ebrown@medicine.ucsf.edu
(415) 514-0167 (voice)
(415) 514-0169 (fax)

Box 2140, UCSF; San Francisco, CA 94143-2140

additional websites:

Brown Lab Website

Harvard College, Cambridge, MA, B.A., 1971, Mathematics
Harvard Medical School, Boston, MA, M.D., 1975, Medicine
LCI/NIAID/NIH, Bethesda, MD, Postdoc, 1977-79, Immunology

(selected from 220 Total)

Schorey, J. S., M. C. Carroll, and E. J. Brown. A novel macrophage invasion mechanism of pathogenic mycobacteria, Science, 277:1091-1093, 1997.

Thomas, M.L., and E.J. Brown, Positive and negative regulation of src kinases by CD45. Immunol. Today, 20:406, 1999.

Green, J. M., A. Zheleznyak, F. P. Lindberg, M. Sarfati, W. A. Frazier, and E. J. Brown. Role of cholesterol in formation and function of a signaling complex involving ƒ¿vƒÀ3, integrin associated protein (IAP, CD47) and heterotrimeric G proteins. J. Cell Biol., 146:673-682, 1999.

Wang, J., and E. J. Brown. Protein kinase A-mediated integrin activation and L-plastin phosphorylation in neutrophils. J. Biol. Chem., 274: 24349-56, 1999.

Wu, A.-L., J. Wang, A. Zheleznyak, and E. J. Brown. Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane. Molec. Cell, 4:619-25, 1999.

Zhao, W., Schorey, J. S., Bong-Mastek, M., Ritchey, J., Brown, E. J., and Ratliff, T. L. Role of a bcg fibronectin attachment protein (fap) in bcg-induced antitumor activity. Int. J. Cancer, 86(1):83-88, 2000.

Middleton, A. M., M. V. Chadwick, A. G. Nicholson, A. Dewar, R. Groger, E. J. Brown, and R. Wilson. The role of Mycobacterium avium-intracellulare fibronectin attachment protein in adherence to the human respiratory mucosa. Molec. Microbiol., 38: 381-91, 2000.

Han, X., Sterling, H., Chen, Y., Saginario, C., Brown, E. J., Frazier, W. A., Lindberg, F. P., and Vignery, A. CD47, a ligand for macrophage fusion receptor, prevents macrophage multinucleation. J. Biol. Chem., 275: 37984-92, 2000.

Kucik, D. F., T. E. O�fToole, A. Zheleznyak, D. K. Buscettini, and E. J. Brown. A cytoplasmic domain mutation enhances ƒ¿IIbƒÀ3 integrin-cytoskeleton interactions that require the cytoplasmic domains of both subunits. Molec. Biol. Cell, 12: 1509-1518, 2001.

Ticchioni, M., V. Raimondi, L. Lamy, J. Wijdenes, F. P. Lindberg, E. J. Brown, and A. Bernard. Integrin-associated protein (CD47/IAP) contributes to T cell arrest on inflammatory vascular endothelium. FASEB J., 15: 341-350, 2001.

Rebres, R., J. M. Green, M. I. Reinhold, M. Ticchioni, and E. J. Brown. Membrane Raft association of CD47 is necessary for actin polymerization and PKCĮ translocation in its synergistic activation of T cells. J. Biol. Chem., 276: 7672-7680, 2001.

E.J. Brown and W.A. Frazier . CD47 and its ligands, Trends Cell Biol., 11:130-135, 2001.

Wang, J., H. Chen, and E. J. Brown. L-plastin peptide activation of ƒ¿vƒÀ3-mediated adhesion requires integrin conformational change and actin filament disassembly. J. Biol. Chem., 276:14474-81, 2001.

Edwards, J. L., E. J. Brown, K. A. Ault, and M. A. Apicella. The role of complement receptor 3 (CR3) in Neisseria gonorrhoeae infection of human cervical epithelia, Cell. Microbiol., 3:611-622, 2001.

Rebres, R., L. E. Vaz, J. M. Green, and E. J. Brown. Normal Ligand Binding and Signaling by CD47 (Integrin-Associated Protein) requires A Long Range Disulfide Bond between the Extracellular and Membrane Spanning Domains, J. Biol. Chem., 276:34607-34616, 2001.

Brown, E.J. Integrin-associated protein (CD47): an unusual activator of G protein signaling. J. Clin. Invest., 107:1499-1500, 2001.

Brown, E.J. and W.A. Frazier . Integrin-associated protein (CD47) and its ligands, Trends Cell Biol., 11:130-135, 2001

Middleton, A. M., M. V. Chadwick, A. G. Nicholson, A. Dewar, R. K. Groger, E. J. Brown, T. L. Ratliff, and R. Wilson. Interaction of Mycobacterium tuberculosis with human respiratory mucosa. Tuberculosis 82:69-78, 2002.

Mateo, V., E. J. Brown, G. Biron, M. Rubio, A. Fischer, F. Le Deist, and M. Sarfati. Mechanisms of CD47-induced caspase-independent cell death in normal and leukemic cells: link between phosphatidylserine exposure and cytoskeleton organization. Blood, 100: 2882-2890, 2002.

