George H. Caughey, MD

Arizona State University, BS, 1975, Chemistry
Stanford University School of Medicine, MD, 1979, Medicine
Pennsylvania Hospital, 1982, Internal Medicine
University of California, San Francisco, 1986, Pulmonary Medicine

• 1988-92
  Assistant Professor, Dept. of Medicine, UCSF
• 1988-98
  Associate Staff, Cardiovascular Research Institute, UCSF
• 1992-98
  Associate Professor, Dept. of Medicine, UCSF
• 1992-present
  Molecular Medicine Program Faculty, UCSF
• 1995-present
  Editorial Board, American Journal of Respiratory Cell and Molecular Biology
• 1996-present
  Member of UCSF Graduate Program in Biomedical Sciences
• 1998-present
  Professor, Dept. of Medicine, UCSF
• 1999-present
  Associate Director, UCSF Adult Cystic Fibrosis Program
• 1999-present
  Investigator, Cardiovascular Research Institute, UCSF
• 2002-present
  Editorial Boards: FASEB Journal and Journal of Childrens Health
• 2002-present
  Member, UCSF Cancer Center and Center for Neurobiology of Digestive Disease
• 2004-present
  Editorial Board, Current Respiratory Medicine Reviews
• 2004-present
  Chief of Pulmonary and Critical Care Medicine, San Francisco VA Medical Center

• 1974
  American Chemical Society Outstanding Undergraduate Award, ASU
• 1975
  Phi Beta Kappa and Merck Award in Chemistry, ASU
• 1986
  NIH Clinical Investigator Award
• 1992
  American Lung Association Career Investigator Award
• 1992
  Elected to American Society for Clinical Investigation
• 2000
  Elected to American Association of Physicians
• 2004
  Recipient of Julius and Lillian Endowed Chair of Medicine

