dairkes@sutterhealth.org
(415) 600-1653 (voice)
(415) 600-1725 (fax)

California Pacific Medical Ctr. Research Institute, 475 Brannan Street, San Francisco, CA 94107

University of Karachi, Pakistan, B.Sc., 1971, Biology
Columbia University, Ph.D., 1976, Human Genetics and Development
University of California, Berkeley, California, Postdoctoral Fellow, 1976, Cell and Molecular Biology

Dairkee, S.H., and Glaser, D.A. A mutagen-testing assay based on heterogeneity in diameter and integrated optical density of mammalian cells. Proc. Natl. Acad. Sci., USA, 81:2112-2116, 1984.

Dairkee, S.H., Blayney, C.M., Smith, H.S., and Hackett, A.J. Monoclonal antibody that defines human myoepithelium. Proc. Natl. Acad. Sci., USA, 82:7409-7412, 1985.

Dairkee, S.H., Blayney-Moore, C.M., Smith, H.S., and Hackett, A.J. Concurrent expression of basal and luminal epithelial markers in cultures of normal human breast analyzed with monoclonal antibodies. Differentiation 32:93-100, 1986.

Dairkee, S.H., Mayall, B.H., Smith, H.S., Hackett, A.J. Monoclonal marker that predicts early recurrence of breast cancer. Lancet, 1:514, 1987.

Smith, H.S., Wolman, S.R, Dairkee, S.H., Hancock, M.C., Lippman, M., Leff, A., Hackett, A.J. Immortalization in culture occurs at a late stage in progression of breast cancer. Journal of National Cancer lnstitute, 78:611-615, 1987.

Dardick, I., Rippstein, P., Skimming, L., Boivin, M., Parks, W.R., Dairkee, S.H. Immunohistochemistry and ultrastructure of myoepithelium and modified myoepithelium of the ducts of human major salivary glands: histogenetic implications for salivary gland tumors. Oral Med. Oral Surg. Oral Pathol., 64:703-715, 1987.

Bjorn, M.J., Smith, H.S., Dairkee, S.H. Response of primary human mammary tumor cell cultures to a monoclonal antibody-recombinant ricin A chain immunotoxin. Cancer Immunol. Immunother., 26:121-124, 1988.

Dairkee, S.H., Puett, L., Hackett, A.J. Expression of basal and luminal epithelium specific keratins in normal, benign and malignant breast tissue. Journal of National Cancer Institute, 80:691-695, 1988.

Dollbaum, C.M., Creasey, A.A., Dairkee, S.H., Hiller, A.J., Rudolph, A.R., Lin, L., Vitt, C., Smith, H.S. Specificity of TNF toxicity for human mammary carcinomas relative to normal mammary epithelium and correlation with response to adriamycin. Proc. Natl. Acad. Sci. USA, 85:4740-4744, 1988.

Dairkee, S.H., and Hackett, A.J. Internal antigens are accessible in breast cancer; implications for tumor targeting. Journal of National Cancer Institute, 80:1216-1220, 1988.

Dardick, I., Claude, A., Parks, W.R., Hoppe, D., Stinson, J., Burns, B.G., Dairkee, S.H. Warthin's Tumor: Ultrastructural and Immunohistochemical study of Basilar Epithelium. Ultrastructural Pathology 12:419-432, 1988.

Tsubura, A., Inui, T., Morii, S., Dairkee, S.H., Oikawa, T., Matsuzawa, A. Loss of basal cell phenotype with acquisition of lung-colonizing capability in mouse mammary tumors. Breast Cancer Res. & Treatment17: 239-243, 1990.

Dairkee, S.H., Puett, L., Counelis, A.M., Hackett, A.J. Accessibility to intracellular antigens within nutritionally-deprived human mammary epithelial cells. Exp. Cell Res. 192:182-188, 1991.

Dairkee, S.H., and Hackett, A.J. Differential retention of Rhodamine 123 by breast carcinoma and normal human mammary tissue. Breast Cancer Res. Treatment 18:57-61, 1991.

Tsubura, A., Okada, H., Sasaki, M., Dairkee, S., Morii, S. Immunohistochemical demonstration of keratins 8 and 14 in benign tumors of the skin appendage. Virchows Archiv. A. Pathol. Anat., 418:503-507, 1991.

Dairkee, S. H., and Heid, H. Cytokeratin profile of immunomagnetically separated epithelial subsets of the human mammary gland. In Vitro Cell. and Dev. Biol., 29A: 427-432, 1993.

Griffey, S.M., Madewell, B.R., Dairkee, S., Hunt, J.E., Naydan, D.K., and Higgins, RJ. Immunohistochemical reactivity of basal and luminal epithelial-specific cytokeratin antibodies within the normal and neoplastic canine mammary gland. Vet. Pathol., 30:155-161, 1993.

