chenx@pharmacy.ucsf.edu
(415) 502-6526 (voice)
(415) 502-4332 (fax)

Box 0446, UCSF; San Francisco, CA 94143-0446

additional websites:

Chen Lab Website

Beijing Medical University, Beijing China, Bachelor of Medicine, 1992, Medicine
Harvard University, Ph.D., 1997, Cell and Developmental Biology

Chen X, Rubock MJ and Whitman M: "A transcriptional partner of MAD proteins in TGF-beta signaling" Nature, Vol. 383, Oct. 1996, pp691-696

Chen X, Weisberg E, Fridmacher V, Watanabe M, Naco G and Whitman M: "Smad4 and FAST-1 in the assembly of activin response factor" Nature, Vol. 389, Sept. 1997, pp85-89

Liu R, Liu H, Chen X, Martha K, Brown PO and Zhao K: "Regulation of CSF1 promoter by the SWI/SNF-like BAF complex" Cell, Vol. 106, Aug. 2001, pp309-318

Chen X, Cheng ST, So SK, Fang ST, Barry C, Higgins J, Lai K, Ji J, Dudoit S, Ng I, vandeRijn M, Botstein D and Brown PO: "Gene expression patterns in human liver cancers" Molecular Biology of the Cell, Vol. 13, Jun. 2002, pp1929-1939

Cheung ST, Chen X, Guan XY, Wong SY, Tai LS, Ng IO, So SK and Fan ST: "Identification of metastasis-associated genes in hepatocellular carcinoma through delineation of the clonal relationship of the multi-nodular liver cancer" Cancer Research, Vol. 62, Aug. 2002, pp4711-4721

Ji J*, Chen X*, Leung SY*, Chi J, Chu KM, Yuen SY, Li R, Chan A, Li J, Dunphy N and So S: "Comprehensive analysis of the gene expression profiles in human gastric cancer cell lines" Oncogene, Vol. 21 (42), Sept. 2002, pp6549-6556

Xu RH, Chen X, Chen DL, Li R, Addicks GC and Thomson JA: "BMP4 initiates human ES cell trophoblast differentiation" Nature Biotechnology, Vol. 20, Dec. 2002, p1261-1264

Leung SY*, Chen X*, Chu KM, Yuen ST, Mathy J, Ji J, Chan A, Li R, Law S, Troyanskaya OG, Tu IP, Wong J, So S, Botstein D and Brown PO: "Phospholipase A2, Group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis" Proce Natl Acd Sci U S A, Vol. 99, Dec. 2002, pp16203-16208

Chen X*, Leung SY*, Yuen ST, Chu KM, Ji J, Li R, Chan A, Law S, Troyanskaya OG, Wong J, So S, Botstein D and Brown PO: "Variation in gene expression patterns in human gastric cancers" Molecular Biology of the Cell, Vol. 14, Aug. 2003, pp3208-3215

Sperger JM*, Chen X*, Draper JS, Antosiewicz JE, Chon C, Jones S, Brooks JD, Andrews PW, Brown PO and Thomson JA: "Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors" Proce Natl Acd Sci U S A, Vol. 100, Nov. 2003, pp13350-13355

West RB, Corless CL, Chen X, Rubin B, Subramanian S, Montgomery K, Zhu S, Ball CA, Nielsen TO, Patel R, Boldblum JR, Heinrich MC, van de Rijn M: "The novel marker, DOG1, is expressed ubiquitously in GI Stromal tumors irrespective of KIT or PDGFRA mutation status" American Journal of Pathology, Vol. 165, July 2004, pp107-113

Leung SY, Yuen ST, Chu KM, Mathy JA, Li R, Chan ASY, Law S, Wong J, Chen X and So S: "Expression profiling identifies chemokine (C-C motif) ligand 18 as an independent prognostic indicator in gastric cancer" Gastroenterology, Vol 127(2), Aug. 2004, pp457-469

