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FRANCES BRODSKY, DPHIL

Professor, Depts. of Biopharmaceutical Sciences, Pharmaceutical Chemistry and Microbiology and Immunology, UCSF

CONTACT

fmarbro@itsa.ucsf.edu
(415) 476-6406 (voice)
(415) 476-6185 (fax)

Box 0552, UCSF; San Francisco, CA 94143-0552

additional websites:

Brodsky Lab Website

EDUCATION
Harvard University, Massachusetts, B.A., 1976, Biochemistry Oxford University, England, D. Phil., 1979, Genetics Harvard University, Massachusetts, Postdoc 1980, Biochemistry Stanford University, California Postdoc, 1980-82, Structural Biology
PROFESSIONAL EXPERIENCE
1976-1979	Graduate Student with Dr. W.F. Bodmer, Genetics Laboratory, Oxford, U.K.
1979-1980	Postdoctoral Fellow with Dr. J.L. Strominger, Harvard University, Cambridge, MA
1980-1982	Postdoctoral Fellow with Dr. P. Parham, Stanford University, School of Medicine, Stanford, CA
1982-1986	Program Manager, Cell Biology, Research and Development Department, Becton Dickinson Immunocytometry Systems
1987-1991	Assistant Professor of Pharmacy and Pharmaceutical Chemistry, School of Pharmacy; Assistant Adjunct Professor of Microbiology, School of Medicine, University of California, San Francisco.
1991-1994	Associate Professor of Pharmacy and Pharmaceutical Chemistry, School of Pharmacy; Associate Professor of Microbiology and Immunology, School of Medicine, University of California, San Francisco
1994-Present	Professor of Biopharmaceutical Sciences and Pharmaceutical Chemistry, School of Pharmacy; Professor of Microbiology and Immunology, School of Medicine, University of California, San Francisco
HONORS & AWARDS
1975	Dreyfus Fellowship (summer research), Phi Beta Kappa-junior year
1976	Graduated Summa cum laude in Biochemical Sciences, Harvard
1976-1979	Marshall Scholarship for study in the United Kingdom
1980-1982	Damon Runyon-Walter Winchell Fund, Postdoctoral Fellowship
1984-1999	Member, Editorial Board of Human Immunology
1987	Pharmaceutical Manufacturers Association Fund Research Starter Grant
1988-1992	Pew Scholar award
2005	Boehinger-Ingelheim Lecturer, McGill University
2005-2007	Honorary Professor, Institute for Molecular Bioscience, University of Queensland
2006-2011	Member, Searle Scholars Advisory Board
2006	Margaret Pittman Lecturer, National Institutes of Health
2006	Visiting fellow, King's College Cambridge
SELECTED PUBLICATIONS
(out of 122)
Näthke, I.S., Heuser, J., Lupas, A., Stock, J., Turck, C.W. and Brodsky, F.M. (1992) Folding and trimerization of the clathrin triskelion hub. Cell 68:899-910.
Liu, S-H., Wong, M.L., Craik, C.S. and Brodsky, F.M. (1995) Regulation of clathrin assembly and trimerization defined using recombinant triskelion hubs. Cell 83:257-267.
Wilde, A., Beattie, E.C., Lem, L., Riethof, D.A., Liu, S-H., Mobley, W.C., Soriano, P. and Brodsky, F.M. (1999) EGF receptor signaling stimulates SRC kinase phosphorylation of clathrin, influencing clathrin redistribution and EGF uptake. Cell 96: 677-687.
Ybe, J.A., Brodsky, F.M., Hofmann, K., Lin, K., Liu, S-H., Chen, L., Earnest, T.N., Fletterick, R.J. and Hwang, P.K. (1999) Clathrin self-assembly is mediated by a tandemly repeated superhelix. Nature 399: 371-375.
Liu, S-H., Towler, M.C., Chen, E., Chen, C-Y., Song, W., Apodaca, G. and Brodsky, F.M. (2001) A novel clathrin homologue that codistributes with cytoskeletal components functions in the trans-Golgi network. EMBO J. 20: 272-284.
