jcostello@cc.ucsf.edu
(415) 514-1183 (voice)
(415) 502-6779 (fax)

Box 0875, UCSF; San Francisco, CA 94143-0875

additional websites:

Costello Lab Website

Marquette University, Milwaukee, WI, B.S., 1984-1988, Biology
Loyola University, Chicago, IL, Ph.D., 1990-1994, Neuroscience
Ludwig Institute, La Jolla, CA, Postdoc, 1994-1999, Molecular Biology of Brain Tumors

Costello JF; Brown MR; Gray TS. Bombesin immunoreactive neurons in the hypothalamic paraventricular nucleus innervate the dorsal vagal complex in the rat. Brain Research, 1991, V542 N1:77-82.

Costello JF; Futscher BW; Kroes RA; Pieper RO. Methylation-related chromatin structure is associated with exclusion of transcription factors from and suppressed expression of the O-6-methylguanine DNA methyltransferase gene in human glioma cell lines. Molecular and Cellular Biology, 1994, 14(10):6515-21.

Costello JF; Futscher BW; Tano K; Graunke DM; Pieper RO. Graded methylation in the promoter and body of the O6-methylguanine DNA methyltransferase (MGMT) gene correlates with MGMT expression in human glioma cells. Journal of Biological Chemistry, 1994, 269(25):17228-37.

Pieper RO; Patel S; Ting SA; Futscher BW; Costello JF. Methylation of CpG island transcription factor binding sites is unnecessary for aberrant silencing of the human MGMT gene. Journal of Biological Chemistry, 1996, 271(23):13916-24.

Costello JF; Berger MS; Huang H-JS; Cavenee WK. Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation. Cancer Research, 1996, 56(10):2405-10.

Costello JF; Plass C; Arap W; Chapman VM; Held WA; Berger M; Huang H- JS; Cavenee WK. Cyclin dependent kinase 6 (CDK6) amplification in human gliomas identified using two dimensional separation of genomic DNA. Cancer Research, 1997, 57:1250-1254.

Costello JF; Plass C; Cavenee WK. Restriction Landmark Genomic Scanning. In: Methods in Molecular Biology; DNA Methylation Protocols. Humana Press, in press, 2000.

Frühwald MC; O'Dorisio MS; Rush L; Reiter JL; Smiraglia DJ; Wenger, G; Costello JF; White PS; Krahe R; Brodeur G; Plass C. Gene amplification in PNET/medulloblastoma: Mapping of a novel amplified gene within the MYCN amplicon. Journal of Medical Genetics 2000, 37:501-509.

Costello JF; Plass C; Cavenee WK. Aberrant methylation of genes in low-grade astrocytomas. Brain Tumor Pathology, 2000, 17: 49-56.

Costello JF; Frühwald MC; Smiraglia DJ; Rush L; Robertson GP; Gao X; Wright FA; Feramisco JD; PeltomŠki P; Lang JC; Schuller DE; Yu L; Bloomfield CD; Caligiuri MA; Yates A; Nishikawa R; Huang HJS; Petrelli NJ; Zhang X; O'Dorisio MS; Held WA; Cavenee WK; Plass C. Aberrant CpG island methylation has non-random and tumor type-specific patterns. Nature Genetics, 2000, 25:132-138.

Costello JF; Plass, C. Methylation Matters. Journal of Medical Genetics, 2001, 38: 285-303.

Smiraglia DJ; Rush LJ; Frühwald M; Dai Z; Held WA; Costello JF; Lang JC; Eng C; Li B; Wright FA; Caligiuri MA; Plass C. Excessive CpG island hypermethylation in cancer cell lines versus primary human malignancies, Human Molecular Genetics, 2001, 10: 1413-1419.

Zardo G; Tiirikainen M, Hong C; Misra A; Feuerstein BG; Volik S; Collins CC; Lamborn KR; Bollen A; Pinkel D; Albertson, DG; Costello JF. Integrated Genomic and Epigenomic Analyses Pinpoint Biallelic Gene Inactivation in Tumors. Nature Genetics, 2002, 32(3): 453-458.

Feltus FA; Lee EK; Costello JF; Plass C; Vertino PM. Predicting aberrant CpG island methylation. Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12253-8.

Hong C; Bollen AW; Costello JF. The Contribution of Genetic and Epigenetic Mechanisms to Gene Silencing in Oligodendrogliomas. Cancer Research, 2003, 63: 7600-7605.

Costello JF. DNA methylation in brain development and gliomagenesis, Frontiers in Biosciences, 2003, 8: S175-S184.

He B; You L; Uematsu K; Zang K; Xu Z; Lee AY; Costello JF; McCormick F; Jablons DM. SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer. Proc Natl Acad Sci U S A. 2003.

Hong C, Maunakea A, Jun P, Bollen AW, Hodgson JG, Goldenberg DD, Weiss WA, Costello JF. Shared epigenetic mechanisms in human and mouse gliomas inactivate expression of the growth suppressor SLC5A8. Cancer Res. 2005 May 1; 65(9):3617-23.

Costello JF. Comparative epigenomics. Nature Genetics 2005 Mar;37(3):211-2.

Stokoe D and Costello JF. Phosphatase and tensin homologue growth suppression without phosphatase, Proc Natl Acad Sci U S A, 2005 Feb 22;102(8):2677-8.

Ching TT, Maunakea AK, Jun P, Hong C, Zardo G, Pinkel D, Albertson DG, Fridlyand J, Mao JH, Shchors K, Weiss WA, Costello JF. Epigenome analyses using BAC microarrays identify evolutionary conservation of tissue-specific methylation of SHANK3. Nature Genetics 2005 June; 37, 645 - 651.

Cuevas IC, Slocum AL, Jun P, Costello JF, Bollen AW, Riggins GJ, McDermott MW, Lal A. Meningioma transcript profiles reveal deregulated Notch signaling pathway. Cancer Res. 2005 Jun 15;65(12):5070-5.

Feltus FA, Lee EK, Costello JF, Plass C, Vertino PM. DNA motifs associated with aberrant CpG island methylation. Genomics. 2006 May; 87(5):572-9.

Reynolds PA, Sigaroudinia M, Zardo G, Wilson MB, Benton GM, Miller CJ, Hong C, Fridlyand J, Costello JF, Tlsty TD. Tumor suppressor P16INK4A regulates polycomb-mediated DNA hypermethylation in human mammary epithelial cells. J Biol Chem. 2006 Aug 25;281(34):24790-802.

Cadieux B, Ching TT, VandenBerg SR, Costello JF. Genome-wide hypomethylation in human glioblastomas associated with specific copy number alteration, MTHFR allele status and increased proliferation. Cancer Research. 2006 Sep 1;66(17):8469-76.

12/7/06