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Miami University, Oxford, OH, B.A., 1966, Biology (Honors)
Washington University, St. Louis, MO, M.D., 1970, Medicine

Rockoff SD, Brasch RC, Kuhn C, Charplyvy M: Contrast media as histamine liberators I. Mast-cell histamine release in vitro by sodium salts of contrast media. Invest Radiology, Nov 5:503, 1970.

Brasch RC, Caldwell JL: Antibodies to radiographic contrast agents. Demonstration of antibody activity in the sera of patients suffering severe reactions. Invest Radiol., Sept-Oct 11:347, 1976.

Brasch RC: Methods of contrast enhancement for NMR imaging and potential applications. Radiology, 147:781-778, 1983.

Weinmann HJ, Brasch RC, Press WR, Wesbey GE: Characteristics of gadolinium-DTPA complex: a potential NMR contrast agent. Am J Roentgenology, 142:619-624, 1984.

Brasch RC, Weinmann HJ, Wesbey GE: Contrast-enhanced NMR imaging: animal studies using gadolinium-DTPA complex. Am J Roentgenology, 142:625-630, 1984.

Schmiedl U, Ogan MD, Paajanen H, Marotti M, Crooks LE, Brito AC and Brasch RC: Albumin labeled with Gd-DTPA as an intravascular, blood pool-enhancing agent for MR imaging: Biodistribution and imaging studies. Radiology, 162:205-210, 1987.

Aicher KP, Dupon JW, White DL, Aukerman SL, Moseley ME, Juster R, Rosenau W, Winkelhake JL, Brasch RC: Contrast-enhanced magnetic resonance imaging of tumor-bearing mice treated with human recombinant tumor-necrosis factor (TNF). Cancer Research, 50:7376-7381, 1990.

Brasch RC: State of the Art: New directions in the development of MR contrast medium. Radiology, 183:1-11, 1992.

Shames DM, Kuwatsuru R, Vexler VS, MŸhler AR, Brasch RC: Measurement of capillary permeability to macromolecules by dynamic magnetic resonance imaging: A quantitative non-invasive technique. Magnetic Resonance in Medicine, 29:616-622, 1993.

Schwickert HC, Stiskal M, van Dijke CF, Mann J, MŸhler A, Shames DM, Demsar F, Brasch RC: Contrast-enhanced MRI assessment of tumor capillary permeability: The effect of pre-irradiation on the tumor deliver of chemotherapy. Radiology, 198(3):893-898, 1995.

van Dijke CF, Brasch RC, Roberts TPL, Weidner N, Mathur A, Shames DM, Mann JS, Demsar F, Lang P, Schwickert HC: Mammary carcinoma model: correlation of macromolecular contrast-enhanced MR imaging characterizations of tumor microvasculature and histologic capillary density. Radiology,198(3):813-8, 1995.

Brasch RC, Pham C, Shames D, Roberts T, van Dijke K, van Bruggen N, Mann J, Ostrowitzki S, Melnyk O: Assessing tumor angiogenesis using macromolecular MRI contrast media. JMRI, 7:68-74, 1997.

Pham C, Roberts TPL, van Bruggen N, Melnyk O, Mann J, Ferrara N, Cohen RL, Brasch RC: Magnetic resonance imaging detects suppression of tumor vascular permeability after administration of antibody to vascular endothelial growth factor. Cancer Investigation, 16(4):225-230, 1998.

Daldrup H, Shames DM, Wendland M, Okuhata Y, Link TM, Rosenau W, Lu Y, Brasch RC: Correlations of dynamic contrast-enhanced magnetic resonance imaging with histologic tumor grade: Comparison of macromolecular and small molecular contrast media. Pediatric Radiology 28:67-78, 1998, and American Journal of Roentgenology, 171:941-949, 1998.

Daldrup H, Shames DM, Husseini W, Wendland WF, Okuhata Y, Brasch RC: Quantification of the extraction fraction for gadopentetate across breast cancer. MRM, 40(4):537-543, 1998.

Gossmann A, Helbich TH, Mesiano S, Shames DM, Wendland MF, Roberts TPL, Ferrara N, Jaffe RB, Brasch RC: Magnetic resonance imaging in ovarian cancer demonstrating altered microvascular permeability following inhibition of vascular endothelial growth factor. American Journal of Obstetrics and Gynecology, 183(4): 956-963, 2000.

Brasch RC, Li KCP, Husband JE, Keogan MT, Neeman M, Padhani AR, Shames DM, Turetschek K: In vivo monitoring of tumor angiogenesis with MR Imaging. Academic Radiology, 7(10): 812-823, 2000.

Daldrup-Link HE, Shames DM, Wendland MF, Muehler A, Gossmann A, Rosenau W, Brasch RC: Comparison of Gadomer-17 and Gadopentetate for differentiation of benign from malignant breast tumors by MR imaging. Academic Radiology, 7(11): 934-944, 2000.

Helbich TH, Roberts TPL, Gossmann A, Wendland MF, Shames DM, Adachi M, Yang S, Huber S, Daldrup H, Brasch RC: Quantitative gadopentetate-enhanced MR imaging of breast tumors: Testing of different analytic methods. Magnetic Resonance in Medicine, 44:915-924, 2000.

Turetschek K, Floyd E, Helbich TH, Roberts TPL, Shames DM, Wendland MF, Carter WO, Brasch RC: MRI assessment of microvascular characteristics in experimental breast tumors using a new blood pool contrast agent (MS-325) with correlations to histopathology.MRI, 14(3):237-242, 2001.

