Frances Brodsky, DPhil

Harvard University, Massachusetts, B.A., 1976, Biochemistry
Oxford University, England, D. Phil., 1979, Genetics
Harvard University, Massachusetts, Postdoc 1980, Biochemistry
Stanford University, California Postdoc, 1980-82, Structural Biology

• 1976-1979
  Graduate Student with Dr. W.F. Bodmer, Genetics Laboratory, Oxford, U.K.
• 1979-1980
  Postdoctoral Fellow with Dr. J.L. Strominger, Harvard University, Cambridge, MA
• 1980-1982
  Postdoctoral Fellow with Dr. P. Parham, Stanford University, School of Medicine, Stanford, CA
• 1982-1986
  Program Manager, Cell Biology, Research and Development Department, Becton Dickinson Immunocytometry Systems
• 1987-1991
  Assistant Professor of Pharmacy and Pharmaceutical Chemistry, School of Pharmacy; Assistant Adjunct Professor of Microbiology, School of Medicine, University of California, San Francisco.
• 1991-1994
  Associate Professor of Pharmacy and Pharmaceutical Chemistry, School of Pharmacy; Associate Professor of Microbiology and Immunology, School of Medicine, University of California, San Francisco
• 1994-Present
  Professor of Biopharmaceutical Sciences and Pharmaceutical Chemistry, School of Pharmacy; Professor of Microbiology and Immunology, School of Medicine, University of California, San Francisco

• 1975
  Dreyfus Fellowship (summer research), Phi Beta Kappa-junior year
• 1976
  Graduated Summa cum laude in Biochemical Sciences, Harvard
• 1976-1979
  Marshall Scholarship for study in the United Kingdom
• 1980-1982
  Damon Runyon-Walter Winchell Fund, Postdoctoral Fellowship
• 1984-1999
  Member, Editorial Board of Human Immunology
• 1987
  Pharmaceutical Manufacturers Association Fund Research Starter Grant
• 1988-1992
  Pew Scholar award
• 2005
  Boehinger-Ingelheim Lecturer, McGill University
• 2005-2007
  Honorary Professor, Institute for Molecular Bioscience, University of Queensland
• 2006-2011
  Member, Searle Scholars Advisory Board
• 2006
  Margaret Pittman Lecturer, National Institutes of Health
• 2006
  Visiting fellow, King's College Cambridge

