urologylab@aol.com
(415) 750-6964 (voice)
(415) 750-6639 (fax)

Veterans Affairs Medical Center, VAMC 112F, San Francisco, CA 94121

Kurukshetra University, India, MS, 1978, Biochemistry
Postgraduate Institute of Medical Education and Research, Chandigarh, India, PhD, 1982, Biochemistry
University of Chicago, Chicago, IL, Post-Doc, 1983-1987, Biochemistry

(selected from a total of 240)

Li, L-C, Chui, R., Nakajima, K., Oh, B.R., Au, H.C. and Dahiya, R. Frequent methylation of estrogen receptor in prostate cancer: Correlation with tumor progression. Cancer Res. 60: 702-706, 2000.

Li, L-C, Yeh, C-C, Nojima, D., and Dahiya, R. Cloning and characterization of human estrogen receptor beta promoter. Biochem. Biophys. Res. Commun. 275: 682-689, 2000.

Li, L-C, Chui, R.M., Nakajima, K, Sasaki, M., Perinchery, G., Au, H., Nojima, D., Carroll, P., and Dahiya, R. A single nucleotide polymorphism in the E-cadherin gene promoter alters transcriptional activities. Cancer Res. 60:873-876 , 2000.

Wang, Y., Hayward, S.W., Donjacour, A.A., Young, P., Jacks, T., Sage, J., Dahiya, R., Cardiff, R.D., Day, M.L. and Cunha, G.R. Sex hormone-induced prostatic carcinogenesis in RB-deficient prostate tissue. Cancer Res. 60:6008-6017, 2000.

Oh, B.R., Sasaki, M., Perinchery, G., Ryu, S.B., Park, Y.I., Carroll, P. and Dahiya, R. Frequent genotype changes at Ð308, and 488 regions of the tumor necrosis factor-a (TNF-a) in patients with prostate cancer. J. Urol. 163:1584-1587, 2000.

Nojima, D., Li, L-C, Dharia, D., Perinchery, G., Ribeiro-Filho, L.A., Alonzo, J., and Dahiya, R. CpG hypermethylation of promoter region inactivates estrogen receptor beta gene in prostate cancer. Cancer 92:2076-83, 2001.

Li, L-C, Zhao, H.,Nakajima, K., Oh, B.R., Ribeiro-Filho, L.A., Carroll, P., and Dahiya, R. A specific methylation pattern of E-cadherin gene promoter is associated with the pathological grades in prostate cancer. J. Urol. 166:705-709, 2001.

Wang, Y. Z., Sudilovsky, D., Zhang, B., Haughney, P.C., Rosen, M.A., Wu, D.S., Cunha, T.J., Dahiya, R., Cunha, G.R. and Hayward, S.W. A human prostatic epithelial model of hormonal carcinogenesis. Cancer Res. 61: 6064-6072, 2001.

Shiina, H., Igawa, M., Urakami, S., Shigeno, K., Yoneda, T., Terashima, M., Deguchi, M., Ribeiro-Filho, L., and Dahiya, R. Alterations of beta- and gamma- catenin in N-Butyl-N-(-4-hydroxybutyl) nitrosamine-induced murine bladder cancer. Cancer Res. 61: 7101-7109, 2001.

Yeh, C-C, Lee, C. and Dahiya, R. DNA mismatch repair enzyme activity and genes expression in prostate cancer. Biochem. Biophys. Res. Commun. 285: 409-413, 2001.

Sasaki, M., Dharia, A., Oh, B.R., Tanaka, Y., Fujimoto, S-I, and Dahiya, R. Progesterone receptor B gene inactivation and CpG hypermethylation in human uterine endometrial cancer. Cancer Res. 61: 97-102, 2001.

Sasaki, M., Kotcherguina, I., Dharia, A., Fujimoto, S-I, and Dahiya, R. Cytosine-phosphoguanine methylation of estrogen receptors in endometrial cancer. Cancer Res. 61: 326-326, 2001.

Sasaki M, Tanaka Y, Perinchery G, Dharia A, Kotcherguina I, Fujimoto S, Dahiya R. Methylation and inactivation of estrogen, progesterone, and androgen receptors in prostate cancer. J Natl Cancer Inst 94:384-90, 2002.

Patra SK, Patra A, Zhao H, Dahiya R. DNA methyltransferase and demethylase in human prostate cancer. Mol Carcinog 33:163-71, 2002.

Tanaka Y, Sasaki M, Kaneuchi M, Fujimoto S, Dahiya R. Single nucleotide polymorphisms of estrogen receptor alpha in human renal cell carcinoma. Biochem Biophys Res Commun 296(5):1200, 2002.

Ribeiro-Filho LA, Franks J, Sasaki M, Shiina H, Li LC, Nojima D, Arap S, Carroll P, Enokida H, Nakagawa M, Yonezawa S, Dahiya R. CpG hypermethylation of promoter region and inactivation of E-cadherin gene in human bladder cancer. Mol Carcinog 34(4):187-98, 2002.

Shiina H, Igawa M, Breault J, Ribeiro-Filho L, Pookot D, Urakami S, Terashima M, Deguchi M, Yamanaka M, Shirai M, Kaneuchi M, Kane CJ, Dahiya R. The human T-cell factor-4 gene splicing isoforms, Wnt signal pathway, and apoptosis in renal cell carcinoma. Clin Cancer Res. 9(6):2121-32, 2003.

