Julius and Lilian Nadel Endowed Chair, UCSF
Chief of Pulmonary and Critical Care Medicine, San Francisco VA Medical Center
| CONTACT | |
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George.Caughey@ucsf.edu Mail Box 111-D, Veterans Affairs Medical Center, San Francisco, CA 94121 |
| EDUCATION | |
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Arizona State University, BS, 1975, Chemistry
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| PROFESSIONAL EXPERIENCE | |
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1988-92 |
Assistant Professor, Dept. of Medicine, UCSF |
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1988-98 |
Associate Staff, Cardiovascular Research Institute, UCSF |
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1992-98 |
Associate Professor, Dept. of Medicine, UCSF |
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1992-present |
Molecular Medicine Program Faculty, UCSF |
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1995-present |
Editorial Board, American Journal of Respiratory Cell and Molecular Biology |
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1996-present |
Member of UCSF Graduate Program in Biomedical Sciences |
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1998-present |
Professor, Dept. of Medicine, UCSF |
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1999-present |
Associate Director, UCSF Adult Cystic Fibrosis Program |
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1999-present |
Investigator, Cardiovascular Research Institute, UCSF |
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2002-present |
Editorial Boards: FASEB Journal and Journal of ChildrenÍs Health |
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2002-present |
Member, UCSF Cancer Center and Center for Neurobiology of Digestive Disease |
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2004-present |
Editorial Board, Current Respiratory Medicine Reviews |
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2004-present |
Chief of Pulmonary and Critical Care Medicine, San Francisco VA Medical Center |
| HONORS & AWARDS | |
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1974 |
American Chemical Society Outstanding Undergraduate Award, ASU |
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1975 |
Phi Beta Kappa and Merck Award in Chemistry, ASU |
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1986 |
NIH Clinical Investigator Award |
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1992 |
American Lung Association Career Investigator Award |
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1992 |
Elected to American Society for Clinical Investigation |
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2000 |
Elected to American Association of Physicians |
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2004 |
Recipient of Julius and Lillian Endowed Chair of Medicine |
| SELECTED PUBLICATIONS | |
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(from a total of 104) |
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Vanderslice P, Ballinger SM, Tam EK, Goldstein SM, Craik CS, Caughey GH. Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family. Proc Natl Acad Sci USA 87:3811-5, 1990. |
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Rubinstein I, Nadel JA, Graf PD, Caughey GH. Mast cell chymase potentiates histamine-induced wheal formation in the skin of ragweed-allergic dogs. J Clin Invest 86:555-9, 1990. |
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Caughey GH, Zerweck EH, Vanderslice P. Structure, chromosomal assignment, and deduced amino acid sequence of a human gene for mast cell chymase. J Biol Chem 266:12956-63, 1991. |
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Ruoss SJ, Hartmann T, Caughey GH. Mast cell tryptase is a mitogen for cultured fibroblasts. J Clin Invest 88:493-9, 1991. |
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Caughey GH, Raymond WW, Bacci E, Lombardy RJ, Tidwell RR. BABIM and related amidines are potent, reversible inhibitors of mast cell tryptases. J Pharmacol Exp Therap 264:676-82, 1993. |
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Caughey GH, Schaumberg TH, Zerweck EH, Butterfield JH, Hanson RD, Silverman GA, Ley TJ. The human mast cell chymase gene (CMA1): mapping to the cathepsin G/granzyme gene cluster and lineage-restricted expression. Genomics 15:614-20, 1993. |
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Raymond WW, Tam EK, Blount JL, Caughey GH. Purification and characterization of dog mast cell protease-3, an oligomeric relative of tryptases. J Biol Chem 270:13164-70, 1995. |
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Fang KC, Raymond WW, Lazarus SC, Caughey GH. Dog mastocytoma cells secrete a 92 kDa gelatinase activated extracellularly by mast cell chymase. J Clin Invest 97:1589-96, 1996. |
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Fang KC, Raymond WW, Blount JL, Caughey GH. Dog mast cell chymase activates progelatinase B by cleaving Phe88-Gln89 and Phe91-Glu92 bonds of the propeptide domain. J Biol Chem 272:25628-35, 1997. |
