Professor, Cancer Research Institute and Anatomic Pathology, UCSF
Member, Biomedical Sciences Graduate Program (BMS), Herbert Boyer Program in Biological Sciences (PIBS), and Immunology Graduate Program, UCSF
Co-Director, Mouse Pathology Core Facility, UCSF Helen Diller Family Comprehensive Cancer Center
| CONTACT | |
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lisa.coussens@ucsf.edu Box 0502, UCSF; San Francisco, CA 94143-0502 |
additional websites: |
| EDUCATION | |
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San Francisco State University, B.A., Biology, 1976-1980 |
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| PROFESSIONAL EXPERIENCE | |
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1981-1988 |
Research Associate, Molec. & Devel. Biology, Genentech, Inc., South San Francisco |
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1997-1999 |
Assistant Research Biochemist, Hormone Research Inst., University of California, San Francisco |
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1999-2004 |
Assistant Professor, In Residence, Cancer Research Institute & Dept of Pathology, University of California, San Francisco |
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2004-2006 |
Associate Professor, In Residence, Cancer Research Institute & Dept. of Pathology, University of California, San Francisco |
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2006-2007 |
Associate Professor, Dept. of Pathology & Cancer Research Institute, University of California, San Francisco |
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2007-present |
Professor, Dept. of Pathology & Cancer Research Institute, University of California, San Francisco |
| HONORS & AWARDS | |
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1985, 1986, 1988 |
Recognition Award, Genentech, Inc. |
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1996-1998 |
Am. Social Health Assoc/Pfizer Postdoctoral Research Fellowship in Sexually Transmitted Diseases |
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2000-2002 |
Hellman Family Award For Early Career Faculty |
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2000-2002 |
V Foundation Scholar, The V Foundation for Cancer Research |
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2000-2003 |
Edward Mallinckrodt, Jr. Foundation Award for Medical Research, Edward Mallinckrodt, Jr. Foundation |
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2001-2002 |
Gertrude B. Elion Cancer Research Award, American Assoc. for Cancer Research |
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2006-2011 |
Era of Hope Scholar Award, Dept. of Defense Breast Cancer Research Program |
| SELECTED PUBLICATIONS | |
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Coussens LM, Hanahan D, Arbeit J. (1996) Genetic predisposition and parameters of malignant progression in K14-HPV16 transgenic mice. Am. J. Pathol. 149:1899-1917. |
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Coussens LM, Raymond WW, Bergers G, Laig-Webster M, Behrendtsen O, Werb Z, Caughey, GH, Hanahan D. (1999) Inflammatory mast cells upregulate angiogenesis during squamous epithelial carcinogenesis. Genes & Development 13:1382-1397. |
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Coussens LM, Tinkle CL, Hanahan DH, Werb Z. (2000) MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis. Cell 103:481-490. |
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Coussens LM, Fingleton B, Matrisian LM. (2002) Matrix metalloproteinases and cancer: Trials and tribulations. Science 295:2387-2392. |
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Coussens LM, Werb Z. (2002) Inflammation and cancer. Nature 420: 860-867. |
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Daniel D, Meyer-Morse N, Bergsland EK, Dehne K, Coussens LM, Hanahan D. (2003) Immune enhancement of skin carcinogenesis by CD4+ T cells. J Exp. Med, 197:1017-1028. |
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Rhee JS, Diaz R, Korets L, Hogson G, Coussens LM. (2004) TIMP-1 alters susceptibility to carcinogenesis. Cancer Research 64:952-961. |
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de Visser KE, Korets LV, Coussens LM. (2004) Early neoplastic progression is complement-independent. Neoplasia 6: 768-776. |
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de Visser KE, Korets LV, Coussens LM. (2005) De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent. Cancer Cell 7:411-423. [link] |
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de Visser KE, Eichten A, Coussens LM. (2006) Paradoxical roles of the immune system during cancer development. Nature Reviews Cancer, 6:24-37. [link] |
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Tlsty TD, Coussens LM. (2006) Tumor stroma and regulation of cancer development. Ann Rev Pathol. Mech of Disease, 1: 119-150. [link] |
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Tan TT, Coussens LM. Humoral immunity, inflammation and cancer. (2007) Curr Opin Immunology 19(2), 209-216 |
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Egeblad M, Shen HCJ, Behonick DJ, Wilmes L, Eichten A, Korets L, Kheradmand F, Werb Z, Coussens LM. (2007). Type I collagen is a modifier of matrix metalloproteinase 2 function in skeletal development. Dev Dynamics, 36:1683-1693. |
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Eichten AE, Hyun WC, Coussens LM. (2007) Distinctive features of angiogenesis and lymphangiogenesis determine their functionality during de novo tumor development. Cancer Research, 67:5211-5220. [link] |
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DeNardo DG, Johansson M, Coussens LM. (2008) Immune cells as mediators of solid tumor metastasis. Cancer Metastasis Rev. 27:11-18. |
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Johansson M, DeNardo DG, Coussens LM. (2008) Polarized immune responses differentially regulate cancer development. Immunol Rev., 222:145-154. |
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Kenny H, Kaur S, Coussens LM, Lengyel E. (2008) Adhesion of OvCa cells to peritoneum is mediated by MMP-2 cleavage of fibronectin, J Clin Invest. 118(4):1367-1379. |
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Watkins GA, Jones EF, Shell MS, VanBrocklin HV, Pan MH, Hanrahan SM, Feng JJ, He J, Sounni NE, Dill KA, Contag CH, Coussens LM, Franc BL. (2009) Development of an optimized activatable MMP-14 targeted SPECT imaging probe. Bioorganic & Medicinal Chemistry, 17:653-659. |
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DeNardo DG, Baretto JB, Andreu P, Vasquez L, Kolhatkar N, Coussens LM. (2009) CD4+ T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell, 16:91-102. [link] |
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9/12/09 |
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