Assistant Adjunct Professor, Surgery, UCSF
| CONTACT | |
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castroa@surgery.ucsf.edu Box 0875, UCSF; San Francisco, CA 94143-0875 |
| EDUCATION | |
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University of Buenos Aires, Argentina, B.Sc., 1988, Biochemistry
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| PROFESSIONAL EXPERIENCE | |
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09/05-present |
Assistant Adjunct Professor, Dept. of Surgery, University of California, San Francisco, CA |
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02/05-08/05 |
Assistant Research Professor, Dept. of Microbiology & Immunology and Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN |
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10/04-01/05 |
Assistant Research Professor, Dept. of Biochemistry & Molecular Biology, Indiana University School of Medicine, Indianapolis, IN |
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06/01-09/04 |
Assistant Scientist, Dept. of Biochemistry & Molecular Biology, Indiana University School of Medicine, Indianapolis, IN |
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08/98-05/01 |
Postdoctoral Fellow, Dept. of Biochemistry & Molecular Biology, Indiana University School of Medicine, Indianapolis, IN |
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1995-07/98 |
Postdoctoral Fellow, Department of Physiology & Biophysics, University of Texas Medical Branch, Galveston, TX. |
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1990-1994 |
Teaching Assistant, Department of Human Biological Chemistry, University of Buenos Aires, Argentina. |
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1989-1994 |
Fellow of the National Research Council of Argentina (CONICET), Institute of Cardiology Research, University of Buenos Aires, Argentina. |
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1984-86 |
Laboratory Technician Assistant, Railroad Workers Hospital, Buenos Aires, Argentina. |
| HONORS & AWARDS | |
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2000 |
Federation of American Societies for Experimental Biology (FASEB), Invitation for research presentation at the FASEB SUMMER RESEARCH CONFERENCE: The Ras superfamily of small GTP-binding proteins, Snowmass, Colorado |
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1995 |
Doctoral Thesis Distinction, Faculty of Pharmacy and Biochemistry (ASESIT), University of Buenos Aires, Argentina |
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1993 |
Mexican Society of Biophysics Award for research, presentation at the Iberoamerican meeting of Biophysics, Puebla, Mexico |
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1989-1994 |
Graduate Student Fellowship of the National Research Council of Argentina |
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1989 |
Pan American Society of Dialysis and Transplant Award for research presentation at the Annual meeting of the Pan American Society of Dialysis and Transplant, Puerto Rico. |
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1986-1988 |
Student Fellowship of the National Institute of Pharmacology, Argentina |
| SELECTED PUBLICATIONS | |
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Amorena, C. E., Castro, A. F., Muller, A., and Villamil, M. F. Direct vascular effects in the rat of the vehicles used for the intravenous and oral administration of cyclosporin A. Clinical Science, 79:149-154, 1990. |
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Amorena, C. E., and Castro, A. F. Control of proximal tubule acidification by the endothelium of the peritubular capillaries. Am. J. Physiol. 41:R691-R694, 1997. |
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Castro, A. F., Altenberg, G. A. Inhibition of drug transport by Genistein in multidrug-resistant cells expressing P-glycoprotein. Biochem. Pharmacol. 53:89-93, 1997. |
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Horton, J. K., Thimmaiah, K. N., Altenberg, G. A., Castro, A. F., Germain, G. S., Gowda, G. K., and Houghton, P. J. Characterization of a novel bis-acridone and comparison with PSC-833 as a potent and poorly reversible modulator of P-glycoprotein. Molecular Pharmacol. 52:948-957, 1997. |
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Castro, A. F., Amorena, C. E., Muller, A., Ottaviano, G., Tellez-Inon, M. T., and Taquini, A. C. Regulation of cGMP levels by protein kinase C in vascular endothelial cells. Am. J. Physiol. 275:C113-C119, 1998. |
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Vanoye, C. G., Castro, A. F., Pourcher, T., Reuss, L., and Altenberg, G. A. Phosphorylation of P-glycoprotein by PKA and PKC modulates swelling activated Chloride channels by different mechanisms. Am. J. Physiol. 276: C370-8, 1999. |
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Wang, C., Castro, A. F., Wilkes, D., Altenberg, G. A. Expression and purification of the first nucleotide-binding domain and linker region of MDR1: comparison of fusions to glutathione-S-transferase, thioredoxin, and maltose-binding protein. Biochem J. 338:77-81, 1999. |
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Quilliam, L.A., Castro, A.F., Rogers-Graham, K.S., Martin, C.B., Der, C.J., and Bi, C. M-Ras/R-Ras3, a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras effector AF6. J Biol Chem. 274:23850-7, 1999. |
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Castro, A.F., Rebun, J.F., and Quilliam, L.Q. Identification of guanine nucleotide exchange factors for the Rap1 GTPase: regulation of MR-GEF by M-Ras-GTP interaction. J. Biol. Chem. 275:34901-34908, 2000. |
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Castro, A. F., Horton, J., Vanoye, C., Altenberg, G.A. Mechanism of inhibition of P-glycoprotein-mediated drug transport by protein kinase C blockers. Biochem. Pharmacol. 58:1723-1733, 1999. |
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Quilliam, L. A., Rebhun, J. F., Zong, H., and Castro, A. F. Analyses of M-Ras/R-Ras3 Signaling and Biology. Methods Enzymol 333:187-202, 2001 |
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Wilkes, D.M., Wang, C., Aristimuno, P., Castro, A.F., and Altenberg, G.A. Nucleotide triphosphatase activity of the N-terminal nucleotide-binding domains of the multidrug resistance proteins P-glycoprotein and MRP1. Biochem. Biophys. Res. Commun. 296:388-394, 2002. |
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Quilliam, L. A., Rebhun, J. F., and Castro, A. F. A growing family of guanine nucleotide exchange factors is responsible for activation of Ras family GTPases. Prog Nucleic Acid Res Mol Biol. 71:391-444, 2002. |
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Castro, A. F. , Rebhun, J. F., Clark, G. J., and Quilliam, L. A. Rheb binds TSC2 and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner. J. Biol. Chem. 278(35):32493-6, 2003. |
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Felekkis, K. N., Narsimhan, R. P., Near, R., Castro, A. F., Zheng, Y., Quilliam, L. A., and Lerner, A. AND-34 activates Phosphatidylinositol 3-kinase and induces anti-estrogen resistance in a SH2 and GDP exchange factor-like domain-dependent manner. Mol Cancer Res. 3:32-41, 2005. |
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Castro, A.F., Rebhun, J.F., Quilliam L.A. Measuring Ras-family GTP levels in vivo-running hot and cold. Methods. 37:190-6, 2005 |
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Yu, L., Asuri, S., Rebhun, J.F., Castro, A.F., Paranavitana, N.C., and Quilliam, L.A. The Rap1 guanine nucleotide exchange factor, Epac2, couples cyclic AMP and Ras signals at the plasma membrane. J Biol Chem. Epub ahead of print Nov 29, 2005. |
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12/8/05 |
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