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Wolters PJ, Raymond WW, Blount JL, Caughey GH. Regulated expression, processing and secretion of dog mast cell dipeptidyl peptidase I. J Biol Chem 273:15514-20, 1998. |
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Pallaoro M, Fejzo MS, Shayesteh L, Blount JL, Caughey GH. Characterization of genes encoding known and novel human tryptases on chromosome 16p13.3. J Biol Chem 274:3355-62, 1999. |
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Ma Y, Longley BJ, Blount JL, Langley K, Caughey GH. Clustering of activating mutations in c-kitÍs juxta- membrane coding region in canine mastocytomas. J Invest Dermatol 112:165-70, 1999. |
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Coussens LM, Raymond WW, Bergers G, Behrendtsen O, Werb Z, Caughey GH, Hanahan D. Inflammatory mast cells potentiate the angiogenic switch during squamous epithelial carcinogenesis. Genes & Development 13:1382-97, 1999. |
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Caughey GH, Raymond WW, Wolters PJ. Angiotensin II generation by mast cell - and -chymases. Biochim Biophys Acta 1480:245-7, 2000. |
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Caughey GH, Raymond WW, Blount JL. Hau LW-T, Pallaoro M, Wolters PJ, Verghese GM. Characterization of human -tryptases, novel members of the chromosome 16p mast cell tryptase and prostasin gene families. J Immunol 164:6566-75, 2000. |
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Steinhoff M, Vergnolle N, Young S, Ennes H, Hollenberg MD, Wallace JL, Caughey GH, Williams LM, Geppetti P, Mayer EA, Bunnett NW. Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism. Nature Med 6:151-8, 2000. |
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Wolters PJ, Muilenburg D, Pham CTN, Ley TJ, Caughey GH. Dipeptidylpeptidase I is essential for in vivo activation of mast cell chymases, but not tryptases. J Biol Chem 276:18551-6, 2001. |
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Brown JK, Jones CA, Rooney LA, Caughey GH. Mast cell tryptase activates extracellular-regulated kinases (p44/p42) in airway smooth muscle cells: importance of proteolytic events, time course and role in mediating mitogenesis. Am J Respir Cell Mol Biol 24:146-54, 2001. |
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Muilenburg DJ, Raymond WW, Wolters PJ, Caughey GH. Lys40 but not Arg143 influences selectivity of angiotensin conversion by human -chymase. Biochim Biophys Acta 1596:346-56, 2002. |
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Caughey GH. New developments in the genetics and activation of mast cell proteases. Mol Immunol 38:1353-7, 2002. |
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Soto D, Malmsten C, Blount JL, Muilenberg DJ and Caughey GH. Genetic deficiency of human mast cell -tryptase. Clin Exp Allergy 32:1000-6, 2002. |
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Bhagwandin VJ, Hau L W-T, Mallen-St. Clair J, Wolters PJ, Caughey GH. Structure and activity of pancreasin, a novel tryptic serine peptidase expressed by the pancreas. J Biol Chem 278:3363-71, 2003. |
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Reiling KK, Krucinski J, Miercke LJW, Raymond WW, Caughey GH, Stroud RM. Structure of human pro- chymase: a model for the activating transition of granule associated proteases. Biochemistry 42:2616- 24, 2003. |
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Raymond WW, Ruggles Waugh S, Craik CS, Caughey GH. Albumin is a substrate of human chymase: Prediction by combinatorial peptide screening and development of a selective inhibitor based on the cleavage site. J Biol Chem 278:34517-24, 2003. |
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Mallen-St. Clair J, Pham CTN, Villalta SA, Caughey GH, Wolters PJ. Mast cell dipeptidyl peptidase I mediates survival from sepsis. J Clin Invest 113:628-34, 2004. |
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Verghese GM, Tong ZY, Bhagwandin V, Caughey GH. Mouse prostasin gene structure, promoter function, and restricted expression in lung and kidney. Am J Respir Cell Mol Biol 30:519-29, 2004. |
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Baluk P, Raymond WW, Ator E, Coussens LM, McDonald DM, Caughey GH. MMP-2 and -9 expression increases in mycoplasma-infected airways but is not required for microvascular remodeling. Am J Physiol 287:L307-17, 2004. |
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Tong ZY, Illek B, Bhagwandin VK, Verghese GM, Caughey GH. Prostasin, a membrane-anchored serine peptidase, regulates sodium currents in JME/CF15 cells, a cystic fibrosis epithelial cell line. Am J Physiol 287:L928-35, 2004. |
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Xu X, Golden JA, Dolganov G, Jones KD, Donnelly S, Weaver T, Caughey GH. Transcript signatures of lymphocytic bronchitis in lung allograft biopsies. J Heart Lung Transplant, in press. |
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Wolters PJ, Mallen-St. Clair J, Lewis CC, Villalta SA, Baluk P, Erle DJ, Caughey GH. Tissue-selective mast cell reconstitution and differential lung gene expression in mast cell-deficient KitWsh/KitWsh Sash mice. Clin Exp Allergy, in press. |
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1/15/05 |
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