UCSF Helen Diller Family Comprehensive Cancer Center

Photo of Harold A. Chapman, MD  Harold A. Chapman, MD

Professor, Department of Medicine, UCSF

Member, UCSF Biomedical Sciences Graduate Program (BMS)
Member, UCSF Herbert W. Boyer Program in Biological Sciences (PIBS)
Member, UCSF Immunology Graduate Program

Contact

(415) 353-2244 (appts)
(415) 476-2283 (fax) (fax)

Box 0130, UCSF; San Francisco, CA 94143-0130

Additional websites:
    Physician Referral Directory
    Chapman Lab Website

Education

Tulane University, 1968, Premedical
University of Alabama School of Medicine, M.D., 1972, Medicine

Professional Experience

  • 1972-1975
    Residency Training in Internal Medicine, University of Utah Affiliated Hospitals, Salt Lake City, UT
  • 1975-1977
    Associate Investigator, V.A. Medical Center, Salt Lake City, UT
  • 1978-1979
    Pulmonary Fellow, University of Utah Affiliated Hospitals, Salt Lake City, UT
  • 1979-1982
    Research Associate in Immunology, V.A. Medical Center, Salt Lake City, UT
  • 1979-1985
    Assistant Professor of Medicine, University of Utah, Department of Medicine, Salt Lake City, UT
  • 1985
    Associate Professor of Medicine, University of Utah, Department of Medicine, Salt Lake City UT
  • 1985-1999
    Associate Professor of Medicine, Harvard Medical School, Department of Medicine, Boston, MA
  • 1992-1999
    Physician, Brigham and Women's Hospital, Boston, MA
  • 1992-1999
    Associate Professor of Environmental Health, Harvard School of Public Health, Boston, MA
  • 2000
    Chief, Pulmonary and Critical Care Medicine Division, University of California, San Francisco
  • 2000
    Professor of Medicine, University of California, San Francisco
  • 2000
    Senior Member, Cardiovascular Research Institute, University of California San Francisco

Honors & Awards

  • 1972
    Alpha Omega Alpha, University of Alabama School of Medicine
  • 1985-1990
    Career Investigator Award, American Lung Association
  • 1987
    American Society for Clinical Investigation
  • 1998
    American Association of Physicians
  • 2001
    MERIT Award, NIH/NHLBI

