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Helen Diller Family Compr Cancer Ctr
MICHAEL J. CAMPBELL, PHD

Assistant Adjunct Professor, Surgery, UCSF

CONTACT

campbellm@surgery.ucsf.edu
(415) 885-3710 (voice)
(415) 885-7617 (fax)

Box 1674, UCSF; San Francisco, CA 94143-1674

EDUCATION

University of Puget Sound, Tacoma, WA, B.S., 1978-1982, Biology
Stanford University, Stanford, CA, Ph.D., 1982-1987, Cancer Biology
Stanford University, Stanford, CA, post-doc, 1987-1989, Tumor immunology and immunotherapy

PROFESSIONAL EXPERIENCE

1989-1991

Research Associate, Department of Medicine/Division of Oncology, Stanford University, School of Medicine, Stanford, CA.

1991-1992

Research Associate, Department of Surgery, Stanford University School of Medicine, Stanford, CA.

1992-1997

Research Assistant Professor, Department of Surgery, Stanford University School of Medicine, Stanford, CA.

1997-present

Assistant Adjunct Professor, Department of Surgery, University of California, San Francisco, CA

HONORS & AWARDS

1982-1986

NIH - National Research Service Award, Graduate Fellowship

1987-1988

Stanford University Dean's Postdoctoral Fellowship Award

1988-1989

NIH - National Research Service Award, Postdoctoral Fellowship

SELECTED PUBLICATIONS

Campbell, M., M. Bieber, R. Levy and N.N.H. Teng. 1986. Influence of avidity and idiotope recognition on the modulation of surface immunoglobulin on malignant human B cells by rat monoclonal anti-idiotype antibodies. J Immunol 136:2983.

Lowder, J.N., T.C. Meeker, M. Campbell, C.F. Garcia, J. Gralow, R.A. Miller, R. Warnke and R. Levy. 1987. Studies on B lymphoid tumors treated with monoclonal anti-idiotype antibodies: Correlation with clinical responses. Blood 69:199.

Campbell, M.J., W. Carroll, S. Kon, K. Thielemans, J.B. Rothbard, S. Levy and R. Levy. 1987. Idiotype vaccination against murine B cell lymphoma. Humoral and cellular responses elicited by tumor-derived immunoglobulin M and its molecular subunits. J Immunol 139:2825.

Campbell, M.J., L. Esserman and R. Levy. 1988. Immunotherapy of established murine B cell lymphoma. Combination of idiotype immunization and cyclophosphamide. J Immunol 141:3227.

Starnes, C.O., W.L. Carroll, M.J. Campbell, L.L. Houston, G. Apell and R. Levy. 1988. Heterogeneity of a murine B cell lymphoma. Isolation and characterization of idiotypic variants. J. Immunol 141:333.

Basham, T.Y., E.R. Race, M.J. Campbell, T.R. Reid, R. Levy and T.C. Merigan. 1988. Synergistic antitumor activity with IFN and monoclonal anti-idiotype for murine B cell lymphoma. Mechanism of action. J Immunol 141:2855.

Campbell, M.J., L. Esserman, N.E. Byars, A.C. Allison, and R. Levy. 1989. Development of a new therapeutic approach to B cell malignancy. The induction of immunity by the host against cell surface receptor on the tumor. Intern Rev Immunol 4:251.

Levy, S., M.J. Campbell, and R. Levy. 1989. Functional immunoglobulin light chain genes are replaced by ongoing rearrangements of germline Vk genes to downstream Jk segments in a murine B cell line. J Exp Med 170:1.

Kwak, L.W., M.J. Campbell, A.D. Zelenetz, and R. Levy. 1990. Combined syngeneic bone marrow transplantation and immunotherapy of a murine B cell lymphoma: active immunization with tumor-derived idiotypic immunoglobulin. Blood 76:2411.

Campbell, M.J., L. Esserman, N.E. Byars, A.C. Allison, and R. Levy. 1990. Idiotype vaccination against murine B cell lymphoma. Humoral and cellular requirements for the full expression of anti-tumor immunity. J Immunol 145:1029.

Kwak, L.W., M.J. Campbell and R. Levy. 1991. Idiotype vaccination post-bone marrow transplantation for B cell lymphoma: initial studies in a murine model. Cancer Detect. Prevent. 15:323.

Bahler, D.W., M.J. Campbell, S. Hart, R. Miller, S. Levy and R. Levy. 1991. Ig VH gene expression among human follicular lymphomas. Blood. 78:1561.