• (out of 122)
• Näthke, I.S., Heuser, J., Lupas, A., Stock, J., Turck, C.W. and Brodsky, F.M. (1992) Folding and trimerization of the clathrin triskelion hub. Cell 68:899-910.
• Liu, S-H., Wong, M.L., Craik, C.S. and Brodsky, F.M. (1995) Regulation of clathrin assembly and trimerization defined using recombinant triskelion hubs. Cell 83:257-267.
• Wilde, A., Beattie, E.C., Lem, L., Riethof, D.A., Liu, S-H., Mobley, W.C., Soriano, P. and Brodsky, F.M. (1999) EGF receptor signaling stimulates SRC kinase phosphorylation of clathrin, influencing clathrin redistribution and EGF uptake. Cell 96: 677-687.
• Ybe, J.A., Brodsky, F.M., Hofmann, K., Lin, K., Liu, S-H., Chen, L., Earnest, T.N., Fletterick, R.J. and Hwang, P.K. (1999) Clathrin self-assembly is mediated by a tandemly repeated superhelix. Nature 399: 371-375.
• Liu, S-H., Towler, M.C., Chen, E., Chen, C-Y., Song, W., Apodaca, G. and Brodsky, F.M. (2001) A novel clathrin homologue that codistributes with cytoskeletal components functions in the trans-Golgi network. EMBO J. 20: 272-284.
• Brodsky, F.M., Chen, C-Y., Knuehl, C., Towler, M.C., Wakeham, D.E. (2001) Biological basketweaving: clathrin-coated vesicle formation and function. Annu. Rev. Cell Dev. Biol. 17: 517-568.
• Yang, D., Buchholz, F., Huang, Z., Goga, A., Chen, C-Y., Brodsky, F.M. and Bishop, J.M. (2002) Short RNA duplexes produced by hydrolysis with Escherichia coli Rnase III mediate effective RNA interference in mammalian cells. Proc. Natl. Acad. Sci. USA 99: 9942-9947.
• Stoddart, A., Dykstra, M.L., Brown, B.K., Song, W., Pierce, S.K. and Brodsky, F.M. (2002) Lipid rafts unite signaling cascades with clathrin to regulate BCR internalization. Immunity 17: 467-472.
• Chen, C-Y., Reese, M.L., Hwang, P.K., Ota, N., Agard, D. and Brodsky, F.M. (2002) Clathrin light and heavy chain interface: -helix binding superhelix via critical tryptophans. EMBO J. 21: 6072-6082.
• Wakeham, D.E., Chen, C-Y., Greene, B., Hwang, P.K. and Brodsky, F.M. (2003) Clathrin self-assembly involves coordinated weak interactions favorable for cellular regulation. EMBO J. 22: 4980-4990.
• Towler, M.C., Kaufman, S.J. and Brodsky, F.M. (2004) Membrane traffic in skeletal muscle. Traffic 5: 129-139.
• Crotzer, V.L., Mabardy, A.S., Weiss, A. and Brodsky, F.M. (2004) T cell receptor engagement leads to phosphorylation of clathrin heavy chain during receptor internalization. J. Exp. Med. 199:981-991.
• Towler, M.C., Gleeson, P.A., Hoshino, S., Rahkila, P., Manalo, V., Ordahl, C. and Brodsky, F.M. (2004) Clathrin isoform CHC22, a component of neuromuscular and myotendinous junctions, binds sorting nexin 5 and has a role in myogenesis and muscle regeneration. Mol. Biol. Cell 15:3181-3195.
• Niiro, H., Allam, A., Stoddart, A., Brodsky, F.M., Marshall, A.J. and Clark, E.A. (2004) The B lymphocyte adaptor molecule of 32 kd regulates B cell antigen receptor internalization. J. Immunol. 173: 5601-5609.
• Brodsky, F.M. (2004) Clathrin's Achilles' ankle.- News and Views. Nature 432: 568-569.
• Wilbur, J., Hwang, P. and Brodsky, F.M. (2005) New faces of the familiar clathrin lattice. Traffic 6:346-350.
• Chen, C.-Y. and Brodsky, F.M. (2005) Hip1/Hip1R bind the conserved sequences of clathrin light chains and thereby influence clathrin assembly in vitro and actin distribution in vivo. J. Biol. Chem. 280: 6109-6117.
• Stoddart, A., Jackson, A.P. and Brodsky, F.M. (2005) Plasticity of B cell receptor internalization upon conditional depletion of clathrin. Mol. Biol. Cell 16, 2339-2348.
• Wakeham, D.E., Abi-Rached, L., Towler, M.C., Wilbur, J.D., Parham, P. and Brodsky, F.M. (2005) Clathrin heavy and light chain isoforms originated by independent mechanisms of gene duplication during chordate evolution. Proc. Natl. Acad. Sci. USA 102, 7209-7214.
• Chen, T.T., Li, L., Chung, D-H., Allen, C.D.C., Torti, S., Torti,F.M., Cyster, J.G., Chen, C-Y., Brodsky, F.M., Niemi, E.C., Nakamura, M.C., Seaman, W.E. and Daws, M.R. (2005) TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis. J. Exp. Med. 202: 955-965.
• Knuehl, C., Chen, C.-Y., Manalo, V., Hwang, P.K., Ota, N. and Brodsky, F.M. (2006) Novel binding sites on clathrin and adaptors regulate distinct aspects of coat assembly. Traffic 7: 1581-1589.