Senior Scientist, Life Sciences Division, Lawrence Berkeley National Laboratory
| CONTACT | |
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jcampisi@lbl.gov
Lawrence Berkeley Nat'l Lab; Mailstop 74-157 |
additional websites: |
| EDUCATION | |
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State University New York, Stony Brook B.A 1974 Chemistry
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| PROFESSIONAL EXPERIENCE | |
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1980-1984 |
Postdoctoral Fellow/Instructor, Dana-Farber Cancer Inst/Harvard University Medical School |
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1984-1989 |
Assistant Professor, Department of Biochemistry, Boston University Medical School |
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1989-1991 |
Associate Professor, Department of Biochemistry, Boston University Medical School |
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1991-present |
Senior Scientist, Life Sciences Division, Lawrence Berkeley National Laboratory |
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1994-1999 |
Head, Department of Cell and Molecular Biology, Lawrence Berkeley National Laboratory |
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1999-present |
Co-Head, Center for Research and Education on Aging, Lawrence Berkeley National Laboratory |
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2002-present |
Professor, Buck Institute for Age Research |
| HONORS & AWARDS | |
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1985 |
Evangeline Athanas Cancer Research Scholar Award, American Cancer Society |
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1988 |
Established Investigator of the American Heart Association |
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1997 |
AlliedSignal Award for Research on Aging |
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1998 |
Ellison Medical Foundation, Senior Scholar Award |
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1999 |
Glenn Foundation Award, Gerontological Society of America |
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2002 |
Irving Wright Award, American Federation for Aging Research |
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1995, 2005 |
MERIT Awards, National Institute on Aging |
| SELECTED PUBLICATIONS | |
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Bischof O, Galande S, Farzaneh F, Kohwi-Shigematsu T, Campisi J. 2001 Selective cleavage of BLM, the Bloom syndrome protein, during apoptotic cell death. J Biol Chem 276: 12068-12075. |
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Bischof O, Kim S, Irving J, Beresten S, Ellis N, Campisi J. 2001 Regulation and localization of the Bloom syndrome protein in response to DNA damage. J Cell Bio 153: 367-380. |
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Kaminker P, Kim S, Taylor R, Zebarjadian Y, Funk W, Morin G, Yaswen P, Campisi J. 2001 TANK2, a new TRF1-associated PARP, causes rapid cell death on overexpression. J Biol Chem 276:35891-35899. |
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Yannone S, Roy S, Chan D, Murphy M, Huang S, Campisi J, Chen D. 2001 Werner syndrome protein, WRN, is regulated and phosphorylated by DNA-dependent protein kinase. J Biol Chem 276: 38242-38248. |
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Krtolica A, Parrinello S, Lockett S, Desprez P, Campisi J. 2001 Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging. Proc Natl Acad Sci USA 98: 12072-12077. |
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Campisi J. 2001 Cellular senescence as a tumor suppressor mechanism. Trends in Cell Bio 11: 27-31. |
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Parrinello S, Lin C, Murata K, Itahana Y, Singh J, Krtolica A, Campisi J, Desprez P. 2001 Id-1, ITF-2 and Id-2 comprise a network of helix-loop-helix proteins that regulate mammary epithelial cell proliferation, differentiation and apoptosis. J Biol Chem 276: 39213-39219. |
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Lim C, Mian I, Dernburg A, Campisi J. 2001 C. elegans clk-2, a gene that limits life span, encodes a telomere length regulator similar to yeast telomere binding protein Tel2p. Curr Biol 11: 1706-1710. |
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Oshima J, Huang S, Pae C, Lee L, Campisi J, Schiestl R. 2002 Lack of WRN facilitates extensive deletion at non-homologous joining ends. Canc Res 62: 547-551. |
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Itahana K, Dimri G, Hara E, Itahana Y, Desprez P, Campisi J. 2002 A role for p53 in maintaining and establishing the quiescence growth arrest in human cells. J Biol Chem 277: 18206-18214. |
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Rubio M. Kim S, Campisi J. 2002 Reversible manipulation of telomerase and telomere length: Implications for the ionizing radiation response and senescence of human cells. J Biol Chem 277: 28609-28617. |
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Dimri G, Martinez J, Jacobs J, Keblusek P, Itahana K, vanLohuizen M, Campisi J, Wazer E, Band V. 2002 BMI-1 oncogene induces telomerase and immortalizes human mammary epithelial cells. Canc Res 62: 4736-4745. |
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Krtolica A, Ortiz de Solorzano C, Lockett S, Campisi J. 2002 Quantification of epithelial cell proliferation in co-culture with fibroblasts by fluorescence image analysis. Cytometry 49: 73-82. |
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Itahana K, Zou Y, Itahana Y, Martinez J, Beausejour C, Jacobs J, van Lohuizen M, Band V, Campisi J, Dimri G. 2003 Control of replicative life span by p16 and the polycomb protein BMI-1. Mol Cell Biol 23: 389-401. |