Selected Publications

  • (from ~100 publications)
  • Shi GP, Munger JS, Meara JP, Rich DH, Chapman HA. Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease. J Biol Chem 1992 15; 267:7258-62.
  • Waltz DA, Sailor LZ, Chapman HA. Cytokines induce urokinase-dependent adhesion of human myeloid cells: A regulatory role for plasminogen activator inhibitors. J Clin Invest. 1993; 91:1541-1550.
  • Ying Wei, Waltz D, Rao N, Drummond R, Rosenberg S, Chapman HA. Identification of the urokinase receptor as an adhesion receptor for vitronectin. J Biol Chem, 1994; 209:32380-32388.
  • Waltz DA, Chapman HA. Reversible cellular adhesion to vitronectin linked to urokinase receptor occupancy. J Biol Chem. 1994; 269:14746-14750.
  • Shi G-P, Webb AC, Foster KE, Knoll JH, Lemere CA, Munger JS, Chapman HA. Human cathespin S: chromosomal localization, gene structure, and tissue distribution. J Biol Chem 1994; 269:11530-11536.
  • Rao NK, Shi GP, Chapman HA. Urokinase receptor is a multifunctional protein: influence of receptor occupancy on macrophage gene expression. J Clin Invest 1995; 96:465-74.
  • Wei Y, Lukasev M, Simon DI, Bodary SC, Rosenberg S, Doyle MV, Chapman HA. Regulation of integrin function by the urokinase receptor. Science 1996; 273:1551-1555.
  • Gelb BD, Shi GP, Chapman HA Jr, Desnick RJ. Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency. Science 1996; 273:1236-1238.
  • Riese R, Wolf P, Bromme D, Natkin L, Villadangos JA, Ploegh H, Chapman HA. Essential role for cathepsin S in MHC class II-associated invariant chain processing and antigen presentation. Immunity 1996; 4:357-366.
  • Simon DI, Rao N, Hui W, Wei Y, Majdic O, Ronne E, Kobzik K, Chapman HA. Mac-1 (CD11b-CD18) and urokinase receptor (CD87) form a functional unit on monocytic cells. Blood 1996; 88:3185-3194.
  • Waltz DA, Natkin L, Fujita RM, Wei Y, and HA Chapman. Plasmin and plasminogen activator type 1 promote cellular motility by regulating the interaction between the urokinase receptor and vitronectin. J Clin Invest 1997; 100:58-67.
  • Sukhova GK, Shi GP, Simon DI, Chapman HA, and P Libby. Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells. J Clin Invest, 1998, 102:576-583.
  • Riese RJ, Mitchell RN, Villadangos JA, Karp ER, DeSanctis GT, Ploegh HL, Chapman HA. Cathepsin S activity regulates antigen presentation and immunity. J Clin Invest 1998, 101:2351-2363.
  • Villadangos JA, Riese RJ, Peters C, Chapman HA, Ploegh HL. Degradation of mouse Ii: Roles of cathepsins S and D and the influence of MHC polymorphism. J Exp Med. 1997, 186:549-560.
  • Wang B, Shi GP, Yao PM, Li Z, Chapman HA and Bromme D. Human cathepsin F. Molecular cloning, functional expression, tissue localization and enzymatic characterization. J Biol Chem 1998, 273:32000- 32008.
  • Chapman, HA. Endosomal proteolysis and MHC class II function. Curr Opin in Immunol 1998;10:93-102.
  • Shi GP, Villadangos J, Dranoff G, Ploegh H, Chapman HA. Cathepsin S required for normal MHC class II peptide loading and germinal center development. Immunity, 1999;10:196-206.
  • Wei Y, Yang X, Quimei Liu, Wilkins JA, and Chapman HA. Role for caveolin and urokinase receptors in integrin-mediated adhesion and signaling. J Cell Biol. 1999;144:1285-1294.
  • Chapman HA. A fas pathway to pulmonary fibrosis (Commentary). J Clin Invest 1999;104:1-2.
  • Shi G-P, Sukhova GK, Grubb A, Libby P, Ducharme A, Rhode LH Lee RT, Ridker PM, Chapman HA. Cystatin C deficiency in human atherosclerosis and aortic aneurysms.. J Clin Invest, 1999; 104:1191-1197.
  • Simon DI, Wei Y, Chen Z, Rao NK, Rosenberg S, Chapman HA. Identification of a Urokinase Receptor-Integrin Interaction Site: Promiscuous Regulator of Integrin Function. J Biol Chem 2000; 275:10228-10234.
  • Villadangos JA, Shi G-P, Chapman HA, Ploegh HL. Early endosomal maturation of MHC class II molecules independently of cysteine proteases and H-2DM.. The Embo Journal 2000; 19:882-891.
  • Shi G-P, Bryant R, Riese, R, Ploegh HL, Chapman HA. Role for cathepsin F in invariant chain processing and MHC class II peptide loading by macrophages. J Exp Med 2000; 191:1177-1185.
  • Wei Y, Ebles JA, Weng Z, Kreidberg JA, and Chapman HA. Urokinase receptors promote b1 Integrin function through interactions with the integrin alpha3/beta1. Mol Biol Cell 2001, 10:2975-86.
  • Riese RJ, Shi GP, Villadangos J, Stetson D, Driessen C, Lennon-Dumenil AM, Chu CL, Naumov Y, Behar SM, Ploegh H, Locksley R, Chapman HA. Regulation of CD1 function and NK1.1+ T cell selection and maturation by Cathepsin S. Immunity 2001, 15:909-919.
  • Zhang F, Tom C, Kugler M, Ching T, Kreidberg J, Wei Y, and Chapman HA. Distinct Ligand Binding Sites in Integrin a_b_ Regulate Matrix Adhesion and Cell:Cell Contact. J Cell Biol. 2003 Oct 13;163(1):177-88
  • Chapman HA. Disorders of lung matrix remodeling. J Clin Invest. 2004 Jan;113(2):148-57.

Updated: September 21, 2010