jachasis@lbl.gov
(415) 476-2201 (voice)

Box 1270, UCSF; San Francisco, CA 94143-1270

Vassar College, Poughkeepsie, NY B.A. 1966 English
New York Univ. School of Medicine M.D. 1970 Medicine

Chasis JA and Mohandas N (1986) Erythrocyte membrane deformability and stability: Two distinct membrane properties which are independently regulated by skeletal protein associations. J Cell Biol 103:343-350.

Chasis JA, Reid ME, Jensen RH, and Mohandas N (1988) Signal transduction by glycophorin A: Role of extracellular and cytoplasmic domains in a modulatable process. J Cell Biol 107:1351-1357.

Chasis JA, Prenant M, Leung A, and Mohandas N (1989) Membrane assembly and remodeling during reticulocyte maturation. Blood 74:1112-1120.

Chasis JA and Schrier S (1989) Membrane deformability and the capacity for shape change in the erythrocyte. Blood 74:2562-2568.

Telen MJ and Chasis JA (1990) Relationship of the human erythrocyte Wrb antigen to an interaction between glycophorin A and band 3. Blood 76:842-848.

Conboy JG, Chan JY, Chasis JA, Kan YW, and Mohandas N (1991) Tissue- and development-specific alternative RNA splicing regulates expression of multiple isoforms of erythroid membrane protein 4.1. J Biol Chem 266:8273-8280.

Mohandas N, Winardi R, Knowles D, Leung A, Parra M, George E, Conboy JG, and Chasis JA (1992) Molecular basis for membrane rigidity of hereditary ovalocytosis: A novel mechanism involving the cytoplasmic domain of band 3. J Clin Invest 89:686-692.

Conboy JG, Chasis JA, Winadri R, Tchernia G, Kan YW, Mohandas N (1992) An isoform specific mutation in the protein 4.1 gene results in hereditary elliptocytosis and complete deficiency of protein 4.1 in erythrocytes but not in nonerythroid cells. J Clin Invest 91:77-82.

Chasis JA, Conboy J, Coulombel L, Andrews K, Kan YW, and Mohandas N (1992) Differentiation-associated switches in protein 4.1 expression: Synthesis of multiple structural isoforms during normal human erythropoiesis. J Clin Invest 91:329-338.

Knowles DW, Chasis JA, Mohandas N and Evans N (1994) Cooperative action between band 3 and glycophorin A in human erythrocytes: immobilization of band 3 induced by antibodies to glycophorin A. Biophys.J 66:1726-1732.

Chasis JA, Coulombel L, McGee S, Lee G, Tchernia G, Conboy J and Mohandas N (1996) Differential utilization of protein 4.1 translation intitiation sites during erythropoiesis: implications for a mutation induced stage specific deficiency of protein 4.1 during erythroid development. Blood 87:5324-5331.

Krauss SW, Larabelle CA, Lockette S, Penman S, Mohandas N and Chasis JA (1997) Skeletal protein 4.1 in the nucleus of human cells: dynamic rearrangements during cell division. J Cell Biol 137:275-289.

Krauss SW, Chasis JA, Rogers C, Narla M, Krockmalnic G, Penman S (1997) Structural protein 4.1 is located in mammalian centrosomes. Proc Natl Acad Sci USA 94:7279-7302.

Knowles DW, Tilley L, Mohandas N, Chasis JA (1997) Erythrocyte membrane vesiculation: Model for the molecular mechanism of protein sorting. Proc Natl Acad Sci USA 94:12969-12974.

Gascard P, Lee G, Coulombel L, Auffray I, Lum M, Parra M, Conboy JG, Mohandas N, Chasis JA (1998) Characterization of multiple isoforms of protein 4.1R expressed during erythroid terminal differentiation. Blood 92: 4404-4414.

Shi Z-T, Afzal V, Coller B, Patel D, Chasis JA, Parra M, Lee G, Paszty C, Stevens M, Walensky L, Mohandas N, Rubin E, Conboy JG (1999) Targeted deletion of translation initiation sites in the protein 4.1R gene leads to deficiency of all 4.1R isoforms and assembly of unstable erythrocyte membranes. J Clin Invest 103:331-340.

Gascard P, Nunomura W, Lee G, Walensky L, Krauss S, Takakuwa Y, Chasis JA, Mohandas N, Conboy JG (1999) Deciphering the nuclear import pathway for the cytoskeletal red cell protein 4.1R. Mol Biol Cell 10:1783-98.

Parsons SF, Spring FA, Chasis JA, and Anstee DJ (1999) Erythroid cell adhesion molecules Lutheran and LW in health and disease. Bailliere’s Clin Haematol 12:729-745.

Parsons SF, Lee G, Spring FA, Willig T-N, Peters LL, Gimm JA, Tanner MJA, Mohandas N, Anstee DJ, Chasis JA (2001) Lutheran blood group glycoprotein and its newly-characterized mouse homologue specifically bind alpha 5 chain-containing human laminin with high affinity. Blood 97:312-320.

Auffray I, Marfatia S, de Jong K, Lee G, Huang CH, Paszty C, Tanner MJA, Mohandas N, Chasis, JA (2001) Glycophorin A dimerization and band 3 interaction during erythroid membrane biogenesis: in vivo studies in human glycophorin A transgenic mice. Blood 97:2872-2878.

Van Dort HM, Knowles DW, Chasis JA, Lee G, Mohandas N, Low PS (2001) Analysis of integral membrane protein contributions to the deformability and stability of the human erythrocyte membrane. J Biol Chem 276(50):46968-46974.

An X, Lecomte MC, Chasis JA, Mohandas N, Gratzer W (2002) Shear-response of the spectrin dimer-tetramer equilibrium in the red blood cell membrane. J Biol Chem 277(35):31796-31800.

Krauss SW, Heald R, Lee G, Nunomura W, Gimm JA, Mohandas N, Chasis JA (2002) Two distinct domains of protein 4.1 critical for assembly of functional nuclei in vitro. J Biol Chem 277(46):44339-44346.

Lee G, Spring FA, Parsons SF, Mankelow TJ, Peters LL, Koury MJ, Mohandas N, Anstee DJ, Chasis JA (2003) Novel secreted isoform of adhesion molecule ICAM-4: Potential regulator of membrane-associated ICAM-4 interactions. Blood 101:1790-1797.

Mankelow TJ, Spring FA, Parsons SF, Brady RL, Mohandas N, Chasis JA and Anstee DJ (2003) Identification of critical amino-acid residues on the erythroid intercellular adhesion molecule-4 (ICAM-4) mediating adhesion to αv integrins. Blood (published online October 16, 2003).

Lee J, Gimm JA, Lo A, Koury M, Mohandas N, Krauss SW, and Chasis JA (2003) Membrane protein sorting during erythroblast enucleation: Role of cytoskeletal connectivity. Blood (published online October 16, 2003).

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