Edwards, J. L., E. J. Brown, M. S. Blake, M. A. Apicella. Opsonic and Non-opsonic Interactions Occur Between Neisseria gonorrhoeae and Complement Receptor 3 on Primary Cervical Epithelial Cells, Cell. Microbiol., 4:571-585, 2002.

Brown, E.J. and H.D. Gresham. Phagocytosis, in Fundamental Immunology, 5th edition, W.E. Paul, ed., Lippincott, Williams, and Wilkins, Philadelphia, PA., 2003.

Brown, E. J. Integrins of macrophages and macrophage like cells, in Pharmacology of Macrophages, Handbook of Experimental Pharmacology, S. Gordon, ed., Springer-Verlag GmbH, Berlin-Heidelberg, Ger., pp. 111-130, 2003.

Brown, E. J. Integrin-associated proteins. Curr. Op. Cell Biol. 14:603-607, 2002.

Gao, L.-Y., R. Groger, J.S. Cox, S.M. Beverley, E. Lawson, and E.J. Brown. Transposon mutagenesis of Mycobacterium marinum reveals a link between pigmentation and intracellular survival. Infect. Immun., 71:922-929, 2003.

Chen, H., Mocsai, A., Zhang, H., Ding, R.-X., Morisaki, J.H., White, M., Rothfork, J.M., Heiser, P., Colucci-Guyon, E., Lowell, C.A., Gresham, H.D., Allen, P.M., Brown, E.J.. Role for Plastin in Host Defense Distinguishes Integrin Signaling from Cell Adhesion and Spreading. Immunity, 19:95-104, 2003.

Gao, L.-Y., F. Laval, E. H. Lawson, R. Groger, A. Woodruff, J. S. Cox, M. Daffe, and E. J. Brown. Requirement for kasB in Mycobacterium Mycolic Acid Biosynthesis, Cell Wall Impermeability, and Intracellular Survival: Implications for Therapy, Molec. Microbiol., 6: 1547-63, 2003.

Stamm, L., Morisaki, J.H., Gao, L.-Y., Jeng. R.L., McDonald, K.L., Smith. R., Heuser, J., Welch, M.D., and Brown, E.J. Mycobacterium marinum is propelled by actin-based motility. J. Exp. Med., 198:1361-1368, 2003.

N�fDiaye, E.-N., And Brown, E.J. The ubiquitin-related protein PLIC-1 regulates heterotrimeric G protein function through association with G β γ. J Cell Biol., 163: 1157-1165, 2003

Lagadec, P., O. Dejoux, M. Ticchioni, F. Cottrez, M. Johansen, E. J. Brown, and A. Bernard. Identification of a CD47-dependent pathway in platelet adhesion on inflamed vascular endothelium under flow. Blood 101: 4836-4843, 2003

Capo, C., Moynault, A. Collette,Y., Olive,D., Brown, E. J., Raoult, D., and J.-L. Mege. Coxiella burnetii avoids macrophage phagocytosis by interfering with spatial distribution of CR3. J. Immunol., 170:4217-25, 2003

Brown, E.J. and E. Dejana. Cell-cell and cell-matrix adhesion: running, jumping, standing still. Curr Op. Cell Biol., 15:505-508, 2003.

Brown, E.J. Integrins, Mast Cells, and Innate Immunity. Blood, 103:1980, 2004.

Brown, E.J.. Clinical Implications of Basic Science: M protein machinations. N. Engl. J. Med., 350:2093-4, 2004.

Chen, T.T., E.J. Brown, E.J. Huang, and W.E. Seaman. Expression and function of SIRPα on astrocytomas. Cancer Res. 64: 117-127, 2004.

Gao, L.-Y., S. Guo, B. McLaughlin, H. Morisaki, J.N. Engel, and E.J. Brown. A mycobacterial gene cluster involved in virulence is required for cytolysis, bacterial spreading, and ESAT-6 secretion, Molec. Microbiol., 53:1677-1693, 2004.

Stamm, L.M. and E.J. Brown. Mycobacterium marinum: the generalization and specialization of a pathogenic mycobacterium. Microbes and Infection, 6:1418-1428, 2004.

Brown, E.J. Leukocyte migration: dismantling inhibition. Trends Cell Biol., 15:393-395, 2005.

Brown, E.J. Complement receptors, adhesion, and phagocytosis, in Molecular Mechanisms of Phagocytosis, C. Rosales, ed., Landes Bioscience, Georgetown, TX. Chapter 4, p. 49-57, 2005.

Rebres, R., K. Kajihara, and E.J. Brown. A novel CD47-dependent intercellular adhesion modulates cell migration, J. Cell. Physiol, 205:182-93, 2005.

Stamm, L.M., M.A. Pak, J.H. Morisaki, S.B. Snapper, K. Rottner, S Lommel, and E.J. Brown. Role of the WASP family proteins for Mycobacterium marinum actin tail formation. Proc. Natl. Acad. Sci., USA, 102:14837-42, 2005.

2/1/07