(415) 353-2966 (appts)
(415) 353-2167 (fax)

Box 0372, UCSF; San Francisco, CA 94143-0372

additional websites:

UCSF Physician Referral Directory

University of British Columbia, 1981
University of British Columbia, MD, 1985, Medicine
Pasqua Hospital, University of Saskatchewan, Regina, Internship, 1985-1986
Plains Health Centre, Regina, Saskatchewan, Residency, 1986-1987
Toronto General Hospital, U of Toronto, Ontario, Residency, 1987-1989
Princess Margaret Hospital, U of Toronto, Ontario, Residency, 1989-1991
Royal College of Physicians & Surgeons, Canada, FRCPS, 1990, Internal Medicine
Royal College of Physicians & Surgeons, Canada, FRCPS, 1991, Medical Oncology

selected from over 133 publications

Chan AA, Lau A, Pirzkall A, Chang SM, Verhey LJ, Larson D, McDermott M, Dillon W, Nelson SJ : 1H MRSI as a tool for evaluating grade IV glioma patients undergoing gammaknife radiosurgery J of Neurosurgery 101:467-75, 2004

Chang S, Parney I, Huang W, Asher T, Bernstein M, Lillehei K, Brem H, Berger M, Laws E and the Glioma Outcomes Project Investigators : Patterns of care for adults with newly diagnosed malignant gliomas: data from the Glioma Outcomes (GO) Project. JAMA 293:557-564, 2005

Parney IF, Kunwar S, McDermott M, Berger M, Prados M, Cha S, Croteau D, Chang S : Neuroradiographic changes following convection enhanced delivery of the conjugated toxin IL-13-PE38QQR for recurrent malignant glioma. J Neurosurgery 102:267-275, 2005

Butowski N, Prados M, Lamborn K, Larson D, Sneed P, Wara W, Malec M, Rabbitt J, Page M, Chang S : Phase II study of concurrent temodar and cis-retinoic acid with radiation for adult patients with glioblastoma multiforme In J Rad Oncol Biol Physics 61(5): 1454-1459, 2005

Parsa AT, Wacchorst S, Lamborn K, Prados M, Berger M, Chang S Prognostic significance of intracranial dissemination in adult glioblastoma multiforme J Neurosurg 102:622-628, 2005

Li X, Vigneron DB, Cha S, Graves EE, Crawford F, Chang SM, Nelson SJ : Relationship of MR-Derived Lactate, Mobile Lipids, and Relative Blood Volume for Gliomas in Vivo. AJNR 26(4): 760-769, 2005

Gomez DR, Missett BT, Wara WM, Lamborn KR, Prados MD, Chang S, Berger MS, Haas-Kogan DA : High failure rate in spinal ependymomas with long-term follow-up. Neuro-Oncology 7, 254-259, 2005

Chang SM, Y Wen PY, Cloughesy T, Conrad C, Fink K, Robins HI, De Angelis L, Razier J, Lamborn KR, Kuhn Dancey J, Prados MD : Phase II study of CCI-779 in recurrent glioblastoma multiforme. Invest New Drugs 23 (4): 357-361, 2005

Smith J, Cha S, Mayo K, McDermott M, Parsa A, Kunwar S, Chang S, Dillon W, Prados M, Berger M : Serial diffusion-weighted MR imaging in glioma: distinguishing tumor recurrence from post-resection injury. J Neuro-surgery 103:428-438, 2005

Lupo JM, Cha S, Chang SM, Nelson SJ : Dynamic susceptibility-weighted perfusion imaging of high grade gliomas: characterization of spatial heterogeneity. AJNR 26:1446-54, 2005

Lee MC, Cha , Chang SM, Nelson SJ : Dynamic susceptibility contrast perfusion imaging of radiation effects in normal appearing brain tissue:changes in the first pass and recirculation phases JMRI 21:683-693, 2005

Cha S, Tihan T, Crawford F, Fischbein N, Chang S, Bollen A, Nelson S, Prados M, Berger M, Dillon W : Differentiation of low-grade oligodendrogliomas from low-grade astrocytomas by using quantitative blood-volume measurements derived from dynamic susceptibility contrast-enhanced MR Imaging AJNR 26:266-73, 2005

Chang SM, Reynolds SL, Butowski NA, Lamborn KR, Buckner JC, Kaplan RS, Bigner DD : GNOSIS- guidelines for neuro-oncology-standards for investigational studies. Reporting of phase I/II clinical trials. Neuro-Oncology 7: on line 05-055, August 25, 2005

