's perspective. SPIE, 5329: 215-221.

Book Edited and Book Chapter

Brasch RC, Editor: MRI Contrast Enhancement of the Central Nervous System: A Case-Study Approach. Raven Press, New York, 1994.

Fournier LS, Brasch RC: The Role of Blood Pool Contrast Media in the Study of Tumor Pathophysiology. In: Jackson A, Buckley D, Parker G. (editors) Dynamic Contrast Enhancement Techniques in Oncology, Springer-Verlag GmbH & Co. KG Berlin-Heidelberg, 2005.

Daldrup-Link HE, Okuhata Y, Wolfe A, Srivastav S, Oie S, Ferrara N, Cohen RL, Shames DM, Brasch RC: Decrease in tumor apparent permeability-surface area product to a MRI macromolecular contrast medium following angiogenesis inhibition with correlations to cytotoxic drug accumulation. Microcirculation, 11: 387-396, 2004.

Wiart M, Fournier LS, Novikov VY, Shames DM, Roberts TPL, Fu Y, Shalinsky DR, Brasch RC: Magnetic Resonance Imaging detects early changes in tumor microvascular permeability of xenograft tumors after treatment with the matrix metalloprotease inhibitor prinomastat. Technology for Cancer Research and Treatment, 3(4): 377-382, August 2004.

Brasch RC, Fournier L, Lucidi V, Berejnoi K, Fu Y, Palley J, Demos SG: Challenges for the development of clinically-useful fluorescing diagnostic contrast agents for optical imaging: A radiologistŐs perspective. SPIE, 5329: 215-221, 2004.

Preda A, Novikov V, Moglich M, Floyd E, Tureschek K, Shames DM, Roberts TPL, Corot C, Carter WO, Brasch RC: Magnetic resonance characterization of tumor microvessels in experimental breast tumors using a slow clearance blood pool contrast agent (carboxymethyldextran-A2-Gd-DOTA) with histopathological correlation. European Radiology 15: 2268-2275, 2005.

Simon GH, Fu Y, Berejnoi K, Fournier LS, Lucidi V, Yeh B, Shames DM, Brasch RC: Initial computed tomography imaging experience using a new macromolecular iodinated contrast medium in experimental breast cancer. Investigative Radiology, 40(9): 614-620, 2005.

Raatschen H0J, Swain R, Shames DM, Fu Y, Boyd Z, Zierhut ML, Wendland MF, Misselwitz B, Weinmann H-J, Wolf K-J, Brasch RC: MRI tumor characterization using Gd-GlyMe-DOTA-perfluorooctyl-mannose-conjugate (Gadofluorine M), a protein-avid contrast agent. Contrast Media and Molecular Imaging, 1(3):113-120, 2006.

Fu, Y, Nitecki DE, Maltby D, Simon GH, Berejnoi K, Raatschen H-J, Yeh, BM, Shames DM and Brasch RC: Dendritic iodinated contrast agents with PEG-Cores for CT imaging: synthesis and preliminary characterization. Bioconjugate Chemistry 17(4):1043-1056, 2006.

Preda A, van Vliet M, Krestin GP, Brasch RC, van Dijke CF: Magnetic resonance macromolecular agents for monitoring tumore microvessels and angiogenesis inhibition. Investigative Radiology 41(3)325-331, 2006.

Daldrup-Link HE, Simon GH, Brasch RC. Imaging of tumor angiogenesis: current approaches and future prospects. Curr Pharm Des 12(21):2661-2672, 2006.

Book Edited and Book Chapter

Brasch RC, Editor: MRI Contrast Enhancement of the Central Nervous System: A Case-Study Approach. Raven Press, New York, 1994.

Fournier LS, Brasch RC: The Role of Blood Pool Contrast Media in the Study of Tumor Pathophysiology. In: Jackson A, Buckley D, Parker G. (editors) Dynamic Contrast Enhancement Techniques in Oncology, Springer-Verlag GmbH & Co. KG Berlin-Heidelberg, 2005.

12/11/06

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