pkcooper@lbl.gov
(510) 486-7346 (voice)
(510) 486-6816 (fax)

Lawrence Berkeley Nat'l Lab; Mailstop 74-157
1 Cyclotron Road; Berkeley, CA 94720

additional websites:

Cooper Lab Website

University of Rochester, Rochester, NY, B.A. (with high distinction), 1966, Biology
Stanford University, Stanford, CA, Ph.D., 1971, Biology
Stanford U. School of Medicine, Stanford, CA, Postdoc., 1971-1973, Genetics

Cooper PK. Excision repair in mutants of E. coli deficient in DNA polymerase I and/or its associated 5' - 3' exonuclease. Mol. Gen. Genet. 150, 1-12 (1977).

Hanawalt PC, Cooper PK, Ganesan AK, and Smith CA. DNA repair in bacteria and mammalian cells. Ann. Rev. of Biochemistry 48, 783-836 (1979).

Cooper PK. Characterization of long patch excision repair of DNA in ultraviolet-irradiated Escherichia coli: an inducible function under Rec-Lex control. Mol. Gen. Genet. 185, 189-197 (1982).

Leadon SA and Cooper PK. Preferential repair of ionizing radiation-induced damage in the transcribed strand of an active human gene is defective in Cockayne Syndrome. Proc. Natl. Acad. Sci. 90, 10499-10503 (1993).

Rydberg B, Löbrich M, and Cooper PK. DNA double-strand breaks induced by high-energy Ne and Fe ions in human fibroblasts. I. Pulsed field gel electrophoresis method. Radiat. Res. 139, 133-141 (1994).

Löbrich M, Rydberg B, and Cooper PK. DNA double-strand breaks induced by high-energy Ne and Fe ions in human fibroblasts. II. Probing individual NotI fragments by hybridization. Radiat. Res. 139, 142-151 (1994).

Löbrich M, Rydberg B, and Cooper PK. Repair of X-ray-induced DNA double-strand breaks in specific NotI restriction fragments in human fibroblasts: joining of correct and incorrect ends. Proc. Natl. Acad. Sci. USA 92, 12050-12054 (1995).

Löbrich M, Rydberg B, and Cooper PK. Random-breakage mapping method applied to human DNA sequences. Nucleic Acids Res. 24, 1802-1809 (1996).

Löbrich M, Cooper PK, and Rydberg B. Non-random distribution of DNA double-strand breaks induced by particle irradiation. Internatl. J. Rad. Biol. 70, 493-503 (1996).

Cooper PK, Nouspikel T, Clarkson SG, and Leadon SA. Defective transcription-coupled repair of oxidative base damage in Cockayne syndrome patients from XP group G. Science 275, 990-993 (1997). Retracted: Science 308, 1740 (2005).

Nouspikel T, Lalle P, Leadon SA, Cooper PK, and Clarkson SG. A common mutational pattern in Cockayne syndrome patients from xeroderma pigmentosum group G: Implications for a second XPG function. Proc. Natl. Acad. Sci. USA 94, 3116-3121 (1997).

Löbrich M, Cooper PK, and Rydberg B. Joining of correct and incorrect DNA ends at double-strand breaks produced by high linear energy transfer radiation in human fibroblasts. Radiat. Res. 150, 619-626 (1998).

Fouladi B, Rydberg B, Waldren CA, and Cooper PK. Comparison of DNA double-strand break repair in identical sequences in primary human fibroblasts and immortal hamster-human hybrid cells harboring a normal human chromosome 11. Radiat. Res. 153, 795-804 (2000).

Le Page F, Kwoh EE, Avrutskaya A, Gentil A, Leadon SA, Sarasin A, and Cooper PK. Transcription-coupled base excision repair and mutation avoidance at 8-oxoguanine: Requirement for XPG, TFIIH, and CSB and implications for Cockayne syndrome. Cell 101, 159-171 (2000). Retracted: Cell 123, 711 (2005)

Weinfeld M, Xing JA, Lee J, Leadon SA, Cooper PK, and Le XC. Factors influencing the removal of thymine glycol from DNA in γ-irradiated human cells. Progr. Nucl. Acid Res. Mol. Biol. 68, 139-149 (2001).

Rydberg B, Heilbronn L, Holley W, Löbrich M, Zeitlin C, Chatterjee A, and Cooper PK. Spatial distribution and yield of DNA DSBs induced by 3-7 MeV helium ions in human fibroblasts. Radiat. Res.158, 32-42 (2002).

Wang J-Y, Sarker AH, Cooper PK, and Volkert MR. The single-strand DNA binding activity of human PC4 prevents mutagenesis and killing by oxidative DNA damage. Mol. Cell. Biol. 24, 6084-6093 (2004).

Rydberg B, Cooper B, Cooper PK, Holley WR, and Chatterjee A. Dose-Dependent Misrejoining of Radiation-Induced DNA Double-Strand Breaks in Human Fibroblasts: Experimental and Theoretical Study for High and Low LET Radiation. Radiat. Res. 163, 526-534 (2005).

Wang J, Pluth JM, Cooper PK, Cowan MJ, Chen DJ, and Yannone SM. Artemis Deficiency Confers a DNA Double-Strand Break Repair Defect and Artemis Phosphorylation Status is Altered by DNA Damage and Cell Cycle Progression. DNA Repair 4, 556-570 (2005).

Kalogeraki VS, Tornaletti S, Cooper PK, and Hanawalt PC. Comparative TFIIS-mediated transcript cleavage by mammalian RNA polymerase II arrested at a lesion in different transcription systems. DNA Repair 4, 1075-1087 (2005).

Sarker AH, Tsutakawa SE, Kostek S, Ng C, Shin DS, Peris M, Campeau E, Tainer JA, Nogales E, and Cooper PK. Recognition of RNA polymerase II and transcription bubbles by XPG, CSB, and TFIIH: Insights for transcription-coupled repair and Cockayne syndrome. Mol. Cell 20, 187-198 (2005).

Fan L, Arvai A, Cooper PK, Iwai S, Hanaoka F, Tainer JA. Conserved XPB core structure and motifs for DNA unwinding: Implications for pathway selection of transcription or excision repair. Mol. Cell 22, 27-37 (2006).

6/08/06