kchin@cc.ucsf.edu
(415) 2476-3630 (voice)
(415) 476-8218 (fax)

Box 0808, UCSF, San Francisco, CA 94143-0808

Nippon Medical School, Tokyo, Japan, M.D, 1983, Medicine
Nippon Medical School, Tokyo, Japan, Ph.D., 1994, Medicine

Chin K, Shimizu K and Shoji T. An experimental study on a chemosensitivity test with alginate microcapsule -feasibility of in vivo succinic dehydrogenase inhibition test- J.Nippon Med.Sch., 61(5):422-434, 1994.

Gray JW, Chin K and Waldman F. A molucular cytogenetics view of chromosomal heterogeneity in solid tumors. Proceedings of the Eight Pezcoller Symposium, Genomic Instability and Immortality in Cancer. 1996.

Barsky SH, Sternlicht MD, Safarians S, Nguyen M, Chin K, Stewart SD, Hiti AL and Gray JW. Evidence of a dominant transcriptional pathway which regulates an undifferentiated and complete metastatic phenotype. Oncogene, 15(17):2077-91, 1997.

Lucito R, Nakimura M, West JA, Han Y, Chin K, Jensen K, McCombie R, Gray JW and Wigler M. Genetic Analysis Using Genomic Representations. Proc. Natl. Acad. Sci. UAS, 95:4487-4492, 1998.

Chin K and Gray JW: Comparative Genomic Hybridization. In Single Cell cDNA Libraries for PCR Methods Manual, (ed Nelson, Peter S.). Academic Press, San Diego, 1999.

Genevieve H. Nonet, Martha R. Stampfer, Koei Chin, Joe W. Gray, Colin C. Collins and Paul Yaswen: The ZNF217 Gene Amplified In Breast Cancers Promotes Immortalization Of Human Mammary Epithelial Cells. Cancer Res., 61:1250-1255, 2001

Chin K, Jain A, B¿rresen-Dale A, Erikstein B, Lonning P, Kaaresen R and Gray J. Quantitative analysis of chromosomal CGH in human breast tumors associates copy number abnormalities with p53 status and patient survival. Proc. Natl. Acad. Sci. USA. 98(14): 7952-7957, 2001

Uematsu K, Yoshimura A, Gemma A, Mochimaru H, Hosoya Y, Kunugi S, Matsuda K, Seike M, Kurimoto F, Takenaka K, Koizumi K, Fukusa Y, Tanaka S, Chin K, Jablons D and Kudoh S. Aberrations in the Fragile Histidine Triad (FHIT) gene in idiopathic pulmonary fibrosis., Cancer Res., 61:8527-8533, 2001

Massion, P., Kuo, W., Stokoe, D., Olshen, A., Treseler, P., Chin, K., Chen, C., Polikoff, D., Jain, A., Pinkel, D., Albertson, D., Jablons, D. and Gray, J., Genomic copy number analysis of non-small cell lung cancer using array comparative genomic hybridization: implications of the phosphatidylinositol 3-kinase pathway. Cancer Res, 2002. 62(13): p. 3636-40.

Miura D, Wada N, Chin K, Magrane GG, Wong M, Duh QY, Clark OH. Anaplastic thyroid cancer: cytogenetic patterns by comparative genomic hybridization., Thyroid. 2003 Mar;13(3):283-90.

Hodgson JG, Chin K, Collins C, Gray JW. Genome amplification of chromosome 20 in breast cancer. Breast Cancer Res Treat. 2003 Apr;78(3):337-45.

Volik S, Zhao S, Chin K, Brebner JH, Herndon DR, Tao Q, Kowbel D, Huang G, Lapuk A, Kuo W-L, Magrane M, de Jong P, Gray JW, and Collins C. End-sequence profiling: sequence-based analysis of aberrant genomes. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7696-701.

Porter D, Weremowicz S, Chin K, Seth P, Keshaviah A, Lahti-Domenici J, Bae YK, Monitto CL, Merlos-Suarez A, Chan J, Hulette CM, Richardson A, Morton CC, Marks J, Duyao M, Hruban R, Gabrielson E, Gelman R, Polyak K. A neural survival factor is a candidate oncogene in breast cancer. Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10931-6.

Langerod A, Stromberg M, Chin K, Kristensen VN, Borresen-Dale AL. BUB1 infrequently mutated in human breast carcinomas. Hum Mutat. 2003 Nov;22(5):420.

Zhao X, Li C, Paez JG, Chin K, JŠnne PA, Chen T, Girard L, Minna J, Christiani D, Leo C, Gray JW, Sellers WR, Meyerson M. An integrated view of copy number and allelic alterations in the cancer genome using single nucleotide polymorphism arrays. Cancer Res. 2004 64: 3060-3071.

