ucsf banner
Helen Diller Family Compr Cancer Ctr
SHAUN R. COUGHLIN, MD, PHD

Distinguished Professorship in Cardiovascular Biology and Medicine, UCSF
Director, Cardiovascular Research Institute, UCSF
Member, Biomedical Sciences Graduate Program (BMS) and Herbert Boyer Program in Biological Sciences (PIBS), UCSF

CONTACT

coughlin@cvrimail.ucsf.edu
(415) 476-6174, 476-3904
(415) 476-8173 (fax)

Box 1753, UCSF; San Francisco, CA 94143-1753

EDUCATION

Massachusetts Institute of Technology, Boston, MA, S.B., S.B., 1976, Biology, Physics
Massachusetts Institute of Technology, Boston, MA, S.M., 1976, Biochemistry
Massachusetts Institute of Technology, Boston, MA, Ph.D., 1981, Neur. and Endo. Reg.
Harvard Medical School, Boston, MA, M.D., 1982, Medicine

PROFESSIONAL EXPERIENCE

1982-1984

Intern and Resident, Medical Services, Massachusetts General Hospital

1984-1985

Assistant Research Cardiologist, Cardiovascular Research Inst., UCSF

1985-1986

Clinical Fellow in Cardiology, University of California, San Francisco

1986-1991

Assistant Professor of Medicine and Associate Staff, Cardiovascular Research Intitute, UCSF

1991-1996

Associate Professor of Medicine and Senior Staff, Cardiovascular Research Institute, UCSF

1992-present

Member, Graduate Program in Biological Sciences and Program in Biomedical Sciences, UCSF

1995-present

Director, Daiichi Research Center, UCSF

1996-present

Professor of Medicine, UCSF

1997-present

Professor of Cellular and Molecular Pharmacology, UCSF

1997-present

Director, Cardiovascular Research Institute, UCSF

HONORS & AWARDS

Established Investigator, AHA; Ted Zimmerman Lecture, ASH, 1991

1992

ASCI

1994

Syntex Prize in Receptor Pharmacology

1997

AAP; Owren Lecture, Oslo; AHA Sol Sherry Lecture

1998

Outstanding Investigator Award, AFMR

2000

Hoeg Award, AHA

2000

Fellow, American Academy of Arts and Sciences

2000

Russel Ross Lecture, AHA

2002

Pasarow Foundation Award for Cardiovascular Research

2003

Basic Science Prize, AHA

2004

14th Bristol-Meyers Squibb Award for Distinguished Achievement in Cardiovascular Research

2004

Member, National Academy of Sciences

SELECTED PUBLICATIONS

Recent Primary Publications

Kahn, M.L., Zheng, Y.-W., Huang, W., Bigornia, V., Zeng, D., Moff, S., Farese, R.V., Jr., Tam, C., and Coughlin, S.R. (1998) A two thrombin receptor system for platelet activation. Nature 394: 690-694.

Kahn, M.L. Hammes, S.R., Botka, C., and Coughlin, S.R. (1998) Gene and locus structure and chromosomal localization of the protease-activated receptor gene family. J. Biol. Chem. 273: 23290-23296.

Shapiro, M.J. and Coughlin, S.R. (1998) Separate signals for agonist-independent and agonist-triggered trafficking of protease-activated receptor-1. J. Biol. Chem. 273: 29009-29014.

Trejo, J. and Coughlin, S.R. (1999) The cytoplasmic tails of protease-activated receptor-1 and substance P receptor specify sorting to lysosomes vs. recycling. J. Biol. Chem. 274: 2216-2224.

Hammes, S.R. and Coughlin, S.R. (1999) Protease-activated receptor-1 can mediate responses to SFLLRN in thrombin-desensitized cells --- Evidence for a novel mechanism for preventing or terminating signaling by PAR1's tethered ligand. Biochemistry 38(8): 2486-2493.

Kahn, M.L., Nakanishi-Matsui, M., Shapiro, M.J., Ishihara, H., and Coughlin, S.R. (1999). Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. J. Clin. Invest. 103: 879-887.

Hammes, S.R. , Shapiro, M.J., and Coughlin, S.R. (1999) Shutoff and agonist-triggered internalization of protease-activated receptor-1 are separable by mutation of putative phosphorylation sites in the cytoplasmic tail. Biochemistry 38: 9308-9316.

Sambrano, G. and Coughlin, S.R. (1999) The carboxyl tail of protease-activated receptor-1 is required for chemotaxis: correlation of signal termination and directional movement. J. Biol. Chem. 274: 20178-20184.

Kahn, M.L., Diacovo, T., Bainton, D.F., Lanza, F., Trejo, J., and Coughlin, S.R. (1999) Glycoprotein V-deficient platelets have undiminished thrombin responsiveness and do not exhibit a Bernard-Soulier phenotype. Blood 94: 4112-4121.

Cunningham, M.A., Rondeau, E., Chen, X., Coughlin, S.R., Holdsworth, S.R., and Tipping, P.G. (2000) Protease-activated receptor-1 mediated, fibrin independent pro-inflammatory actions of thrombin in crescentic glomerulonephritis. J. Exp. Med. 191(3): 455-461..