Kwak, L.W., M.J. Campbell, A.D. Zelenetz, and R. Levy. 1991. Transfer of specific immunity to B cell lymphoma with syngeneic bone marrow in mice: A strategy for using autologous marrow as an anti-tumor therapy. Blood. 78:2768.

Campbell, M.J., A.D. Zelenetz, S. Levy, and R. Levy. 1992. Use of family specific leader region primers for PCR amplification of the human heavy chain variable region gene repertoire. Mol. Immunol. 29:193.

Kwak, L.W., M.J. Campbell, D.K. Czerwinski, S. Hart, R.A. Miller, and R. Levy. 1992. Induction of immune responses in patients with B-cell lymphma against the surface-immunoglobulin idiotype expressed by their tumors. N.Engl. J. Med. 327:1209.

Clayberger C., S. Luna-Fineman, J.E. Lee, A. Pillai , M. Campbell, R. Levy, and A.M. Krensky. 1992. Interleukin 3 is a growth factor for human follicular B cell lymphoma. J. Exp. Med. 175:371.

Hsu, F.J., L. Kwak, M. Campbell, T. Liles, D. Czerwinski, S. Hart, A. Syrengelas, R. Miller, and R. Levy. 1993. Clinical trials of idiotype-specific vaccine in B-cell lymphomas. Ann. N.Y. Acad. Sci. 690:385.

Campbell, M.J. 1993. Biology of lung cancer. In Current therapy in oncology. J.E. Niederhuber, ed. Mosby-Year Book, St Louis. P. 175.

Drebin, J.A., S.W. Hartzell, C. Griffen, M.J. Campbell, and J.E. Niederhuber. 1995. Molecular cloning and chromosomal localization of the human homologue of a B-lymphocyte specific protein tyrosine kinase (blk). Oncogene. 10:477.

Campbell, M.J. 1995. Lipofection reagents prepared by a simple ethanol injection technique. Biotechniques. 18:1027-1032.

Lin, Y.H., E.J. Shin, M.J. Campbell, and J.E. Niederhuber. 1995. Transcription of the blk gene in human B lymphocytes is controlled by two promoters. J. Biol. Chem. 270:25968-25975.

Campbell, M.J., P.J. McFall, and J.E. Niederhuber. 1995. Production and characterization of a monoclonal antibody against Schistosoma japonicum glutathione S-transferase. J. Immunol. Meth. 188:73-78.

Campbell, M.J., A. Meier, Y.H. Lin, and J.E. Niederhuber. 1997. Oncogenic activity and aberrant hypermethylation of the human blk gene. Proc. Am. Assoc. Cancer Res. 38:178.

Esserman, L.J., T. Lopez, R. Montes, L.N. Bald, B.M. Fendly, and M.J. Campbell. 1999. Vaccination with the extracellular domain of p185neu prevents mammary tumor development in neu transgenic mice. Cancer Immunol. Immunother. 47:337-342.

Borden, E.C., L. Esserman, D.J. Linder, M.J. Campbell, and A.M. Fulton. 1999. Biological therapies for breast carcinoma: concepts for improvements in survival. Seminars in Oncol. 26:28-40.

Mukherjee, S., S.G. Louie, M.J. Campbell, L.J. Esserman, and G. Shyamala. 2000. Ductal growth is impeded in mammary glands of C-neu transgenic mice. Oncogene 19:5982-5987.

Jabrane-Ferrat, N., M. Campbell, M. Peterlin, and L. Esserman. 2000. Antigen presentation prevents tumor development in tumor challenged Her-2 transgenic mice. Breast Cancer Res Treat. 64:34.

Campbell, M.J., J. Scott, L.J. Esserman, and H. Maecker. 2000. Analysis of type 1 and type 2 T cells in breast cancer by intracellular cytokine staining and flow cytometry. Breast Cancer Res Treat. 64:112.

Park, J.W., D. Tripathy, M.J. Campbell, and L.J. Esserman. 2000. Biological therapy of breast cancer. BioDrugs. 14:221.

Campbell, M.J., W. Wollish, and L.J. Esserman. Epithelial and fibroblast cell lines derived from a spontaneous mammary carcinoma in a MMTV/neu transgenic mouse. Breast Cancer ResTreat (in press).

Campbell, M.J., K. Scully, and L.J. Esserman. Genomic instability in mammary tumors from MMTV-neu transgenic mice detected by random amplified polymorphic DNA (RAPD) analysis. Molecular Carcinogenesis. (submitted)

Campbell, M., B. Hamilton, M. Shoemaker, I. Cohen, and D. Tripathy. Effects of some medicinal plants used in traditional Chinese medicine on the in vitro growth of breast cancer cell lines. JNCI. (submitted)

12/27/01

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