Professor, Cancer Research Institute and Anatomic Pathology, UCSF
Member, Biomedical Sciences Graduate Program (BMS) and Herbert Boyer Program in Biological Sciences (PIBS), UCSF
Co-Director, Mouse Pathology Core Facility, UCSF Helen Diller Family Comprehensive Cancer Center
| CONTACT | |
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lisa.coussens@ucsf.edu Box 0502, UCSF; San Francisco, CA 94143-0502 |
additional websites: |
| EDUCATION | |
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San Francisco State University, B.A., Biology, 1976-1980 |
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| PROFESSIONAL EXPERIENCE | |
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1981 - 1988 |
Research Associate, Molec. & Devel. Biology, Genentech, Inc., South San Francisco |
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1997 - 1999 |
Assistant Research Biochemist, Hormone Research Inst., University of California, San Francisco |
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1999 - 2004 |
Assistant Professor, In Residence Cancer Research Institute & Dept of Pathology, University of California, San Francisco |
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2004 - 2006 |
Associate Professor, In Residence Cancer Research Institute & Dept. of Pathology, University of California, San Francisco |
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2006 - 2007 |
Associate Professor, Dept. of Pathology & Cancer Research Institute, University of California, San Francisco |
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2007 - present |
Professor, Dept. of Pathology & Cancer Research Institute, University of California, San Francisco |
| HONORS & AWARDS | |
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1985, 1986, 1988 |
Recognition Award, Genentech, Inc. |
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1996-1998 |
Am. Social Health Assoc/Pfizer Postdoctoral Research Fellowship in Sexually Transmitted Diseases |
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2000-2002 |
Hellman Family Award For Early Career Faculty |
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2000-2002 |
V Foundation Scholar, The V Foundation for Cancer Research |
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2000-2003 |
Edward Mallinckrodt, Jr. Foundation Award for Medical Research, Edward Mallinckrodt, Jr. Foundation |
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2001-2002 |
Gertrude B. Elion Cancer Research Award, American Assoc. for Cancer Research |
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2006-2011 |
Era of Hope Scholar Award, Dept. of Defense Breast Cancer Research Program |
| SELECTED PUBLICATIONS - PEER-REVIEWED | |
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Mosthaf L, Grako D, Dull T, Coussens L, Ullrich A, McClain D. (1990) Functionally distinct insulin receptors generated by tissue-specific alternative splicing. EMBO J. 9(8): 2409-2413. | |
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Coussens LM, Yokoyama K, Chiu R. (1994) Transforming Growth Factor b1-mediated induction of junB is selectively inhibited by expression of Ad.12-E1A. J. Cell. Physio. 160:435-444. | |
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Coussens LM, Hanahan D, Arbeit J. (1996) Genetic predisposition and parameters of malignant progression in K14-HPV16 transgenic mice. Am. J. Pathol. 149:1899-1917. | |
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Coussens LM, Werb Z. (1996) Matrix metalloproteinases and the development of cancer. Chem. & Biol. 3:895-904. | |
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Bergers G, Hanahan D, Coussens LM. (1998) Angiogenesis and apoptosis are cellular parameters regulating neoplastic progression in transgenic mouse models of tumorigenesis. Int. J. Dev. Biol. 42:995-1002. | |
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Coussens LM, Raymond W, Bergers G, Laig-Webster M, Behrendtsen O, Werb Z, Caughey G, Hanahan D. (1999) Inflammatory mast cells upregulate angiogenesis during squamous carcinogenesis. Genes & Development. 13:1382-1397. | |
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McKerrow JM, Bhargava V, Hansell E, Kuwahara T, Matley M, Coussens LM, Warren R. (2000) A functional proteomics screen of proteases in colorectal carcinomas. Molecular Medicine, 6: 450-460. | |
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Bergers G, Coussens LM. (2000) Extrinsic regulators of epithelial tumor progression: metalloproteinases. Curr. Opin. Genetics & Development, 10:120-127. | |
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Coussens LM, Tinkle CL, Hanahan DH, Werb Z. (2000) MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis. Cell 103:481-490. | |
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Coussens LM, Werb, Z. (2001) Inflammatory cells and cancer: Think Different! J. Exp. Med., 193:F23-F26. | |
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Coussens LM, Fingleton B, Matrisian LM. (2002) Status of matrix metalloproteinase inhibitors as anti-cancer therapeutics. Science, 295:2387-2392. | |
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Rhee JS, Coussens LM (2002) RECKing MMP Function: Implications for cancer development. Trends in Cell Biology, 12: 209-211. | |
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van Kempen LCL, Coussens LM. (2002) MMP9 potentiates pulmonary metastasis formation. Cancer Cell, 2:251-252. | |
