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Helen Diller Family Compr Cancer Ctr
LISA M. COUSSENS, PHD

Professor, Cancer Research Institute and Anatomic Pathology, UCSF
Member, Biomedical Sciences Graduate Program (BMS) and Herbert Boyer Program in Biological Sciences (PIBS), UCSF
Co-Director, Mouse Pathology Core Facility, UCSF Helen Diller Family Comprehensive Cancer Center

CONTACT

lisa.coussens@ucsf.edu
(415) 502-6378 and 514-0231 (voice)
(415) 514-0878 (fax)

Box 0502, UCSF; San Francisco, CA 94143-0502

additional websites:

Coussens Lab Website

EDUCATION

San Francisco State University, B.A., Biology, 1976-1980
University of California, Los Angeles, Ph.D., Biological Chemistry, 1988-1993
University of California, San Francisco, Postdoctoral Fellow, Cancer Biology, 1993-1997

PROFESSIONAL EXPERIENCE

1981 - 1988

Research Associate, Molec. & Devel. Biology, Genentech, Inc., South San Francisco

1997 - 1999

Assistant Research Biochemist, Hormone Research Inst., University of California, San Francisco

1999 - 2004

Assistant Professor, In Residence Cancer Research Institute & Dept of Pathology, University of California, San Francisco

2004 - 2006

Associate Professor, In Residence Cancer Research Institute & Dept. of Pathology, University of California, San Francisco

2006 - 2007

Associate Professor, Dept. of Pathology & Cancer Research Institute, University of California, San Francisco

2007 - present

Professor, Dept. of Pathology & Cancer Research Institute, University of California, San Francisco

HONORS & AWARDS

1985, 1986, 1988

Recognition Award, Genentech, Inc.

1996-1998

Am. Social Health Assoc/Pfizer Postdoctoral Research Fellowship in Sexually Transmitted Diseases

2000-2002

Hellman Family Award For Early Career Faculty

2000-2002

V Foundation Scholar, The V Foundation for Cancer Research

2000-2003

Edward Mallinckrodt, Jr. Foundation Award for Medical Research, Edward Mallinckrodt, Jr. Foundation

2001-2002

Gertrude B. Elion Cancer Research Award, American Assoc. for Cancer Research

2006-2011

Era of Hope Scholar Award, Dept. of Defense Breast Cancer Research Program

SELECTED PUBLICATIONS - PEER-REVIEWED

Mosthaf L, Grako D, Dull T, Coussens L, Ullrich A, McClain D. (1990) Functionally distinct insulin receptors generated by tissue-specific alternative splicing. EMBO J. 9(8): 2409-2413.

Coussens LM, Yokoyama K, Chiu R. (1994) Transforming Growth Factor b1-mediated induction of junB is selectively inhibited by expression of Ad.12-E1A. J. Cell. Physio. 160:435-444.

Coussens LM, Hanahan D, Arbeit J. (1996) Genetic predisposition and parameters of malignant progression in K14-HPV16 transgenic mice. Am. J. Pathol. 149:1899-1917.

Coussens LM, Werb Z. (1996) Matrix metalloproteinases and the development of cancer. Chem. & Biol. 3:895-904.

Bergers G, Hanahan D, Coussens LM. (1998) Angiogenesis and apoptosis are cellular parameters regulating neoplastic progression in transgenic mouse models of tumorigenesis. Int. J. Dev. Biol. 42:995-1002.

Coussens LM, Raymond W, Bergers G, Laig-Webster M, Behrendtsen O, Werb Z, Caughey G, Hanahan D. (1999) Inflammatory mast cells upregulate angiogenesis during squamous carcinogenesis. Genes & Development. 13:1382-1397.

McKerrow JM, Bhargava V, Hansell E, Kuwahara T, Matley M, Coussens LM, Warren R. (2000) A functional proteomics screen of proteases in colorectal carcinomas. Molecular Medicine, 6: 450-460.

Bergers G, Coussens LM. (2000) Extrinsic regulators of epithelial tumor progression: metalloproteinases. Curr. Opin. Genetics & Development, 10:120-127.

Coussens LM, Tinkle CL, Hanahan DH, Werb Z. (2000) MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis. Cell 103:481-490.

Coussens LM, Werb, Z. (2001) Inflammatory cells and cancer: Think Different! J. Exp. Med., 193:F23-F26.

Coussens LM, Fingleton B, Matrisian LM. (2002) Status of matrix metalloproteinase inhibitors as anti-cancer therapeutics. Science, 295:2387-2392.

Rhee JS, Coussens LM (2002) RECKing MMP Function: Implications for cancer development. Trends in Cell Biology, 12: 209-211.

van Kempen LCL, Coussens LM. (2002) MMP9 potentiates pulmonary metastasis formation. Cancer Cell, 2:251-252.

van Kempen LCL, Rhee JS, Dehne K, Lee J, Edwards DR, Coussens LM. (2002) Epithelial carcinogenesis: Dynamic interplay between neoplastic cells and their microenvironment. Differentiation, 70: 610-623

Coussens LM, Werb Z. (2002) Inflammation and cancer. Nature, 420: 860-867.

