Jason.Cyster@ucsf.edu
(415) 502-6427 and 514-2943 (voice)
(415) 502-8424 (fax)

Box 0414, UCSF; San Francisco, CA 94143-0414

additional websites:

Cyster Lab Website

University of Western Australia, B.S., 1988, Biochemistry and Microbiology
University of Oxford, England, D.Phil., 1992, Immunology
Stanford Univ. Med Center, Stanford, CA, PD Fellow, 1992-1995, Immunology

Schmidt, K.N., Hsu, C.W., Griffin, C.T., Goodnow, C.C. and Cyster, J.G. 1998. Spontaneous follicular exclusion of SHP1-deficient B cells is conditional on the presence of competitor B cells. J. Exp. Med. 187, 929-37.

Gunn, M.D., Ngo, V.N., Ansel, K.M., Ekland, E.H. Cyster, J.G. and Williams, L.T. 1998. A B-cell homing chemokine made in lymphoid follicles activates the BLR1 receptor. Nature 391, 799-803.

Ngo, V.N., Tang, H.L. and Cyster, J.G. 1998. EBI-1 ligand chemokine is expressed by dendritic cells in lymphoid tissues and strongly attracts naive T cells and activated B cells. J. Exp. Med. 188, 181-191.

Schmidt, K.N. and Cyster, J.G. 1999. Follicular exclusion and rapid elimination of HEL-binding B cells is dependent on competitor B cells but not on T cells. J. Immunol. 162, 284-291.

Ngo, V.N., Korner, H., Gunn, M.D., Schmidt, K.N., Riminton, S.D., Cooper, M.D., Browning, J.L., Sedgwick, J.D. and Cyster, J.G. 1999. Lymphotoxin-alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen. J. Exp. Med. 189, 403-412.

Tang, H.L. and Cyster J.G. 1999. Chemokine upregulation and activated T cell attraction by maturing dendritic cells. Science 284, 819-822.

Ansel, K.M., McHeyzer-Williams, L.J., Vu N. Ngo, McHeyzer-Williams, M.G. and Cyster, J.G. 1999. In vivo activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines. J. Exp. Med. 190, 1123-1134.

Cyster, J.G. 1999. Chemokines and cell migration in lymphoid organs (review). Science 286, 2098-2101.

Reif, K. and Cyster, J.G. 2000. RGS molecule expression in murine B lymphocytes and ability to downregulate chemotaxis to lymphoid chemokines. J.Immunol. 164, 4720-4729.

Luther, S.A., Lopez, T., Bai, W., Hanahan, D. and Cyster, J.G. 2000. BLC expression in pancreatic islets causes B cell recruitment and lymphotoxin-dependent lymphoid neogenesis. Immunity 12, 471-481.

Ansel, K.M., Ngo, V.N., Hyman, P.L., Luther, S.A., Forster, R., Sedgwick, J.D., Browning, J.L., Lipp, M. and Cyster, J.G. 2000. A chemokine driven positive feedback loop organizes lymphoid follicles. Nature 406, 309-314.

Matloubian, M., David, A., Engel, S., Ryan, J.E. and Cyster, J.G. 2000. A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo. Nature Immunology 1, 298-304.

Luther, S.A., Tang, H.L., Hyman, P.L., Farr, A.G. and Cyster, J.G. 2000. Co-expression of ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouse. Proc. Natl. Acad. Sci. USA 97, 12694-9.

Luther, S.A. and Cyster, J.G. 2001. Chemokines as regulators of T cell differentiation (review). Nature Immunol. 2, 102-107.

Ansel, K.M. and Cyster, J.G. 2001. Chemokines in lymphopoiesis and lymphoid organ development (review). Curr. Opin. Immunol. 13, 172-179.

Hargreaves, D.C., Hyman, P.L., Lu, T.T., Ngo, V.N., Bidgol, A., Suzuki, G., Zou, Y-R, Littman, D.R. and Cyster, J.G. 2001. A coordinated change in chemokine responsiveness guides plasma cell movements. J. Exp. Med. 194, 45-56.

Ansel, K.M., Harris, R.B.S. and Cyster, J.G. 2002. CXCL13 is required for B1 cell homing, natural antibody production and body cavity immunity. Immunity 16, 67-76.

Reif, K., Ekland, E.H., Ohl, L., Nakano, H., Lipp, M., Forster, R. and Cyster, J.G. 2002. Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position. Nature 416, 94-99.

Luther, S.A., Bidgol, A., Hargreaves, D.C., Schmidt, A., Xu, Y., Painiyadi, J., Matloubian, M. and Cyster, J.G. 2002. Differing activities of homeostatic chemokines CCL19, CCL21 and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis. J. Immunol. 169, 424-433.

