Joseph F. Costello, PhD

Marquette University, Milwaukee, WI, B.S., 1984-1988, Biology
Loyola University, Chicago, IL, Ph.D., 1990-1994, Neuroscience
Ludwig Institute, La Jolla, CA, Postdoc, 1994-1999, Molecular Biology of Brain Tumors

• 1992-1994
  Teaching Assistant, Medical Neuroscience, Loyola Medical Center, Chicago, IL.
• 1990-1994
  Graduate Student, Ph.D. Certificate in Neuroscience, Loyola University Graduate School, Chicago, IL (Advisor: Russell O. Pieper, PhD)
• 1994-1999
  Postdoctoral Fellow, Ludwig Institute for Cancer Research, San Diego (Advisor: Webster K. Cavenee, PhD
• 2000-2005
  Assistant Professor, University of California, San Francisco, Dept. of Neurological Surgery and The Brain Tumor Research Center
• 2005-present
  Associate Professor, University of California, San Francisco
• 2005-present
  Karen Osney Brownstein Endowed Chair in Molecular Neuro-Oncology

• (of 45 total)
• Costello JF; Brown MR; Gray TS. Bombesin immunoreactive neurons in the hypothalamic paraventricular nucleus innervate the dorsal vagal complex in the rat. Brain Research, 1991, V542 N1:77-82.
• Costello JF; Futscher BW; Kroes RA; Pieper RO. Methylation-related chromatin structure is associated with exclusion of transcription factors from and suppressed expression of the O-6-methylguanine DNA methyltransferase gene in human glioma cell lines. Molecular and Cellular Biology, 1994, 14(10):6515-21.
• Costello JF; Futscher BW; Tano K; Graunke DM; Pieper RO. Graded methylation in the promoter and body of the O6-methylguanine DNA methyltransferase (MGMT) gene correlates with MGMT expression in human glioma cells. Journal of Biological Chemistry, 1994, 269(25):17228-37.
• Pieper RO; Patel S; Ting SA; Futscher BW; Costello JF. Methylation of CpG island transcription factor binding sites is unnecessary for aberrant silencing of the human MGMT gene. Journal of Biological Chemistry, 1996, 271(23):13916-24.
• Costello JF; Berger MS; Huang H-JS; Cavenee WK. Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation. Cancer Research, 1996, 56(10):2405-10.
• Costello JF; Plass C; Arap W; Chapman VM; Held WA; Berger M; Huang H- JS; Cavenee WK. Cyclin dependent kinase 6 (CDK6) amplification in human gliomas identified using two dimensional separation of genomic DNA. Cancer Research, 1997, 57:1250-1254.
• Costello JF; Plass C; Cavenee WK. Restriction Landmark Genomic Scanning. In: Methods in Molecular Biology; DNA Methylation Protocols. Humana Press, in press, 2000.
• Frhwald MC; O'Dorisio MS; Rush L; Reiter JL; Smiraglia DJ; Wenger, G; Costello JF; White PS; Krahe R; Brodeur G; Plass C. Gene amplification in PNET/medulloblastoma: Mapping of a novel amplified gene within the MYCN amplicon. Journal of Medical Genetics 2000, 37:501-509.
• Costello JF; Plass C; Cavenee WK. Aberrant methylation of genes in low-grade astrocytomas. Brain Tumor Pathology, 2000, 17: 49-56.
• Costello JF; Frhwald MC; Smiraglia DJ; Rush L; Robertson GP; Gao X; Wright FA; Feramisco JD; Peltomki P; Lang JC; Schuller DE; Yu L; Bloomfield CD; Caligiuri MA; Yates A; Nishikawa R; Huang HJS; Petrelli NJ; Zhang X; O'Dorisio MS; Held WA; Cavenee WK; Plass C. Aberrant CpG island methylation has non-random and tumor type-specific patterns. Nature Genetics, 2000, 25:132-138.
• Costello JF; Plass, C. Methylation Matters. Journal of Medical Genetics, 2001, 38: 285-303.
• Smiraglia DJ; Rush LJ; Frhwald M; Dai Z; Held WA; Costello JF; Lang JC; Eng C; Li B; Wright FA; Caligiuri MA; Plass C. Excessive CpG island hypermethylation in cancer cell lines versus primary human malignancies, Human Molecular Genetics, 2001, 10: 1413-1419.
• Zardo G; Tiirikainen M, Hong C; Misra A; Feuerstein BG; Volik S; Collins CC; Lamborn KR; Bollen A; Pinkel D; Albertson, DG; Costello JF. Integrated Genomic and Epigenomic Analyses Pinpoint Biallelic Gene Inactivation in Tumors. Nature Genetics, 2002, 32(3): 453-458.
• Feltus FA; Lee EK; Costello JF; Plass C; Vertino PM. Predicting aberrant CpG island methylation. Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12253-8.
• Hong C; Bollen AW; Costello JF. The Contribution of Genetic and Epigenetic Mechanisms to Gene Silencing in Oligodendrogliomas. Cancer Research, 2003, 63: 7600-7605.