Lapuk A, Volik S, Vincent R, Chin K, Kuo WL, de Jong P and Gray JW. Computational BAC Clone Contig Assembly for Comprehensive Genome Analysis. Genes Chromosomes Cancer. 2004 40:66-71

Chin K, Ortiz de Solorzano C, Knowles D, Jones A, Chou W, Rodriguez EG, Kuo WL, Ljung BM, Chew K, Myambo K, Miranda M, Krig S, Garbe J, Stampfer M, Yaswen P, Gray JW and Lockett SJ. In situ analysis of genome instablility in breast cancer. Nature Genetics. Nat Genet. 2004 36:984-8.

Scacheri PC, Kennedy AL, Chin K, Miller MT, Hodgson JG, Gray JW, Marx SJ, Spiegel AM, Collins FS. Pancreatic insulinomas in multiple endocrine neoplasia, type I knockout mice can develop in the absence of chromosome instability or microsatellite instability. Cancer Res. 2004 64:7039-44.

Chin K, Argilla D, Singh M, Hodgson JG, Bosenberg M, de Solorzano CO, Lockett S, Depinho RA, Gray J, Hanahan D. Absence of telomerase and shortened telomeres have minimal effects on skin and pancreatic carcinogenesis elicited by viral oncogenes. Cancer Cell. 2004 6(4):373-85.

Baldocchi R, Glynne R, Chin K, Kowbel D, Collins C, Mack D and Gray JW. Design considerations for array CGH to oligonucleotide arrays. Cytometry A. 2005 67(2):129-36.

Kim S, Chin K, Gray J and Bishop JM. A screen for genes that suppress loss of contact inhibition: identification of ING4 as a candidate tumor suppressor gene in human cancer. Proc Natl Acad Sci U S A. 2004 101(46):16251-6.

Bussey KJ, Chin K, Lababadi S, Reinhold WC, Kuo WL, Gwadry F, Kouros-Mehr H, Fridlyand F, Jain A, Collins C, Nishizuka S, Tonon, G, Roschke A, Stover K, Kirsch I, Scudiero DA, Gray J and Weinstein JN. Integrating data on DNA copy number with gene expression levels and drug sensitivities in the NCI-60 cell line panel. Mol Cancer Ther. 2006 5(4):853-67.

Fridlyand J, Snijders A, Ylstra B, Li H, Olshen A, Segraves R, Dairkee S, Tokuyasu T, Ljung BM, Jain AN, McLennan J, Ziegler J, Chin K, Devries S, Feiler H, Gray J, Waldman F, Pinkel D and Albertson D. Breast tumor copy number aberration phenotypes and genomic instability. BMC Cancer. 2006 18(6):96.

Rai R, Dai H, Multani AS, Li K, Chin K, Gray J, Lahad JP, Liang J, Mills GB, Meric-Bernstam F and Lin SY. BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer. Cancer Cell. 2006 10(2):145-57.

Lorenzi PL, Reinhold WC, Rudelius M, Gunsior M, Shankavaram U, Bussey KJ, Scherf U, Eichler GS, Martin SE, Chin K, Gray JW, Kohn EC, Horak ID, Von Hoff DD, Raffeld M, Goldsmith PK, Caplen NJ, Weinstein JN. Asparagine synthetase as a causal, predictive biomarker for L-asparaginase activity in ovarian cancer cells. Mol Cancer Ther. 2006 5(11):2613-23.

Sternlicht MD, Dunning AM, Moore DH, Pharoah PD, Ginzinger DG, Chin K, Gray JW, Waldman FM, Ponder BA, Werb Z. Prognostic value of PAI1 in invasive breast cancer: evidence that tumor-specific factors are more important than genetic variation in regulating PAI1 expression. Cancer Epidemiol Biomarkers Prev. 2006 15(11):2107-14.

Chin K, DeVries S, Fridlyand J, Spellman P, Roydasgupta R, Kuo W-L, Lapuk A, Neve R, Qian Z, Ryder T, Chen F, Feiler H, Tokuyasu T, Kingsley C, Dairkee S, Meng Z, Chew C, Pinkel D, Jain A, Ljung B-M, Esserman L, Albertson D, Waldman F and Gray J. Genomic and transcriptional aberrations linked to breast cancer pathophysiologies. Cancer Cell. 2006 10(6):529-41.

Neve R, Chin K, Fridlyand F, Yeh J, Baehner F, Fevr T, Clark L, Bayani N, Coppe J-P, Tong F, Speed T, Spellman P, DeVries S, Lapuk A, Wang N, Kuo W-L, Stilwell J, Pinkel D, Johnson M, Lippman M, Ethier S, Gazdar A, and Gray J. A collection of breast cancer cell lines for study of functionally distinct cancer subtypes. Cancer Cell. 2006 10(6):515-27.

Wang Y, Moorhead M, Karlin-Neumann G, Wang NJ, Ireland J, Lin S, Chen C, Heiser LM, Chin K, Esserman L, Gray JW, Spellman PT and Faham M. Performance of molecular inversion probes (MIP) in allele copy number determination. Genome Biol. 2007 Nov 20;8(11):R246

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