Okada, T., Ngo, V.N., Ekland, E., Fšrster, Lipp, M., Littman, D. R., and Cyster, J.G. 2002. Chemokine requirements for B cell entry to lymph nodes and Peyer's patches. J. Exp. Med. 196, 65-75.

Lu, T. and Cyster, J.G. 2002. Integrin-mediated long-term B cell retention in the splenic marginal zone. Science 297, 409-412.

Reif, K. and Cyster, J.G. 2002. The CDM protein DOCK2 in lymphocyte migration (review). Trends Cell Biol. 12, 368-373.

Lo, C.G, Lu T.T, Cyster J.G. 2003. Integrin-dependence of lymphocyte entry into the splenic white pulp. J Exp Med. 197, 353-61.

Cyster, J.G. 2003. Homing of antibody secreting cells (review). Immunol. Rev. 194:48-60.

Luther, S.A., Ansel, K.M. and Cyster, J.G. 2003. Overlapping roles of CXCL13, IL-7 receptoralpha and CCR7 ligands in lymph node development. J Exp. Med. 197, 1191-1198.

Cyster, J.G. 2003. Lymphoid organ development and cell migration (Introduction to volume). Immunol. Rev. 195, 3-14.

Cyster, J.G. and von Andrian, U. 2003. Dynamics of B cell migration to secondary lymph organs. Chapter in Molecular Biology of B Cells, F. W. Alt, T. Honjo and M.S. Neuberger, Eds. In Press.

Matloubian, M., Lo, C.G., Cinamon, G., Lesneski. M.J., Xu, Y., Brinkmann. V., Allende. M.L., Proia, R.L., Cyster. J.G. 2004. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 427, 355-360

Ekland, E.H., Forster, R., Lipp, M. and Cyster J.G. 2004. Requirements for follicular exclusion and competitive elimination of autoantigen binding B cells. J. Immunol. 172, 4700-4708

Lesley, R., Xu, Y., Kalled, S.L., Hess, D.M., Schwab, S., Shu, H-B. and Cyster J.G. 2004. Reduced competititveness of autoantigen-engaged B cells due to increased dependence on BAFF. Immunity 20, 441-453.

Cinamon G, Matloubian M, Lesneski MJ, Xu Y, Low C, Lu T, Proia RL, Cyster, JG. 2004. Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone. Nat Immunol. 5, 713-20.

Reif K, Okkenhaug K, Sasaki T, Penninger JM, Vanhaesebroeck B, Cyster JG. 2004. Cutting edge: differential roles for phosphoinositide 3-kinases, p110 gamma and p110 delta, in lymphocyte chemotaxis and homing. J Immunol 173, 2236-40.

Allen, C.D., Ansel, K.M., Low, C., Lesley, R., Tamamura, H., Fujii, N., Cyster, J.G. 2004. Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5. Nat Immunol. 5, 943-52.

Cyster, J.G. 2004. Chemokines, Sphingosine-1-Phosphate, and Cell Migration in Secondary Lymphoid Organs. Annu Rev Immunol. 23, 127-59.

Lo, C.G., Ying, X., Proia, R.L. and Cyster, J.G. 2005. Cyclical modulaton of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit. J Exp. Med. 201, 291-301.

Okada, T., Miller, M.J., Parker, I., Krummel, M.F., Neighbors, M., Hartley, S.B., OÕGarra, A., Cahalan, M.D. and Cyster, J.G. 2005. Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells. PLoS Biology 3, e150.

Kabashima, K., Banks, T.A., Ansel, K.M., Lu, T.T., Ware, C.F. and Cyster, J.G. 2005. Intrinsic lymphotoxin-b receptor requirement for homeostasis of lymphoid tissue dendritic cells. Immunity 22, 439-450.

Schwab, S., Pereira, J.P., Matloubian, M., Xu, Y., Huang, Y. and Cyster, J.G. 2005. Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science 309, 1735-1739.

Okada T, and Cyster J.G. 2006. B cell migration and interactions in the early phase of antibody responses. Curr Opin Immunol. 18, 278-85.

Shiow, L.R., Rosen, D.B., Brdickova, N., Xu, Y., An, J., Lanier, L.L., and Cyster, J.G.*, Matloubian, M.* 2006. CD69 acts downstream of interferon-alpha/beta to inhibit S1P(1) and lymphocyte egress from lymphoid organs. Nature 440, 540-4. *corresponding authors

Lesley, R., Kelly, L.M., Xu, Y. and Cyster, J.G. 2006. Na•ve CD4 T cells constitutively express CD40L and augment autoreactive B cell survival. Proc. Natl. Acad. Sci. 103, 10717-22.

12/8/06