Daniel D, Meyer-Morse N, Bergsland EK, Dehne K, Coussens LM, Hanahan D. (2003) Immune enhancement of squamous epithelial carcinogenesis by CD4+ T cells. J Exp. Med, 197:1017-1028.

van Kempan LCL, Ruitter DJ, van Muijen GNP, Coussens LM. (2003) The tumor microenvironment: a critical determinant of neoplastic evolution. Euro. J. Cell Biol, 82:539-548.

Rhee JS, Diaz R, Korets L, Hogson G, Coussens LM. (2004) TIMP-1 alters susceptibility to carcinogenesis. Cancer Research, 64:952-961.

Chantrain CF, Shimada H, Groshen S, Ye W, Shalinsky DR, Werb Z, Coussens LM, DeClerck YA. (2004) Stromal matrix metalloproteinase-9 (MMP-9) regulates the vascular architecture in neuroblastoma by promoting pericyte recruitment. Cancer Research, 64:1675-1686.

Baluk P, Raymond WW, Ator E, Coussens LM, McDonald DM, Caughey GH. (2004) MMP-2 and -9 expression increases in mycoplasma-infected airways but is not required for vascular remodeling. Am J Physiol Lung Cell Mol Physiol, 287:307-317.

Balkwill F, Coussens LM. (2004) Inflammation and cancer Ð the missing link? Nature 431:405-406.

deVisser K, Korets L, Coussens LM. (2004) Early neoplastic progression is complement-independent. Neoplasia, 6: 768-776.

Robinson S, Coussens LM. (2005) Soluble mediators of inflammation during tumor development. Adv Cancer Research 93:159-187.

Jodele S, Chantrain CF, Blavier L, Crooks GM, Shimada H, Coussens LM, DeClerck YA. (2005) The contribution of bone marrow-derived cells to the tumor vasculature in neuroblastoma is matrix metalloproteinase-9-dependent. Cancer Research, 65: 3200-3208

de Visser KE, Korets LV, Coussens LM. (2005) De novo carcinogenesis promoted by chronic inflammation is B lymphocyte-dependent. Cancer Cell, 7:411-423.

de Visser KE, Coussens LM. (2005) The interplay between innate and adaptive immunity regulates cancer development. Cancer Immunology & Immunotherapy, 54:1143-1152.

Fingleton B, Coussens LM. (2005) Host-tumor interactions influencing cancer progression. Drug Discovery Today: Disease Mechanisms, 2:199-204

de Visser KE, Eichten A, Coussens LM. (2006) Paradoxical roles of the immune system during cancer development. Nature Reviews Cancer, 6:24-37.

Tlsty TD, Coussens LM. (2006) Tumor stroma and regulation of cancer development. Ann Rev Pathol. Mech of Disease, 1: 119-150

van Kempen LCL, de Visser KE, Coussens LM. (2006) Inflammation, Proteases and Cancer. Euro J Cancer, 42: 728-734

Yuan F, Verhelst HL, Blum G, Coussens LM, Bogyo M. (2006) A selective activity-based probe for the papain family cysteine protease dipeptidyl peptidase I/Cathepsin C. J Am Chem Society, 128: 5616-5617.

Tan TT, Coussens LM. Humoral immunity, inflammation and cancer. (2007) Curr Opin Immunology 19(2), 209-216.

Johansson M, Tan T, de Visser KE, Coussens LM. (2007) Immune cells as anti-cancer therapeutic targets and tools. J Cellular Biochemistry, in press. Epub ahead of press Jan 30, 2007.

Schwartz DR, Moin K, Yao B, Matrisian LM, Coussens LM, Bugge TH, Fingleton B, Acuff KB, Sinnamon M, Nassar H, Krawetz SA, Linebaug BE, Sloane, BF. (2007) Hu/Mu ProtIn oligonucleotide microarray: dual species array for profiling protease and protease inhibitor gene expression in tumors and their microenvironment. Mol Cancer Res, 5:443-454.

Egeblad M, Shen HCJ, Behonick DJ, Wilmes L, Eichten A, Korets L, Kheradmand F, Werb Z, Coussens LM. (2007). Type I collagen is a modifier of matrix metalloproteinase 2 function in skeletal development. Dev Dynamics, 36:1683-1693.

Eichten AE, Hyun WC, Coussens LM. (2007) Distinctive features of angiogenesis and lymphangiogenesis determine their functionality during de novo tumor development. Cancer Research, 67:5211-5220.

Affara NI, Coussens LM. (2007) IKKalpha at the crossroads of inflammation and metastasis. Cell, 129: 25-26.

6/7/07

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