Cloughesy TF, Kuhn J, Robins IH, Abrey L, Wen P, Fink K, Lieberman F, Mehta M, Chang S, Yung A, DeAngelis L, Schiff D, Junck L, Groves M, Wright J, Lamborn K, Sebti S, Prados M : A phase I trial of Tipifarnib in patients with recurrent malignant glioma taking EIAEDs: A NABTC study. J Clin Oncology 23:6647-6656, 2005

Chang SM, Barker FGII. Marital status, treatment and survival in glioblastoma multiforme: a population-based study.Cancer 104:1975-84, 2005

Lassman AB, Rossi MR, Razier JR, Abrey LE, Grefe CN, Lamborn K, Pao W, Shih AH, Wilson R, Nowak NJ, Cowell JK, DeAngelis LM, Wen P, Gilbert MR, Chang S, Yung WKA, Prados M, Holland EC Molecular study of malignant gliomas treated with the EGFR inhibitor erlotinib (OSI-774): tissue analysis from the North American Tumor Consortium (NABTC) trial 01-03 Clinical Cancer Research 11:7841-7850, 2005.

Chang S : Temsirolimus (CCI-779) in Recurrent Glioblastoma Multiforme, Nature Clinical Practice Oncology- Practice Point 3, 70-71, 2006

Lee MC, Cha S, Chang SM, Nelson SJ. Partial-volume model for determining white matter and gray matter cerebral blood volume for analysis of gliomas. J Magn Reson Imaging 23:256-266 (2006).

Butowski N, Sneed P, Chang S : Diagnosis and management of recurrent malignant astrocytoma., J Clin Oncol- special issue 24: 1273-1280, 2006

Prados MD, Lamborn KR, Yung WAY, Jaeckle K, Robins HI, Mehta M, Fine H, Wen PY, Cloughesy T, Chang SM, Nicholas MK, Schiff D, Greenberg H, Junck L, Fink K, Hess K, Kuhn J. Phase 2 trial of irinotecan in patients with recurrent malignant glioma: A North American Brain Tumor Consortium Study. Neuro-Oncology 8: 189-193, 2006

Barker FG, Chang SM : Improving resection of malignant glioma. Lancet Oncology 7: 359-360, 2006

Chang S, Butowski N, Sneed P, Garner I : Standard Treatment and Experimental Targeted Drug Therapy for Recurrent Glioblastoma Multiforme. Neurosurgical Focus 20 (4):E4, 2006

Kunwar S, Chang SM, Prados MD, Berger MS, Croteau D, Sherman JW, Grahn A, Shu V, Dul J, Pedain C P, Puri RK : Intraparenchymal Convection-Enhanced Delivery: Safety Experience from Early Phase Studies with Cintredekin Besudotox. Neurosurgical Focus, 20(3):E15, 2006

Cloughesy TF, Wen P, Robins HI, Chang SM, Groves M, Fink K, Junck L, Schiff D, Abrey L, Gilbert M, Puduvalli V, Nicholas K, Conrad C, Grren berg H, Lieberman F, Kuhn J, DeAngelis LM, Burton E, Mehat M, Hess K, Torres-Trejo A, Raizer J, Yung WKA, Kuhn J, Lamborn K, Prados M : Phase II trial of Tipifarnib in patients with recurrent malignant glioma either on or not on enzyme-inducing antiepileptic drugs: a North American Brain Tumor Consortium. J Clin Oncol 24:3651-3656, 2006

Tihan T, Barletta J, Parney I, Lamborn K, Sneed PK, Chang S : Prognostic value of detecting recurrent glioblastoma multiforme in surgical specimens from patients following radiotherapy: should pathology evaluation alter treatment decisions? Human Pathology 37:272-82, 2006

Keles EG, Chang EF, Lamborn KR, Tihan T, Chang CJ, Chang SM, Berger MS : Volumetric extent of resection and residual contrast enhancement at initial surgery as predictors of outcome in adult patients with hemispheric anaplastic astrocytoma. J Neuro-surg 105:34-40, 2006

Prados MD, Lamborn KR, Chang SM, Burton E, Butowski N, Malec M, Kapadia A, Rabbitt J, Page M, Federoff A : Phase I study of erlotinib HCL alone and in combination with temozolomide in patients with stable or recurrent malignant glioma. Neuro-oncology 8:67-78, 2006

12/7/06