Sasaki M, Tanaka Y, Kaneuchi M, Sakuragi N, Dahiya R. CYP1B1 gene polymorphisms have higher risk for endometrial cancer, and positive correlations with estrogen receptor alpha and estrogen receptor beta expressions. Cancer Res. 63(14):3913-8, 2003.

Sasaki M, Kaneuchi M, Sakuragi N, Dahiya R. Multiple Promoters of Catechol-O-methyltransferase Gene Are Selectively Inactivated by CpG Hypermethylation in Endometrial Cancer. Cancer Res. 63(12):3101-3106, 2003.

Tanaka, Y., Sasaki, M., Kaneuchi, M., Shiina, H. and Dahiya, R. Polymorphisms of Estrogen receptor alpha in prostate cancer. Molecular Carcinogen. 37: 202-208, 2003.

Mutaguchi, K., Yasumoto, H., Mita, K., Matsubara, A., Shiina, H., Igawa, M., Dahiya, R., and Usui, T. Restoration of IGFBP-rP1 has a tumor-suppressive activity through induction of apoptosis in human prostate cancer. Cancer Res. 63: 7717-7723, 2003.

Li, L-C, Zhao, H., Shiina, H., Kane, C. and Dahiya, R. PGDB: a curated and integrated database of genes related to the prostate. Nucleic Acid Res. 31:291-293, 2003.

Enokida H, Shiina H, Igawa M, Ogishima T, Kawakami T, Bassett WW, Anast JW, Li LC, Urakami S, Terashima M, Verma M, Kawahara M, Nakagawa M, Kane CJ, Carroll PR, Dahiya R. CpG hypermethylation of MDR1 gene contributes to the pathogenesis and progression of human prostate cancer. Cancer Res. 64(17):5956-62, 2004.

Sasaki M, Tanaka Y, Okino ST, Nomoto M, Yonezawa S, Nakagawa M, Fujimoto S, Sakuragi N, Dahiya R. Polymorphisms of the CYP1B1 gene as risk factors for human renal cell cancer. Clin Cancer Res. 10(6):2015-9, 2004.

Li LC, Shiina H, Deguchi M, Zhao H, Okino ST, Kane CJ, Carroll PR, Igawa M, Dahiya R. Age-dependent methylation of ESR1 gene in prostate cancer. Biochem Biophys Res Commun. 321(2):455-461, 2004.

Mochizuki, H., Matsubara, A, Teishima, J., Mutaguchi, K., Yasumoto, H., Shiina, H., Dahiya, R. Usui, T., and Kamiya, K. Interaction of ligand receptor system between stromal-cell-derived factor-1 and CXC chemokine receptor 4 in human prostate cancer: a possible predictor of metastasis. Biochem. Biophys. Res. Commun 320, 656-663, 2004.

Li LC, Okino ST, Dahiya R. DNA methylation in prostate cancer. Biochim Biophys Acta. 1704(2):87-102, 2004.

Li, L-C, Carroll, PR, Dahiya, R. Epigenetics changes in prostate cancer: implication for diagnosis and treatment. J. Natl. Cancer Institute 97: 103-115, 2005.

Shiina, H, Igawa, M, Breault, J, Enokida, H, Li, L-C, Deguchi, M, Terashima, M., Yoneda, T, Shigeno, K, Carroll, PR, and Dahiya, R. Epigenetic and epigenetic regulation of gamma-catenin gene in human prostate cancer. Cancer Res. 65(6):2130-8,+ 2005

Breault, JE, Shiina, H., Igawa, M., Ribeiro-Filho, LA, Deguchi, M, Enokida, H, Urakami, S., Terashima, M., Nakagawa, M, Kane, CJ, Carroll, PR, and Dahiya, R. Methylation of the {gamma}-Catenin gene is associated with poor prognosis of renal cell carcinoma. Clinical Cancer Res. 11:557-564, 2005.

Enokida, H., Shiina, H., Urakami, S., Igawa, M., Ogishima, T., Kawakami, T., Tokisane T, Pookot, D., Li, L-C, Tabatabai L, Kawahara, M., Nakagawa, M., Carroll, PR and Dahiya, R. Race-related differences in CpG hypermethylation of the GSTPI gene promoter among African American, Caucasian and Japanese patients with prostate cancer. Inter. J. cancer 116: 174-181, 2005.

Ogishima, T., Shiina, H., Igawa, M., Breault, J.E., Bassett, W.W., Terashima, M., Enokida, H., Li, L-C, Kawakami, T., Urakami, S, Pookot, D., Fujime, M and Dahiya, R. Increased heparanase expression is caused by promoter hypomethylation and up-regulation of transcriptional factor EGR-1 in human prostate cancer. Clinical Cancer Res. 11:1028-1036, 2005.

Enokida H, Shiina H, Urakami S, Terashima M, Ogishima T, Li LC, Kawahara M, Nakagawa M, Kane CJ, Carroll PR, Igawa M, Dahiya R. Smoking influences aberrant CpG hypermethylation of multiple genes in human prostate carcinoma. Cancer 106(1):79-86, 2006.

Urakami S, Shiina H, Enokida H, Kawakami T, Tokizane T, Ogishima T, Tanaka Y, Li LC, Ribeiro-Filho LA, Terashima M, Kikuno N, Adachi H, Yoneda T, Kishi H, Shigeno K, Konety BR, Igawa M, Dahiya R. Epigenetic inactivation of Wnt inhibitory factor-1 plays an important role in bladder cancer through aberrant canonical Wnt/beta-catenin signaling pathway. Clin Cancer Res. 12(2):383-91, 2006.

1/30/07