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van Kempen LCL, Rhee JS, Dehne K, Lee J, Edwards DR, Coussens LM. (2002) Epithelial carcinogenesis: Dynamic interplay between neoplastic cells and their microenvironment. Differentiation, 70: 610-623 | |
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Coussens LM, Werb Z. (2002) Inflammation and cancer. Nature, 420: 860-867. | |
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Daniel D, Meyer-Morse N, Bergsland EK, Dehne K, Coussens LM, Hanahan D. (2003) Immune enhancement of squamous epithelial carcinogenesis by CD4+ T cells. J Exp. Med, 197:1017-1028. | |
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van Kempan LCL, Ruitter DJ, van Muijen GNP, Coussens LM. (2003) The tumor microenvironment: a critical determinant of neoplastic evolution. Euro. J. Cell Biol, 82:539-548. | |
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Rhee JS, Diaz R, Korets L, Hogson G, Coussens LM. (2004) TIMP-1 alters susceptibility to carcinogenesis. Cancer Research, 64:952-961. | |
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Chantrain CF, Shimada H, Groshen S, Ye W, Shalinsky DR, Werb Z, Coussens LM, DeClerck YA. (2004) Stromal matrix metalloproteinase-9 (MMP-9) regulates the vascular architecture in neuroblastoma by promoting pericyte recruitment. Cancer Research, 64:1675-1686. | |
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Baluk P, Raymond WW, Ator E, Coussens LM, McDonald DM, Caughey GH. (2004) MMP-2 and -9 expression increases in mycoplasma-infected airways but is not required for vascular remodeling. Am J Physiol Lung Cell Mol Physiol, 287:307-317. | |
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Balkwill F, Coussens LM. (2004) Inflammation and cancer Ð the missing link? Nature 431:405-406. | |
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deVisser K, Korets L, Coussens LM. (2004) Early neoplastic progression is complement-independent. Neoplasia, 6: 768-776. | |
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Robinson S, Coussens LM. (2005) Soluble mediators of inflammation during tumor development. Adv Cancer Research 93:159-187. | |
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Jodele S, Chantrain CF, Blavier L, Crooks GM, Shimada H, Coussens LM, DeClerck YA. (2005) The contribution of bone marrow-derived cells to the tumor vasculature in neuroblastoma is matrix metalloproteinase-9-dependent. Cancer Research, 65: 3200-3208 | |
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de Visser KE, Korets LV, Coussens LM. (2005) De novo carcinogenesis promoted by chronic inflammation is B lymphocyte-dependent. Cancer Cell, 7:411-423. | |
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de Visser KE, Coussens LM. (2005) The interplay between innate and adaptive immunity regulates cancer development. Cancer Immunology & Immunotherapy, 54:1143-1152. | |
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Fingleton B, Coussens LM. (2005) Host-tumor interactions influencing cancer progression. Drug Discovery Today: Disease Mechanisms, 2:199-204 | |
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de Visser KE, Eichten A, Coussens LM. (2006) Paradoxical roles of the immune system during cancer development. Nature Reviews Cancer, 6:24-37. | |
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Tlsty TD, Coussens LM. (2006) Tumor stroma and regulation of cancer development. Ann Rev Pathol. Mech of Disease, 1: 119-150 | |
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van Kempen LCL, de Visser KE, Coussens LM. (2006) Inflammation, Proteases and Cancer. Euro J Cancer, 42: 728-734 | |
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Yuan F, Verhelst HL, Blum G, Coussens LM, Bogyo M. (2006) A selective activity-based probe for the papain family cysteine protease dipeptidyl peptidase I/Cathepsin C. J Am Chem Society, 128: 5616-5617. | |
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Tan TT, Coussens LM. Humoral immunity, inflammation and cancer. (2007) Curr Opin Immunology 19(2), 209-216. | |
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Johansson M, Tan T, de Visser KE, Coussens LM. (2007) Immune cells as anti-cancer therapeutic targets and tools. J Cellular Biochemistry, in press. Epub ahead of press Jan 30, 2007. | |
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Schwartz DR, Moin K, Yao B, Matrisian LM, Coussens LM, Bugge TH, Fingleton B, Acuff KB, Sinnamon M, Nassar H, Krawetz SA, Linebaug BE, Sloane, BF. (2007) Hu/Mu ProtIn oligonucleotide microarray: dual species array for profiling protease and protease inhibitor gene expression in tumors and their microenvironment. Mol Cancer Res, 5:443-454. | |
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Egeblad M, Shen HCJ, Behonick DJ, Wilmes L, Eichten A, Korets L, Kheradmand F, Werb Z, Coussens LM. (2007). Type I collagen is a modifier of matrix metalloproteinase 2 function in skeletal development. Dev Dynamics, 36:1683-1693. | |
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Eichten AE, Hyun WC, Coussens LM. (2007) Distinctive features of angiogenesis and lymphangiogenesis determine their functionality during de novo tumor development. Cancer Research, 67:5211-5220. | |
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Affara NI, Coussens LM. (2007) IKKalpha at the crossroads of inflammation and metastasis. Cell, 129: 25-26. | |
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6/7/07 |
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