Brodsky, F.M., Chen, C-Y., Knuehl, C., Towler, M.C., Wakeham, D.E. (2001) Biological basketweaving: clathrin-coated vesicle formation and function. Annu. Rev. Cell Dev. Biol. 17: 517-568.
Yang, D., Buchholz, F., Huang, Z., Goga, A., Chen, C-Y., Brodsky, F.M. and Bishop, J.M. (2002) Short RNA duplexes produced by hydrolysis with Escherichia coli Rnase III mediate effective RNA interference in mammalian cells. Proc. Natl. Acad. Sci. USA 99: 9942-9947.
Stoddart, A., Dykstra, M.L., Brown, B.K., Song, W., Pierce, S.K. and Brodsky, F.M. (2002) Lipid rafts unite signaling cascades with clathrin to regulate BCR internalization. Immunity 17: 467-472.
Chen, C-Y., Reese, M.L., Hwang, P.K., Ota, N., Agard, D. and Brodsky, F.M. (2002) Clathrin light and heavy chain interface: α-helix binding superhelix via critical tryptophans. EMBO J. 21: 6072-6082.
Wakeham, D.E., Chen, C-Y., Greene, B., Hwang, P.K. and Brodsky, F.M. (2003) Clathrin self-assembly involves coordinated weak interactions favorable for cellular regulation. EMBO J. 22: 4980-4990.
Towler, M.C., Kaufman, S.J. and Brodsky, F.M. (2004) Membrane traffic in skeletal muscle. Traffic 5: 129-139.
Crotzer, V.L., Mabardy, A.S., Weiss, A. and Brodsky, F.M. (2004) T cell receptor engagement leads to phosphorylation of clathrin heavy chain during receptor internalization. J. Exp. Med. 199:981-991.
Towler, M.C., Gleeson, P.A., Hoshino, S., Rahkila, P., Manalo, V., Ordahl, C. and Brodsky, F.M. (2004) Clathrin isoform CHC22, a component of neuromuscular and myotendinous junctions, binds sorting nexin 5 and has a role in myogenesis and muscle regeneration. Mol. Biol. Cell 15:3181-3195.
Niiro, H., Allam, A., Stoddart, A., Brodsky, F.M., Marshall, A.J. and Clark, E.A. (2004) The B lymphocyte adaptor molecule of 32 kd regulates B cell antigen receptor internalization. J. Immunol. 173: 5601-5609.
Brodsky, F.M. (2004) Clathrin's Achilles' ankle.- News and Views. Nature 432: 568-569.
Wilbur, J., Hwang, P. and Brodsky, F.M. (2005) New faces of the familiar clathrin lattice. Traffic 6:346-350.
Chen, C.-Y. and Brodsky, F.M. (2005) Hip1/Hip1R bind the conserved sequences of clathrin light chains and thereby influence clathrin assembly in vitro and actin distribution in vivo. J. Biol. Chem. 280: 6109-6117.
Stoddart, A., Jackson, A.P. and Brodsky, F.M. (2005) Plasticity of B cell receptor internalization upon conditional depletion of clathrin. Mol. Biol. Cell 16, 2339-2348.
Wakeham, D.E., Abi-Rached, L., Towler, M.C., Wilbur, J.D., Parham, P. and Brodsky, F.M. (2005) Clathrin heavy and light chain isoforms originated by independent mechanisms of gene duplication during chordate evolution. Proc. Natl. Acad. Sci. USA 102, 7209-7214.
Chen, T.T., Li, L., Chung, D-H., Allen, C.D.C., Torti, S., Torti,F.M., Cyster, J.G., Chen, C-Y., Brodsky, F.M., Niemi, E.C., Nakamura, M.C., Seaman, W.E. and Daws, M.R. (2005) TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis. J. Exp. Med. 202: 955-965.
Knuehl, C., Chen, C.-Y., Manalo, V., Hwang, P.K., Ota, N. and Brodsky, F.M. (2006) Novel binding sites on clathrin and adaptors regulate distinct aspects of coat assembly. Traffic 7: 1581-1589.
1/22/07

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