Sambrano, G.R., Huang, W., Faruqi, T., Mahrus, T., Craik, C., and Coughlin, S.R. (2000) Protease-activated receptor-4 mediates human platelet activation by cathepsin G. J. Biol. Chem. 275: 6819-6823.

Nakanishi-Matsui, M., Zheng, Y.-W., Weiss, E.J., Sulciner, D., and Coughlin, S.R. (2000) PAR3 is a cofactor for PAR4 activation by thrombin. Nature 404: 609-613..

Camerer, E., Huang, W., and Coughlin, S.R. (2000) Tissue factor- and Factor X-dependent activation of PAR2 by Factor VIIa. Proc. Natl. Acad. Sci. USA 97(10): 5255-5260.

Faruqi, T.R., Weiss, E.J., Huang, W., and Coughlin, S.R. (2000) Structure- function analysis of protease-activated receptor-4 tethered ligand peptides: Determinants of specificity and utility in assays of receptor function. J. Biol. Chem. 275:19728-34.

Shapiro, M.J., Weiss, E.J., Faruqui, T.R., and Coughlin, S.R. (2000) Protease-activated receptors 1 and 4 are shutoff with distinct tempos after activation by thrombin. J. Biol. Chem. 275:25216-21.

Takeuchi, T., Harris, J.L., Huang, W., Yan, K.W., Coughlin, S.R., and Craik, C.S. (2000) Cellular localization of MT-SP1 and identification of PAR2 and sc-uPA as substrates. J. Biol. Chem. 275:26333-26342.

Trejo, J., Alschuler, Y., Fu, H.-W., Mostov, K.E., and Coughlin, S.R. (2000) A Mutant HeLa Cell Line Reveals Distinct Requirements for Recruitment of Protease-Activated Receptor-1 vs. дк2-Adrenergic Receptor to Clathrin-Coated Pits. J. Biol. Chem. 275:31255-31265.

Linder, J.R., Kahn, M.L., Coughlin, S.R., Schauble, E., Bernstein, D., Foy, D., Harezi-Moghadam, A., and Ley, K. (2000) Delayed onset of inflammation in protease-activated receptor 2-deficient mice. J. Immunology 165:6504.

Sambrano, G., Weiss, E., Zheng, Y.W., Huang, W., and Coughlin, S.R. (2001) Role of thrombin signaling in platelets in hemostasis and thrombosis. Nature 413: 74-78.

Griffin, C.T., Srinivasan, Y., Zheng, Y.W., Huang, W., and Coughlin, S.R. (2001) A role for thrombin receptor signaling in endothelial cells during embryonic development. Science 293: 1666-1670.

Camerer, E., Kataoka, H., Zheng, Y.-W., Kahn, M.L., Lease, K., and Coughlin, S.R. (2002) Genetic evidence that protease-activated receptors mediate factor Xa signaling in endothelial cells. J. Biol. Chem. 277:16081-16087.

Weiss, E.J., Hamilton, J.R., Lease, K.E., and Coughlin, S.R. (2002) Protection against thrombosis in mice lacking PAR3. Blood 100(9):3240-3244.

Eisenhaure TM, Francis SA, Willison LD, Coughlin SR, Lerner DJ. (2003) The Rho guanine nucleotide exchange factor Lsc homo-oligomerizes and is negatively regulated through domains in its carboxyl terminus that are absent in novel splenic isoforms. J. Biol. Chem. 278(33):30975-84.

Camerer, E., Duong, D.N., Hamilton, J.R., and Coughlin, S.R. (2004) Combined deficiency of protease-activated receptor-4 and fibrinogen recapitulates the hemostatic defect but not the embryonic lethality of prothrombin deficiency. Blood 103(1):152-4.

Ludeman, M.J., Zheng, Y.W., Ishii, K., and Coughlin, S.R. (2004) Regulated shedding of PAR1 N-terminal exodomain from endothelial cells. J. Biol. Chem. 279:186592-9.

Camerer, E., Qazi, A.A., Duong, D.N., Cornelissen, I., and Coughlin, S.R. (2004) Platelets, protease-activated receptors and fibrinogen in hematogenous metastasis. Blood (In press).

Hamilton, J.R., Cornelissen, I., and Coughlin, S.R. (2004) Impaired hemostasis and protection against thrombosis in PAR4-deficient mice is due to lack of thrombin signaling in platelets. J. Thrombos. Haemostas. (In press).

Selected earlier publications:

Vu, T.-K.H., Hung, D.H., Wheaton, V.I., and Coughlin, S.R. (1991) Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 64:1057-1068

Connolly, A., Ishihara, H., Kahn, M., Farese, R.V., Jr., and Coughlin, S.R. (1996) Role of the thrombin receptor in development and evidence for a second receptor. Nature 381: 516-519.

3/15/05

This site will look much better in a browser that supports web standards, but it is accessible to any browser or Internet device. Please upgrade your browser.