V. Courtney Broaddus, MD

Duke University, Durham, North Carolina, B.S., Summa Cum Laude, 1975, Zoology
University of Pennsylvania, Philadelphia, PA, M.D., 1979, Medicine
University of Pennsylvania, Philadelphia, PA, Intern and Resident, 1979-82, Internal Medicine
University of California San Francisco, CA, Fellow, 1983-84, Pulmonary Disease

• 1986-88
  Instructor in Medicine, University of California, San Francisco, CA
• 1988-1995
  Assistant Professor in Medicine, University of California, San Francisco, CA
• 1991-present
  Member, Lung Biology Center, University of California, San Francisco, CA
• 1995-2001
  Associate Professor in Medicine, University of California, San Francisco, CA
• 1998-present
  Chief, Division of Pulmonary and Critical Care, University of California, San Francisco, CA
• 2001-present
  Professor in Medicine, University of California, San Francisco, CA
• 2001-2002
  Visiting Scientist, Comprehensive Cancer Center, Dr. Gerard Evan's Laboratory
• 2004-present
  Associate Director, Lung Biology Center, Univ. of Calif., San Francisco

• 1978
  Alpha Omega Alpha, University of Pennsylvania
• 1979
  Janet M. Glasgow Memorial Award and Citation for Outstanding Female Medical Student
• 1987-1992
  Clinical Investigator Award, NHLBI
• 1988
  American Physiological Society (elected)
• 1991
  Associate, Scientific Staff, Cardiovascular Research Institute, UCSF (elected)
• 1991
  Distinction in Teaching Award, University of California, San Francisco, CA
• 1992
  Pretenure Award, University of California, San Francisco, CA
• 1998-2001
  UC Tobacco Related Disease Program Award for "Programmed Cell Death in Cigarette- Induced Lung Disease"
• 1999-2002
  President, International Mesothelioma Interest Group

• Boylan AM, Rüegg CR, Kim KJ, Hébert CA, Hoeffel JM, Pytela R, Sheppard D, Goldstein IM, BROADDUS VC. Evidence of a role for mesothelial cell derived interleukin-8 in the pathogenesis of asbestos-induced pleurisy in rabbits. J Clin Invest 1992; 89:1257-1267.
• BROADDUS VC, Hoeffel JM, Boylan AM, Sadick M, Chuntharapai A, Kim KJ, Hebert CA. Neutralization of interleukin-8 inhibits neutrophil influx in a rabbit model of endotoxin-induced pleurisy. J Immunol 1994; 152:2960-2967.
• Folkesson HG, Matthay MA, Hebert CA, BROADDUS VC. Acid aspiration lung injury in rabbits is mediated by interleukin-8 dependent mechanisms. J Clin Invest 1995; 96:107-116.
• Boylan AM, Sanan D, Sheppard D, BROADDUS VC. Vitronectin enhances internalization of crocidolite asbestos by rabbit pleural mesothelial cells via the integrin v5. J Clin Invest 1995; 96:1987-2001.
• BROADDUS VC, Yang L, Scavo LM, Ernst JD, Boylan AM. Asbestos induces apoptosis of human and rabbit pleural mesothelial cells via reactive oxygen species. J Clin Invest 1996; 98 (9):2050-2059.
• BROADDUS VC. Asbestos, the mesothelial cell and malignancy: a matter of life or death. Am J Respir Cell Mol Biol 1997; 17:657-659.
• Narasimhan SR, Yang L, Gerwin BI, BROADDUS, VC. Resistance of pleural mesothelioma cell lines to apoptosis: relation to expression of Bcl-2 and Bax. Am J Physiol (Lung Cell Mol Physiol) 1998; 275(19):L165-L171.
• Ernst JD, Yang L, BROADDUS VC. Preparation and characterization of an endogenously fluorescent annexin for detection of apoptotic cells. Anal Biochem 1998; 260:18-23.
• Levresse V, Renier A, Levy F, BROADDUS VC, Jaurand M-C. DNA breakage in asbestos-treated normal and transformed (TSV40) rat pleural mesothelial cells. Mutagenesis 2000; 15(3):239-244.
• Liu W, Ernst JD, BROADDUS VC. Phagocytosis of crocidolite asbestos induces oxidative stress, DNA damage and apoptosis in mesothelial cells. Am J Respir Cell Mol Biol 2000; 23(3):371-78.
• Marchi E, Liu W, BROADDUS VC. Mesothelial cell apoptosis is confirmed in vivo by morphologic change in cytokeratin distribution. Am J Physiol (Lung Cell Mol Physiol) 2000; 278:L528-L535.
• Cambier S, Mu D, Boylen K, Travis W, Liu W, BROADDUS VC, Nishimura SL. The integrin v8 negatively regulates growth of human airway epithelium. Cancer Res 2000; 60(24):7084-7093.
• Wu J, Liu W, Koenig K, Idell SI, BROADDUS VC. Vitronectin adsorption to chrysotile asbestos increases phagocytosis and toxicity for mesothelial cells. Am J Physiol (Lung Cell Mol Physiol) 2000:279:L916-L923.
• Liu W, Bodle E, Chen JY, Rosen GD, BROADDUS VC. TNF-related apoptosis inducing ligand (TRAIL) and chemotherapy cooperate to induce apoptosis in human mesothelioma cell lines. Am J Respir Cell Mol Biol 2001; 25(1):111-8.
• Mu D, Cambier S, Fjellbirkeland L, Baron JL, Munger JS, Kawakatsu H, Sheppard D, BROADDUS VC, Nishimura SL. The integrin v8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-1. J Cell Biol 2002; 157(3):493-507.
• Crapo JD, BROADDUS VC, Brody AR, Malindzak G, Samet J, Wright JR; American Thoracic Society. ATS-NIEHS Workshop on lung disease and the environment; Where do we go from here? Am J Respir Crit Care Med 2003; 168(2):250-254.
• Fjellbirkeland L, Cambier S, BROADDUS VC, Hill A, Brunetta P, Dolganov G, Jablons D, Nishimura SL. Integrin v8-mediated activation of TGF- inhibits human airway epithelial proliferation in intact bronchial tissue. Am J Pathol 2003; 163(2):533-542.
• Vivo C, Liu WH, BROADDUS VC. C-Jun N-terminal kinase contributes to apoptotic synergy induced by TRAIL plus DNA damage in chemoresistant, p53 inactive mesothelioma cells. J Biol Chem 2003; 278(28):25461-25467.
• Leard LE, BROADDUS VC. Mesothelial cell proliferation and apoptosis. Respirology 2004; 9:292-299.
• Geiser T, Ishigaki M, van Leer C, Matthay MA, BROADDUS VC. H2O2 inhibits alveolar epithelial wound repair in vitro by induction of apoptosis. Am J Physiol (Lung Cell Mol Physiol) 2004; 287:L448-L453.
• Mutti L, BROADDUS VC. Malignant mesothelioma as both a challenge and an opportunity. Oncogene 2004; 23(57): 9155-9161.
• BROADDUS VC, Dansen TB, Abayasiriwardana KS, Finch AF, Swigart LB, Hunt AE, Evan GI. BID mediates apoptotic synergy between TRAIL and DNA damage. J Biol Chem 2005; 280(13):12486-12493.
• Kim KU, Abayasiriwardana KS, Wilson SM, Collins R, Fjellbirkeland L, Xu Z, Jablons DM, Nishimura SL, BROADDUS VC. Human mesothelioma tissue used in vitro as a model for studying in vivo tumor biology and apoptotic resistance. In review.