CBroaddus@medsfgh.ucsf.edu
(415) 206-3513 (voice)
(415) 206-4123 (fax)

Box 0854, UCSF; San Francisco, CA 94143-0854

Duke University, Durham, North Carolina, B.S., Summa Cum Laude, 1975, Zoology
University of Pennsylvania, Philadelphia, PA, M.D., 1979, Medicine
University of Pennsylvania, Philadelphia, PA, Intern and Resident, 1979-82, Internal Medicine
University of California San Francisco, CA, Fellow, 1983-84, Pulmonary Disease

Boylan AM, Rüegg CR, Kim KJ, Hébert CA, Hoeffel JM, Pytela R, Sheppard D, Goldstein IM, BROADDUS VC. Evidence of a role for mesothelial cell derived interleukin-8 in the pathogenesis of asbestos-induced pleurisy in rabbits. J Clin Invest 1992; 89:1257-1267.

BROADDUS VC, Hoeffel JM, Boylan AM, Sadick M, Chuntharapai A, Kim KJ, Hebert CA. Neutralization of interleukin-8 inhibits neutrophil influx in a rabbit model of endotoxin-induced pleurisy. J Immunol 1994; 152:2960-2967.

Folkesson HG, Matthay MA, Hebert CA, BROADDUS VC. Acid aspiration lung injury in rabbits is mediated by interleukin-8 dependent mechanisms. J Clin Invest 1995; 96:107-116.

Boylan AM, Sanan D, Sheppard D, BROADDUS VC. Vitronectin enhances internalization of crocidolite asbestos by rabbit pleural mesothelial cells via the integrin v5. J Clin Invest 1995; 96:1987-2001.

BROADDUS VC, Yang L, Scavo LM, Ernst JD, Boylan AM. Asbestos induces apoptosis of human and rabbit pleural mesothelial cells via reactive oxygen species. J Clin Invest 1996; 98 (9):2050-2059.

BROADDUS VC. Asbestos, the mesothelial cell and malignancy: a matter of life or death. Am J Respir Cell Mol Biol 1997; 17:657-659.

Narasimhan SR, Yang L, Gerwin BI, BROADDUS, VC. Resistance of pleural mesothelioma cell lines to apoptosis: relation to expression of Bcl-2 and Bax. Am J Physiol (Lung Cell Mol Physiol) 1998; 275(19):L165-L171.

Ernst JD, Yang L, BROADDUS VC. Preparation and characterization of an endogenously fluorescent annexin for detection of apoptotic cells. Anal Biochem 1998; 260:18-23.

Levresse V, Renier A, Levy F, BROADDUS VC, Jaurand M-C. DNA breakage in asbestos-treated normal and transformed (TSV40) rat pleural mesothelial cells. Mutagenesis 2000; 15(3):239-244.

Liu W, Ernst JD, BROADDUS VC. Phagocytosis of crocidolite asbestos induces oxidative stress, DNA damage and apoptosis in mesothelial cells. Am J Respir Cell Mol Biol 2000; 23(3):371-78.

Marchi E, Liu W, BROADDUS VC. Mesothelial cell apoptosis is confirmed in vivo by morphologic change in cytokeratin distribution. Am J Physiol (Lung Cell Mol Physiol) 2000; 278:L528-L535.

Cambier S, Mu D, Boylen K, Travis W, Liu W, BROADDUS VC, Nishimura SL. The integrin v8 negatively regulates growth of human airway epithelium. Cancer Res 2000; 60(24):7084-7093.

Wu J, Liu W, Koenig K, Idell SI, BROADDUS VC. Vitronectin adsorption to chrysotile asbestos increases phagocytosis and toxicity for mesothelial cells. Am J Physiol (Lung Cell Mol Physiol) 2000:279:L916-L923.

Liu W, Bodle E, Chen JY, Rosen GD, BROADDUS VC. TNF-related apoptosis inducing ligand (TRAIL) and chemotherapy cooperate to induce apoptosis in human mesothelioma cell lines. Am J Respir Cell Mol Biol 2001; 25(1):111-8.

Mu D, Cambier S, Fjellbirkeland L, Baron JL, Munger JS, Kawakatsu H, Sheppard D, BROADDUS VC, Nishimura SL. The integrin v8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-1. J Cell Biol 2002; 157(3):493-507.

Crapo JD, BROADDUS VC, Brody AR, Malindzak G, Samet J, Wright JR; American Thoracic Society. ATS-NIEHS Workshop on lung disease and the environment; Where do we go from here? Am J Respir Crit Care Med 2003; 168(2):250-254.

Fjellbirkeland L, Cambier S, BROADDUS VC, Hill A, Brunetta P, Dolganov G, Jablons D, Nishimura SL. Integrin v8-mediated activation of TGF- inhibits human airway epithelial proliferation in intact bronchial tissue. Am J Pathol 2003; 163(2):533-542.

Vivo C, Liu WH, BROADDUS VC. C-Jun N-terminal kinase contributes to apoptotic synergy induced by TRAIL plus DNA damage in chemoresistant, p53 inactive mesothelioma cells. J Biol Chem 2003; 278(28):25461-25467.

Leard LE, BROADDUS VC. Mesothelial cell proliferation and apoptosis. Respirology 2004; 9:292-299.

Geiser T, Ishigaki M, van Leer C, Matthay MA, BROADDUS VC. H2O2 inhibits alveolar epithelial wound repair in vitro by induction of apoptosis. Am J Physiol (Lung Cell Mol Physiol) 2004; 287:L448-L453.

Mutti L, BROADDUS VC. Malignant mesothelioma as both a challenge and an opportunity. Oncogene 2004; 23(57): 9155-9161.

BROADDUS VC, Dansen TB, Abayasiriwardana KS, Finch AF, Swigart LB, Hunt AE, Evan GI. BID mediates apoptotic synergy between TRAIL and DNA damage. J Biol Chem 2005; 280(13):12486-12493.

Kim KU, Abayasiriwardana KS, Wilson SM, Collins R, Fjellbirkeland L, Xu Z, Jablons DM, Nishimura SL, BROADDUS VC. Human mesothelioma tissue used in vitro as a model for studying in vivo tumor biology and apoptotic resistance. In review.

5/15/05