Jason G. Cyster, PhD

University of Western Australia, B.S., 1988, Biochemistry and Microbiology
University of Oxford, England, D.Phil., 1992, Immunology
Stanford Univ. Med Center, Stanford, CA, PD Fellow, 1992-1995, Immunology

• 1995-2000
  Assistant Professor, Dept. of Microbiology and Immunology, Univ. of California, San Francisco
• 2000-present
  Investigator, Howard Hughes Medical Institute
• 2000-2004
  Associate Professor, Dept. of Microbiology and Immunology, Univ. of California, San Francisco
• 2004-present
  Professor, Dept of Microbiology & Immunology, Univ. of California, San Francisco

• 1984
  The Beazely Award for secondary education in Western Australia
• 1988
  J.A. Wood Memorial prize from the University of Western Australia
• 1989-1992
  Commonwealth Overseas Studentship
• 1992-1995
  Cancer Research Institute Postdoctoral Fellowship
• 1996-2000
  Pew Scholar in the Biomedical Sciences
• 1997
  Cheryl Whitlock Memorial Prize for Postdoctoral Studies
• 1998-2003
  David and Lucile Packard Foundation Fellowship
• 2005
  AAI BD Biosciences Investigator Award

• Cyster, J.G. 2004. Chemokines, Sphingosine-1-Phosphate, and Cell Migration in Secondary Lymphoid Organs. Annu Rev Immunol. 23, 127-59.
• Okada, T., Miller, M.J., Parker, I., Krummel, M.F., Neighbors, M., Hartley, S.B., O’Garra, A., Cahalan, M.D. and Cyster, J.G. 2005. Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells. PLoS Biology 3, e150.
• Schwab, S., Pereira, J.P., Matloubian, M., Xu, Y., Huang, Y. and Cyster, J.G. 2005. Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science 309, 1735-1739.
• Kabashima, K., Haynes, N.M., Xu, Y., Nutt, S.L., Allende, M.L., Proia, R.L. and Cyster, J.G. 2006. Plasma cell S1P1 expression determines secondary lymphoid organ retention versus bone marrow tropism. J. Exp. Med. 203: 2683-90
• Allen, C.D.C., Okada, T., Tang, H.L. and Cyster, J.G. 2007. Imaging of Germinal Center Selection Events During Affinity Maturation. Science 315, 528-31.
• Phan, T.G., Grigorova, I., Okada, T. & Cyster, J.G. 2007. Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells. Nat. Immunol. 8, 992-1000
• Cinamon, G., Zachariah, M.A., Lam, O.M., Foss, F.W. and Cyster, J.G. 2008. Follicular shuttling of marginal zone B cells facilitates antigen transport. Nat. Immunol. 9, 54-62
• Pham, T.H.M., Okada, T., Matloubian, M., Lo, C.G. and Cyster, J.G. 2008. S1P1 receptor signaling overrides retention mediated by Gai-coupled receptors to promote T cell egress. Immunity 28, 122-33
• Shiow, L.R., Roadcap R.W., Paris K., Watson S.R, Grigorova, I.L., Levet T., An J., Xu Y., Jenne C.N., Foger N., Sorensen R.U., Goodnow C.C., Bear J.E., Puck J.M. and Cyster J.G. 2008. Coronin-1A is mutated in a thymic egress mouse strain and a T-B+NK+ SCID patient. Nat. Immunol. 9, 1307-1315.
• Grigorova, I.L., Schwab, S.R., Phan, T.G., Pham, T.H., Okada, T. and Cyster J.G. 2009. Cortical sinus probing, S1P1-dependent enter and flow-based capture of egressing T cells. Nat. Immunol. 10, 58-65.
• Pereira, J. P., An, J., Xu, Y., Huang, Y. and Cyster, J.G. 2009. Cannabionoid receptor 2 meidates the retention of immature B cells in bone marrow sinusoids. Nat. Immunol. 10, 403-11.
• Phan, T.G.,Green, J.A., Gray, E., Xu Y. and Cyster J.G. 2009. Immune complex relay by subcapsular sinus macrophages and noncognate B cells drives antibody affinity maturation. Nat. Immunol. 10, 786-93.
• Suzuki, K., Grigorova, I., Phan, T.G., Kelly, L.M., Cyster, J.G. 2009. Visualizing B cell capture of cognate antigen from follicular dendritic cells. J Exp Med. 206, 1485-93.
• Pereira, J.P., Kelly, L.M., Xu, Y. and Cyster, J.G. 2009. EBI2 mediates B cell segregation between the outer and center follicle. Nature 460, 1122-6.
• Pham TH, Baluk P, Xu Y, Grigorova I, Bankovich AJ, Pappu R, Coughlin SR, McDonald DM, Schwab SR, Cyster JG. 2010. Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning. J Exp Med. 207,17-27