Dairkee, S.H., Deng, G., Stampfer, M.R., Waldman, F.M., and Smith, H.S. Selective cell culture of primary breast carcinoma. Cancer Research, 55:2516-2519, 1995.

Dairkee, S.H., Paulo, E.C., Traquina, P., Moore, D.H., Ljung, B-M., Smith, H.S. Partial Enzymatic Degradation of Stroma Allows Enrichment and Expansion of Primary Breast Tumor Cells. Cancer Research, 57:1590-1596, 1997.

Dairkee, S.H., Smith, H.S. Biological Basis of Genetic Predisposition to Breast Cancer. Advances in Oncobiology 2: 137-158, 1998.

Collins, C., Rommens, J.M., Kowbel, D., Godfrey, T., Tanner, M., Hwang, S., Polikoff, D., Nonet, G., Cochran, J., Myambo, K., Jay, K.E., Froula, J., Cloutier, T., Kuo, W., Yaswen, P., Dairkee, S., Giovanola, J., Hutchinson, G.B., Isola, J., Kallioniemi, O., Palazzolo, M., Martin, C., Erickson, C., Pinkel, D., Albertson, D., Li, W., Gray, J.W. Positional Cloning of ZABC1 and AIBC1: Genes Amplified at 20q13.2 and Overexpressed in Breast Carcinomas. Proc. Natl. Acad. Sci. USA 95:8703-8708, 1998.

Pinkel, D., Segraves, R., Sudar, D., Clark, S., Poole, I., Collins, C., Kuo, W., Chen, C., Zhai, Y., Dairkee, S., Ljung, B., Gray, J.W., Albertson, D.A. Comparative Genomic Hybridization to DNA Microarrays: High Resolution Analysis of Complex Patterns of Deletion and Amplification. Nature Genetics, 20: 207-211, 1998.

Li, Z., Bustos, V., Miner, J., Paulo, E., Meng, Z., Zlotnikov, G., Ljung, B-M., Dairkee, S.H. Propagation of Genetically Altered Tumor Cells Derived from Fine Needle Aspirates of Primary Breast Carcinoma. Cancer Research, 58: 5271-5274, 1998.

Albertson, D.G., Ylstra, B., Segraves, R., Collins, C., Dairkee, S.H., Kowbel, D., Kuo, W-L., Gray, J.W., Pinkel, D. Quantitative Mapping of Amplicon Structure by Array CGH Identifies Vitamin D 24 Hydroxylase (CYP 24) as a Candidate Oncogene. Nature Genetics, 25: 144-146, 2000.

Li, Z., Moore, D.H., Meng, Z., Ljung, B-M., Gray, J.W., Dairkee, S.H. Increased Risk of Local Recurrence is Associated with Allelic Loss in Normal Lobules of Breast Cancer Patients. Cancer Research, 62: 1000-1003, 2002.

Li, Z., Meng, Z., Chandrasekharan, R., Kuo, W-L., Collins, C.C., Gray, J.W., Dairkee, S.H. Biallelic Inactivation of the Thyroid Hormone Receptor ¤1 Gene in Early Stage Breast Cancer. Cancer Research, 62: 1939-1943, 2002.

Li, Z., Meng, Z., Shalaby, R., Ljung, B-M., Dairkee, S.H. Genome wide Alleotyping of a New In Vitro Model System Reveals Early Events in Breast Cancer Progression. Cancer Research, 62: 5980-5987, 2002.

Parmar, H., Young, P., Emerman, J.T., Neve, R.M., Dairkee, S.H., Cunha, G.R. A novel method for growing human breast epithelium in vivo using mouse and human mammary fibroblasts. Endocrinology, 143:4886-4896, 2002.

Korkola, J. E., DeVries, S., Fridlyand, J., Hwang, E. S., Estep, A. L., Chen, Y. Y., Chew, K. L., Dairkee, S. H., Jensen, R. M., Waldman, F. M. Differentiation of lobular versus ductal breast carcinomas by expression microarray analysis. Cancer Research, 63: 7167-7175, 2003.

Dairkee, S.H., Ji, Y., Ben, Y., Moore, D.H., Meng, Z., Jeffrey, S.S. A molecular 'signature' of primary breast cancer cultures; patterns resembling tumor tissue. BMC Genomics, 5: 47, 2004.

Meng, Z., Ben, Y., Li, Z., Chew, K., Ljung, B-M., Lagios, M.D., Dairkee, S.H. Breast cancer susceptibility gene aberrations occur early in sporadic breast tumors and in the acquisition of breast epithelial immortalization. Genes Chromosomes and Cancer, 41: 214-222, 2004.

3/15/05