Brasch RC, Gossmann A, Helbich TH, Kuriyama N, Roberts TPL, Shames DM, van Bruggen N, Wendland MF, Israel MA: Can a small-molecular gadolinium contrast agent be applied successfully with dynamic MRI to quantitatively define brain tumor microvascular responses to angiogenesis inhibition? Contrast Media Research Symposium, Capri, Italy, Oct. 14-18, 2001 Acad. Radiology 9(S2):S326-7, 2002.

Fournier LS, Lucidi V, Rosenau W, Demos SG, Brasch RC: In-vivo NIR autofluorescence of rat mammary tumors discriminates pathological malignancy. SPIE, 5141:33, 2003.

Daldrup-Link HE, Okuhata Y, Wolfe A, Srivastav S, Oie S, Ferrara N, Cohen RL, Shames DM, Brasch RC: Decrease in tumor apparent permeability-surface area product to a MRI macromolecular contrast medium following angiogenesis inhibition with correlations to cytotoxic drug accumulation. Microcirculation, 11: 387-396, 2004.

Wiart M, Fournier LS, Novikov VY, Shames DM, Roberts TPL, Fu Y, Shalinsky DR, Brasch RC: Magnetic Resonance Imaging detects early changes in tumor microvascular permeability of xenograft tumors after treatment with the matrix metalloprotease inhibitor prinomastat. Technology for Cancer Research and Treatment, 3(4): 377-382, August 2004.

Brasch RC, Fournier L, Lucidi V, Berejnoi K, Fu Y, Palley J, Demos SG: Challenges for the development of clinically-useful fluorescing diagnostic contrast agents for optical imaging: A radiologist's perspective. SPIE, 5329: 215-221.

Book Edited and Book Chapter

Brasch RC, Editor: MRI Contrast Enhancement of the Central Nervous System: A Case-Study Approach. Raven Press, New York, 1994.

Fournier LS, Brasch RC: The Role of Blood Pool Contrast Media in the Study of Tumor Pathophysiology. In: Jackson A, Buckley D, Parker G. (editors) Dynamic Contrast Enhancement Techniques in Oncology, Springer-Verlag GmbH & Co. KG Berlin-Heidelberg, 2005.

Daldrup-Link HE, Okuhata Y, Wolfe A, Srivastav S, Oie S, Ferrara N, Cohen RL, Shames DM, Brasch RC: Decrease in tumor apparent permeability-surface area product to a MRI macromolecular contrast medium following angiogenesis inhibition with correlations to cytotoxic drug accumulation. Microcirculation, 11: 387-396, 2004.

Wiart M, Fournier LS, Novikov VY, Shames DM, Roberts TPL, Fu Y, Shalinsky DR, Brasch RC: Magnetic Resonance Imaging detects early changes in tumor microvascular permeability of xenograft tumors after treatment with the matrix metalloprotease inhibitor prinomastat. Technology for Cancer Research and Treatment, 3(4): 377-382, August 2004.

Brasch RC, Fournier L, Lucidi V, Berejnoi K, Fu Y, Palley J, Demos SG: Challenges for the development of clinically-useful fluorescing diagnostic contrast agents for optical imaging: A radiologistÕs perspective. SPIE, 5329: 215-221, 2004.

Preda A, Novikov V, Moglich M, Floyd E, Tureschek K, Shames DM, Roberts TPL, Corot C, Carter WO, Brasch RC: Magnetic resonance characterization of tumor microvessels in experimental breast tumors using a slow clearance blood pool contrast agent (carboxymethyldextran-A2-Gd-DOTA) with histopathological correlation. European Radiology 15: 2268-2275, 2005.

Simon GH, Fu Y, Berejnoi K, Fournier LS, Lucidi V, Yeh B, Shames DM, Brasch RC: Initial computed tomography imaging experience using a new macromolecular iodinated contrast medium in experimental breast cancer. Investigative Radiology, 40(9): 614-620, 2005.

Raatschen H0J, Swain R, Shames DM, Fu Y, Boyd Z, Zierhut ML, Wendland MF, Misselwitz B, Weinmann H-J, Wolf K-J, Brasch RC: MRI tumor characterization using Gd-GlyMe-DOTA-perfluorooctyl-mannose-conjugate (Gadofluorine M), a protein-avid contrast agent. Contrast Media and Molecular Imaging, 1(3):113-120, 2006.

Fu, Y, Nitecki DE, Maltby D, Simon GH, Berejnoi K, Raatschen H-J, Yeh, BM, Shames DM and Brasch RC: Dendritic iodinated contrast agents with PEG-Cores for CT imaging: synthesis and preliminary characterization. Bioconjugate Chemistry 17(4):1043-1056, 2006.

Preda A, van Vliet M, Krestin GP, Brasch RC, van Dijke CF: Magnetic resonance macromolecular agents for monitoring tumore microvessels and angiogenesis inhibition. Investigative Radiology 41(3)325-331, 2006.

Daldrup-Link HE, Simon GH, Brasch RC. Imaging of tumor angiogenesis: current approaches and future prospects. Curr Pharm Des 12(21):2661-2672, 2006.

Book Edited and Book Chapter

Brasch RC, Editor: MRI Contrast Enhancement of the Central Nervous System: A Case-Study Approach. Raven Press, New York, 1994.

Fournier LS, Brasch RC: The Role of Blood Pool Contrast Media in the Study of Tumor Pathophysiology. In: Jackson A, Buckley D, Parker G. (editors) Dynamic Contrast Enhancement Techniques in Oncology, Springer-Verlag GmbH & Co. KG Berlin-Heidelberg, 2005.

12/11/06