• Costello JF. DNA methylation in brain development and gliomagenesis, Frontiers in Biosciences, 2003, 8: S175-S184.
• He B; You L; Uematsu K; Zang K; Xu Z; Lee AY; Costello JF; McCormick F; Jablons DM. SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer. Proc Natl Acad Sci U S A. 2003.
• Hong C, Maunakea A, Jun P, Bollen AW, Hodgson JG, Goldenberg DD, Weiss WA, Costello JF. Shared epigenetic mechanisms in human and mouse gliomas inactivate expression of the growth suppressor SLC5A8. Cancer Res. 2005 May 1; 65(9):3617-23.
• Costello JF. Comparative epigenomics. Nature Genetics 2005 Mar;37(3):211-2.
• Stokoe D and Costello JF. Phosphatase and tensin homologue growth suppression without phosphatase, Proc Natl Acad Sci U S A, 2005 Feb 22;102(8):2677-8.
• Ching TT, Maunakea AK, Jun P, Hong C, Zardo G, Pinkel D, Albertson DG, Fridlyand J, Mao JH, Shchors K, Weiss WA, Costello JF. Epigenome analyses using BAC microarrays identify evolutionary conservation of tissue-specific methylation of SHANK3. Nature Genetics 2005 June; 37, 645 - 651.
• Cuevas IC, Slocum AL, Jun P, Costello JF, Bollen AW, Riggins GJ, McDermott MW, Lal A. Meningioma transcript profiles reveal deregulated Notch signaling pathway. Cancer Res. 2005 Jun 15;65(12):5070-5.
• Feltus FA, Lee EK, Costello JF, Plass C, Vertino PM. DNA motifs associated with aberrant CpG island methylation. Genomics. 2006 May; 87(5):572-9.
• Smith JS, Costello JF. A broad band of silence. Nature Genetics 2006 May;38(5):504-6.
• Reynolds PA, Sigaroudinia M, Zardo G, Wilson MB, Benton GM, Miller CJ, Hong C, Fridlyand J, Costello JF, Tlsty TD. Tumor suppressor P16INK4A regulates polycomb-mediated DNA hypermethylation in human mammary epithelial cells. J Biol Chem. 2006 Aug 25;281(34):24790-802.
• Cadieux B, Ching TT, VandenBerg SR, Costello JF. Genome-wide hypomethylation in human glioblastomas associated with specific copy number alteration, MTHFR allele status and increased proliferation. Cancer Research. 2006 Sep 1;66(17):8469-76.
• Chen Y, Toland AE, McLennan J, Fridlyand J, Costello JF, Crawford B, Costello JF, and Ziegler JL. Lack of Germline Promoter Methylation in BRCA1 Negative Families with Familial Breast Cancer. Genetic Testing. 2006, 10(4):281-4.
• Brena RM, Plass C, Costello JF. Mining methylation for early detection of common cancers. PLoS Medicine, 2006 Dec;3(12):e479.
• Hong C, Moorefield KS, Jun P, Aldape K, Kharbanda S, Phillips HS, Costello JF. Epigenome scans and cancer genome sequencing converge on WNK2, a kinase-independent suppressor of cell growth. Proc Natl Acad Sci USA, 2007, June: 104 (26), 10974-10979.
• Carvalho LH, Smirnov I, Baia GS, Modrusan Z, Smith JS, Jun P, Costello JF, McDermott MW, Vandenberg SR, Lal A. Molecular signatures define two main classes of meningiomas. Mol Cancer. 2007 Oct 15;6(1):64
• Brena RM, Costello JF. Genome-epigenome interactions in cancer. Hum Mol Genet. 2007 Apr 15;16.
• Smith JF, Mahmood S, Song F, Morrow A, Smiraglia D, Zhang X, Rajput A, Higgins MJ, Krumm A, Petrelli NJ, Costello JF, Nagase H, Plass C, Held WA. Identification of DNA Methylation in 3' Genomic Regions that are Associated with Upregulation of Gene Expression in Colorectal Cancer. Epigenetics, 2007 Sep;2(3):161-72.
• Silber J, Lim DA, Petritsch C, Persson AI, Maunakea AK, Yu M, Vandenberg SR, Ginzinger DG, James CD, Costello JF, Bergers G, Weiss WA, Alvarez-Buylla A, Hodgson JG. miR-124 and miR-137 inhibit proliferation of GBM cells and induce differentiation of brain tumor stem cells. BMC Med. 2008 Jun 24;6(1):14.
• Costello JF. Stem Cells: Tips for priming potency (editorial). Nature 2008 July 3, 454, 45-46.
• American Association for Cancer Research Human Epigenome Task Force; European Union, Network of Excellence, Scientific Advisory Board. Moving AHEAD with an international human epigenome project. Nature. 2008 Aug 7;454(7205):711-5.
• Yi JM, Tsai HC, Glckner SC, Lin S, Ohm JE, Easwaran H, James CD, Costello JF, Riggins G, Eberhart CG, Laterra J, Vescovi AL, Ahuja N, Herman JG, Schuebel KE, Baylin SB. Abnormal DNA methylation of CD133 in colorectal and glioblastoma tumors. Cancer Res. 2008 Oct 1;68(19):8094-103