(415) 353-7720 (appts)
(415) 476-0133 (fax)

Box 0663, UCSF; San Francisco, CA 94143-0663

additional websites:

UCSF Division of Hematology/Oncology

University of Wisconsin, Madison, BS, Honors, 1988, Mol. Biology /Biochemistry
Northwestern University Medical School, Chicago, PhD, 1994, Tumor Cell Biology
Northwestern University Medical School, Chicago, MD, 1997, Medicine
University of California, San Francisco, Residency, 1998-2000, Pediatrics
Oakland Children's Hospital Clin. Fellow, 2000-2003, Ped Hem/Oncology
University of California, San Francisco, Research Postdoctoral Fellowship, 2001-2003, Nuero-Oncology
University of California, San Francisco, Clin. Fellow, 2003-2004, Ped Hem/Oncology

Johnson, M, H Choi-Kim, L Chesler, G Tsao-Wu, N Bouck and P Polverini (1994). Inhibition of angiogenesis by tissue inhibitor of metalloproteinase. J. Cell Physiol. 113:121-127.

Cohn S, A Look, V Joshi, T Holbrook H Salwen, D Chagnovich, L Chesler, S Rowe, M Valentine, H Komuro, et al. (1995). Lack of correlation of n myc gene amplification with prognosis in localized neuroblastoma: a pediatric oncology group study. Cancer Research. 55(4):721 6.

Chesler, L, D Golde, N Bersch, and M Johnson (1995). Metalloproteinase inhibition and erythroid potentiation are independent activities of tissue inhibitor of metalloproteinases-1. Blood 86(12):4506-4515.

Vodovotz, Y, AG Geiser, L Chesler, J Letterio, A Campbell, MS Lucia , MB Sporn, and AB Roberts (1996). Spontaneously increased production of nitric oxide and aberrant expression of the inducible nitric oxide synthase in vivo in the transforming growth factor 1 null mouse. J. Exp. Med. 183:2337 2342.

Volpert, O, W Ward, M Lingen, L Chesler, D Solt, M Johnson, A Molteni, P Polverini, and N Bouck (1996). Anti-angiogenic effect of captopril correlates with inhibition of metalloproteinase activity and inhibition of tumor cell proliferation. J Clin. Invest. 98(3):1-9.

Vodovotz, Y., Letterio, J.J., Geiser, A.G., Chesler, L., Roberts, A.B., and Sparrow, J. (1996). Control of nitric oxide production by endogenous TGF-beta1 and systemic nitric oxide in retinal pigment epithelial cells and peritoneal macrophages. J Leukoc Biol 60, 261-270.

Vodovotz, Y., Lucia, M.S., Flanders, K.C., Chesler, L., Xie, Q.W., Smith, T.W., Weidner, J., Mumford, R., Webber, R., Nathan, C., Roberts, A.B., Lippa, C.F., and Sporn, M.B. (1996). Inducible nitric oxide synthase in tangle-bearing neurons of patients with Alzheimer's disease. J Exp Med 184, 1425-1433.

Vodovotz Y, Chesler L, Chong H, Kim SJ, Simpson JT, DeGraff W, Cox GW, Roberts AB, Wink DA, Barcellos-Hoff MH (1999). Regulation of transforming growth factor beta1 by nitric oxide. Cancer Res 59(9):2142-9

Chesler, L., Hwang, L., Patton, W., and Heyman, M.B. Henoch-Schšnlein Purpura with Severe Jejunitis and Absence of the Typical Skin Lesions (1999). J Ped GI & Nutrition, 2000 Jan, 30(1):92-5

Chesler, L and Weiss, W. Book Review: Tumor Models in Cancer Research, B. A. Teicher, ed., 690 pp, Humana Press, 2002

Chesler, L and Feusner, J. Use of TPA for Lysis of Catheter Associated Thrombi in Small Children with Cancer. (2002). J Ped Hem Onc, 2002 Nov, 24(8):653-656.

Chesler, L, Goldenberg, D, Kim, G, Kenney, A, Matthay, K, Rowitch, D and Weiss, W. W. (2006). Inhibition of PI3-kinase destabilizes Mycn protein and blocks malignant progression in neuroblastoma. Cancer Research. 66(16): 8139-46.

Chesler, L, Goldenberg, D, Collins, R, Weiss, W, and Tihan, T (2006). Development of a regulable mouse model of medulloblastoma with Doxycyline-regulable MYCN expression. Manuscript in preparation, AJP.

Chesler, L, Goldenberg, Seales, I, D, Kim, G and Weiss, W (2006). Malignant and Angiogenic Progression in a Transgenic Mouse Model for Neuroblastoma. Submitted to CA Research, 2006.

Meyer, G, Chesler, L, Goldenberg, D, Youngren, J, and Weiss, W. W. (2006). Inhibition of neuroblastoma growth by targeted therapyÑcombined inhibition of the phosphoinositide-3 (PI3) kinase and insulin-like growth factor receptor (IGFR-I) using low molecular weight compounds. In review, Oncogene.

ABSTRACTS

Johnson, M, HR Choi-Kim, L Chesler and N Bouck (1991). Inhibition of angiogenesis by TIMP-1. Proc. Amer. Assoc. Cancer Research. 33:224.

Chesler, L and M Johnson (1992). Point mutations of TIMP-1 that correlate with the ability to bind zinc. Proc. Amer. Assoc. Cancer Research. 34:121.

Grinblatt, D, L Chesler, S Weitzman and M Johnson (1992). TIMP-1 induction during megakaryocytic differentiation and purification from human platelets. Proc. Amer. Soc. Hematology. 40:312.

Hoang, T, V Sundaresan, L Chesler and M Johnson (1994). Metalloproteinase activity disrupts focal adhesion plaque structure and actin cytoskeleton. Proc. Amer. Assoc. Cancer Research. 35:200.

Vodovotz, Y, AB Roberts, L Chesler, NS Roche, MS Lucia, S Thorgeirsson, and MB Sporn (1995). Systemic induction of nitric oxide synthesis in response to wounding in mice: control by transforming growth factor 1. Wound Rep. Reg. 3:105

Chesler, L and J Feusner (2001). Use of TPA for Lysis of Thrombi Associated with Central Venous Catheters in Small Children with Cancer. Proc. Amer. Soc. Ped. Hem. Onc.

Chesler, L and W Weiss. Development of a Mouse Model for Human Neuroblastoma Featuring Regulable MYCN Expression and Early Detection of Tumors (2002). AACR Minisymposium Plenary Presentation: Mouse Models of Human Cancer, Presentation #: 2422

Chesler, L and W Weiss. A Second Generation Mouse Model for Human Neuroblastoma (2002). Association of Neuroblastoma Research Meeting, Abstract Presentation.

Chesler, L and W Weiss. Development of a Mouse Model for Human Neuroblastoma Featuring Regulable MYCN Expression and Early Detection of Tumors (2002). AACR Minisymposium Plenary Presentation: Mouse Models of Human Cancer, Presentation #: 2422

Chesler, L, A Kenney, D Rowitch and W Weiss. Role of PI3-kinase pathway in Mycn destabilization in Neuroblastoma (2004). Association of Neuroblastoma Research Meeting, Abstract Presentation.

Chesler, L, Goldenberg, D, McMillan, A, Seales, I, Kenney, A, Matthay, K, Rowitch, D, Weiss, W. PI3-kinase blockade antagonizes Mycn, and represents an effective preclinical therapy for neuroblastoma (2005). AACR Poster Session abstract #1511.

12/11/06