• (from a total of 104)
• Vanderslice P, Ballinger SM, Tam EK, Goldstein SM, Craik CS, Caughey GH. Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family. Proc Natl Acad Sci USA 87:3811-5, 1990.
• Rubinstein I, Nadel JA, Graf PD, Caughey GH. Mast cell chymase potentiates histamine-induced wheal formation in the skin of ragweed-allergic dogs. J Clin Invest 86:555-9, 1990.
• Caughey GH, Zerweck EH, Vanderslice P. Structure, chromosomal assignment, and deduced amino acid sequence of a human gene for mast cell chymase. J Biol Chem 266:12956-63, 1991.
• Ruoss SJ, Hartmann T, Caughey GH. Mast cell tryptase is a mitogen for cultured fibroblasts. J Clin Invest 88:493-9, 1991.
• Caughey GH, Raymond WW, Bacci E, Lombardy RJ, Tidwell RR. BABIM and related amidines are potent, reversible inhibitors of mast cell tryptases. J Pharmacol Exp Therap 264:676-82, 1993.
• Caughey GH, Schaumberg TH, Zerweck EH, Butterfield JH, Hanson RD, Silverman GA, Ley TJ. The human mast cell chymase gene (CMA1): mapping to the cathepsin G/granzyme gene cluster and lineage-restricted expression. Genomics 15:614-20, 1993.
• Raymond WW, Tam EK, Blount JL, Caughey GH. Purification and characterization of dog mast cell protease-3, an oligomeric relative of tryptases. J Biol Chem 270:13164-70, 1995.
• Fang KC, Raymond WW, Lazarus SC, Caughey GH. Dog mastocytoma cells secrete a 92 kDa gelatinase activated extracellularly by mast cell chymase. J Clin Invest 97:1589-96, 1996.
• Fang KC, Raymond WW, Blount JL, Caughey GH. Dog mast cell chymase activates progelatinase B by cleaving Phe88-Gln89 and Phe91-Glu92 bonds of the propeptide domain. J Biol Chem 272:25628-35, 1997.
• Wolters PJ, Raymond WW, Blount JL, Caughey GH. Regulated expression, processing and secretion of dog mast cell dipeptidyl peptidase I. J Biol Chem 273:15514-20, 1998.
• Pallaoro M, Fejzo MS, Shayesteh L, Blount JL, Caughey GH. Characterization of genes encoding known and novel human tryptases on chromosome 16p13.3. J Biol Chem 274:3355-62, 1999.
• Ma Y, Longley BJ, Blount JL, Langley K, Caughey GH. Clustering of activating mutations in c-kits juxta- membrane coding region in canine mastocytomas. J Invest Dermatol 112:165-70, 1999.
• Coussens LM, Raymond WW, Bergers G, Behrendtsen O, Werb Z, Caughey GH, Hanahan D. Inflammatory mast cells potentiate the angiogenic switch during squamous epithelial carcinogenesis. Genes & Development 13:1382-97, 1999.
• Caughey GH, Raymond WW, Wolters PJ. Angiotensin II generation by mast cell - and -chymases. Biochim Biophys Acta 1480:245-7, 2000.
• Caughey GH, Raymond WW, Blount JL. Hau LW-T, Pallaoro M, Wolters PJ, Verghese GM. Characterization of human -tryptases, novel members of the chromosome 16p mast cell tryptase and prostasin gene families. J Immunol 164:6566-75, 2000.
• Steinhoff M, Vergnolle N, Young S, Ennes H, Hollenberg MD, Wallace JL, Caughey GH, Williams LM, Geppetti P, Mayer EA, Bunnett NW. Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism. Nature Med 6:151-8, 2000.
• Wolters PJ, Muilenburg D, Pham CTN, Ley TJ, Caughey GH. Dipeptidylpeptidase I is essential for in vivo activation of mast cell chymases, but not tryptases. J Biol Chem 276:18551-6, 2001.
• Brown JK, Jones CA, Rooney LA, Caughey GH. Mast cell tryptase activates extracellular-regulated kinases (p44/p42) in airway smooth muscle cells: importance of proteolytic events, time course and role in mediating mitogenesis. Am J Respir Cell Mol Biol 24:146-54, 2001.
• Muilenburg DJ, Raymond WW, Wolters PJ, Caughey GH. Lys40 but not Arg143 influences selectivity of angiotensin conversion by human -chymase. Biochim Biophys Acta 1596:346-56, 2002.
• Caughey GH. New developments in the genetics and activation of mast cell proteases. Mol Immunol 38:1353-7, 2002.
• Soto D, Malmsten C, Blount JL, Muilenberg DJ and Caughey GH. Genetic deficiency of human mast cell -tryptase. Clin Exp Allergy 32:1000-6, 2002.
• Bhagwandin VJ, Hau L W-T, Mallen-St. Clair J, Wolters PJ, Caughey GH. Structure and activity of pancreasin, a novel tryptic serine peptidase expressed by the pancreas. J Biol Chem 278:3363-71, 2003.
• Reiling KK, Krucinski J, Miercke LJW, Raymond WW, Caughey GH, Stroud RM. Structure of human pro- chymase: a model for the activating transition of granule associated proteases. Biochemistry 42:2616- 24, 2003.
• Raymond WW, Ruggles Waugh S, Craik CS, Caughey GH. Albumin is a substrate of human chymase: Prediction by combinatorial peptide screening and development of a selective inhibitor based on the cleavage site. J Biol Chem 278:34517-24, 2003.
• Mallen-St. Clair J, Pham CTN, Villalta SA, Caughey GH, Wolters PJ. Mast cell dipeptidyl peptidase I mediates survival from sepsis. J Clin Invest 113:628-34, 2004.
• Verghese GM, Tong ZY, Bhagwandin V, Caughey GH. Mouse prostasin gene structure, promoter function, and restricted expression in lung and kidney. Am J Respir Cell Mol Biol 30:519-29, 2004.
• Baluk P, Raymond WW, Ator E, Coussens LM, McDonald DM, Caughey GH. MMP-2 and -9 expression increases in mycoplasma-infected airways but is not required for microvascular remodeling. Am J Physiol 287:L307-17, 2004.
• Tong ZY, Illek B, Bhagwandin VK, Verghese GM, Caughey GH. Prostasin, a membrane-anchored serine peptidase, regulates sodium currents in JME/CF15 cells, a cystic fibrosis epithelial cell line. Am J Physiol 287:L928-35, 2004.