Harold A. Chapman, MD

Tulane University, 1968, Premedical
University of Alabama School of Medicine, M.D., 1972, Medicine

• 1972-1975
  Residency Training in Internal Medicine, University of Utah Affiliated Hospitals, Salt Lake City, UT
• 1975-1977
  Associate Investigator, V.A. Medical Center, Salt Lake City, UT
• 1978-1979
  Pulmonary Fellow, University of Utah Affiliated Hospitals, Salt Lake City, UT
• 1979-1982
  Research Associate in Immunology, V.A. Medical Center, Salt Lake City, UT
• 1979-1985
  Assistant Professor of Medicine, University of Utah, Department of Medicine, Salt Lake City, UT
• 1985
  Associate Professor of Medicine, University of Utah, Department of Medicine, Salt Lake City UT
• 1985-1999
  Associate Professor of Medicine, Harvard Medical School, Department of Medicine, Boston, MA
• 1992-1999
  Physician, Brigham and Women's Hospital, Boston, MA
• 1992-1999
  Associate Professor of Environmental Health, Harvard School of Public Health, Boston, MA
• 2000
  Chief, Pulmonary and Critical Care Medicine Division, University of California, San Francisco
• 2000
  Professor of Medicine, University of California, San Francisco
• 2000
  Senior Member, Cardiovascular Research Institute, University of California San Francisco

• 1972
  Alpha Omega Alpha, University of Alabama School of Medicine
• 1985-1990
  Career Investigator Award, American Lung Association
• 1987
  American Society for Clinical Investigation
• 1998
  American Association of Physicians
• 2001
  MERIT Award, NIH/NHLBI

• (from ~100 publications)
• Shi GP, Munger JS, Meara JP, Rich DH, Chapman HA. Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease. J Biol Chem 1992 15; 267:7258-62.
• Waltz DA, Sailor LZ, Chapman HA. Cytokines induce urokinase-dependent adhesion of human myeloid cells: A regulatory role for plasminogen activator inhibitors. J Clin Invest. 1993; 91:1541-1550.
• Ying Wei, Waltz D, Rao N, Drummond R, Rosenberg S, Chapman HA. Identification of the urokinase receptor as an adhesion receptor for vitronectin. J Biol Chem, 1994; 209:32380-32388.
• Waltz DA, Chapman HA. Reversible cellular adhesion to vitronectin linked to urokinase receptor occupancy. J Biol Chem. 1994; 269:14746-14750.
• Shi G-P, Webb AC, Foster KE, Knoll JH, Lemere CA, Munger JS, Chapman HA. Human cathespin S: chromosomal localization, gene structure, and tissue distribution. J Biol Chem 1994; 269:11530-11536.
• Rao NK, Shi GP, Chapman HA. Urokinase receptor is a multifunctional protein: influence of receptor occupancy on macrophage gene expression. J Clin Invest 1995; 96:465-74.
• Wei Y, Lukasev M, Simon DI, Bodary SC, Rosenberg S, Doyle MV, Chapman HA. Regulation of integrin function by the urokinase receptor. Science 1996; 273:1551-1555.
• Gelb BD, Shi GP, Chapman HA Jr, Desnick RJ. Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency. Science 1996; 273:1236-1238.
• Riese R, Wolf P, Bromme D, Natkin L, Villadangos JA, Ploegh H, Chapman HA. Essential role for cathepsin S in MHC class II-associated invariant chain processing and antigen presentation. Immunity 1996; 4:357-366.
• Simon DI, Rao N, Hui W, Wei Y, Majdic O, Ronne E, Kobzik K, Chapman HA. Mac-1 (CD11b-CD18) and urokinase receptor (CD87) form a functional unit on monocytic cells. Blood 1996; 88:3185-3194.
• Waltz DA, Natkin L, Fujita RM, Wei Y, and HA Chapman. Plasmin and plasminogen activator type 1 promote cellular motility by regulating the interaction between the urokinase receptor and vitronectin. J Clin Invest 1997; 100:58-67.
• Sukhova GK, Shi GP, Simon DI, Chapman HA, and P Libby. Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells. J Clin Invest, 1998, 102:576-583.
• Riese RJ, Mitchell RN, Villadangos JA, Karp ER, DeSanctis GT, Ploegh HL, Chapman HA. Cathepsin S activity regulates antigen presentation and immunity. J Clin Invest 1998, 101:2351-2363.
• Villadangos JA, Riese RJ, Peters C, Chapman HA, Ploegh HL. Degradation of mouse Ii: Roles of cathepsins S and D and the influence of MHC polymorphism. J Exp Med. 1997, 186:549-560.
• Wang B, Shi GP, Yao PM, Li Z, Chapman HA and Bromme D. Human cathepsin F. Molecular cloning, functional expression, tissue localization and enzymatic characterization. J Biol Chem 1998, 273:32000- 32008.
• Chapman, HA. Endosomal proteolysis and MHC class II function. Curr Opin in Immunol 1998;10:93-102.
• Shi GP, Villadangos J, Dranoff G, Ploegh H, Chapman HA. Cathepsin S required for normal MHC class II peptide loading and germinal center development. Immunity, 1999;10:196-206.
• Wei Y, Yang X, Quimei Liu, Wilkins JA, and Chapman HA. Role for caveolin and urokinase receptors in integrin-mediated adhesion and signaling. J Cell Biol. 1999;144:1285-1294.
• Chapman HA. A fas pathway to pulmonary fibrosis (Commentary). J Clin Invest 1999;104:1-2.
• Shi G-P, Sukhova GK, Grubb A, Libby P, Ducharme A, Rhode LH Lee RT, Ridker PM, Chapman HA. Cystatin C deficiency in human atherosclerosis and aortic aneurysms.. J Clin Invest, 1999; 104:1191-1197.
• Simon DI, Wei Y, Chen Z, Rao NK, Rosenberg S, Chapman HA. Identification of a Urokinase Receptor-Integrin Interaction Site: Promiscuous Regulator of Integrin Function. J Biol Chem 2000; 275:10228-10234.
• Villadangos JA, Shi G-P, Chapman HA, Ploegh HL. Early endosomal maturation of MHC class II molecules independently of cysteine proteases and H-2DM.. The Embo Journal 2000; 19:882-891.
• Shi G-P, Bryant R, Riese, R, Ploegh HL, Chapman HA. Role for cathepsin F in invariant chain processing and MHC class II peptide loading by macrophages. J Exp Med 2000; 191:1177-1185.
• Wei Y, Ebles JA, Weng Z, Kreidberg JA, and Chapman HA. Urokinase receptors promote b1 Integrin function through interactions with the integrin alpha3/beta1. Mol Biol Cell 2001, 10:2975-86.
• Riese RJ, Shi GP, Villadangos J, Stetson D, Driessen C, Lennon-Dumenil AM, Chu CL, Naumov Y, Behar SM, Ploegh H, Locksley R, Chapman HA. Regulation of CD1 function and NK1.1+ T cell selection and maturation by Cathepsin S. Immunity 2001, 15:909-919.
• Zhang F, Tom C, Kugler M, Ching T, Kreidberg J, Wei Y, and Chapman HA. Distinct Ligand Binding Sites in Integrin a_b_ Regulate Matrix Adhesion and Cell:Cell Contact. J Cell Biol. 2003 Oct 13;163(1):177-88
• Chapman HA. Disorders of lung matrix remodeling. J Clin Invest. 2004 Jan;113(2):148-57.