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Hasty P, Campisi J, Hoeijmakers J, van Steeg H, Vijg J. 2003 Aging and genome maintenance: Lessons from the mouse? Science 299: 1355-1359. |
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Kim S, Parrinello S, Kim, J Campisi. 2003 Mus musculus and Mus spretus homologues of the human telomere associated protein TIN2. Genomics 81: 422-432. |
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Campisi J. 2003 Cancer and ageing: Rival demons? Nature Cancer Rev 3: 339-349. |
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Kim S, Han S, Chen D, Campisi J. 2003 The human telomere-associated protein TIN2 stimulates interactions between telomeric DNA tracts in vitro. EMBO Rep 4: 685-691. |
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Parrinello S, Samper E, Krtolica A, Goldstein J, Melov S, Campisi J. 2003 Oxygen sensitivity severely limits the replicative life span of murine cells. Nature Cell Biol 5: 741-747. |
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Beausejour C, Krtolica A, Galimi F, Narita M, Lowe S, Yaswen Y, Campisi J. 2003 Reversal of human cellular senescence: Roles of the p53 and p16 pathways. EMBO J 22:4212-4222. |
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Chen L, Huang S, Lee L, Davalos A, Schiestl R, Campisi J, Oshima J. 2003 WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair. Aging Cell 2: 191-199. |
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Davalos A, Campisi J. 2003 Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks. J Cell Biol 162: 1197-1209. |
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Tan S, Guschin D, Davalos A, Lee Y, Snowden A, Jouvenot Y, Zhang H, Howes K, McNamara A, Lai A, Ullman C, Reynolds L, Moore M, Isalan M, Berg LP, Campos B, Qi H, Spratt S, Case C, Pabo C, Campisi J, Gegrory P. 2003 ZFP target regulation: Genome-wide single gene specificity. Proc Natl Acad Sci 100:11997-12002. |
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Chen D, Xu W, Bales E, Colmenares C, ConacciSorrell M, Ishii S, Stavenezer E, Campisi J, Fisher D, Ben-Ze'fev A, Medrano E. 2003 SKI activates Wnt/β-catenin signaling in human melanoma. Canc Res 63: 6626-6634. |
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Busuttil RA, Rubio M, Dolle MET, Campisi J, Vijg J. 2003 Oxygen accelerates the accumulation of mutations during senescence and immortalization of murine cells in culture. Aging Cell 2: 287-294. |
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Rubio M, Davalos A, Campisi J. 2004 Telomere length regulates the effects of telomerase on the cellular response to genotoxic stress. Exp Cell Res. 298: 17-27. |
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Chiang J, Hatchcock K, Kim SH, Campisi J, Hodes R. 2004 Telomere associated protein TIN2 is essential for early embryonic development through a telomerase independent pathway. Molec Cell Biol 24:6631-6634. |
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Kim SH, Beausejour C, Davalos AR, Kaminker P, Heo SJ, Campisi J. 2004 TIN2 mediates the functions of TRF2 at telomeres. J Biol Chem 279:43799-43804. |
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Davalos AR, Kaminker P, Hansen RK, Campisi J. 2004 ATR and ATM-dependent movement of BLM helicase during replication stress ensures optimal ATM activity and 53BP1 focus formation. Cell Cycle 3: 1579-1586. |
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Parrinello S, Coppe JP. Krtolica A, Campisi J. 2005 Stromal-epithelial interactions in aging and cancer: Senescent fibroblasts alter epithelial cell differentiation. J Cell Sci 118: 485-496. |
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Kaminker P, Plachot C, Kim SH, Chung P, Crippin D, Petersen OW, Bissell MJ, Campisi J, Lelievere SA. 2005 Higher order nuclear organization in growth arrest of human mammary epithelial cells: A novel role for telomere-associated protein TIN2. J Cell Sci 118: 1321-1330. |
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Campisi J. 2005 Senescent cells, tumor suppression & aging: Good citizens, bad neighbors. Cell 120: 513-22. |
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Goldstein J, Rodier F, Garbe JC, Stampfer MR, Campisi J. 2005 Caspase-independent cytochrome c release is a sensitive measure of low level apoptosis in cell culture models. Aging Cell 4: 217-222. |
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Campisi J. 2005. Suppressing cancer: The importance of being senescent. Science 309: 886-887. |
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Patil CK, Mian IS, Campisi J. 2005 The thorny path linking cellular senescence to organismal aging. Mech Ageing Dev 126:1040-1045. |
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Huang S, Chen L, Libina N, Janes J, Martin GM, Campisi J, Oshima J. 2006 Correction of cellular phenotypes of Hutchinson-Gilford Progeria cells by RNA interference. Hum Molec Genet 118: 444-450. |
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Busuttil RA, Rubio M, Dolle MET, Campisi J, Vijg J. 2006 Mutation frequencies and spectra depend on growth state and passage number in cells cultured from lacZ-plasmid reporter mice. DNA Repair 5: 52-60. |
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Chiang J, Nguyen M, Gurunathan S, Kaminker P, Tessarollo L, Campisi J, Hodes R. 2006. Generation and characterization of telomere length maintenance in tankyrase2-deficient mice. Molec Cell Biol 26: 2037-43. |
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6/09/06 |