Chen X, Higgins J, Cheung ST, Li R, Mason V, Montgomery K, Fan ST, van de Rijn M, and So S: "Novel endothelial cell markers in hepatocellular carcinoma" Modern Pathology, Vol 17(10), Oct. 2004, pp1198-1210

Patil MA, Chua MS, Pan KH, Lin R, Lih CJ, Cheung ST, Ho C, Li R, Fan ST, Cohen SN, Chen X and So S: "An integrated data analysis approach to characterize genes highly expressed in hepatocellular carcinoma" Oncogene, Vol. 24(23), May 2005, pp3737-3747

Furge KA, Dykema KJ, Ho C and Chen X: "Comparsion of array-based Comparative genomic hybridization with gene expression-based regional expression biases to identify genetic abnormalities in hepatocellular carcinoma" BMC Genomics, Vol. 6(1), May 2005: 67

Patil MA, Gutgemann I, Zhang J, Ho C, Cheung ST, Gindinger D, Li R, Dykema KJ, So S, Fan ST, Kakar S, Furge KA, Buttner R and Chen X: "Array-based comparative genomic hybridization reveals recurrent chromosomal aberrations and Jab1 as potential target for 8q gain in hepatocellular carcinoma" Carcinogenesis, Vol. 26, Dec. 2005, pp2050-2057

Giacomini C, Leung SY, Chen X, Yuen ST, KimY, Bair E, Tibshirani R, Pollack JR: "A legacy gene-expression signature of genetic instability in colon cancer" Cancer Research, Vol. 65, Oct. 2005, pp9200-9205

Guo DL, Zhang J, Yuen ST, Tsui WY, Chan ASY, Ho C, Ji J, Leung SY and Chen X: "Reduced expression of EphB2 that parallels invasion and metastasis in colorectal tumors" Carcinogenesis, Vol. 27(3), Mar. 2006, pp454-464

Wang YC, Juri D, Francisco B, Yu RX, Duran G, Chen K, Chen X and Sikic BI: "Regional activation of chromosome 7q with and without gene amplification in taxane-selected human ovarian carcinoma cell lines" Genes, Chromosomes and Cancer, Epub Dec. 2005

Lamba JK, Chen X, Lan KB, Kim JW, Relling MV, Kazuto Y, Watkins PB, Strom S, Sun D, Schuetz JD and Schuetz EG: "Increased CYP3A4 copy number in TONG/HCC cells but not in DNA from other humans" Pharmacogenetics, Vol. 16(6), Jun, 2005, pp415-427

Aggarwal A, Guo DL, Hoshida Y, Yuen ST, Chu KM, So S, Boussioutas A, Chen X, Bowtell D, Aburatani H, Leung SY and Tan P: "Topological and functional discovery in a gene co-expression meta-network of gastric cancer" Cancer Research, Vol. 66 (1), Jan. 2006, pp232-241

Patil MA, Zhang J, Ho C, Cheung ST, Fan ST and Chen X: "Hedgehog signaling in human hepatocellular carcinoma" Cancer Biology and Therapy, Vol. 5(1), Jan. 2006, pp111-117

Leung SY, Ho C, Tu IP, Li R, So S, Chu KM, Yuen ST and Chen X: "Comprehensive analysis of 19q12 amplification in human gastric cancers" Modern Pathology, Vol. 19(6), Jun. 2006, pp654-863

Ho JC, Cheng ST, Patil MA, Chen X and Fan ST: "Increased expression of GPI anchor attachment protein (GPAA1) is associated with gene amplification in hepatocellular carcinoma" International Journal of Cancer, Vol. 119(6), Sept. 2006, pp1330-1337

Zhang S, Lovejoy K, Shima JE, Lagpacan LL, Shu Y, Lapuk A, Gray JW, Chen X, Lippard SJ and Giacomini KM: "Organic cation transporters are determinants of oxaliplatin cytotoxicity" Cancer Research, Vol. 66(17), Sept., 2006, pp8847

11/28/06